Experts and Doctors on male in Nijmegen, Gelderland, Netherlands


Locale: Nijmegen, Gelderland, Netherlands
Topic: male

Top Publications

  1. van der Horst H, de Wall L. Hypospadias, all there is to know. Eur J Pediatr. 2017;176:435-441 pubmed publisher
    ..What is New: • Long-term complications include urinary tract symptoms and sexual and cosmetic issues. • New developments allow a more individualized approach, hopefully leading to less complications and more patient satisfaction. ..
  2. Richters A, Melis R, van Exel N, Olde Rikkert M, van der Marck M. Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity. Alzheimers Res Ther. 2017;9:26 pubmed publisher
    ..The predictive power of perseverance time scores for living situation exceeds the predictive power of other burden measures and indicates informal care as an important factor for maintaining the patient at home. ..
  3. Lessel D, Schob C, Küry S, Reijnders M, Harel T, Eldomery M, et al. De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Disorder. Am J Hum Genet. 2017;101:716-724 pubmed publisher
    ..Thus, our findings highlight the prominent role of translation control in development and function of the central nervous system and also provide molecular insight into how DHX30 dysfunction might cause a neurodevelopmental disorder. ..
  4. Schepers S, van Oers H, Maurice Stam H, Huisman J, Verhaak C, Grootenhuis M, et al. Health related quality of life in Dutch infants, toddlers, and young children. Health Qual Life Outcomes. 2017;15:81 pubmed publisher
    ..0. However, it remains unclear whether these HRQoL instruments can distinguish between healthy children and children with a chronic health condition under the age of 5. ..
  5. McKay J, Hung R, Han Y, Zong X, Carreras Torres R, Christiani D, et al. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet. 2017;49:1126-1132 pubmed publisher
    ..Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer...
  6. Hoa L, Tuan N, My P, Huong T, Chi N, Hau Thu T, et al. Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam. J Gen Virol. 2017;98:2011-2016 pubmed publisher
    ..5 %) seropositive for A/H5 and 123/1105 (11.1 %) seropositive for A/H9]. ..
  7. Tachmazidou I, Süveges D, Min J, Ritchie G, Steinberg J, Walter K, et al. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. Am J Hum Genet. 2017;100:865-884 pubmed publisher
    ..Our results highlight the potential of WGS strategies to enhance biologically relevant discoveries across the frequency spectrum. ..
  8. Smits L, Grelack A, Derikx L, de Jong D, van Esch A, Boshuizen R, et al. Long-Term Clinical Outcomes After Switching from Remicade® to Biosimilar CT-P13 in Inflammatory Bowel Disease. Dig Dis Sci. 2017;62:3117-3122 pubmed publisher
    ..These 1-year data suggest that switching to CT-P13 in Remicade®-treated IBD patients is safe and feasible. ..
  9. Pierrache L, Kimchi A, Ratnapriya R, Roberts L, Astuti G, Obolensky A, et al. Whole-Exome Sequencing Identifies Biallelic IDH3A Variants as a Cause of Retinitis Pigmentosa Accompanied by Pseudocoloboma. Ophthalmology. 2017;124:992-1003 pubmed publisher
    ..We observed both phenotypes in 2 siblings carrying the same compound heterozygous variants, which could be explained by variable disease expression and warrants caution when making assertions about genotype-phenotype correlations. ..

More Information

Publications140 found, 100 shown here

  1. Butt J, Werner S, Willhauck Fleckenstein M, Michel A, Waterboer T, Zörnig I, et al. Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors. Int J Cancer. 2017;141:897-904 pubmed publisher
    ..98, 95% CI: 1.18-7.57). Antibody responses to SGG are associated with CRC and its precursors. The newly identified SGG six-marker panel and associations found with precancerous lesions should be further explored. ..
  2. Arts E, Fransen J, den Broeder A, van Riel P, Popa C. Low disease activity (DAS28?3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent Cox regression analysis in a large cohort study. Ann Rheum Dis. 2017;76:1693-1699 pubmed publisher
    ..Our results strengthen the use of tight control strategies in daily clinical practice to achieve low stable disease activity or remission in patients with RA as soon as possible. ..
