Experts and Doctors on glutathione transferase in Nijmegen, Gelderland, Netherlands


Locale: Nijmegen, Gelderland, Netherlands
Topic: glutathione transferase

Top Publications

  1. Knapen M, van Der Wildt B, Sijtsma E, Peters W, Roelofs H, Steegers E. Glutathione S-transferase Alpha 1-1 and aminotransferases in umbilical cord blood. Early Hum Dev. 1999;54:129-35 pubmed
    ..Umbilical cord GSTA1-1 may provide a valuable indicator of neonatal condition immediately after birth, the clinical relevance of which needs to be further established. ..
  2. Kavishe R, Bousema T, Shekalaghe S, Sauerwein R, Mosha F, van der Ven A, et al. Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children. Am J Trop Med Hyg. 2009;81:363-5 pubmed
    ..0% against 10.3% mild malaria, P = 0.004). We concluded that GSTP1 and possibly GSTM1 may protect against severe falciparum malaria in children. ..
  3. Dura P, Salomon J, Te Morsche R, Roelofs H, Kristinsson J, Wobbes T, et al. No role for glutathione S-transferase genotypes in Caucasian esophageal squamous cell or adenocarcinoma etiology: an European case-control study. BMC Gastroenterol. 2013;13:97 pubmed publisher
    ..Functional genotypes in GST genes are not involved in EAC or ESCC susceptibility in Caucasians, in contrast to results on ESCC from Asia or Africa. ..
  4. Friederich P, Berkhout M, Roelofs H, van Goor H, van Krieken J, Peters W, et al. Decreased levels of mucosal detoxification enzymes in the pouch of patients with familial adenomatous polyposis. Br J Surg. 2006;93:1108-14 pubmed
    ..After IPAA, GST detoxification activity in the pouch is significantly lower than that in the afferent ileal loop, which may promote tumorigenesis. ..
  5. Zusterzeel P, Peters W, Burton G, Visser W, Roelofs H, Steegers E. Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. Gynecol Obstet Invest. 2007;63:209-13 pubmed
    ..Women withthe simultaneous occurrence of two or more genetic polymorphisms in the above-mentioned biotransformation enzymes, most probably resulting in a disturbed detoxification capacity, may be at increased risk for pre-eclampsia. ..
  6. Heemskerk S, Masereeuw R, Moesker O, Bouw M, Van Der Hoeven J, Peters W, et al. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med. 2009;37:417-23, e1 pubmed publisher
    ..This mechanism may account for the observed improvement in renal function. ..
  7. Mulder T, Peters W, Court D, Jansen J. Sandwich ELISA for glutathione S-transferase Alpha 1-1: plasma concentrations in controls and in patients with gastrointestinal disorders. Clin Chem. 1996;42:416-9 pubmed
    ..In contrast, plasma GSTA1-1 concentrations were increased to a similar extent as alanine aminotransferase activities in patients with liver disorders (n= 37). ..
  8. de Bruin W, Wagenmans M, Board P, Peters W. Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers. Carcinogenesis. 1999;20:1453-7 pubmed
    ..In conclusion, in both normal human colonic and gastric mucosa, GSTT1-1 and GSTT2-2 are present at high levels, whereas after malignant degeneration, expression is not influenced or is even downregulated. ..
  9. Raijmakers M, Roelofs H, Steegers E, Steegers Theunissen R R, Mulder T, Knapen M, et al. Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa. Fertil Steril. 2003;79:169-72 pubmed
    ..496) were found. The presence of glutathione S-transferases A1-1 and P1-1 in seminal fluid suggests a role in the protection against (oxidative) damage of spermatozoa, whereas glutathione may play a role in male fertility. ..

More Information


  1. van der Logt E, Bergevoet S, Roelofs H, van Hooijdonk Z, te Morsche R, Wobbes T, et al. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. Carcinogenesis. 2004;25:2407-15 pubmed
    ..In conclusion, the data suggest that the presence of variant UGT1A6 and UGT1A7 genotypes with expected reduced enzyme activities, might enhance susceptibility to CRC. ..
  2. Berkhout M, Roelofs H, te Morsche R, Dekker E, van Krieken J, Nagengast F, et al. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. Br J Surg. 2008;95:499-505 pubmed
    ..Although the variant genotypes of UGT1A3 were less common in patients with FAP than in those without, this did not modulate the severity of duodenal adenomatosis. ..
  3. Ramakers B, Riksen N, Stal T, Heemskerk S, van den Broek P, Peters W, et al. Dipyridamole augments the antiinflammatory response during human endotoxemia. Crit Care. 2011;15:R289 pubmed publisher
    ..ClinicalTrials (NCT): NCT01091571. ..
  4. Odenthal J, van Heumen B, Roelofs H, Te Morsche R, Marian B, Nagengast F, et al. The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97. Nutr Cancer. 2012;64:856-63 pubmed publisher
    ..In summary, enhancement of the detoxification capacity by low dose of the potential anticarcinogens curcumin, quercetin, or EPA seems only a minor factor in explaining their anticarcinogenic properties. ..