Experts and Doctors on animals in Nijmegen, Gelderland, Netherlands


Locale: Nijmegen, Gelderland, Netherlands
Topic: animals

Top Publications

  1. Blom A, van Lent P, Libregts S, Holthuysen A, van der Kraan P, Van Rooijen N, et al. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum. 2007;56:147-57 pubmed
    ..Synovial macrophages are crucial in early MMP activity and appear to mediate MMP production in synovium rather than cartilage. ..
  2. den Hollander A, Koenekoop R, Mohamed M, Arts H, Boldt K, Towns K, et al. Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nat Genet. 2007;39:889-95 pubmed
    ..Members of this interactome represent candidate genes for LCA and other ciliopathies. Our findings emphasize the emerging role of disrupted ciliary processes in the molecular pathogenesis of LCA. ..
  3. Joosten L, Abdollahi Roodsaz S, Heuvelmans Jacobs M, Helsen M, van den Bersselaar L, Oppers Walgreen B, et al. T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17. Arthritis Rheum. 2008;58:98-108 pubmed publisher
    ..These findings indicate that the TNFalpha dependence of arthritis is lost during the erosive stage, when Th17 cells become crucial. IL-1beta dependence remains strong, consistent with its pivotal role in the generation of Th17 cells. ..
  4. Kan H, Veltien A, Arnts H, Nabuurs C, Luijten B, de Haan A, et al. Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase. NMR Biomed. 2009;22:523-31 pubmed publisher
  5. Kortenoeven M, Li Y, Shaw S, Gaeggeler H, Rossier B, Wetzels J, et al. Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. Kidney Int. 2009;76:44-53 pubmed publisher
    ..Blocking lithium entry with amiloride attenuates lithium-induced diabetes insipidus, thus providing a rationale for its use in treating this disorder...
  6. Nierkens S, den Brok M, Roelofsen T, Wagenaars J, Figdor C, Ruers T, et al. Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice. PLoS ONE. 2009;4:e8368 pubmed publisher
    ..We studied whether the efficacy of CpG as an adjuvant in cancer immunotherapy is dependent on the route of CpG administration, in particular when the tumor is destructed in situ...
  7. Cools R, Nakamura K, Daw N. Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology. 2011;36:98-113 pubmed publisher
  8. de Jong G, Bleichrodt R, Eek A, Oyen W, Boerman O, Hendriks T. Experimental study of radioimmunotherapy versus chemotherapy for colorectal cancer. Br J Surg. 2011;98:436-41 pubmed publisher
    ..Survival after treatment with RIT did not differ from that after chemotherapy (P = 0·911). RIT is as effective as chemotherapy in experimental colorectal cancer. ..
  9. Kox M, Vaneker M, Van Der Hoeven J, Scheffer G, Hoedemaekers C, Pickkers P. Effects of vagus nerve stimulation and vagotomy on systemic and pulmonary inflammation in a two-hit model in rats. PLoS ONE. 2012;7:e34431 pubmed publisher
    ..These results questions the clinical applicability of stimulation of the cholinergic anti-inflammatory pathway in systemically inflamed patients admitted to the ICU where MV is initiated. ..

More Information

Publications320 found, 100 shown here

  1. van Mölken T, de Caluwe H, Hordijk C, Leon Reyes A, Snoeren T, van Dam N, et al. Virus infection decreases the attractiveness of white clover plants for a non-vectoring herbivore. Oecologia. 2012;170:433-44 pubmed publisher
    ..Consequently, it is conceivable that viruses play a more beneficial role in plant-herbivore interactions than generally thought. ..
  2. Estrada Cuzcano A, Roepman R, Cremers F, den Hollander A, Mans D. Non-syndromic retinal ciliopathies: translating gene discovery into therapy. Hum Mol Genet. 2012;21:R111-24 pubmed
  3. van Kampen J, van Hooij O, Jansen C, Smit F, van Noort P, Schultz I, et al. miRNA-520f Reverses Epithelial-to-Mesenchymal Transition by Targeting ADAM9 and TGFBR2. Cancer Res. 2017;77:2008-2017 pubmed publisher
    ..Collectively, our results show that miR-520f exerts anti-invasive and antimetastatic effects in vitro and in vivo, warranting further study in clinical settings. Cancer Res; 77(8); 2008-17. ©2017 AACR. ..
