Experts and Doctors on carrier proteins in Warsaw, Masovian Voivodeship, Poland


Locale: Warsaw, Masovian Voivodeship, Poland
Topic: carrier proteins

Top Publications

  1. Bronisz A, Gajkowska B, Domanska Janik K. PKC and Raf-1 inhibition-related apoptotic signalling in N2a cells. J Neurochem. 2002;81:1176-84 pubmed
    ..In this case, only simultaneous inhibition of PKC and PI3-K is able to induce apoptosis. ..
  2. Paciorek J. Virulence properties of Escherichia coli faecal strains isolated in Poland from healthy children and strains belonging to serogroups O18, O26, O44, O86, O126 and O127 isolated from children with diarrhoea. J Med Microbiol. 2002;51:548-56 pubmed
    ..There was also strong correlation between haemolytic activity (Hly) and the presence of P-fimbriae. No correlation was found between the presence of the cnf1 gene and CD, Hly or P-fimbriae. ..
  3. Rozynek E, Dzierzanowska Fangrat K, Jozwiak P, Popowski J, Korsak D, Dzierzanowska D. Prevalence of potential virulence markers in Polish Campylobacter jejuni and Campylobacter coli isolates obtained from hospitalized children and from chicken carcasses. J Med Microbiol. 2005;54:615-9 pubmed
    ..2% of chicken C. coli isolates. This different distribution of genetic markers between human and chicken isolates indicates that some Campylobacter infections in children may have additional sources other than contaminated chicken meat. ..
  4. Brzoska K, Stępkowski T, Kruszewski M. Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice. Redox Rep. 2011;16:129-33 pubmed publisher
    ..The highest expression was found in the liver and the lowest in the spleen and kidney. Based on literature data, we propose the involvement of Nrf2, AP-1, and NF-?B transcription factors in Pir up-regulation in Sod1(-/-) mice. ..
  5. Sobczynska Tomaszewska A, Bak D, Oralewska B, Oracz G, Norek A, Czerska K, et al. Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2006;43:299-306 pubmed
    ..No association between CFTR mutations and pancreatitis was observed. The importance of AAT variants remains speculative. ..
  6. Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska Anyszka M, Wyslouch Cieszynska A, Dadlez M, et al. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol. 2002;319:615-35 pubmed
    ..Phosphorylation of 4E-BP1 at Ser65 and Thr70 is insufficient to prevent binding to eIF4E. Enhancement of the eIF4E affinity for cap occurs after binding to eIF4G peptides. ..
  7. Boraska V, Franklin C, Floyd J, Thornton L, Huckins L, Southam L, et al. A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014;19:1085-94 pubmed publisher
    ..The accrual of large genotyped AN case-control samples should be an immediate priority for the field. ..
  8. Filipek R, Rzychon M, Oleksy A, Gruca M, Dubin A, Potempa J, et al. The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease. J Biol Chem. 2003;278:40959-66 pubmed publisher
    ..Mutations in this residue lead to a loss of affinity of the inhibitor for protease and convert the inhibitor into a substrate...
  9. Daniluk P, Lesyng B. A novel method to compare protein structures using local descriptors. BMC Bioinformatics. 2011;12:344 pubmed publisher
    ..It is well suited to improving automatic classification of structure domains, helping analyze protein fold space, or to improving protein classification schemes. DEDAL is available online at ..