  3. Koemans T, Kleefstra T, Chubak M, Stone M, Reijnders M, de Munnik S, et al. Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder. PLoS Genet. 2017;13:e1006864 pubmed publisher
    ..Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of ID/ASD-related disorders. ..
  4. Navarro Schröder T, Haak K, Zaragoza Jimenez N, Beckmann C, Doeller C. Functional topography of the human entorhinal cortex. elife. 2015;4: pubmed publisher
    ..Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans. ..
  5. Bramswig N, Lüdecke H, Hamdan F, Altmuller J, Beleggia F, Elcioglu N, et al. Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability. Hum Genet. 2017;136:821-834 pubmed publisher
  6. de Swart L, Smith A, MacKenzie M, Symeonidis A, Neukirchen J, Mikulenkova D, et al. Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance. Ann Hematol. 2017;96:1105-1112 pubmed publisher
    ..Our data show that in general, the inter-observer agreement was high and a very low percentage of misdiagnosed cases had been entered into the EUMDS registry. Further studies including histomorphology are warranted. ..
  7. Poort H, Kaal S, Knoop H, Jansen R, Prins J, Manten Horst E, et al. Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls. Support Care Cancer. 2017;25:2911-2918 pubmed publisher
    ..QoL is significantly affected by severe fatigue, stressing the importance of detection and management of this symptom in those patients affected by a life-changing diagnosis of cancer in late adolescence or young adulthood. ..
  8. Luymes C, Poortvliet R, van Geloven N, de Waal M, Drewes Y, Blom J, et al. Deprescribing preventive cardiovascular medication in patients with predicted low cardiovascular disease risk in general practice - the ECSTATIC study: a cluster randomised non-inferiority trial. BMC Med. 2018;16:5 pubmed publisher
    ..An attempt to deprescribe medication can be considered, taking patient preferences into consideration. This study was registered with Dutch trial register on 20 June 2012 ( NTR3493 ). ..
  9. Gonçalves B, Pett H, Tiono A, Murry D, Sirima S, Niemi M, et al. Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..This study has been registered at under registration no. NCT01935882.). ..
  10. Karssemeijer E, Bossers W, Aaronson J, Kessels R, Olde Rikkert M. The effect of an interactive cycling training on cognitive functioning in older adults with mild dementia: study protocol for a randomized controlled trial. BMC Geriatr. 2017;17:73 pubmed publisher
    ..The results of this study may be used for physical and mental activity recommendations in older adults with dementia. The Netherlands National Trial Register NTR5581 . Registered 14 February 2016. ..
  11. Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, et al. A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance. J Infect Dis. 2017;216:457-467 pubmed publisher
    ..The early sterilizing effects of PQ may not be explained by the preferential clearance of male gametocytes and may be due to an effect on gametocyte fitness. ..
  12. Trung N, Hoi L, Thuong N, Toan T, Huong T, Hoa T, et al. Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. Am J Trop Med Hyg. 2017;96:1084-1087 pubmed publisher
    ..These results provide data on baseline population characteristics that may help inform development of Rickettsia serological testing criteria in future clinical studies. ..
  13. Chaturvedi A, Yauw S, Lomme R, Hendriks T, van Goor H. Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surg Infect (Larchmt). 2017;18:670-675 pubmed publisher
    ..Ultrapure alginate gel does not interfere with repair of ileal anastomoses constructed under conditions in which chances of anastomotic dehiscence are high. The alginate gel performs better than the HA/CMC film. ..
  14. Kaal S, Husson O, van Duivenboden S, Jansen R, Manten Horst E, Servaes P, et al. Empowerment in adolescents and young adults with cancer: Relationship with health-related quality of life. Cancer. 2017;123:4039-4047 pubmed publisher
  15. van der Heijde D, van T Hof M, van Riel P, Theunisse L, Lubberts E, van Leeuwen M, et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis. 1990;49:916-20 pubmed
    ..The rheumatologists' decisions to prescribe slow acting antirheumatic drugs, or not, were mainly based on articular symptoms. ..
  16. Mohsin J, Khalili S, Van Den Ende A, Khamis F, Petersen E, de Hoog G, et al. Imported Talaromycosis in Oman in Advanced HIV: A Diagnostic Challenge Outside the Endemic Areas. Mycopathologia. 2017;182:739-745 pubmed publisher
    ..This case is reported for its rarity and unusual presentation to alert clinicians and microbiologists to consider T. marneffei as an etiology in high risk individuals. Our case is the first recorded diagnosis of T. marneffei in Oman. ..
