Experts and Doctors on enzyme activation in Wako, Saitama, Japan


Locale: Wako, Saitama, Japan
Topic: enzyme activation

Top Publications

  1. Saito Nakano Y, Nakano A. Sed4p functions as a positive regulator of Sar1p probably through inhibition of the GTPase activation by Sec23p. Genes Cells. 2000;5:1039-48 pubmed
    ..We propose a model that Sed4p counteracts the GAP action of Sec23p on to Sar1p. ..
  2. Igaki T, Yamamoto Goto Y, Tokushige N, Kanda H, Miura M. Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC. J Biol Chem. 2002;277:23103-6 pubmed
    ..These results suggest the existence of a novel mechanism for cell death signaling in Drosophila that is mediated by DRONC and Dark. ..
  3. Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem. 2002;277:34287-94 pubmed
    ..These data suggest that procaspase-9 is a substrate of caspase-12 and that ER stress triggers a specific cascade involving caspase-12, -9, and -3 in a cytochrome c-independent manner. ..
  4. Katoh I, Tomimori Y, Ikawa Y, Kurata S. Dimerization and processing of procaspase-9 by redox stress in mitochondria. J Biol Chem. 2004;279:15515-23 pubmed
  5. Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, et al. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem. 2005;280:15229-37 pubmed
  6. Kamada K, Hanaoka F. Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Mol Cell. 2005;19:497-509 pubmed publisher
    ..Complementary biochemical experiments demonstrate that the YoeB toxin has an in vitro RNase activity that preferentially cleaves at the 3' end of purine ribonucleotides...
  7. Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, et al. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. FASEB J. 2012;26:1204-17 pubmed publisher
    ..These findings implicate that calpain activation plays a pivotal role in the A?-triggered pathological cascade, highlighting a target for pharmacological intervention in the treatment of AD. ..
  8. Campbell D, Okamoto H. Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization. J Cell Biol. 2013;203:657-72 pubmed publisher
  9. Khan K, Schneider Poetsch T, Ishfaq M, Ito A, Yoshimoto R, Mukaida N, et al. Splicing inhibition induces gene expression through canonical NF-?B pathway and extracellular signal-related kinase activation. FEBS Lett. 2014;588:1053-7 pubmed publisher
    ..Systematic deletion studies suggested that NF-?B activation is mainly responsible for SSA-induced promoters activation. ..

More Information


  1. Nakanishi K, Maruyama M, Shibata T, Morishima N. Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development. J Biol Chem. 2001;276:41237-44 pubmed
    ..Our results show that the specific antibody is useful for in situ detection of caspase-9 activation in programmed cell death. ..
  2. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, et al. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol. 2002;4:705-10 pubmed
    ..Taken together, our results indicate that DIAP1 may modulate cell death by regulating JNK activation through a ubiquitin#150;proteasome pathway. ..
  3. Endo S, Nairn A, Greengard P, Ito M. Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor. Neurosci Res. 2003;45:79-89 pubmed
    ..These results characterize further the inhibition of PP-1 and PP-2A by phospho-G-substrate, and demonstrate its physiological phosphorylation in rat Purkinje cells. ..
  4. Nakagawa Y. Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads. Biosci Biotechnol Biochem. 2012;76:1262-74 pubmed
    ..This review focuses on artificial analogs of phorbol esters, teleocidins, and aplysiatoxins, and discusses their potential as biochemical tools and therapeutic leads. ..