Genomes and Genes
Experts and Doctors on carrier proteins in Warsaw, Masovian Voivodeship, Poland
Locale: Warsaw, Masovian Voivodeship, Poland
Topic: carrier proteins
- Liguz Lecznar M, Nowicka D, Czupryn A, Skangiel Kramska J. Dissociation of synaptic zinc level and zinc transporter 3 expression during postnatal development and after sensory deprivation in the barrel cortex of mice. Brain Res Bull. 2005;66:106-13 pubmed..These results suggest that in the barrel cortex ZnT3, synapsin I or synaptophysin are not determinant for the activity-dependent regulation of the synaptic zinc level. ..
- Dolinska M, Zabłocka B, Sonnewald U, Albrecht J. Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons. Neurochem Int. 2004;44:75-81 pubmed..System N-mediated (threonine+MeAiB-inhibitable) Gln uptake showed comparable activities in all four types of cells, which is compatible with the ubiquitous expression of NAT2 mRNA-a mouse brain-specific N-system isoform. ..
- Lisik W, Gong Y, Tejpal N, Skelton T, Bremer E, Kloc M, et al. Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model. Genesis. 2010;48:8-19 pubmed publisher..These novel findings may have important clinical implications for inhibition of chronic rejection in transplant recipients. ..
- Matyja E, Pronicki M, Kowalski P, Czarnowska E, Taybert J. Remodelling of skeletal muscle cells in children with SCO2 gene mutation - ultrastructural study. Folia Neuropathol. 2009;47:20-32 pubmed..SCO2 gene mutation should be included in differential diagnosis in children with such a pattern; however, lack of neurogenic changes does not exclude SCO2 gene mutation. ..
- Sobczak A, Debowska K, Blazejczyk M, Kreutz M, Kuznicki J, Wojda U. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochim Biophys Acta. 2011;1813:1025-37 pubmed publisher..This article is part of a Special Issue entitled: 11th European Symposium on Calcium. ..
- Borzęcka K, Płóciennikowska A, Björkelund H, Sobota A, Kwiatkowska K. CD14 mediates binding of high doses of LPS but is dispensable for TNF-? production. Mediators Inflamm. 2013;2013:824919 pubmed publisher..6-fold. The data indicate that CD14 together with SR participates in the binding of high doses of sLPS. However, CD14 contribution to TNF ? production induced by high concentrations of sLPS and rLPS can be limited. ..
- Karkusiewicz I, Rempola B, Gromadka R, Grynberg M, Rytka J. Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein. Biochem Biophys Res Commun. 2004;319:349-57 pubmed..The primary defect is apparently due to inefficient processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites. ..
- Kucharczyk R, Kierzek A, Slonimski P, Rytka J. The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae. J Cell Sci. 2001;114:3137-45 pubmed..These data suggest that Ccz1p and Ypt7p interact physically. Coimmunoprecipitation experiments provide direct evidence that this indeed is the case. A possible mechanism of Ccz1p action is discussed. ..
- Wojtczak L, Schonfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1993;1183:41-57 pubmed..As anionic amphiphiles, long-chain fatty acids increase the negative surface charge of biomembranes, thus interfering in their enzymic and transporting functions. ..
- Kevenaar J, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias C, et al. Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity. Curr Biol. 2016;26:849-61 pubmed publisher..We propose that misregulation of KBP-controlled kinesin motors may represent the underlying molecular mechanism that contributes to the neuropathological defects observed in GOSHS patients. ..
- Grzybowska E, Zayat V, Konopinski R, Trebinska A, Szwarc M, Sarnowska E, et al. HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing. FEBS J. 2013;280:256-72 pubmed publisher..These results suggest that HAX-1 may be involved in the regulation of expression of bound transcripts, possibly as part of the stress response. ..
- Hryniewicz M, Sirko A, Pałucha A, Bock A, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding. J Bacteriol. 1990;172:3358-66 pubmed..Preliminary sequence data from the corresponding region of the Salmonella typhimurium chromosome showed strictly homologous counterparts of the E. coli cysP and cysT genes. ..
- Blackford A, Nieminuszczy J, Schwab R, Galanty Y, Jackson S, Niedzwiedz W. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Mol Cell. 2015;57:1133-1141 pubmed publisher..Taken together, our findings provide molecular insights into a key tumor suppressor and genome stability network. ..
- Kroczynska B, Rafidi R, Majchrzak Kita B, Kościuczuk E, Blyth G, Jemielity J, et al. Interferon Î³ (IFNÎ³) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses. J Biol Chem. 2016;291:2389-96 pubmed publisher..Together, our findings establish a central role for mTORC2 in IFNÎ³ signaling and type II IFN responses. ..
