Experts and Doctors on ldl receptors in Leiden, South Holland, Netherlands


Locale: Leiden, South Holland, Netherlands
Topic: ldl receptors

Top Publications

  1. Goudriaan J, Tacken P, Dahlmans V, Gijbels M, van Dijk K, Havekes L, et al. Protection from obesity in mice lacking the VLDL receptor. Arterioscler Thromb Vasc Biol. 2001;21:1488-93 pubmed
    ..These results suggest that the VLDLR plays a role in the delivery of VLDL-derived fatty acids into adipose tissue. ..
  2. Espirito Santo S, Pires N, Boesten L, Gerritsen G, Bovenschen N, van Dijk K, et al. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood. 2004;103:3777-82 pubmed
    ..1 vs 219.1 +/- 86.0 10(3)microm(2), P =.003). Our data indicate that hepatic LRP plays a clear protective role in atherogenesis independent of plasma cholesterol, possibly due to maintaining low levels of its proatherogenic ligands. ..
  3. Van Eck M, Singaraja R, Ye D, Hildebrand R, James E, Hayden M, et al. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2006;26:929-34 pubmed
    ..However, the possibly beneficial effects of specific upregulation of macrophage ABCA1 on atherogenesis are still unknown...
  4. Van Eck M, Ye D, Hildebrand R, Kar Kruijt J, de Haan W, Hoekstra M, et al. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ Res. 2007;100:678-85 pubmed
    ..Most importantly, we show for the first time that bone marrow-derived CETP is an important contributor to total serum CETP activity and mass. ..
  5. de Nooijer R, Bot I, von der Thüsen J, Leeuwenburgh M, Overkleeft H, Kraaijeveld A, et al. Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:188-94 pubmed publisher
    ..Leukocyte CatS deficiency results in considerably altered plaque morphology, with smaller necrotic cores, reduced apoptosis, and decreased SMC content and collagen deposition and may thus be critical in plaque stability. ..
  6. Verschuren L, Kooistra T, Bernhagen J, Voshol P, Ouwens D, van Erk M, et al. MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res. 2009;105:99-107 pubmed publisher
  7. Van Es T, van Puijvelde G, Ramos O, Segers F, Joosten L, van den Berg W, et al. Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem Biophys Res Commun. 2009;388:261-5 pubmed publisher
    ..In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis. ..
  8. Tacken P, Hofker M, Havekes L, van Dijk K. Living up to a name: the role of the VLDL receptor in lipid metabolism. Curr Opin Lipidol. 2001;12:275-9 pubmed
  9. Van Eck M, Bos I, Hildebrand R, Van Rij B, Van Berkel T. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am J Pathol. 2004;165:785-94 pubmed
    ..It thus appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogenic, indicating a unique dual role in the pathogenesis of atherosclerosis. ..

More Information


  1. Hauer A, Habets K, van Wanrooij E, de Vos P, Krueger J, Reisfeld R, et al. Vaccination against TIE2 reduces atherosclerosis. Atherosclerosis. 2009;204:365-71 pubmed publisher
    ..Therefore, vaccination strategies that target cells that contribute to atherosclerosis, may be of potential use in the development of novel treatments of atherosclerosis. ..
  2. Van Es T, van Puijvelde G, Foks A, Habets K, Bot I, Gilboa E, et al. Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis. Atherosclerosis. 2010;209:74-80 pubmed publisher
    ..The results illustrate the important role for Foxp3-expressing regulatory T cells in atherosclerosis, thereby providing a potential opportunity for therapeutic intervention against this disease. ..
  3. Jong M, Dahlmans V, van Gorp P, van Dijk K, Breuer M, Hofker M, et al. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest. 1996;98:2259-67 pubmed
    ..60+/-10 and 38+/-7 mmol/liter, respectively). From these studies we conclude that, in the absence of the LDLR, apoC1 inhibits the hepatic uptake of VLDL via a RAP-sensitive pathway. ..
  4. Van Eck M, Hoekstra M, Out R, Bos I, Kruijt J, Hildebrand R, et al. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. J Lipid Res. 2008;49:136-46 pubmed
    ..In conclusion, SR-BI plays an important physiological role in the metabolism of VLDL (remnants). ..
  5. Hoekstra M, Li Z, Kruijt J, Van Eck M, Van Berkel T, Kuiper J. The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status. J Hepatol. 2010;52:244-51 pubmed publisher
    ..It appears that the NAFLD-related gene PNPLA3 is highly responsive to metabolic changes in hepatocytes within the liver and its relative change in expression level suggests an essential function in lipogenesis. ..
  6. Hoekstra M, Korporaal S, Li Z, Zhao Y, Van Eck M, Van Berkel T. Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice. Am J Physiol Endocrinol Metab. 2010;299:E1038-43 pubmed publisher
    ..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice. ..