More Information


  1. Liguz Lecznar M, Nowicka D, Czupryn A, Skangiel Kramska J. Dissociation of synaptic zinc level and zinc transporter 3 expression during postnatal development and after sensory deprivation in the barrel cortex of mice. Brain Res Bull. 2005;66:106-13 pubmed
    ..These results suggest that in the barrel cortex ZnT3, synapsin I or synaptophysin are not determinant for the activity-dependent regulation of the synaptic zinc level. ..
  2. Dolinska M, Zabłocka B, Sonnewald U, Albrecht J. Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons. Neurochem Int. 2004;44:75-81 pubmed
    ..System N-mediated (threonine+MeAiB-inhibitable) Gln uptake showed comparable activities in all four types of cells, which is compatible with the ubiquitous expression of NAT2 mRNA-a mouse brain-specific N-system isoform. ..
  3. Lisik W, Gong Y, Tejpal N, Skelton T, Bremer E, Kloc M, et al. Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model. Genesis. 2010;48:8-19 pubmed publisher
    ..These novel findings may have important clinical implications for inhibition of chronic rejection in transplant recipients. ..
  4. Matyja E, Pronicki M, Kowalski P, Czarnowska E, Taybert J. Remodelling of skeletal muscle cells in children with SCO2 gene mutation - ultrastructural study. Folia Neuropathol. 2009;47:20-32 pubmed
    ..SCO2 gene mutation should be included in differential diagnosis in children with such a pattern; however, lack of neurogenic changes does not exclude SCO2 gene mutation. ..
  5. Sobczak A, Debowska K, Blazejczyk M, Kreutz M, Kuznicki J, Wojda U. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochim Biophys Acta. 2011;1813:1025-37 pubmed publisher
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium. ..
  6. Borzęcka K, Płóciennikowska A, Björkelund H, Sobota A, Kwiatkowska K. CD14 mediates binding of high doses of LPS but is dispensable for TNF-? production. Mediators Inflamm. 2013;2013:824919 pubmed publisher
    ..6-fold. The data indicate that CD14 together with SR participates in the binding of high doses of sLPS. However, CD14 contribution to TNF ? production induced by high concentrations of sLPS and rLPS can be limited. ..
  7. Karkusiewicz I, Rempola B, Gromadka R, Grynberg M, Rytka J. Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein. Biochem Biophys Res Commun. 2004;319:349-57 pubmed
    ..The primary defect is apparently due to inefficient processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites. ..
  8. Kucharczyk R, Kierzek A, Slonimski P, Rytka J. The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae. J Cell Sci. 2001;114:3137-45 pubmed
    ..These data suggest that Ccz1p and Ypt7p interact physically. Coimmunoprecipitation experiments provide direct evidence that this indeed is the case. A possible mechanism of Ccz1p action is discussed. ..
  9. Wojtczak L, Schonfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1993;1183:41-57 pubmed
    ..As anionic amphiphiles, long-chain fatty acids increase the negative surface charge of biomembranes, thus interfering in their enzymic and transporting functions. ..
  10. Kevenaar J, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias C, et al. Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity. Curr Biol. 2016;26:849-61 pubmed publisher
    ..We propose that misregulation of KBP-controlled kinesin motors may represent the underlying molecular mechanism that contributes to the neuropathological defects observed in GOSHS patients. ..
  11. Grzybowska E, Zayat V, Konopinski R, Trebinska A, Szwarc M, Sarnowska E, et al. HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing. FEBS J. 2013;280:256-72 pubmed publisher
    ..These results suggest that HAX-1 may be involved in the regulation of expression of bound transcripts, possibly as part of the stress response. ..
  12. Hryniewicz M, Sirko A, Pałucha A, Bock A, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding. J Bacteriol. 1990;172:3358-66 pubmed
    ..Preliminary sequence data from the corresponding region of the Salmonella typhimurium chromosome showed strictly homologous counterparts of the E. coli cysP and cysT genes. ..
  13. Blackford A, Nieminuszczy J, Schwab R, Galanty Y, Jackson S, Niedzwiedz W. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Mol Cell. 2015;57:1133-1141 pubmed publisher
    ..Taken together, our findings provide molecular insights into a key tumor suppressor and genome stability network. ..
  14. Kroczynska B, Rafidi R, Majchrzak Kita B, Kościuczuk E, Blyth G, Jemielity J, et al. Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses. J Biol Chem. 2016;291:2389-96 pubmed publisher
    ..Together, our findings establish a central role for mTORC2 in IFNγ signaling and type II IFN responses. ..
  15. Fiedorowicz M, Makarewicz D, Stańczak Mrozek K, Grieb P. CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. Acta Neurobiol Exp (Wars). 2008;68:389-97 pubmed
    ..In the context of the well-known excellent safety profile of citicoline, these data suggest that clinical evaluation of the efficacy of the drug in human birth asphyxia may be warranted...
  16. Golan M, Melquist S, Safranow K, Styczynska M, Słowik A, Kobryś M, et al. Analysis of UBQLN1 variants in a Polish Alzheimer's disease patient: control series. Dement Geriatr Cogn Disord. 2008;25:366-71 pubmed publisher