- Fiedorowicz M, Makarewicz D, Stańczak Mrozek K, Grieb P. CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. Acta Neurobiol Exp (Wars). 2008;68:389-97 pubmed..In the context of the well-known excellent safety profile of citicoline, these data suggest that clinical evaluation of the efficacy of the drug in human birth asphyxia may be warranted...
- Golan M, Melquist S, Safranow K, Styczynska M, Słowik A, Kobryś M, et al. Analysis of UBQLN1 variants in a Polish Alzheimer's disease patient: control series. Dement Geriatr Cogn Disord. 2008;25:366-71 pubmed publisher..However, the association observed seems to be driven mostly by rare (<5%) haplotypes. Results suggest a need for additional association studies and in silico analysis of the UBQLN1 locus. ..
- Mikosa M, Sochacka Pietal M, Baj J, Bartosik D. Identification of a transposable genomic island of Paracoccus pantotrophus DSM 11072 by its transposition to a novel entrapment vector pMMB2. Microbiology. 2006;152:1063-73 pubmed
- Grzybowska E, Sarnowska E, Konopinski R, Wilczynska A, Sarnowski T, Siedlecki J. Identification and expression analysis of alternative splice variants of the rat Hax-1 gene. Gene. 2006;371:84-92 pubmed..Interestingly, high mRNA level in testes does not translate into high protein level, suggesting the existence of tissue-specific translational regulation or regulated protein degradation. ..
- Sirko A, Zatyka M, Sadowy E, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins. J Bacteriol. 1995;177:4134-6 pubmed..The single cysP and sbp mutants are able to utilize both sulfate and thiosulfate as a sole sulfur source, while the inactivation of both genes leads to cysteine auxotrophy resulting from the block in the transport of both ions. ..
- Banach Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M. Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem J. 2009;423:389-400 pubmed publisher..In a broader sense, these results contribute to an emerging theme of endocytic proteins playing alternative roles in the cell nucleus. ..
- Lehner M, Wisłowska Stanek A, Skórzewska A, Maciejak P, Szyndler J, Turzyńska D, et al. Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning. Neurobiol Learn Mem. 2010;94:499-508 pubmed publisher..The obtained data may also help to better explain the neurobiological mechanisms that operate in clinical situations where anxious patients subjected to exposure therapy are exposed to an aversive, contextual and conditioning stimulus. ..
- Kaminska J, Gajewska B, Hopper A, Zoładek T. Rsp5p, a new link between the actin cytoskeleton and endocytosis in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:6946-8 pubmed..iv) rsp5-w1 mutants are resistant to latrunculin A, a drug that sequesters actin monomers and depolymerizes actin filaments, consistent with the fact that Rsp5p is involved in actin cytoskeleton dynamics. ..
- Geiger J, Lipka J, Segura I, Hoyer S, Schlager M, Wulf P, et al. The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Dev Cell. 2014;28:381-93 pubmed publisher..Together, our results show a regulatory role for GRIP1 during microtubule-based transport and suggest a crucial function for 14-3-3 proteins in controlling kinesin-1 motor attachment during neuronal development. ..
- Acuna Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham S, van Dam S, et al. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017;13:e1006683 pubmed publisher..Drawing on previous studies of somatic SETBP1 mutations in leukemia, our results reveal a genotype-phenotype correlation in germline SETBP1 mutations spanning a molecular, cellular and clinical phenotype. ..
- Sirko A, Hryniewicz M, Hulanicka D, Bock A. Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster. J Bacteriol. 1990;172:3351-7 pubmed..Expression of the four genes was analyzed in the T7 promoter-polymerase system. ..
- King F, Wawrzynow A, Hohfeld J, Zylicz M. Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J. 2001;20:6297-305 pubmed..The results presented here provide possible molecular mechanisms that can help to explain the observed in vivo role of molecular chaperones in the stabilization and cellular localization of wild-type and mutant p53 protein. ..
- Wisniewska M, Nagalski A, Dabrowski M, Misztal K, Kuznicki J. Novel ?-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability. BMC Genomics. 2012;13:635 pubmed publisher..This implies that the transcriptional activity of ?-catenin is necessary for the proper excitability of thalamic neurons, may influence activity in the thalamocortical circuit, and may contribute to thalamic pathologies. ..
- Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem. 2009;284:18115-28 pubmed publisher..We propose that APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex. ..
- Pronicki M, Kowalski P, Piekutowska Abramczuk D, Taybert J, Karkucinska Wieckowska A, Szymanska Debinska T, et al. A homozygous mutation in the SCO2 gene causes a spinal muscular atrophy like presentation with stridor and respiratory insufficiency. Eur J Paediatr Neurol. 2010;14:253-60 pubmed publisher