  17. Bouman C, van Herwaarden N, van den Hoogen F, van der Maas A, van den Bemt B, den Broeder A. Prediction of successful dose reduction or discontinuation of adalimumab, etanercept, or infliximab in rheumatoid arthritis patients using serum drug levels and antidrug antibody measurement. Expert Opin Drug Metab Toxicol. 2017;13:597-604 pubmed publisher
  18. Busweiler L, Henneman D, Dikken J, Fiocco M, van Berge Henegouwen M, Wijnhoven B, et al. Failure-to-rescue in patients undergoing surgery for esophageal or gastric cancer. Eur J Surg Oncol. 2017;43:1962-1969 pubmed publisher
    ..Next to morbidity and mortality, failure-to-rescue should be considered as an important outcome measure after esophagogastric cancer resections. ..
  19. Ju Y, Ooms S, Sutphen C, Macauley S, Zangrilli M, Jerome G, et al. Slow wave sleep disruption increases cerebrospinal fluid amyloid-? levels. Brain. 2017;140:2104-2111 pubmed publisher
    ..These effects are specific to neuronally-derived proteins, which suggests they are likely driven by changes in neuronal activity during disrupted sleep. ..
  20. Desar I, Mulder S, Stillebroer A, van Spronsen D, van der Graaf W, Mulders P, et al. The reverse side of the victory: flare up of symptoms after discontinuation of sunitinib or sorafenib in renal cell cancer patients. A report of three cases. Acta Oncol. 2009;48:927-31 pubmed publisher
  21. Aarts E, Ederveen T, Naaijen J, Zwiers M, Boekhorst J, Timmerman H, et al. Gut microbiome in ADHD and its relation to neural reward anticipation. PLoS ONE. 2017;12:e0183509 pubmed publisher
    ..This increase in microbiome function relates to decreased neural responses to reward anticipation. Decreased neural reward anticipation constitutes one of the hallmarks of ADHD. ..
  22. Smith M, Saad F, Rathkopf D, Mulders P, de Bono J, Small E, et al. Clinical Outcomes from Androgen Signaling-directed Therapy after Treatment with Abiraterone Acetate and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302. Eur Urol. 2017;72:10-13 pubmed publisher
    ..This analysis does not support prioritization of subsequent abiraterone acetate plus prednisone or enzalutamide following initial therapy with abiraterone acetate plus prednisone. ..
  23. Hariri A, Velaga S, Girach A, Ip M, Le P, Lam B, et al. Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia. Am J Ophthalmol. 2017;179:110-117 pubmed publisher
    ..These variables would be potential anatomic outcome measures for CHM clinical trials and could be studied and tracked longitudinally in choroideremia. ..
  24. Donk R, Verbeek A, Verhagen W, Groenewoud H, Hosman A, Bartels R. What's the best surgical treatment for patients with cervical radiculopathy due to single-level degenerative disease? A randomized controlled trial. PLoS ONE. 2017;12:e0183603 pubmed publisher
    ..Due to the small study sample size, this statement should be considered as inconclusive so far. ISRCTN41681847. ..
  25. Aung T, Ozaki M, Lee M, Schlötzer Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993-1004 pubmed publisher
    ..3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology. ..
  26. Maas R, Iwanicka Pronicka K, Kalkan Ucar S, Alhaddad B, AlSayed M, Al Owain M, et al. Progressive deafness-dystonia due to SERAC1 mutations: A study of 67 cases. Ann Neurol. 2017;82:1004-1015 pubmed publisher
    ..MEGDHEL syndrome is a progressive deafness-dystonia syndrome with frequent and reversible neonatal liver involvement and a strikingly homogenous course of disease. Ann Neurol 2017;82:1004-1015. ..
