Experts and Doctors on ion channels in Suita, Ōsaka, Japan


Locale: Suita, Ōsaka, Japan
Topic: ion channels

Top Publications

  1. Nakamura T, Iwata Y, Sampaolesi M, Hanada H, Saito N, Artman M, et al. Stretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters. Am J Physiol Cell Physiol. 2001;281:C690-9 pubmed
    ..6 hamster myotubes. These results suggest a possible mechanism by which cell damage might occur in this animal model of muscular dystrophy. ..
  2. Okamura Y, Murata Y, Iwasaki H. Voltage-sensing phosphatase: actions and potentials. J Physiol. 2009;587:513-20 pubmed publisher
    ..The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed. ..
  3. Fujiwara Y, Kurokawa T, Takeshita K, Kobayashi M, Okochi Y, Nakagawa A, et al. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun. 2012;3:816 pubmed publisher
  4. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399:483-7 pubmed
    ..Our results indicate that the Bcl-2 family of proteins bind to the VDAC in order to regulate the mitochondrial membrane potential and the release of cytochrome c during apoptosis. ..
  5. Shimizu S, Tsujimoto Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A. 2000;97:577-82 pubmed
    ..These findings indicated the involvement of a different mechanism in BH3-only, protein-induced apoptogenic cytochrome c release. ..
  6. Sugiyama T, Shimizu S, Matsuoka Y, Yoneda Y, Tsujimoto Y. Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim. Oncogene. 2002;21:4944-56 pubmed
    ..These results indicate that Bim has an ability to activate directly the VDAC, which plays an important role in apoptosis of mammalian cells. ..
  7. Yamada S, Isojima Y, Yamatodani A, Nagai K. Uncoupling protein 2 influences dopamine secretion in PC12h cells. J Neurochem. 2003;87:461-9 pubmed
    ..Thus, UCP2 appears to be regulated by the excitatory stimulus via the cAMP-PKA cascade and serves to negatively control the synaptic output by reducing intracellular ATP levels. ..
  8. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, et al. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens. 2004;22:97-102 pubmed
    ..These data indicate that the polymorphism of the UCP2 gene is associated with hypertension, and suggest the possibility of UCP2 as a target molecule for studies on the etiology and treatment of hypertension. ..
  9. Yasuda O, Fukuo K, Sun X, Nishitani M, Yotsui T, Higuchi M, et al. Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. J Biol Chem. 2006;281:23899-907 pubmed
    ..Our findings, thus, indicate that the expression of Apop-1 induces apoptosis though CypD-dependent pathway and that Apop-1 plays roles in cell death under physiological conditions. ..

More Information


  1. Kitahara T, Horii A, Kizawa K, Maekawa C, Kubo T. Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy. Neurosci Res. 2007;59:237-42 pubmed
    ..These findings suggest that mitochondrial UCPs could play both a neuro-protective role against oxidative damage and a thermal signaling role for neuro-modulation in vestibular nerve. ..
  2. Okochi Y, Sasaki M, Iwasaki H, Okamura Y. Voltage-gated proton channel is expressed on phagosomes. Biochem Biophys Res Commun. 2009;382:274-9 pubmed publisher
    ..These are consistent with the idea that voltage-gated proton channels help NADPH oxidase in phagocytes to produce reactive oxygen species. ..
  3. Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson H, Okamura Y. Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol. 2013;591:627-40 pubmed publisher
  4. Kurokawa T, Okamura Y. Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection. Biochim Biophys Acta. 2014;1838:382-7 pubmed publisher
    ..These findings suggest an inner vestibule lined by several residues on S2 including F146, D108 on S1, and the C-terminal half of S4. ..
  5. Takeshita K, Sakata S, Yamashita E, Fujiwara Y, Kawanabe A, Kurokawa T, et al. X-ray crystal structure of voltage-gated proton channel. Nat Struct Mol Biol. 2014;21:352-7 pubmed publisher
    ..These findings provide a platform for understanding the general principles of voltage sensing and proton permeation. ..
  6. Maeda Y, Ide T, Koike M, Uchiyama Y, Kinoshita T. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat Cell Biol. 2008;10:1135-45 pubmed publisher
    ..After reconstitution in planar lipid bilayers, GPHR exhibited a voltage-dependent anion-channel activity that may function in counterion conductance. Thus, GPHR modulates Golgi functions through regulation of acidification...
  7. Sakata S, Kurokawa T, Nørholm M, Takagi M, Okochi Y, von Heijne G, et al. Functionality of the voltage-gated proton channel truncated in S4. Proc Natl Acad Sci U S A. 2010;107:2313-8 pubmed publisher
    ..These findings provide important clues to the molecular mechanism underlying voltage sensing and proton permeation in Hv channels. ..