Experts and Doctors on monocytes in Utrecht, Netherlands


Locale: Utrecht, Netherlands
Topic: monocytes

Top Publications

  1. de Jong P, Schadenberg A, van den Broek T, Beekman J, van Wijk F, Coffer P, et al. STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PLoS ONE. 2012;7:e35070 pubmed publisher
    ..Thus, STAT3 might be a potential molecular target for pharmacological intervention in clinical syndromes characterized by systemic inflammation. ..
  2. van Zuiden M, Heijnen C, Maas M, Amarouchi K, Vermetten E, Geuze E, et al. Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study. Psychoneuroendocrinology. 2012;37:1822-36 pubmed publisher
    ..Notably, PTSD, depressive and fatigue symptoms were differentially associated with GC-sensitivity of monocytes and T-cells and therefore may have different biological underpinnings. ..
  3. Willemen H, Campos P, Lucas E, Morreale A, Gil Redondo R, Agut J, et al. A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J. 2014;459:427-39 pubmed publisher
    ..These potent in vivo effects suggested p38 MAPK docking-site-targeted inhibitors as a potential novel strategy for the treatment of inflammatory pain. ..
  4. Schipper H, Nuboer R, Prop S, van den Ham H, de Boer F, Kesmir C, et al. Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes. Diabetologia. 2012;55:2800-2810 pubmed publisher
    ..Our results indicate that inflammatory mechanisms linking obesity to its metabolic and cardiovascular complications are already activated in childhood obesity. ..
  5. Oude Engberink R, Blezer E, Hoff E, van der Pol S, van der Toorn A, Dijkhuizen R, et al. MRI of monocyte infiltration in an animal model of neuroinflammation using SPIO-labeled monocytes or free USPIO. J Cereb Blood Flow Metab. 2008;28:841-51 pubmed
    ..The use of SPIO-labeled monocytes provides a better tool to specifically assess the time window of monocyte infiltration. ..
  6. Ravetto A, Hoefer I, den Toonder J, Bouten C. A membrane-based microfluidic device for mechano-chemical cell manipulation. Biomed Microdevices. 2016;18:31 pubmed publisher
    ..Overall, this analysis shows that the device has potential applications as a cellular assay for analyzing cell-drug interaction. ..
  7. Budding K, van de Graaf E, Kardol Hoefnagel T, Broen J, Kwakkel van Erp J, Oudijk E, et al. A Promoter Polymorphism in the CD59 Complement Regulatory Protein Gene in Donor Lungs Correlates With a Higher Risk for Chronic Rejection After Lung Transplantation. Am J Transplant. 2016;16:987-98 pubmed publisher
    ..These findings support a role for complement in the pathogenesis of this posttransplant complication and are the first to show a deleterious association of a donor CD59 promoter polymorphism in lung transplantation. ..
  8. Nijhuis M, Pasterkamp G, Sluis N, de Kleijn D, Laman J, Ulfman L. Peptidoglycan increases firm adhesion of monocytes under flow conditions and primes monocyte chemotaxis. J Vasc Res. 2007;44:214-22 pubmed
    ..This study demonstrates that PG activation of monocytes results in an increase in adhesive and migratory capacities of these cells. This might be a mechanism by which PG promotes atherosclerotic disease in vivo. ..
  9. de Haas C, van der Tol M, van Kessel K, Verhoef J, van Strijp J. A synthetic lipopolysaccharide-binding peptide based on amino acids 27-39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human blood. J Immunol. 1998;161:3607-15 pubmed
    ..The ability of pep27-39 to antagonize specifically the effects of LPS in the complex environment of human blood suggests that pep27-39 may be a novel therapeutic agent in the treatment of gram-negative sepsis. ..

