Experts and Doctors on callithrix in Rijswijk, South Holland, Netherlands
Locale: Rijswijk, South Holland, Netherlands
van Helden H, Trap H, Oostdijk J, Kuijpers W, Langenberg J, Benschop H. Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: lowest observable effect level. Toxicol Appl Pharmacol. 2003;189:170-9 pubmed
t Hart B, Massacesi L. Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J Neuropathol Exp Neurol. 2009;68:341-55 pubmed publisher
..Moreover, this model provides new insights into possible pathogenetic mechanisms in MS. ..
Jagessar S, Kap Y, Heijmans N, van Driel N, van Straalen L, Bajramovic J, et al
. Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete freund adjuvant. J Neuropathol Exp Neurol. 2010;69:372-85 pubmed publisher
Kap Y, van Driel N, Blezer E, Parren P, Bleeker W, Laman J, et al
. Late B cell depletion with a human anti-human CD20 IgG1? monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets. J Immunol. 2010;185:3990-4003 pubmed publisher
..In conclusion, B cell depletion prevents the development of clinical and pathological signs of EAE, which is associated with impaired activation of MOG-reactive T cells in lymphoid organs. ..
Kap Y, Bauer J, Driel N, Bleeker W, Parren P, Kooi E, et al
. B-cell depletion attenuates white and gray matter pathology in marmoset experimental autoimmune encephalomyelitis. J Neuropathol Exp Neurol. 2011;70:992-1005 pubmed publisher
..These data underline the central role of B cells in CNS inflammatory-demyelinating disease...
t Hart B, Abbott D, Nakamura K, Fuchs E. The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease. Drug Discov Today. 2012;17:1160-5 pubmed publisher
..In this Feature article we will highlight the common marmoset, a small-bodied nonhuman primate (NHP), as a useful model in biomedical and preclinical translational research. ..
Jagessar S, Heijmans N, Oh L, Bauer J, Blezer E, Laman J, et al
. Antibodies against human BLyS and APRIL attenuate EAE development in marmoset monkeys. J Neuroimmune Pharmacol. 2012;7:557-70 pubmed publisher
..In conclusion, treatment with anti-BLyS and anti-APRIL delays the development of neurological disease in a relevant preclinical model of MS. The two mAbs achieve this effect via different mechanisms...
van der Wiel M, Otting N, de Groot N, Doxiadis G, Bontrop R. The repertoire of MHC class I genes in the common marmoset: evidence for functional plasticity. Immunogenetics. 2013;65:841-9 pubmed publisher
..These data highlight the extreme plasticity of the MHC class I gene system. ..