  4. Westdorp H, Kolders S, Hoogerbrugge N, de Vries I, Jongmans M, Schreibelt G. Immunotherapy holds the key to cancer treatment and prevention in constitutional mismatch repair deficiency (CMMRD) syndrome. Cancer Lett. 2017;403:159-164 pubmed publisher
    ..Neoantigen-based vaccines might also be a preventive treatment option in healthy biallelic MMR mutation carriers. Future studies need to reveal the safety and efficacy of immunotherapies for patients with CMMRD. ..
  5. Khetarpal S, Zeng X, Millar J, Vitali C, Somasundara A, Zanoni P, et al. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017;23:1086-1094 pubmed publisher
    ..This protective mechanism has the potential to be exploited as a new therapeutic approach to reduce apoC-III levels and circulating TRL burden. ..
  6. Vree T, Vree J, Beneken Kolmer N, Hekster Y, Shimoda M, Nouws J, et al. Oxidation and O-dealkylation of sulphamonomethoxine by the turtle Pseudemys scripta elegans. Vet Q. 1989;11:186-90 pubmed
    ..No N4-acetylation takes place. The yield of the oxidation reaction is twice that of the O-demethylation reaction. ..
  7. Deprés Brummer P, Buijs J, van Engelenburg K, Oosten H. Capnocytophaga canimorsus sepsis presenting as an acute abdomen in an asplenic patient. Neth J Med. 2001;59:213-7 pubmed
    ..We describe the atypical presentation of a fatal C. canimorsus-sepsis in a 46-year-old man, who underwent traumatic splenectomy two decades earlier...
  8. Dijkman H, Gerlofs Nijland M, van der Laak J, Wetzels J, Groenen P, Assmann K. Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase A mAb. Nephron Exp Nephrol. 2003;94:e85-93 pubmed
    ..Extended studies at day 7 demonstrated uncoupling of albuminuria, podocytic foot process effacement and CD2AP staining. Changes in podocin more closely paralleled changes in albuminuria. ..
  9. Blaney Davidson E, Vitters E, van Lent P, van de Loo F, van den Berg W, van der Kraan P. Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling. Arthritis Res Ther. 2007;9:R102 pubmed
    ..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix. ..
  10. Loesberg W, Walboomers X, van Loon J, Jansen J. Simulated microgravity activates MAPK pathways in fibroblasts cultured on microgrooved surface topography. Cell Motil Cytoskeleton. 2008;65:116-29 pubmed
    ..The results are in agreement that application of microgravity to fibroblasts promotes a change in their morphological appearance and their expression of cell-substratum proteins through the MAPK intracellular signalling pathways. ..
  11. van Helden S, van den Dries K, Oud M, Raymakers R, Netea M, van Leeuwen F, et al. TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation. J Immunol. 2010;184:1280-91 pubmed publisher
  12. Oliveira M, Arntz O, Blaney Davidson E, van Lent P, Koenders M, van der Kraan P, et al. Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation. J Nutr Biochem. 2016;30:74-84 pubmed publisher
    ..Our study adds BMEVs to the list of milk components that can affect bone formation and may shed new light on the contradictory claims of milk on bone formation. ..
  13. Lubberts E, Joosten L, Chabaud M, van den Bersselaar L, Oppers B, Coenen de Roo C, et al. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest. 2000;105:1697-710 pubmed
    ..IL-4 also enhanced synthesis of type I procollagen, suggesting that it promoted tissue repair. These findings may have significant implications for the prevention of bone erosion in arthritis. ..
  14. Boelens W, Croes Y, de Jong W. Interaction between alphaB-crystallin and the human 20S proteasomal subunit C8/alpha7. Biochim Biophys Acta. 2001;1544:311-9 pubmed
  15. Nuininga J, van Moerkerk H, Hanssen A, Hulsbergen C, Oosterwijk Wakka J, Oosterwijk E, et al. A rabbit model to tissue engineer the bladder. Biomaterials. 2004;25:1657-61 pubmed
    ..In this model, besides tissue regeneration, also some of the clinical problems are seen such as encrustation of foreign body material in the bladder. These aspects are subject for further pre-clinical studies in this animal model. ..
