Experts and Doctors on glucocorticoids in Leiden, South Holland, Netherlands
Locale: Leiden, South Holland, Netherlands
van der Laan S, Lachize S, Vreugdenhil E, de Kloet E, Meijer O. Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene. Endocrinology. 2008;149:725-32 pubmed
..We conclude that modulation of coregulator activity may play a role in the control of the hypothalamus-pituitary-adrenal axis. ..
van der Laan S, Sarabdjitsingh R, Van Batenburg M, Lachize S, Li H, Dijkmans T, et al
. Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain. J Neurochem. 2008;106:2515-23 pubmed publisher
Hoekstra M, Korporaal S, van der Sluis R, Hirsch Reinshagen V, Bochem A, Wellington C, et al
. LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function. J Lipid Res. 2013;54:358-64 pubmed publisher
..These findings further highlight the important novel role for HDL as cholesterol donor for the synthesis of glucocorticoids by the adrenals. ..
Straathof C, Overweg Plandsoen W, van den Burg G, van der Kooi A, Verschuuren J, de Groot I. Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophy. J Neurol. 2009;256:768-73 pubmed publisher
..Our data suggest that prednisone 10 on/10 off has relatively few side effects and extends the ambulant phase by 1 year compared to historical controls...
Hoekstra M, Korporaal S, Li Z, Zhao Y, Van Eck M, Van Berkel T. Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice. Am J Physiol Endocrinol Metab. 2010;299:E1038-43 pubmed publisher
..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice. ..
Speksnijder N, Christensen K, Didriksen M, de Kloet E, Datson N. Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context. J Mol Neurosci. 2012;48:209-18 pubmed publisher
..At the same time, GR influences MEF2 activity and DNA binding. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity. ..
Claessens S, Belanoff J, Kanatsou S, Lucassen P, Champagne D, de Kloet E. Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy. Brain Res. 2012;1482:1-12 pubmed publisher
..These acute alterations in the neonate brain might underlie later functional impairments reported in DEX-treated animals and humans and further illustrate the impact of early GR activation on brain development. ..
Smolen J, Landewe R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, et al
. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960-977 pubmed publisher