  27. Rossato M, Affandi A, Thordardottir S, Wichers C, Cossu M, Broen J, et al. Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis. Arthritis Rheumatol. 2017;69:1891-1902 pubmed publisher
  28. De Bari B, Stish B, Ball M, Habboush Y, Sargos P, Krengli M, et al. Adult prostatic sarcoma: A contemporary multicenter Rare Cancer Network study. Prostate. 2017;77:1160-1166 pubmed publisher
    ..55%) and OS (49% vs. 58%). Adult PS has a poor prognosis. Locally advanced tumors have poor LC and OS rates. Curative RT should be considered part of the multidisciplinary approach to PS. ..
  29. Bouman C, van Herwaarden N, van den Hoogen F, Fransen J, van Vollenhoven R, Bijlsma J, et al. Long-term outcomes after disease activity-guided dose reduction of TNF inhibition in rheumatoid arthritis: 3-year data of the DRESS study - a randomised controlled pragmatic non-inferiority strategy trial. Ann Rheum Dis. 2017;76:1716-1722 pubmed publisher
    ..Safety and efficacy of disease activity guided TNFi DR in RA are maintained up to 3?years, with a large reduction in TNFi use, but no other benefits. Implementation of DR would vastly improve the cost-effective use of TNFi. ..
  30. Voigt Radloff S, de Werd M, Leonhart R, Boelen D, Olde Rikkert M, Fliessbach K, et al. Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning. Alzheimers Res Ther. 2017;9:22 pubmed publisher
    ..Structured relearning improved the performance of activities of daily living. Improvements were maintained for 6 months. EL had no additional effect over TEL. German Register of Clinical Trials DRKS00003117 . Registered 31 May 2011. ..
  31. Bokma J, Winter M, Kornaat E, Vliegen H, van Dijk A, van Melle J, et al. Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system (REDEFINE) trial: Rationale and design of a randomized, double-blind, placebo-controlled clinical trial. Am Heart J. 2017;186:83-90 pubmed publisher
    ..In addition, laboratory measurements, echocardiography, and cardiopulmonary exercise testing are performed. The REDEFINE trial will study the effects of RAAS inhibition with losartan in TOF patients with RV dysfunction. ..
  32. van Nierop J, van Trier D, van der Burgt I, Draaisma J, Mylanus E, Snik A, et al. Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11. Int J Pediatr Otorhinolaryngol. 2017;97:228-234 pubmed publisher
    ..Otological and audiological examinations in NS and NSML are important, and for those with severe hearing loss, the CI surgery improved the audiological outcome regardless of age. ..
  33. Niemeijer N, Rijken J, Eijkelenkamp K, van der Horst Schrivers A, Kerstens M, Tops C, et al. The phenotype of SDHB germline mutation carriers: a nationwide study. Eur J Endocrinol. 2017;177:115-125 pubmed publisher
  34. Trimpert C, Wesche D, de Groot T, Pimentel Rodriguez M, Wong V, van den Berg D, et al. NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. PLoS ONE. 2017;12:e0183774 pubmed publisher
    ..As NDFIP1/2 bind many NEDD4 family E3 ligases, which are implicated in several cellular processes, NDFIP1/2 may be the missing link for AQP2 ubiquitination and degradation from different subcellular locations. ..
  35. Schoffelen T, Kampschreur L, van Roeden S, Wever P, den Broeder A, Nabuurs Franssen M, et al. Coxiella burnetii infection (Q fever) in rheumatoid arthritis patients with and without anti-TNF? therapy. Ann Rheum Dis. 2014;73:1436-8 pubmed publisher
  36. Timmers L, Boons C, Verbrugghe M, van den Bemt B, Van Hecke A, Hugtenburg J. Supporting adherence to oral anticancer agents: clinical practice and clues to improve care provided by physicians, nurse practitioners, nurses and pharmacists. BMC Cancer. 2017;17:122 pubmed publisher
    ..A multidisciplinary approach is recommended in which the role of the pharmacist could be expanded. ..
  37. Noordermeer S, Luman M, Weeda W, Buitelaar J, Richards J, Hartman C, et al. Risk factors for comorbid oppositional defiant disorder in attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2017;26:1155-1164 pubmed publisher
    ..The identified risk factors may prove to be essential in preventive interventions for comorbid ODD in ADHD, highlighting the need for parent-focused interventions to take these factors into account. ..