  16. van Kempen L, Meier F, Egeblad M, Kersten Niessen M, Garbe C, Weidle U, et al. Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis. J Invest Dermatol. 2004;122:1293-301 pubmed
    ..ALCAM induction could, thus, provide an attractive target for proteolysis as a part of a more complex cellular program that couples growth and migration and facilitates dissemination. ..
  17. Nijenhuis T, Vallon V, Van Der Kemp A, Loffing J, Hoenderop J, Bindels R. Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest. 2005;115:1651-8 pubmed
    ..Thus, Trpm6 downregulation may represent a general mechanism involved in the pathogenesis of hypomagnesemia accompanying NCC inhibition or inactivation...
  18. Lambers T, Bindels R, Hoenderop J. Coordinated control of renal Ca2+ handling. Kidney Int. 2006;69:650-4 pubmed
    ..Thus, the magnitude of Ca2+ entry via TRPV5 controls the expression of the other Ca2+ transport proteins underlining the gatekeeper function of this Ca2+ channel in the renal Ca2+ handling. ..
  19. Huls M, van den Heuvel J, Dijkman H, Russel F, Masereeuw R. ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. Kidney Int. 2006;69:2186-93 pubmed
    ..Furthermore, we showed for the first time expression and subcellular localization of abcb11 and abca3 in mouse kidney...
  20. Raijmakers R, Vogelzangs J, Raats J, Panzenbeck M, Corby M, Jiang H, et al. Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice. J Comp Neurol. 2006;498:217-26 pubmed
  21. Grauer O, Nierkens S, Bennink E, Toonen L, Boon L, Wesseling P, et al. CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo. Int J Cancer. 2007;121:95-105 pubmed
    ..These data illustrate that intratumoral accumulation and activation of CD4+FoxP3+ Treg act as a dominant immune escape mechanism for gliomas and underline the importance of controlling tumor-infiltrating Treg in glioma immunotherapy. ..
  22. Loonen A, Knoers N, Van Os C, Deen P. Aquaporin 2 mutations in nephrogenic diabetes insipidus. Semin Nephrol. 2008;28:252-65 pubmed publisher
    ..This review describes the current knowledge on AQP2 mutations in nephrogenic diabetes insipidus...
  23. Oesterholt M, Alifrangis M, Sutherland C, Omar S, Sawa P, Howitt C, et al. Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya. PLoS ONE. 2009;4:e4364 pubmed publisher
    ..The absence of wild-type infections is likely to have reduced our power to detect differences. Our data further support the use of ACT to reduce the transmission of drug-resistant malaria parasites. ..
  24. Brom M, Andrałojć K, Oyen W, Boerman O, Gotthardt M. Development of radiotracers for the determination of the beta-cell mass in vivo. Curr Pharm Des. 2010;16:1561-7 pubmed
    ..In this review, the targets and the corresponding radiotracers evaluated so far for the determination of the BCM in vivo in humans will be discussed. ..
  25. Jansen E, Hafmans T, Martens G. V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells. Mol Biol Cell. 2010;21:3330-9 pubmed publisher
    ..Together, our results show that the V-ATPase accessory subunit Ac45 represents the first regulator of the proton pump and controls V-ATPase-mediated granular acidification that is necessary for efficient prohormone processing...
  26. Cronin K, Van Leeuwen E, Mulenga I, Bodamer M. Behavioral response of a chimpanzee mother toward her dead infant. Am J Primatol. 2011;73:415-21 pubmed publisher
  27. Santegoets K, van Bon L, van den Berg W, Wenink M, Radstake T. Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?. FEBS Lett. 2011;585:3660-6 pubmed publisher
    ..In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings. ..
  28. Oosting M, Ter Hofstede H, Sturm P, Adema G, Kullberg B, Van der Meer J, et al. TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes. PLoS ONE. 2011;6:e25998 pubmed publisher
    ..TLR6 polymorphisms lead to a minor modified cytokine production. This study indicates a dominant role for TLR1/TLR2 heterodimers in the induction of the early inflammatory response by Borrelia spirochetes in humans. ..
