Experts and Doctors on neuropeptides in Suita, Ōsaka, Japan


Locale: Suita, Ōsaka, Japan
Topic: neuropeptides

Top Publications

  1. Liu J, Wu X, Zhang H, Qiu R, Yoshikawa K, Lu Q. Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters. Dev Neurobiol. 2016;76:587-99 pubmed publisher
    ..These data present a resource useful for further investigation of the molecular regulations and functions of projection neurons and interneurons. ..
  2. Nakamura T, Jeromin A, Mikoshiba K, Wakabayashi S. Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011;109:512-23 pubmed publisher
    ..NCS-1 is an important regulator of immature heart function and hypertrophy, and it functions in part by promoting IP(3)R function, followed by CaMKII-dependent signal activation. ..
  3. Imaizumi K, Morihara T, Mori Y, Katayama T, Tsuda M, Furuyama T, et al. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. J Biol Chem. 1999;274:7975-81 pubmed
    ..Thus, the induction of DP5 mRNA and the interaction of DP5 and Bcl-xl could play significant roles in neuronal degeneration following exposure to A beta. ..
  4. Matsubae M, Kurihara T, Tachibana T, Imamoto N, Yoneda Y. Characterization of the nuclear transport of a novel leucine-rich acidic nuclear protein-like protein. FEBS Lett. 2000;468:171-5 pubmed
    ..mLANP-L NLS bound preferentially to Rch1 and NPI-1, but not to the Qip1 subfamily of importin alpha. These findings suggest that mLANP-L is transported into the nucleus by Rch1 and/or NPI-1. ..
  5. Hashimoto M, Shinohara K, Wang J, Ikeuchi S, Yoshiba S, Meno C, et al. Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol. 2010;12:170-6 pubmed publisher
    ..These results suggest that posterior positioning of the basal body, which provides the posterior tilt to node cilia, is determined by planar polarization mediated by noncanonical Wnt signalling. ..
  6. Miyazato M, Mori K, Ida T, Kojima M, Murakami N, Kangawa K. Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S. Regul Pept. 2008;145:37-41 pubmed
    ..These findings suggest that NMS is implicated in the regulation of circadian rhythm and feeding behavior. ..
  7. Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, et al. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron. 1998;20:905-15 pubmed
    ..These results suggest that tomosyn is an important component in the neurotransmitter release process where it may stimulate SNARE complex formation. ..
  8. Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y. Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am J Physiol Cell Physiol. 2002;282:C1396-403 pubmed
    ..Therefore, the Kir channel may be involved in formation of the resting membrane potential of the spines and, thus, would affect the response of N-methyl-D-aspartic acid receptor channels at the excitatory postsynaptic membrane. ..
  9. Hashimoto H, Shintani N, Baba A. Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants. Biochem Biophys Res Commun. 2002;297:427-31 pubmed
    ..A functional comparison between PACAP and amnesiac underlines phylogenetically conserved functions across phyla and may provide insights into the possible mechanisms of action and evolution of this neuropeptidergic system. ..

