Experts and Doctors on zebrafish in Oslo, Norway


Locale: Oslo, Norway
Topic: zebrafish

Top Publications

  1. Lindeman L, Andersen I, Reiner A, Li N, Aanes H, Østrup O, et al. Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Dev Cell. 2011;21:993-1004 pubmed publisher
    ..Our data suggest that histone modifications are instructive for the developmental gene expression program. ..
  2. Evensen L, Johansen P, Koster G, Zhu K, Herfindal L, Speth M, et al. Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 2016;8:862-77 pubmed publisher
    ..These results show that zebrafish embryo is a powerful system for microscopy-based screening of NPs on the route to preclinical testing. ..
  3. Lindeman L, Vogt Kielland L, Alestrom P, Collas P. Fish'n ChIPs: chromatin immunoprecipitation in the zebrafish embryo. Methods Mol Biol. 2009;567:75-86 pubmed publisher
    ..We also incorporated key steps from a recently published ChIP assay for small cell numbers. We report here a protocol for immunoprecipitation of modified histones from mid-term blastula zebrafish embryos. ..
  4. Mamińska A, Bartosik A, Banach Orłowska M, Pilecka I, Jastrzębski K, Zdżalik Bielecka D, et al. ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors. Sci Signal. 2016;9:ra8 pubmed publisher
    ..These data suggest that ESCRTs constitutively control the distribution of cytokine receptors in their ligand-free state to restrict their signaling, which may represent a general mechanism to prevent spurious activation of NF-κB. ..
  5. Mikalsen A, Torgersen J, Alestrom P, Hellemann A, Koppang E, Rimstad E. Protection of atlantic salmon Salmo salar against infectious pancreatic necrosis after DNA vaccination. Dis Aquat Organ. 2004;60:11-20 pubmed
    ..A high level of protection was induced only by the plasmid combination that contained a plasmid expressing all the large ORF polyprotein. ..
  6. Hurem S, Martín L, Brede D, Skjerve E, Nourizadeh Lillabadi R, Lind O, et al. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. PLoS ONE. 2017;12:e0179259 pubmed publisher
    ..The present findings show that continuous gamma irradiation (? 0.54 mGy/h) during early gastrula causes gene expression changes that are linked to developmental defects in zebrafish embryos. ..
  7. Lagos L, Tandberg J, Repnik U, Boysen P, Ropstad E, Varkey D, et al. Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..1, and ighm, was upregulated, thus confirming the immunogenic properties of F. noatunensis subsp. orientalis-derived MVs. ..
  8. Brudal E, Ulanova L, O Lampe E, Rishovd A, Griffiths G, Winther Larsen H. Establishment of three Francisella infections in zebrafish embryos at different temperatures. Infect Immun. 2014;82:2180-94 pubmed publisher
    ..The results demonstrate the usefulness of the zebrafish embryo model for studying infections caused by different Francisella species at a wide range of temperatures and highlight their interactions with immune cells. ..
  9. Aanes H, Østrup O, Andersen I, Moen L, Mathavan S, Collas P, et al. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. BMC Genomics. 2013;14:331 pubmed publisher
    ..Our data display an array of isoform-related functional changes and represent a valuable resource complementary to existing early embryo transcriptomes. ..

More Information


  1. Hurem S, Gomes T, Brede D, Lindbo Hansen E, Mutoloki S, Fernandez C, et al. Parental gamma irradiation induces reprotoxic effects accompanied by genomic instability in zebrafish (Danio rerio) embryos. Environ Res. 2017;159:564-578 pubmed publisher
    ..The results therefore highlight the necessity for multi- and transgenerational studies to assess the environmental impact of gamma radiation. ..
  2. Fraser T, Khezri A, Jusdado J, Lewandowska Sabat A, Henry T, Ropstad E. Toxicant induced behavioural aberrations in larval zebrafish are dependent on minor methodological alterations. Toxicol Lett. 2017;276:62-68 pubmed publisher
    ..As such, our results have significant consequences for human and environmental risk assessment. ..
  3. Andersen I, Lindeman L, Reiner A, Østrup O, Aanes H, Alestrom P, et al. Epigenetic marking of the zebrafish developmental program. Curr Top Dev Biol. 2013;104:85-112 pubmed publisher
    ..From these observations, a concept of epigenetic prepatterning of the embryonic gene expression program prior to the onset of ZGA is emerging. The recent data collectively start shedding light on how ZGA may be programmed and regulated...
  4. Lyche J, Nourizadeh Lillabadi R, Karlsson C, Stavik B, Berg V, Skåre J, et al. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquat Toxicol. 2011;102:197-204 pubmed publisher
  5. Lindeman L, Reiner A, Mathavan S, Alestrom P, Collas P. Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS ONE. 2010;5:e15651 pubmed publisher
    ..We have designed and validated for the scientific community a comprehensive high-resolution tiling microarray for investigations of epigenetic states in zebrafish, a widely used developmental and disease model organism. ..
  6. Andersen I, Ostrup O, Lindeman L, Aanes H, Reiner A, Mathavan S, et al. Epigenetic complexity during the zebrafish mid-blastula transition. Biochem Biophys Res Commun. 2012;417:1139-44 pubmed publisher
    ..Thus enrichment in trimethylated H3K9 or H3K27 is associated with local remodeling of chromatin manifested by changes in H3K4me3 density. We propose that metagenes can provide information on the multivalency of chromatin sates...
  7. Aanes H, Winata C, Lin C, Chen J, Srinivasan K, Lee S, et al. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome Res. 2011;21:1328-38 pubmed publisher
    ..Taken together, our data constitute a useful genomic information and valuable transcriptome resource for gene discovery and for understanding the mechanisms of early embryogenesis in zebrafish. ..
  8. Nourizadeh Lillabadi R, Seilø Torgersen J, Vestrheim O, König M, Alestrom P, Syed M. Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants. PLoS ONE. 2010;5:e13573 pubmed publisher
  9. Lindeman L, Winata C, Aanes H, Mathavan S, Alestrom P, Collas P. Chromatin states of developmentally-regulated genes revealed by DNA and histone methylation patterns in zebrafish embryos. Int J Dev Biol. 2010;54:803-13 pubmed publisher
    ..Our results suggest that differentially expressed embryonic genes are regulated by various patterns of histone modifications on unmethylated DNA, which create a developmentally permissive chromatin state. ..
  10. Nourizadeh Lillabadi R, Lyche J, Almaas C, Stavik B, Moe S, Aleksandersen M, et al. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). J Toxicol Environ Health A. 2009;72:112-30 pubmed publisher
    ..The effects observed in the experimental zebrafish model raise the question of whether chemical pollution represents a risk to the reproductive health of wild fish inhabiting the freshwater system. ..
  11. Collas P, Alestrom P. Nuclear localization signals enhance germline transmission of a transgene in zebrafish. Transgenic Res. 1998;7:303-9 pubmed
    ..In addition, high-resolution FISH analysis of transgenic F1s reveals that the use of NLS increases the number of distinct transgene integration sites along chromatin fibres. ..