  38. van Sluisveld N, Oerlemans A, Westert G, van der Hoeven J, Wollersheim H, Zegers M. Barriers and facilitators to improve safety and efficiency of the ICU discharge process: a mixed methods study. BMC Health Serv Res. 2017;17:251 pubmed publisher
  39. Wang J, Xu Monette Z, Jabbar K, Shen Q, Manyam G, Tzankov A, et al. AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma. Am J Pathol. 2017;187:1700-1716 pubmed publisher
    ..This study demonstrates the clinical and therapeutic implications of AKT hyperactivation in DLBCL and suggests that AKT inhibitors need to be combined with other targeted agents for DLBCL to achieve optimal clinical efficacy. ..
  40. Kersten E, Geerlings M, den Hollander A, de Jong E, Fauser S, Peto T, et al. Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene. JAMA Ophthalmol. 2017;135:1037-1044 pubmed publisher
  41. Oosten L, Chamuleau M, Thielen F, de Wreede L, Siemes C, Doorduijn J, et al. Treatment of sporadic Burkitt lymphoma in adults, a retrospective comparison of four treatment regimens. Ann Hematol. 2018;97:255-266 pubmed publisher
    ..These differences may help guide future choice of treatment. ..
  42. Leijendekkers R, Hinte G, Sman A, Staal J, Nijhuis van der Sanden M, Hoogeboom T. Clinimetric properties of hip abduction strength measurements obtained using a handheld dynamometer in individuals with a lower extremity amputation. PLoS ONE. 2017;12:e0179887 pubmed publisher
    ..HHD-technique 2 is a test-retest reproducible and valid measuring technique The technique may be further optimised by the use of an external device to stabilise the HHD. ..
  43. Bongers E, Shelton L, Milatz S, Verkaart S, Bech A, Schoots J, et al. A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations. J Am Soc Nephrol. 2017;28:3118-3128 pubmed publisher
    ..These data suggest that pathogenic CLDN10 mutations affect TAL paracellular ion transport and cause a novel tight junction disease characterized by a non-BS, non-GS autosomal recessive hypokalemic-alkalotic salt-losing phenotype. ..
  44. Storms I, van den Brand M, Schneeberger P, van t Hullenaar N. Aggregatibacter actinomycetemcomitans pneumonia with chest and abdominal wall involvement. BMJ Case Rep. 2017;2017: pubmed publisher
    ..It is capable of causing infections in humans including periodontitis, soft tissue abscesses and systemic invasive infections, most commonly endocarditis. ..
  45. McCarthy C, van Kimmenade R, Gaggin H, Simon M, Ibrahim N, Gandhi P, et al. Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Who Underwent Diagnostic Coronary Angiography (from the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study). Am J Cardiol. 2017;120:25-32 pubmed publisher
    ..001); such risk extended to at least to 4 years. In conclusion, in a cohort of patients who underwent coronary angiography, we describe a novel multiple biomarker score for incident MACE within 1 year (NCT00842868). ..
  46. Andela C, Repping Wuts H, Stikkelbroeck N, Pronk M, Tiemensma J, Hermus A, et al. Enhanced self-efficacy after a self-management programme in pituitary disease: a randomized controlled trial. Eur J Endocrinol. 2017;177:59-72 pubmed publisher
    ..Future research should focus on the refinement and implementation of this SMI into clinical practice. ..
  47. Hirschmann J, Schoffelen J, Schnitzler A, van Gerven M. Parkinsonian rest tremor can be detected accurately based on neuronal oscillations recorded from the subthalamic nucleus. Clin Neurophysiol. 2017;128:2029-2036 pubmed publisher
    ..LFP-based markers of tremor could be useful control signals for closed-loop deep brain stimulation. ..
  48. Koch S, Holland R, Hengstler M, Van Knippenberg A. Body locomotion as regulatory process: stepping backward enhances cognitive control. Psychol Sci. 2009;20:549-50 pubmed publisher
  49. Myers K, Mandelstam S, Ramantani G, Rushing E, de Vries B, Koolen D, et al. The epileptology of Koolen-de Vries syndrome: Electro-clinico-radiologic findings in 31 patients. Epilepsia. 2017;58:1085-1094 pubmed publisher
    ..Epilepsy surgery should be undertaken with care given the widespread neuroanatomic abnormalities; however, tumors are a rare, yet important, occurrence. ..