More Information


  1. Rutten B, Roest M, McClellan E, Sels J, Stubbs A, Jukema J, et al. Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention. Thromb Haemost. 2016;115:353-60 pubmed publisher
    ..These findings may imply that a high platelet density per monocyte protects against recurrence of adverse events. ..
  2. Paauw A, Leverstein van Hall M, Van Kessel K, Verhoef J, Fluit A. Yersiniabactin reduces the respiratory oxidative stress response of innate immune cells. PLoS ONE. 2009;4:e8240 pubmed publisher
  3. Marx J, Kartikasari A, Georgiou N. Can iron chelators influence the progression of atherosclerosis?. Hemoglobin. 2008;32:123-34 pubmed publisher
    ..Iron chelators may be effective in preventing vascular damage in patients with high concentrations of NTBI as found in thalassemia. ..
  4. van Erp E, van Kasteren P, Guichelaar T, Ahout I, de Haan C, Luytjes W, et al. In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants. J Virol. 2017;91: pubmed publisher
    ..Our data contribute to a better understanding of the impact of antibodies on RSV disease in infants. ..
  5. Vazirpanah N, Kienhorst L, van Lochem E, Wichers C, Rossato M, Shiels P, et al. Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout. Ann Rheum Dis. 2017;76:1313-1319 pubmed publisher
    ..005). Patients with gout have shorter telomeres than healthy participants, reflecting increased cellular senescence. Telomere shortening was associated with the number of flares and with cardiovascular disease in people with gout. ..
  6. Kumar D, Puan K, Andiappan A, Lee B, Westerlaken G, Haase D, et al. A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus. Genome Med. 2017;9:18 pubmed publisher
    ..Notably, the genetic regulation is achieved by a single CpG-SNP, which controls the overall methylation state of the promoter gene segment. ..
  7. Bardoel B, Vos R, Bouman T, Aerts P, Bestebroer J, Huizinga E, et al. Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3. J Mol Med (Berl). 2012;90:1109-20 pubmed publisher
    ..This unique function of SSL3 adds to the arsenal of immune evasive molecules that S. aureus can employ to subvert both innate and adaptive immunity...
  8. van de Weert van Leeuwen P, van Meegen M, Speirs J, Pals D, Rooijakkers S, van der Ent C, et al. Optimal complement-mediated phagocytosis of Pseudomonas aeruginosa by monocytes is cystic fibrosis transmembrane conductance regulator-dependent. Am J Respir Cell Mol Biol. 2013;49:463-70 pubmed publisher
  9. Bloemers B, van Bleek G, Kimpen J, Bont L. Distinct abnormalities in the innate immune system of children with Down syndrome. J Pediatr. 2010;156:804-9, 809.e1-809.e5 pubmed publisher
    ..Most strikingly, they had a high number of proinflammatory CD14(dim)CD16(+) monocytes. This elevated level of CD14(dim)CD16(+) monocytes may play an important role in the onset and maintenance of chronic inflammatory disease in DS. ..
  10. Gijsberts C, Ellenbroek G, Ten Berg M, Huisman A, van Solinge W, Lam C, et al. Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort. Am J Cardiol. 2017;120:911-916 pubmed publisher
    ..In conclusion, MLR is strongly related to HF markers and predicts HF hospitalizations during follow-up in patients with CAD. ..
  11. Pereira C, Middel J, Jansen G, Verhoef J, Nottet H. Enhanced expression of fractalkine in HIV-1 associated dementia. J Neuroimmunol. 2001;115:168-75 pubmed
    ..We propose that fractalkine produced during interactions between astrocytes and HIV-infected macrophages plays a role in HAD by regulating the trafficking of monocytic cells in the brain parenchyma. ..
  12. Wensink A, Kemp V, Fermie J, Garcia Laorden M, van der Poll T, Hack C, et al. Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes. Proc Natl Acad Sci U S A. 2014;111:5974-9 pubmed publisher
    ..We conclude that extracellular GrK is an unexpected direct modulator of LPS-TLR4 signaling during the antimicrobial innate immune response. ..
  13. Fokkema S. Peripheral blood monocyte responses in periodontitis. Int J Dent Hyg. 2012;10:229-35 pubmed publisher