    ..However, the association observed seems to be driven mostly by rare (<5%) haplotypes. Results suggest a need for additional association studies and in silico analysis of the UBQLN1 locus. ..
  17. Mikosa M, Sochacka Pietal M, Baj J, Bartosik D. Identification of a transposable genomic island of Paracoccus pantotrophus DSM 11072 by its transposition to a novel entrapment vector pMMB2. Microbiology. 2006;152:1063-73 pubmed
  18. Grzybowska E, Sarnowska E, Konopinski R, Wilczynska A, Sarnowski T, Siedlecki J. Identification and expression analysis of alternative splice variants of the rat Hax-1 gene. Gene. 2006;371:84-92 pubmed
    ..Interestingly, high mRNA level in testes does not translate into high protein level, suggesting the existence of tissue-specific translational regulation or regulated protein degradation. ..
  19. Filipek R, Potempa J, Bochtler M. A comparison of staphostatin B with standard mechanism serine protease inhibitors. J Biol Chem. 2005;280:14669-74 pubmed publisher
  20. Sirko A, Zatyka M, Sadowy E, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins. J Bacteriol. 1995;177:4134-6 pubmed
    ..The single cysP and sbp mutants are able to utilize both sulfate and thiosulfate as a sole sulfur source, while the inactivation of both genes leads to cysteine auxotrophy resulting from the block in the transport of both ions. ..
  21. Banach Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M. Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem J. 2009;423:389-400 pubmed publisher
    ..In a broader sense, these results contribute to an emerging theme of endocytic proteins playing alternative roles in the cell nucleus. ..
  22. Puhakka N, Bot A, Vuokila N, Dębski K, Lukasiuk K, Pitkanen A. Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury. PLoS ONE. 2017;12:e0172521 pubmed publisher
  23. Michowski W, Ferretti R, Wisniewska M, Ambrozkiewicz M, Beresewicz M, Fusella F, et al. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta. 2010;1803:1043-9 pubmed publisher
  24. Lehner M, Wisłowska Stanek A, Skórzewska A, Maciejak P, Szyndler J, Turzyńska D, et al. Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning. Neurobiol Learn Mem. 2010;94:499-508 pubmed publisher
    ..The obtained data may also help to better explain the neurobiological mechanisms that operate in clinical situations where anxious patients subjected to exposure therapy are exposed to an aversive, contextual and conditioning stimulus. ..
  25. Kaminska J, Gajewska B, Hopper A, Zoładek T. Rsp5p, a new link between the actin cytoskeleton and endocytosis in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:6946-8 pubmed
    ..iv) rsp5-w1 mutants are resistant to latrunculin A, a drug that sequesters actin monomers and depolymerizes actin filaments, consistent with the fact that Rsp5p is involved in actin cytoskeleton dynamics. ..
  26. Geiger J, Lipka J, Segura I, Hoyer S, Schlager M, Wulf P, et al. The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Dev Cell. 2014;28:381-93 pubmed publisher
    ..Together, our results show a regulatory role for GRIP1 during microtubule-based transport and suggest a crucial function for 14-3-3 proteins in controlling kinesin-1 motor attachment during neuronal development. ..
  27. Acuna Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham S, van Dam S, et al. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017;13:e1006683 pubmed publisher
    ..Drawing on previous studies of somatic SETBP1 mutations in leukemia, our results reveal a genotype-phenotype correlation in germline SETBP1 mutations spanning a molecular, cellular and clinical phenotype. ..
  28. Sirko A, Hryniewicz M, Hulanicka D, Bock A. Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster. J Bacteriol. 1990;172:3351-7 pubmed
    ..Expression of the four genes was analyzed in the T7 promoter-polymerase system. ..
  29. King F, Wawrzynow A, Hohfeld J, Zylicz M. Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J. 2001;20:6297-305 pubmed
    ..The results presented here provide possible molecular mechanisms that can help to explain the observed in vivo role of molecular chaperones in the stabilization and cellular localization of wild-type and mutant p53 protein. ..
  30. Wisniewska M, Nagalski A, Dabrowski M, Misztal K, Kuznicki J. Novel ?-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability. BMC Genomics. 2012;13:635 pubmed publisher
    ..This implies that the transcriptional activity of ?-catenin is necessary for the proper excitability of thalamic neurons, may influence activity in the thalamocortical circuit, and may contribute to thalamic pathologies. ..
  31. Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem. 2009;284:18115-28 pubmed publisher
    ..We propose that APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex. ..
  32. Pronicki M, Kowalski P, Piekutowska Abramczuk D, Taybert J, Karkucinska Wieckowska A, Szymanska Debinska T, et al. A homozygous mutation in the SCO2 gene causes a spinal muscular atrophy like presentation with stridor and respiratory insufficiency. Eur J Paediatr Neurol. 2010;14:253-60 pubmed publisher