  29. Ji W, Yang F, Ma J, Bouma M, Boerman O, Chen Z, et al. Incorporation of stromal cell-derived factor-1? in PCL/gelatin electrospun membranes for guided bone regeneration. Biomaterials. 2013;34:735-45 pubmed publisher
    ..In conclusion, the results of current study indicate the potential for using SDF-1? loaded PCL/gelatin electrospun membrane as a bioactive membrane, which is beneficial for optimizing clinical application of GBR strategies. ..
  30. Meijer I, van Rotterdam W, van Zoelen E, van Leeuwen J. Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively. Cell Signal. 2013;25:470-8 pubmed publisher
    ..We conclude that Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively. ..
  31. De Lange M, Schimmer B, Vellema P, Hautvast J, Schneeberger P, VAN Duijnhoven Y. Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands. Epidemiol Infect. 2014;142:1231-44 pubmed publisher
    ..Subtyping human, cattle, goat, and sheep C. burnetii strains might elucidate their role in the infection risk of sheep farm residents...
  32. Hendriks R, Carvalheiro L, Kleukers R, Biesmeijer J. Temporal-spatial dynamics in orthoptera in relation to nutrient availability and plant species richness. PLoS ONE. 2013;8:e71736 pubmed publisher
    ..To fully evaluate the negative effects of nitrogen deposition on higher trophic levels it is essential to take into account species life-history traits. ..
  33. Frazão N, Hermans P, van Selm S, Sá Leão R, de Lencastre H, Tomasz A, et al. Ability of Antibiotic-Resistant Nonvaccine-Type Pneumococcal Clones to Cause Otitis Media in an Infant Mouse Model of Pneumococcal-Influenza Virus Coinfection. Microb Drug Resist. 2016;22:97-101 pubmed publisher
    ..The 6A and 19A clonal types induced OM, while 15A induced pneumococcal pneumonia and bloodstream infection, suggesting potential for invasive disease. ..
  34. Wang P, Swain H, Kunkler A, Chen C, Hutzen B, Arnold M, et al. Neuroblastomas vary widely in their sensitivities to herpes simplex virotherapy unrelated to virus receptors and susceptibility. Gene Ther. 2016;23:135-43 pubmed publisher
    ..Our results also suggest that profiling the expression of known viral entry receptors on neuroblastoma cells may not be entirely predictive of their susceptibility to Seprehvir therapy. ..
  35. Barone F, Gustafson D, Crystal H, Moreno H, Adamski M, Arai K, et al. First translational 'Think Tank' on cerebrovascular disease, cognitive impairment and dementia. J Transl Med. 2016;14:50 pubmed publisher
    ..Below summarizes the new data-presentations, concepts, novel directions and specific discussion topics addressed by this international translational team at our "First Leo and Anne Albert Charitable Trust 'Think Tank' VCI workshop". ..
  36. van Diepen J, Jansen P, Ballak D, Hijmans A, Rutjes F, Tack C, et al. Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes. Sci Rep. 2016;6:21906 pubmed publisher
    ..In conclusion, absence of vanin-1 activity improves insulin sensitivity in HFD-fed animals, yet short-term inhibition of vanin activity may have limited value as an anti-diabetic strategy. ..
  37. Pironi L, Arends J, Bozzetti F, Cuerda C, Gillanders L, Jeppesen P, et al. ESPEN guidelines on chronic intestinal failure in adults. Clin Nutr. 2016;35:247-307 pubmed publisher
    ..As a consequence, most of the recommendations have a low or very low grade of evidence. However, two-thirds of the recommendations are considered strong. Specialized management and organization underpin these recommendations. ..
  38. Quabius E, Balm P, Wendelaar Bonga S. Interrenal stress responsiveness of tilapia (Oreochromis mossambicus) is impaired by dietary exposure to PCB 126. Gen Comp Endocrinol. 1997;108:472-82 pubmed
    ..Since PCB did not affect Na,K-ATPase activities and plasma ion concentrations, it is concluded that the effects of PCB 126 on the HPI axis in tilapia are not secondary to ionoregulatory dysfunction...