  50. Ritter S, Ferguson S. Happy creativity: Listening to happy music facilitates divergent thinking. PLoS ONE. 2017;12:e0182210 pubmed publisher
  51. Nies M, Dekker B, Sulkers E, Huizinga G, Klein Hesselink M, Maurice Stam H, et al. Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study. Eur J Endocrinol. 2018;178:215-223 pubmed publisher
    ..Social development was slightly more favorable in DTC survivors than in other CCS, but was similar on autonomy and psychosexual domains. ..
  52. Gijzel S, van de Leemput I, Scheffer M, Roppolo M, Olde Rikkert M, Melis R. Dynamical Resilience Indicators in Time Series of Self-Rated Health Correspond to Frailty Levels in Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72:991-996 pubmed publisher
    ..By mirroring the dynamical resilience indicators to a frailty index, we delivered a first empirical base to validate and quantify the construct of systemic resilience in older adults in a dynamic way. ..
  53. Schweren L, Groenman A, von Rhein D, Weeda W, Faraone S, Luman M, et al. Stimulant Treatment Trajectories Are Associated With Neural Reward Processing in Attention-Deficit/Hyperactivity Disorder. J Clin Psychiatry. 2017;78:e790-e796 pubmed publisher
    ..No striatal or structural changes were found. ..
  54. Kraaijenga V, Ramakers G, Smulders Y, van Zon A, Stegeman I, Smit A, et al. Objective and Subjective Measures of Simultaneous vs Sequential Bilateral Cochlear Implants in Adults: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2017;143:881-890 pubmed publisher
    ..To date, no randomized clinical trial on the comparison between simultaneous and sequential bilateral cochlear implants (BiCIs) has been performed...
  55. Joncour A, Desroy N, Housseman C, Bock X, Bienvenu N, Cherel L, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. J Med Chem. 2017;60:7371-7392 pubmed publisher
    ..Compound 40 was also able to decrease the plasma LPA levels upon oral administration to rats. ..
  56. Flak J, Arble D, Pan W, Patterson C, Lanigan T, Goforth P, et al. A leptin-regulated circuit controls glucose mobilization during noxious stimuli. J Clin Invest. 2017;127:3103-3113 pubmed publisher
    ..Thus, decreased leptin action on PAG LepRb neurons augments the autonomic response to noxious stimuli, ensuring sufficient glucose mobilization during periods of acute demand in the face of diminished energy stores. ..
  57. Moyakine A, Herwegen B, van der Vleuten C. Use of the Hemangioma Severity Scale to facilitate treatment decisions for infantile hemangiomas. J Am Acad Dermatol. 2017;77:868-873 pubmed publisher
    ..The HSS with cutoff values of 6 or lower and 11 or higher could be used as a triage tool for propranolol treatment. Patient age, IH type, and parental preference may also contribute to treatment decisions. ..
  58. Hoek P, Schers H, Bronkhorst E, Vissers K, Hasselaar J. The effect of weekly specialist palliative care teleconsultations in patients with advanced cancer -a randomized clinical trial. BMC Med. 2017;15:119 pubmed publisher
    ..The Netherlands National Trial Register", NTR2817 , prospectively registered: March 21, 2011. ..
  59. Niehues H, Tsoi L, van der Krieken D, Jansen P, Oortveld M, Rodijk Olthuis D, et al. Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity. J Invest Dermatol. 2017;137:2380-2388 pubmed publisher
    ..Our findings identify an unknown biological function for LCE3 proteins and suggest a role in epidermal host defense and LCE3B/C-del-mediated psoriasis risk. ..
  60. Wang X, Zhang R, Wu W, Wang A, Wan Z, van de Veerdonk F, et al. New and recurrent STAT1 mutations in seven Chinese patients with chronic mucocutaneous candidiasis. Int J Dermatol. 2017;56:e30-e33 pubmed publisher
  61. van den Bosch M, Blom A, van de Loo F, Koenders M, Lafeber F, van den Berg W, et al. Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis. Arthritis Rheumatol. 2017;69:1978-1983 pubmed publisher
    ..Wnt signaling in the synovium may potently induce progression of OA via increased production of MMPs. ..
