Experts and Doctors on axons in Hachiōji, Tokyo, Japan
Locale: Hachiōji, Tokyo, Japan
Suzuki A, Hoshi T, Ishibashi T, Hayashi A, Yamaguchi Y, Baba H. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice. Glia. 2004;46:274-83 pubmed
..Thus, the paranodal junction significantly influences the retention of Nav1.6 in the node, which is followed by disorganization of nodal structures. However, its importance may differ between the central and peripheral nervous system. ..
Hoshi T, Suzuki A, Hayashi S, Tohyama K, Hayashi A, Yamaguchi Y, et al
. Nodal protrusions, increased Schmidt-Lanterman incisures, and paranodal disorganization are characteristic features of sulfatide-deficient peripheral nerves. Glia. 2007;55:584-94 pubmed
..Therefore, these results indicate that sulfatide may play an important role in the PNS, especially in the regions where myelin-axon interactions occur. ..
Kajigaya H, Tanaka K, Hayashi A, Suzuki A, Ishibashi T, Ikenaka K, et al
. Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:415-24 pubmed
..However, BrdU(+) proliferating OPCs were more abundant in CST-deficient mice. These results suggest that sulfated glycolipids may be involved in proliferation of OPCs in vivo. ..
Hayashi A, Kaneko N, Tomihira C, Baba H. Sulfatide decrease in myelin influences formation of the paranodal axo-glial junction and conduction velocity in the sciatic nerve. Glia. 2013;61:466-74 pubmed publisher
..Thus, the fine regulation of myelin sulfatide content by CST is important for normal function of myelinated axons. ..