  39. van Lieshout E, Van der Heijden I, Hendriks W, Van der Zee C. A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen-related protein tyrosine phosphatase activity. Neuroscience. 2001;102:833-41 pubmed
    ..Thus, LAR protein tyrosine phosphatase activity appears crucial for size, number and target projection of basal forebrain cholinergic neurons, further strengthening a role for LAR in CNS development. ..
  40. Meeren H, van Cappellen van Walsum A, van Luijtelaar E, Coenen A. Auditory evoked potentials from auditory cortex, medial geniculate nucleus, and inferior colliculus during sleep-wake states and spike-wave discharges in the WAG/Rij rat. Brain Res. 2001;898:321-31 pubmed
    ..This suggests that apart from the thalamic burst firing mode, additional mechanisms must exist for the enlargement of the AEP during EEG-synchronized states at the prethalamic and cortical level. ..
  41. Gerlofs Nijland M, Assmann K, van Son J, Dijkman H, Te Loeke N, van der Zee R, et al. Epitope mapping of monoclonal antibodies directed to aminopeptidase A and their relevance for albuminuria in mice. Nephron Exp Nephrol. 2003;94:e25-34 pubmed
    ..Our data suggest that ASD-41 modulates the binding of ASD-37 to its epitope and/or vice versa. As a consequence, ASD-37 and ASD-41 act synergistically, not only in inhibiting enzyme activity but also in inducing albuminuria. ..
  42. Franke B, Klootwijk R, Lemmers B, de Kovel C, Steegers Theunissen R, Mariman E. Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation. Birth Defects Res A Clin Mol Teratol. 2003;67:979-84 pubmed
    ..Bent tail appears to be a folinic acid-, myo-inositol-, and zinc-insensitive mouse model for NTDs. ..
  43. Brouwers A, Verel I, van Eerd J, Visser G, Steffens M, Oosterwijk E, et al. PET radioimmunoscintigraphy of renal cell cancer using 89Zr-labeled cG250 monoclonal antibody in nude rats. Cancer Biother Radiopharm. 2004;19:155-63 pubmed
    ..In the present study, scintigraphic tumor imaging using chimeric moAb G250 labeled with 89Zr (immuno-PET) or 111In (RIS), and [18F]FDG-(PET) was explored in rats with s.c. renal cell carcinoma (RCC) tumors...
  44. van den Hurk W, Martens G, Geurts van Kessel A, van Groningen J. Isolation and characterization of the Xenopus laevis orthologs of the human papillary renal cell carcinoma-associated genes PRCC and MAD2L2 (MAD2B). Cytogenet Genome Res. 2004;106:68-73 pubmed
    ..Therefore, the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC and xMad2B in the intricate processes of cell cycle control. ..
  45. Tolmacheva E, van Luijtelaar G. Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats. Neurosci Lett. 2007;416:17-21 pubmed
  46. Link D, van den Dolder J, van den Beucken J, Wolke J, Mikos A, Jansen J. Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles. Biomaterials. 2008;29:675-82 pubmed
    ..The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process. ..
  47. Blaney Davidson E, Vitters E, van Beuningen H, van de Loo F, van den Berg W, van der Kraan P. Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. Arthritis Rheum. 2007;56:4065-73 pubmed
    ..Our findings demonstrate that the role of BMP during the onset of TGFbeta-induced and experimental OA-induced osteophyte formation is limited. The latter finding does not rule out a role of BMP during osteophyte maturation. ..
  48. Abdollahi Roodsaz S, Joosten L, Koenders M, Devesa I, Roelofs M, Radstake T, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest. 2008;118:205-16 pubmed
  49. Collin R, Chellappa R, Pauw R, Vriend G, Oostrik J, van Drunen W, et al. Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding. Hum Mutat. 2008;29:545-54 pubmed publisher
    ..Furthermore, mutations in this gene do not seem to be a rare cause of hearing impairment in the Dutch population, and the POU4F3 gene may thus be suitable for implementation in diagnostic testing. ..