  62. Mocking R, Nap T, Westerink A, Assies J, Vaz F, Koeter M, et al. Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity. Psychoneuroendocrinology. 2017;79:84-92 pubmed publisher
    ..Future studies in independent samples are needed to replicate and test the clinical applicability of these biological predictors for treatment response to result in a precision/personalized medicine approach for treatment. ..
  63. ter Huurne N, Lozano Soldevilla D, Onnink M, Kan C, Buitelaar J, Jensen O. Diminished modulation of preparatory sensorimotor mu rhythm predicts attention-deficit/hyperactivity disorder severity. Psychol Med. 2017;47:1947-1956 pubmed publisher
    ..This could explain disruptive motor activity in ADHD. These results provide further evidence that impaired modulation of α band oscillations is involved in the pathogenesis of ADHD. ..
  64. Swider K, Wronka E, Oosterman J, Van Rijn C, Jongsma M. Influence of transient spatial attention on the P3 component and perception of painful and non-painful electric stimuli in crossed and uncrossed hands positions. PLoS ONE. 2017;12:e0182616 pubmed publisher
    ..Our results also suggest that hand position may modulate the strength of the cueing effect, although differences between painful and non-painful stimuli exist. ..
  65. Poort H, Peters M, Verhagen S, Verhoeven J, van der Graaf W, Knoop H. Time to practice what we preach? Appreciating the autonomy of cancer patients on deciding whether they want to be informed about interventional studies for fatigue. Palliat Med. 2016;30:897-8 pubmed publisher
  66. Abdul S, Boender J, Malfliet J, Eikenboom J, Fijn van Draat K, Mauser Bunschoten E, et al. Plasma levels of plasminogen activator inhibitor-1 and bleeding phenotype in patients with von Willebrand disease. Haemophilia. 2017;23:437-443 pubmed publisher
    ..In young female VWD patients, we observed that low PAI-1 levels were associated with a higher bleeding score, which may partly explain the observed variability in bleeding phenotype in VWD patients. ..
  67. Bonaca M, Storey R, Theroux P, Steg P, Bhatt D, Cohen M, et al. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017;70:1368-1375 pubmed publisher
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  68. Coebergh van den Braak R, Sieuwerts A, Kandimalla R, Lalmahomed Z, Bril S, van Galen A, et al. High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients. PLoS ONE. 2017;12:e0185607 pubmed publisher
    ..This association could however not be confirmed in two independent smaller cohorts, suggesting that further extensive validation is needed to confirm the prognostic value of SYK(S) expression in chemonaive LNN colon cancer. ..
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    ..Rejecting the external validity of studies from countries believed to display an exceptional incidence rates may therefore not be justified. ..
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  72. van der Wees P, Wammes J, Akkermans R, Koetsenruijter J, Westert G, van Kampen A, et al. Patient-reported health outcomes after total hip and knee surgery in a Dutch University Hospital Setting: results of twenty years clinical registry. BMC Musculoskelet Disord. 2017;18:97 pubmed publisher
    ..Our study shows the feasibility of the routine collection of PRO data in patients with total hip and knee replacement. The use of PRO data provides opportunities for continuous quality improvement. ..
  73. Renkema G, Visser G, Baertling F, Wintjes L, Wolters V, van Montfrans J, et al. Mutated PET117 causes complex IV deficiency and is associated with neurodevelopmental regression and medulla oblongata lesions. Hum Genet. 2017;136:759-769 pubmed publisher
    ..This case presentation thus implicates mutations in PET117 as a novel cause of mitochondrial disease. ..
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    ..Our results suggest that comprehension is perspective dependent, but not on the perspective suggested by the text, but on the reader's (situational) preference. ..
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    ..When compared with eculizumab upon recurrence, neither eculizumab induction nor lifelong eculizumab prophylaxis resulted in more QALYs, but did yield far higher costs. Therefore, eculizumab upon recurrence of aHUS is more acceptable. ..
  76. Plouvier A, olde Hartman T, Verhulst C, Bloem B, van Weel C, Lagro Janssen A. Parkinson's disease: patient and general practitioner perspectives on the role of primary care. Fam Pract. 2017;34:227-233 pubmed publisher
    ..However, GPs should feel more confident of the added value of their generalist approach to care for patients with a complex chronic disorder as PD. If generalist and specialized care reinforce each other, PD patients benefit. ..
