Genomes and Genes
Experts and Doctors on neuropeptides in Suita, Ōsaka, Japan
Locale: Suita, Ōsaka, Japan
- Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, et al. Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic ? cells. Biochem Biophys Res Commun. 2017;493:677-683 pubmed publisher..Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. ..
- Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, et al. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. J Biol Chem. 2013;288:10176-87 pubmed publisher..Thus, Rheb-dependent mTORC1 activation becomes essential for cardiomyocyte hypertrophic growth after early postnatal period. ..
- Morishita H, Murata Y, Esumi S, Hamada S, Yagi T. CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity. Neuroreport. 2004;15:2595-9 pubmed..This pattern of CNR/Pcdhalpha expression suggests its involvement in the development of neocortical connectivity. ..
- Shintani N, Mori W, Hashimoto H, Imai M, Tanaka K, Tomimoto S, et al. Defects in reproductive functions in PACAP-deficient female mice. Regul Pept. 2002;109:45-8 pubmed..These data suggest a role for endogenous PACAP in female reproductive processes. ..
- Sun J, Tadokoro S, Imanaka T, Murakami S, Nakamura M, Kashiwada K, et al. Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. FEBS Lett. 1998;437:304-8 pubmed..The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. ..
- Yasui Y, Yamaguchi M, Jikihara H, Yamamoto T, Kanzaki T, Murata Y. Expression of prolactin-releasing peptide in human placenta and decidua. Endocr J. 2001;48:397-401 pubmed..These findings suggest that PrRP produced by the human placenta and decidua does not affect decidual PRL secretion due to a lack of the receptor, and that it may play other roles during pregnancy. ..
- Hashimoto H, Shintani N, Tanaka K, Mori W, Hirose M, Matsuda T, et al. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001;98:13355-60 pubmed..The present study provides evidence that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors. ..
- Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, et al. Interactions of drebrin and gephyrin with profilin. Biochem Biophys Res Commun. 1998;243:86-9 pubmed..These proteins had a proline-rich domain and directly interacted with profilin. ..
- Ensho T, Maruyama K, Mori K, Miyazato M, Kangawa K, Nakahara K, et al. Neuromedin U precursor-related peptide (NURP) exerts neuromedin U-like sympathetic nerve action in the rat. Biochem Biophys Res Commun. 2017;492:412-418 pubmed publisher..These results suggest that although NURP33 and 36 do not activate the NMU receptors, they might exert NMU-like sympathetic nerve action in the brain. ..
- Matsuo N, Kawamoto S, Matsubara K, Okubo K. A novel SCG10-related gene uniquely expressed in the nervous system. Gene. 1998;215:477-81 pubmed..The identification of HiAT3 suggests that there may be an elaborate destabilizing regulation for microtubule dynamics in neurons in addition to the stabilizing effect of multiple microtubule-associated proteins (MAPs). ..
- Sato H, Fukutani Y, Yamamoto Y, Tatara E, Takemoto M, Shimamura K, et al. Thalamus-derived molecules promote survival and dendritic growth of developing cortical neurons. J Neurosci. 2012;32:15388-402 pubmed publisher..Taken together, these results suggest that the thalamus-specific molecules NRN1 and VGF play an important role in the dendritic growth and survival of cortical neurons in a cell type-specific manner. ..
- Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, et al. Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene. FEBS Lett. 1999;442:151-6 pubmed..Our data suggest that humans have two homologues of gcm like mice and that human gcm genes form a novel family which may function not only during fetal development but also in the postnatal or pathological stage. ..
- Mishiro Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, et al. Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem. 2010;114:1097-106 pubmed publisher..Taken together, we deduce that VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and GI tract. ..
- Usui S, Konno D, Hori K, Maruoka H, Okabe S, Fujikado T, et al. Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin. J Biol Chem. 2003;278:10619-28 pubmed..Thus, these data suggest that the PSD-Zip45-shank and PSD-95-GKAP complexes form different synaptic compartments, and PSD-Zip45 alone or PSD-Zip45-shank is involved in the synaptic accumulation of F-actin. ..
- Saito H, Kimura M, Inanobe A, Ohe T, Kurachi Y. An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem Biophys Res Commun. 2002;296:523-9 pubmed..Both Homer proteins bound to mGluR5b in vitro. Therefore, the N-terminal portion of Homer1d may facilitate trafficking of Homer1-mGluR5 complex from the ER to the PM. ..
- Nakamura T, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, et al. Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. J Cell Biol. 2006;172:1081-91 pubmed..We propose that NCS-1 is a novel survival-promoting factor up-regulated in injured neurons that mediates the GDNF survival signal via the phosphatidylinositol 3-kinase-Akt pathway. ..
- Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, et al. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 2005;24:325-35 pubmed..These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. ..
- Morishita H, Kawaguchi M, Murata Y, Seiwa C, Hamada S, Asou H, et al. Myelination triggers local loss of axonal CNR/protocadherin alpha family protein expression. Eur J Neurosci. 2004;20:2843-7 pubmed..Thus, myelination may be a trigger for the local loss of axonal CNR/Pcdh alpha protein, and this process may be important in the maturation of neural circuits. ..
- Yanase H, Sugino H, Yagi T. Genomic sequence and organization of the family of CNR/Pcdhalpha genes in rat. Genomics. 2004;83:717-26 pubmed..The relative expression profiles of the rat CNRs (v1-v13) show that all the CNRs are transcribed, but there are variations in the expression ratios among the CNRs. ..
- Mutoh T, Hamada S, Senzaki K, Murata Y, Yagi T. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1. Exp Cell Res. 2004;294:494-508 pubmed..These results indicate that CNR1 has a heterophilic, calcium-dependent cell adhesion activity with the beta1 integrin subfamily, and raise the possibility of CNR-beta1 integrin association in synaptogenesis. ..
- Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, et al. Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. J Pharmacol Exp Ther. 2004;309:796-803 pubmed