  50. Van Wijk E, Kersten F, Kartono A, Mans D, Brandwijk K, Letteboer S, et al. Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein. Hum Mol Genet. 2009;18:51-64 pubmed publisher
    ..The direct association of Nlp(isoB) with USH2A(isoB) and lebercilin indicates that Nlp can be considered as a novel candidate gene for USH, LCA and allied retinal ciliopathies. ..
  51. van der Linden M, Murre J, van Turennout M. Birds of a feather flock together: experience-driven formation of visual object categories in human ventral temporal cortex. PLoS ONE. 2008;3:e3995 pubmed publisher
    ..These data provide evidence for experience-induced shaping of occipitotemporal responses that are involved in category learning in the human brain. ..
  52. Grevers L, van Lent P, Koenders M, Walgreen B, Sloetjes A, Nimmerjahn F, et al. Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis. Arthritis Rheum. 2009;60:396-407 pubmed publisher
    ..This study was undertaken to determine the role of IL-17 in FcgammaR-mediated cartilage destruction in IC-mediated arthritis and to compare its effect with that of IFNgamma...
  53. Hato S, Sorgeloos F, Ricour C, Zoll J, Melchers W, Michiels T, et al. Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus. Cell Microbiol. 2010;12:310-7 pubmed publisher
    ..We show that in this mengovirus background the L protein is more potent than FMDV L(pro) in suppressing IFN-alpha/beta responses. Yet, FMDV L(pro) is important to antagonize infection-limiting responses both in vitro and in vivo. ..
  54. Bojak I, Liley D. Axonal velocity distributions in neural field equations. PLoS Comput Biol. 2010;6:e1000653 pubmed publisher
    ..Thus we provide here a comprehensive analysis of empirically constrained activity propagation in the context of MFMs, which will allow more realistic studies of mammalian brain activity in the future. ..
  55. Berende A, Oosting M, Kullberg B, Netea M, Joosten L. Activation of innate host defense mechanisms by Borrelia. Eur Cytokine Netw. 2010;21:7-18 pubmed publisher
    ..Understanding these pathways provides not only a better insight into the pathogenesis, but also provides potential, novel, therapeutic targets during active disease or post-infection complications. ..
  56. Ten Broek R, Grefte S, Von den Hoff J. Regulatory factors and cell populations involved in skeletal muscle regeneration. J Cell Physiol. 2010;224:7-16 pubmed publisher
    ..Knowledge about the factors regulating satellite cell activity and skeletal muscle regeneration can be used to improve the treatment of muscle injuries and diseases. ..
  57. Vegt E, Melis M, Eek A, de Visser M, Brom M, Oyen W, et al. Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice. Eur J Nucl Med Mol Imaging. 2011;38:623-32 pubmed publisher
    ..Small-animal SPECT is an accurate tool, allowing in vivo quantification of renal uptake and serial measurements in individual mice. ..
  58. Walschot L, Schreurs B, Verdonschot N, Buma P. The effect of impaction and a bioceramic coating on bone ingrowth in porous titanium particles. Acta Orthop. 2011;82:372-7 pubmed publisher
    ..The osteoconductive potential of porous Ti particles should be studied further with larger-sized particles, which may allow bone ingrowth after impaction through larger inter-particle pores. ..
  59. Doeller C, Barry C, Burgess N. From cells to systems: grids and boundaries in spatial memory. Neuroscientist. 2012;18:556-66 pubmed publisher
    ..Within this framework, this article aims to translate findings from the single cell level in rodents to understand the neural and systems level mechanisms of spatial cognition in the human brain. ..
  60. van Geel R, Debets M, Löwik D, Pruijn G, Boelens W. Detection of transglutaminase activity using click chemistry. Amino Acids. 2012;43:1251-63 pubmed publisher
    ..This new method for labeling TG2 substrate proteins introduces flexibility in the detection and/or purification of crosslinked proteins, allowing differential labeling of cellular proteins. ..
  61. Alghamdi H, Bosco R, van den Beucken J, Walboomers X, Jansen J. Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats. Biomaterials. 2013;34:3747-57 pubmed publisher
    ..Evidently, the use of osteogenic surface coatings has a favorable effect on the bone implant interface in both osteoporotic and sham-operated conditions. ..