  77. Arbogast T, Iacono G, Chevalier C, Afinowi N, Houbaert X, van Eede M, et al. Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition. PLoS Genet. 2017;13:e1006886 pubmed publisher
    ..31 deletion. Together, these novel mouse models provide new genetic tools valuable for the development of therapeutic approaches. ..
  78. Mertens J, Thurlings R, Kievit W, Seyger M, Radstake T, de Jong E. Long-term outcome of eosinophilic fasciitis: A cross-sectional evaluation of 35 patients. J Am Acad Dermatol. 2017;77:512-517.e5 pubmed publisher
    ..All patients with EF had detectable residual damage. Impairment of HRQoL correlated to the extent of residual damage. Advanced age and signs of severe disease at presentation were associated with the severity of residual damage. ..
  79. Santolini I, Celli R, Cannella M, Imbriglio T, Guiducci M, Parisi P, et al. Alterations in the ?2 ? ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies. Epilepsia. 2017;58:1993-2001 pubmed publisher
    ..These findings suggest that thrombospondin-1 may have a role in the pathogenesis of IGE/GGEs. ..
  80. SÅ‚owikowska Hilczer J, Hirschberg A, Claahsen van der Grinten H, Reisch N, Bouvattier C, Thyen U, et al. Fertility outcome and information on fertility issues in individuals with different forms of disorders of sex development: findings from the dsd-LIFE study. Fertil Steril. 2017;108:822-831 pubmed publisher
    ..The care of patients with DSD is complex, should be individualized, and new treatment possibilities incorporated. A close collaboration in multidisciplinary teams is therefore essential to improve the situation for individuals with DSD. ..
  81. Schmitz M, Hannink G, Gardeniers J, Verdonschot N, Slooff T, Schreurs B. Acetabular Reconstructions with Impaction Bone-Grafting and a Cemented Cup in Patients Younger Than 50 Years of Age: A Concise Follow-up, at 27 to 35 Years, of a Previous Report. J Bone Joint Surg Am. 2017;99:1640-1646 pubmed publisher
    ..Cemented impaction bone-grafting is a reasonable long-term solution for demanding primary and revision acetabular reconstructions in young patients with acetabular bone defects...
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    ..In some subjects, a smaller part of the updating error was also related to the change of visual frame orientation. We conclude that the brain relies primarily on a gravity-based reference to remember line orientation during head roll...
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    ..In total, 700 patients are estimated to be enrolled from >20 countries. Final analysis will be performed once the last enrolled patient has been followed up with for 24 months ( identifier: Nbib2303444). ..
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    ..The results will add new insights into the prevailing notion that exercise may slow the rate of cognitive decline in MCI. NCT02913053. ..
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    ..These findings suggest that BU is accompanied by significantly longer LTL. ..
  87. Rao D, Peitzsch M, Prejbisz A, Hanus K, Fassnacht M, Beuschlein F, et al. Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma. Eur J Endocrinol. 2017;177:103-113 pubmed publisher
    ..9% vs 49.3%). While the benefit of additional measurements of plasma methoxytyramine for the detection of PPGLs is modest, the measurements do assist with positive confirmation of disease and are useful for the detection of HNPGLs. ..
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    ..Leiden mice. The observed reduction of inflammation in adipose tissue and in the liver provides a rationale for these comprehensive health effects. ..
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    ..71). We defined sets of responder criteria for multicomponent non-pharmacological treatment in fibromyalgia. Further research should focus on the validation of those sets with acceptable performance. ..
  91. Persad P, Heid I, Weeks D, Baird P, de Jong E, Haines J, et al. Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Invest Ophthalmol Vis Sci. 2017;58:4027-4038 pubmed publisher
    ..0020, OR = 2.17, 95% CI = 1.34-3.60). These results show that joint tests of main effects and gene-gene interaction reveal associations at some novel loci that were missed when considering main effects alone. ..
  92. Khetarpal S, Zeng X, Millar J, Vitali C, Somasundara A, Zanoni P, et al. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017;23:1086-1094 pubmed publisher
    ..This protective mechanism has the potential to be exploited as a new therapeutic approach to reduce apoC-III levels and circulating TRL burden. ..