Experts and Doctors on intracellular signaling peptides and proteins in Utrecht, Netherlands


Locale: Utrecht, Netherlands
Topic: intracellular signaling peptides and proteins

Top Publications

  1. Slim C, Lázaro Diéguez F, Bijlard M, Toussaint M, de Bruin A, Du Q, et al. Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes. PLoS Biol. 2013;11:e1001739 pubmed publisher
    ..Proliferating hepatocytes thus display an asymmetric inheritance of their apical domains via a mechanism that involves Par1b and LGN, which we postulate serves the unique tissue architecture of the developing liver parenchyma. ..
  2. de Bie P, van De Sluis B, Burstein E, Duran K, Berger R, Duckett C, et al. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J. 2006;398:63-71 pubmed
    ..Taken together, these data support the significance of COMMD protein-protein interactions and provide new mechanistic insight into the function of this protein family in NF-kappaB signalling. ..
  3. Hindriksen S, Bramer A, Truong M, Vromans M, Post J, Verlaan Klink I, et al. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS ONE. 2017;12:e0179514 pubmed publisher
    ..Tagging of the CPC recruitment factor Haspin with the fluorescent reporter YFP allowed us to study its native localization as well as recruitment to the cohesin subunit Pds5B. ..
  4. Lebbink R, de Ruiter T, Verbrugge A, Bril W, Meyaard L. The mouse homologue of the leukocyte-associated Ig-like receptor-1 is an inhibitory receptor that recruits Src homology region 2-containing protein tyrosine phosphatase (SHP)-2, but not SHP-1. J Immunol. 2004;172:5535-43 pubmed
    ..Screening human and mouse cell lines for mLAIR-1 and human LAIR-1 binding partners identified several lines expressing putative ligand(s) for both receptors. ..
  5. Camargo N, Goudriaan A, van Deijk A, Otte W, Brouwers J, Lodder H, et al. Oligodendroglial myelination requires astrocyte-derived lipids. PLoS Biol. 2017;15:e1002605 pubmed publisher
    ..We conclude that lipid synthesis by oligodendrocytes is heavily supplemented by astrocytes in vivo and that horizontal lipid flux is a major feature of normal brain development and myelination. ..
  6. de Groot R, Farin H, Macůrková M, van Es J, Clevers H, Korswagen H. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. PLoS ONE. 2013;8:e76971 pubmed publisher
  7. Janssen A, van der Burg M, Szuhai K, Kops G, Medema R. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science. 2011;333:1895-8 pubmed publisher
    ..Our data show that segregation errors can cause translocations and provide insights into the role of whole-chromosome instability in tumorigenesis...
  8. Hogan B, Herpers R, Witte M, Helotera H, Alitalo K, Duckers H, et al. Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development. 2009;136:4001-9 pubmed publisher
    ..We propose that this mechanism contributes to the differential response of developing arteries and veins to a constant source of Vegfc present in the embryo during angiogenesis. ..
  9. van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf P, Heck A, et al. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. FEBS Lett. 2008;582:2838-42 pubmed publisher
    ..We also found that SNAP25 bound to the same region in Zwint-1 as rab3c, suggesting a new role for the kinetochore protein Zwint-1 in presynaptic events that are regulated by rab3 and SNAP25. ..

More Information


  1. Demircan T, Berezikov E. The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano. Stem Cells Dev. 2013;22:2174-85 pubmed publisher
    ..This work establishes M. lignano as a productive model for investigation of the Hippo pathway. ..
  2. van Mil A, Vrijsen K, Goumans M, Metz C, Doevendans P, Sluijter J. MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells. J Mol Med (Berl). 2013;91:1001-12 pubmed publisher
  3. Szypowska A, de Ruiter H, Meijer L, Smits L, Burgering B. Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. Antioxid Redox Signal. 2011;14:563-78 pubmed publisher
    ..Conversely, NLK-dependent inhibition of FOXO4 activity can provide a means to downregulate this defensive program, when oxidative stress reaches a level beyond which repair is no longer feasible and cells need to undergo apoptosis. ..
  4. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..These results demonstrate that SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of Wls from other retromer cargo. ..
  5. Sartori da Silva M, Tee J, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, et al. Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo. PLoS ONE. 2010;5:e14023 pubmed publisher
  6. de Keizer P, Packer L, Szypowska A, Riedl Polderman P, van den Broek N, de Bruin A, et al. Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res. 2010;70:8526-36 pubmed publisher
    ..Together, these findings support a model in which FOXOs mediate a trade-off between cancer and aging. ..
  7. Galli G, Carrara M, Yuan W, Valdes Quezada C, Gurung B, Pepe Mooney B, et al. YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers. Mol Cell. 2015;60:328-37 pubmed publisher
    ..Our results here uncover the molecular mechanisms employed by YAP to exert its growth and oncogenic functions, and suggest strategies for intervention. ..
  8. Ylikallio E, Woldegebriel R, Tumiati M, Isohanni P, Ryan M, Stark Z, et al. MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability. Brain. 2017;140:2093-2103 pubmed publisher
    ..The identification of MCM3AP variants in affected individuals from multiple centres establishes it as a disease gene for childhood-onset recessively inherited Charcot-Marie-Tooth neuropathy with intellectual disability. ..