  62. Boutens L, Stienstra R. Adipose tissue macrophages: going off track during obesity. Diabetologia. 2016;59:879-94 pubmed publisher
    ..Finally, we will highlight how these changes affect adipose tissue inflammation and may be targeted for therapeutic interventions to improve insulin sensitivity in obese individuals. ..
  63. van Aubel R, Smeets P, Peters J, Bindels R, Russel F. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002;13:595-603 pubmed
    ..It is concluded that MRP4 is a novel apical organic anion transporter and the putative efflux pump for cAMP and cGMP in human kidney proximal tubules. ..
  64. Scharstuhl A, Diepens R, Lensen J, Vitters E, van Beuningen H, van der Kraan P, et al. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Osteoarthritis Cartilage. 2003;11:773-82 pubmed
    ..We conclude that in chondrocytes distinct TGF-beta activities are differentially regulated by Smad-6 and Smad-7. ..
  65. Scharstuhl A, Vitters E, van der Kraan P, van den Berg W. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum. 2003;48:3442-51 pubmed
    ..This is the first study to demonstrate that endogenous BMPs are involved in osteophyte formation and synovial thickening in experimental OA. ..
  66. de Hooge A, van de Loo F, Koenders M, Bennink M, Arntz O, Kolbe T, et al. Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum. 2004;50:2014-23 pubmed
    ..Exacerbation of arthritis in STAT-1(-/-) mice suggests an opposing effect of STAT-1, i.e., suppression of joint inflammation. The expression of SOCS-1 could be the underlying mechanism by which STAT-1 controls joint inflammation. ..
  67. Koppe M, Bleichrodt R, Soede A, Verhofstad A, Goldenberg D, Oyen W, et al. Biodistribution and therapeutic efficacy of (125/131)I-, (186)Re-, (88/90)Y-, or (177)Lu-labeled monoclonal antibody MN-14 to carcinoembryonic antigen in mice with small peritoneal metastases of colorectal origin. J Nucl Med. 2004;45:1224-32 pubmed
    ..The present study indicates that (131)I and (177)Lu are the most suitable radionuclides for the radioimmunotherapy of small peritoneal metastases. ..
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    ..Apaziquone showed an excellent antitumor activity. The effectiveness of apaziquone in this orthotopic rat bladder tumor model corroborates the clinical observations and implies the validity of this model. ..
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    ..Heterozygous deletion of TRPM6 results in a mild hypomagnesemia. The Mg(2+)-enriched diet could not compensate for either embryonic lethality or hypomagnesemia caused by TRPM6 deficiency. ..
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    ..These results demonstrate that S100A8 stimulated osteoclast formation and activity and suggest that both S100A8 and TLR-4 are important factors in mediating osteoclastic bone destruction in experimental arthritis. ..
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    ..These data show that inhibition of VEGF signalling cannot be optimized by additional PDGFR inhibition and support the concept that diffuse infiltrative areas in gliomas are resistant to anti-angiogenic therapy. ..
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    ..This dual action of platinum compounds may extend their therapeutic application in cancer patients and provides a rationale for their use in combination with immunostimulatory compounds. ..
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    ..This confirms the predictive value of these markers. These findings from the EAE model may help to develop a molecular diagnosis for the early stage MScl in humans. ..
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    ..Po nucleus might be the primary thalamic counterpart to the somatosensory-cortex in the generation of the cortico-thalamic-cortical oscillations referred to as SWD. ..
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    ..In an MFC culture medium, FBS can be replaced by 10% PRP or 20% PRP without altering proliferation and gene expression of human MFCs. ..
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    ..Together, our analysis provides insight into DNA methylation dynamics in cultured ESCs paralleling early developmental processes. ..
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    ..More generally, their study provokes an interesting reflection on the use of animal studies in order to understand features of the human linguistic system. ..
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    ..AADAC is a candidate susceptibility factor for GTS and the present findings warrant further genomic and functional studies to investigate the role of this gene in the pathogenesis of GTS. ..
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    ..In addition, the reduced single channel water permeability of AQP2-A47V (40%) and AQP2-T125M (25%) might become of therapeutic value when chemical chaperones can be found that restore their routing to the plasma membrane. ..
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