  14. Gerrits A, Koekman C, Yildirim C, Nieuwland R, Akkerman J. Insulin inhibits tissue factor expression in monocytes. J Thromb Haemost. 2009;7:198-205 pubmed publisher
    ..Insulin inhibits TF expression in monocytes and monocyte-derived microparticles through interference with G(i)alpha(2)-mediated cAMP suppression, which attenuates Ca(2+)-mediated TF synthesis. ..
  15. de Groot D, Haverslag R, Pasterkamp G, de Kleijn D, Hoefer I. Targeted deletion of the inhibitory NF-kappaB p50 subunit in bone marrow-derived cells improves collateral growth after arterial occlusion. Cardiovasc Res. 2010;88:179-85 pubmed publisher
    ..Its absence in circulating cells improves tissue perfusion restoration after femoral artery ligation by increasing macrophage influx into the growing collateral vessels. ..
  16. Steevels T, van Avondt K, Westerlaken G, Stalpers F, Walk J, Bont L, et al. Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes. Eur J Immunol. 2013;43:1297-308 pubmed publisher
    ..We propose that SIRL-1 on phagocytes sets an activation threshold to prevent inappropriate production of oxygen radicals. Upon infection, SIRL-1 expression is downregulated, allowing microbial killing and clearance of the pathogen...
  17. Nieuwenhuizen L, Falkenburg W, Schutgens R, Roosendaal G, Van Veghel K, Biesma D, et al. Stimulation of naïve monocytes and PBMCs with coagulation proteases results in thrombin-mediated and PAR-1-dependent cytokine release and cell proliferation in PBMCs only. Scand J Immunol. 2013;77:339-49 pubmed publisher
    ..These data demonstrate that naïve monocytes are not triggered by coagulation proteases, whereas thrombin is able to elicit pro-inflammatory events in a PAR-1-dependent manner in PBMCs. ..
  18. Schoneveld A, Hoefer I, Sluijter J, Laman J, de Kleijn D, Pasterkamp G. Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. Atherosclerosis. 2008;197:95-104 pubmed
    ..However, with advanced stages of atherosclerotic disease, circulating blood cells become less responsive to TLR ligation, which may be due to chronic TLR engagement by endogenous EDA. ..
  19. Niers L, Timmerman H, Rijkers G, van Bleek G, van Uden N, Knol E, et al. Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines. Clin Exp Allergy. 2005;35:1481-9 pubmed
    ..These specific strains may be favorable to use in prevention or treatment of atopic disease. ..
  20. Versteeg D, Dol E, Hoefer I, Flier S, Buhre W, de Kleijn D, et al. Toll-like receptor 2 and 4 response and expression on monocytes decrease rapidly in patients undergoing arterial surgery and are related to preoperative smoking. Shock. 2009;31:21-7 pubmed publisher
    ..These results point to a significant role for TLRs in the induction of postoperative immune tolerance. Furthermore, smoking is negatively related to baseline TLR response. ..
  21. Kamphuis S, Kavelaars A, Brooimans R, Kuis W, Zegers B, Heijnen C. T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells. J Neuroimmunol. 1997;79:91-9 pubmed
    ..IL-4 and IL-10 do not induce PPE mRNA via the same pathways. We could observe that PKA is involved in IL-4 mediated PPE mRNA induction, whereas IL-10 apparently uses another route. ..
  22. Steevels T, Lebbink R, Westerlaken G, Coffer P, Meyaard L. Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. J Immunol. 2010;184:4741-8 pubmed publisher
    ..Thus, SIRL-1 is a novel inhibitory immune receptor belonging to the growing family of ITIM-bearing receptors that is implied in the regulation of phagocytes. ..
  23. Bouwman J, Diepersloot R, Visseren F. Intracellular infections enhance interleukin-6 and plasminogen activator inhibitor 1 production by cocultivated human adipocytes and THP-1 monocytes. Clin Vaccine Immunol. 2009;16:1222-7 pubmed publisher
    ..Thus, infection of adipose tissue evokes an inflammatory response, leading to adipose tissue dysfunction and subsequent overproduction of IL-6 and PAI-1. This may further compound the atherogenic effects of obesity. ..