Experts and Doctors on chondrocytes in Leiden, South Holland, Netherlands


Locale: Leiden, South Holland, Netherlands
Topic: chondrocytes

Top Publications

  1. Hoogendam J, Farih Sips H, van Beek E, Lowik C, Wit J, Karperien M. Novel late response genes of PTHrP in chondrocytes. Horm Res. 2007;67:159-70 pubmed
    ..The expression of late PTHrP response genes varied between ATDC5 chondrocytes, KS483 osteoblasts and metatarsals, suggesting that the expression of late response genes is dependent on the cellular context of the PTHrP responsive cells. ..
  2. Bos S, Slagboom P, Meulenbelt I. New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol. 2008;20:553-9 pubmed publisher
    ..Major therapeutic advances may come from a focus on factors that enhance phenotypic stability of the articular chondrocyte during life, promoting the healthy articular cartilage. ..
  3. Miclea R, van der Horst G, Robanus Maandag E, Lowik C, Oostdijk W, Wit J, et al. Apc bridges Wnt/?-catenin and BMP signaling during osteoblast differentiation of KS483 cells. Exp Cell Res. 2011;317:1411-21 pubmed publisher
    ..Apc knockdown blocks the osteogenic differentiation of skeletal progenitor cells, a process that can be overruled by high BMP signaling. ..
  4. Deckers M, Smits P, Karperien M, Ni J, Tylzanowski P, Feng P, et al. Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro. Bone. 2001;28:14-20 pubmed
    ..These results suggest that Ecm1a acts as a novel negative regulator of endochondral bone formation. ..
  5. Romeo S, Bovee J, Grogan S, Taminiau A, Eilers P, Cleton Jansen A, et al. Chondromyxoid fibroma resembles in vitro chondrogenesis, but differs in expression of signalling molecules. J Pathol. 2005;206:135-42 pubmed
    ..Morphological similarities reflect common steps in cartilage differentiation, albeit driven by different molecular mechanisms. The proteins we have found to be differentially expressed seem crucial for neoplastic chondrogenesis...
  6. Romeo S, Eyden B, Prins F, Briaire de Bruijn I, Taminiau A, Hogendoorn P. TGF-beta1 drives partial myofibroblastic differentiation in chondromyxoid fibroma of bone. J Pathol. 2006;208:26-34 pubmed
    ..Fibronectin-EDA levels were low. We have therefore substantiated the presence of morphological, immunohistochemical, and immuno-electron microscopic partial myofibroblastic differentiation in CMF, driven by TGF-beta1 signalling...
  7. Emons J, Chagin A, Malmlöf T, Lekman M, Tivesten A, Ohlsson C, et al. Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development. J Endocrinol. 2010;205:61-8 pubmed publisher
    ..We conclude that estrogens regulate VEGF expression in the epiphyseal growth plate, although the precise role of VEGF in estrogen-mediated growth plate fusion remains to be clarified. ..
  8. de Andrea C, Prins F, Wiweger M, Hogendoorn P. Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. J Pathol. 2011;224:160-8 pubmed publisher
    ..g., lack of PEI gradients). The cells in the reduced PEI-stained areas are likely associated with loss-of-function mutations in the EXT genes, and they might contribute to tumour initiation by disrupting the gradients...
  9. Miclea R, Siebelt M, Finos L, Goeman J, Lowik C, Oostdijk W, et al. Inhibition of Gsk3? in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway. Osteoarthritis Cartilage. 2011;19:1363-72 pubmed publisher
    ..Short term ?-catenin up-regulation in cartilage secondary to Gsk3? inhibition may be sufficient to induce osteoarthritis-like features in vivo. ..

More Information


  1. Mohseny A, Cai Y, Kuijjer M, Xiao W, van den Akker B, de Andrea C, et al. The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma. Eur J Cancer. 2012;48:3429-38 pubmed publisher
    ..This may imply that drugs restoring impaired signalling pathways in osteosarcoma might change the tumour's aggressive clinical course, however targeted pathway modulation in vitro did not affect cell proliferation...