More Information


  1. Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, et al. Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic ? cells. Biochem Biophys Res Commun. 2017;493:677-683 pubmed publisher
    ..Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. ..
  2. Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, et al. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. J Biol Chem. 2013;288:10176-87 pubmed publisher
    ..Thus, Rheb-dependent mTORC1 activation becomes essential for cardiomyocyte hypertrophic growth after early postnatal period. ..
  3. Tanaka H, Nogi T, Yasui N, Iwasaki K, Takagi J. Structural basis for variant-specific neuroligin-binding by α-neurexin. PLoS ONE. 2011;6:e19411 pubmed publisher
  4. Morishita H, Murata Y, Esumi S, Hamada S, Yagi T. CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity. Neuroreport. 2004;15:2595-9 pubmed
    ..This pattern of CNR/Pcdhalpha expression suggests its involvement in the development of neocortical connectivity. ..
  5. Shintani N, Mori W, Hashimoto H, Imai M, Tanaka K, Tomimoto S, et al. Defects in reproductive functions in PACAP-deficient female mice. Regul Pept. 2002;109:45-8 pubmed
    ..These data suggest a role for endogenous PACAP in female reproductive processes. ..
  6. Sun J, Tadokoro S, Imanaka T, Murakami S, Nakamura M, Kashiwada K, et al. Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. FEBS Lett. 1998;437:304-8 pubmed
    ..The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. ..
  7. Yasui Y, Yamaguchi M, Jikihara H, Yamamoto T, Kanzaki T, Murata Y. Expression of prolactin-releasing peptide in human placenta and decidua. Endocr J. 2001;48:397-401 pubmed
    ..These findings suggest that PrRP produced by the human placenta and decidua does not affect decidual PRL secretion due to a lack of the receptor, and that it may play other roles during pregnancy. ..
  8. Hashimoto H, Shintani N, Tanaka K, Mori W, Hirose M, Matsuda T, et al. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001;98:13355-60 pubmed
    ..The present study provides evidence that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors. ..
  9. Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, et al. Interactions of drebrin and gephyrin with profilin. Biochem Biophys Res Commun. 1998;243:86-9 pubmed
    ..These proteins had a proline-rich domain and directly interacted with profilin. ..
  10. Ensho T, Maruyama K, Mori K, Miyazato M, Kangawa K, Nakahara K, et al. Neuromedin U precursor-related peptide (NURP) exerts neuromedin U-like sympathetic nerve action in the rat. Biochem Biophys Res Commun. 2017;492:412-418 pubmed publisher
    ..These results suggest that although NURP33 and 36 do not activate the NMU receptors, they might exert NMU-like sympathetic nerve action in the brain. ..
  11. Matsuo N, Kawamoto S, Matsubara K, Okubo K. A novel SCG10-related gene uniquely expressed in the nervous system. Gene. 1998;215:477-81 pubmed
    ..The identification of HiAT3 suggests that there may be an elaborate destabilizing regulation for microtubule dynamics in neurons in addition to the stabilizing effect of multiple microtubule-associated proteins (MAPs). ..
  12. Sato H, Fukutani Y, Yamamoto Y, Tatara E, Takemoto M, Shimamura K, et al. Thalamus-derived molecules promote survival and dendritic growth of developing cortical neurons. J Neurosci. 2012;32:15388-402 pubmed publisher
    ..Taken together, these results suggest that the thalamus-specific molecules NRN1 and VGF play an important role in the dendritic growth and survival of cortical neurons in a cell type-specific manner. ..
  13. Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, et al. Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene. FEBS Lett. 1999;442:151-6 pubmed
    ..Our data suggest that humans have two homologues of gcm like mice and that human gcm genes form a novel family which may function not only during fetal development but also in the postnatal or pathological stage. ..
  14. Mishiro Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, et al. Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem. 2010;114:1097-106 pubmed publisher
    ..Taken together, we deduce that VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and GI tract. ..
  15. Usui S, Konno D, Hori K, Maruoka H, Okabe S, Fujikado T, et al. Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin. J Biol Chem. 2003;278:10619-28 pubmed
    ..Thus, these data suggest that the PSD-Zip45-shank and PSD-95-GKAP complexes form different synaptic compartments, and PSD-Zip45 alone or PSD-Zip45-shank is involved in the synaptic accumulation of F-actin. ..
  16. Saito H, Kimura M, Inanobe A, Ohe T, Kurachi Y. An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem Biophys Res Commun. 2002;296:523-9 pubmed
    ..Both Homer proteins bound to mGluR5b in vitro. Therefore, the N-terminal portion of Homer1d may facilitate trafficking of Homer1-mGluR5 complex from the ER to the PM. ..
  17. Nakamura T, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, et al. Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. J Cell Biol. 2006;172:1081-91 pubmed
    ..We propose that NCS-1 is a novel survival-promoting factor up-regulated in injured neurons that mediates the GDNF survival signal via the phosphatidylinositol 3-kinase-Akt pathway. ..
  18. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, et al. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 2005;24:325-35 pubmed
    ..These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. ..
  19. Morishita H, Kawaguchi M, Murata Y, Seiwa C, Hamada S, Asou H, et al. Myelination triggers local loss of axonal CNR/protocadherin alpha family protein expression. Eur J Neurosci. 2004;20:2843-7 pubmed
    ..Thus, myelination may be a trigger for the local loss of axonal CNR/Pcdh alpha protein, and this process may be important in the maturation of neural circuits. ..
  20. Yanase H, Sugino H, Yagi T. Genomic sequence and organization of the family of CNR/Pcdhalpha genes in rat. Genomics. 2004;83:717-26 pubmed
    ..The relative expression profiles of the rat CNRs (v1-v13) show that all the CNRs are transcribed, but there are variations in the expression ratios among the CNRs. ..
  21. Mutoh T, Hamada S, Senzaki K, Murata Y, Yagi T. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1. Exp Cell Res. 2004;294:494-508 pubmed
    ..These results indicate that CNR1 has a heterophilic, calcium-dependent cell adhesion activity with the beta1 integrin subfamily, and raise the possibility of CNR-beta1 integrin association in synaptogenesis. ..
  22. Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, et al. Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. J Pharmacol Exp Ther. 2004;309:796-803 pubmed