Experts and Doctors on brain in Wako, Saitama, Japan


Locale: Wako, Saitama, Japan
Topic: brain

Top Publications

  1. Sun X, Sato S, Murayama O, Murayama M, Park J, Yamaguchi H, et al. Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett. 2002;321:61-4 pubmed
  2. Matsumata M, Inada H, Osumi N. Fatty acid binding proteins and the nervous system: Their impact on mental conditions. Neurosci Res. 2016;102:47-55 pubmed publisher
    ..This might provide a good example of how nutritional environment can affect psychiatric conditions at the molecular level. ..
  3. Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima Ando K, Iijima K, et al. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS ONE. 2006;1:e51 pubmed
    ..These results indicate that, despite speculation to the contrary, the phosphorylation state of APP at Thr668 does not play an obvious role in governing the physiological levels of brain Abeta40 or Abeta42 in vivo. ..
  4. Sadakata T, Washida M, Furuichi T. Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. BMC Neurosci. 2007;8:25 pubmed
  5. Nagae M, Kanagawa M, Morita Matsumoto K, Hanashima S, Kizuka Y, Taniguchi N, et al. Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins. Sci Rep. 2016;6:22973 pubmed publisher
    ..Restriction of glycan flexibility by certain sugar residues may be more common than previously thought and impinges on the mechanism of glycoform-dependent biological functions. ..
  6. Nakahara H, Hikosaka O. Learning to represent reward structure: a key to adapting to complex environments. Neurosci Res. 2012;74:177-83 pubmed publisher
  7. Kobayashi T, Haruta M, Sasagawa K, Matsumata M, Eizumi K, Kitsumoto C, et al. "Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca(2+) fluoroimaging". Sci Rep. 2016;6:21247 pubmed publisher
    ..The device succeeded in activating cells locally by selective photostimulation, and the physiological Ca(2+) dynamics of neural cells were visualized simultaneously by fluorescence imaging. ..
  8. Nagatsuka Y, Horibata Y, Yamazaki Y, Kinoshita M, Shinoda Y, Hashikawa T, et al. Phosphatidylglucoside exists as a single molecular species with saturated fatty acyl chains in developing astroglial membranes. Biochemistry. 2006;45:8742-50 pubmed
    ..This saturated fatty acyl chain composition comprising a single molecular species rarely occurs in known mammalian lipids and provides a molecular basis for why PtdGlc resides in raftlike lipid microdomains. ..
  9. Miyamoto D, Murayama M. The fiber-optic imaging and manipulation of neural activity during animal behavior. Neurosci Res. 2016;103:1-9 pubmed publisher
    ..The present review introduces recent progress in fiber-optic imaging and manipulation methods, while also discussing fiber-optic system designs that are suitable for a given experimental protocol. ..

More Information


  1. Takashima A. [Drug development for tauopathy and Alzheimer's disease]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2010;30:177-80 pubmed
    ..Therefore, inhibition of oligomer tau, and granular tau aggregation is expected to block the progression of AD symptoms by preventing synapse loss and neuronal loss. ..
  2. Takashima A. Amyloid-beta, tau, and dementia. J Alzheimers Dis. 2009;17:729-36 pubmed publisher
  3. Matsunaga E, Okanoya K. Expression analysis of cadherins in the songbird brain: relationship to vocal system development. J Comp Neurol. 2008;508:329-42 pubmed publisher
    ..These patterns of song nuclei related expression suggest the possibility that cadherins are involved in the formation and maintenance of the song nuclei or neural pathways of the song system. ..
  4. Lee Y, Kurosawa N, Hamamoto T, Nakaoka T, Tsuji S. Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. Eur J Biochem. 1993;216:377-85 pubmed
    ..This enzyme exhibited the transferase activity toward only the disaccharide moiety of Gal beta 1,3GalNAc of glycoproteins and glycolipids, no significant activity being detected for the other substrates tested. ..
  5. Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor E, Taniguchi N. Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. J Biol Chem. 2014;289:11253-61 pubmed publisher
    ..These results reveal a new epigenetic mechanism of brain-specific GnT-IX expression regulated by defined chromatin modifiers, providing new insights into the tissue-specific expression of glycosyltransferases. ..
  6. Shikata Y, Okada T, Hashimoto M, Ellis T, Matsumaru D, Shiroishi T, et al. Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Dev Biol. 2011;349:147-59 pubmed publisher
    ..These data indicated that endogenous Ptch1 mediates the broad effects of Shh on the transition from VZ progenitors to IPCs and activation of proliferation of the IPCs in the cortex during late gestational stages. ..
  7. Matsunaga E, Okanoya K. Vocal area-related expression of the androgen receptor in the budgerigar (Melopsittacus undulatus) brain. Brain Res. 2008;1208:87-94 pubmed publisher
  8. Fukuda M, Mikoshiba K. The N-terminal cysteine cluster is essential for membrane targeting of B/K protein. Biochem J. 2001;360:441-8 pubmed
    ..Based on our findings, we propose that the N-terminal domain of B/K protein contains a novel cysteine-based protein motif that may allow B/K protein to localize in the trans-Golgi network. ..
  9. Huang J, Furuya A, Furuichi T. Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2. J Cell Biol. 2007;179:539-52 pubmed
    ..These findings suggest that v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth. ..
  10. Tomomura M, Morita N, Yoshikawa F, Konishi A, Akiyama H, Furuichi T, et al. Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neuroscience. 2007;148:510-21 pubmed
  11. Liu H, Nakagawa T, Kanematsu T, Uchida T, Tsuji S. Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. J Neurochem. 1999;72:1781-90 pubmed
    ..Our results suggested that these GDAP genes might be involved in the signal transduction pathway that is triggered through the expression of a single sialyltransferase gene to induce neurite-like differentiation of Neuro2a cells. ..
  12. Yano R, Yap C, Yamazaki Y, Muto Y, Kishida H, Okada D, et al. Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. Neuroscience. 2003;117:373-81 pubmed
  13. Sassa T, Gomi H, Itohara S. Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Cell Tissue Res. 2004;315:147-56 pubmed
    ..These results suggest that cdkl2 functions mainly in mature neurons and that mechanisms governing regulation of this gene expression in mice are distinct from those of immediate-early genes. ..
  14. Hoshino J, Aruga J, Ishiguro A, Mikoshiba K. Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Brain Res Mol Brain Res. 2003;120:57-64 pubmed
    ..In addition, Dorz1 expression was up-regulated in cultured cells overexpressing Zic1. These results suggest that Dorz1 expression is positively regulated by Zic1 during cerebellar development. ..
  15. Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, et al. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem. 2005;280:15229-37 pubmed
  16. Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, et al. Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Brain Res Mol Brain Res. 2003;112:103-12 pubmed
    ..These results suggest that, in addition to its role in cell death in mature neurons, AATYK has a unique role in promoting neurite extension through its tyrosine kinase activity in developing neurons. ..
  17. Tanemura K, Chui D, Fukuda T, Murayama M, Park J, Akagi T, et al. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006;281:5037-41 pubmed
  18. Lee Y, Kaufmann M, Kitazume Kawaguchi S, Kono M, Takashima S, Kurosawa N, et al. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. J Biol Chem. 1999;274:11958-67 pubmed
    ..Although the substrate specificity of this enzyme is similar to that of ST6GalNAc III, ST6GalNAc IV prefers O-glycans to glycolipids. Glycolipids, however, are better substrates for ST6GalNAc III. ..
  19. Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura Takagi Y, Morita N, et al. Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. PLoS ONE. 2010;5:e13932 pubmed publisher
    ..The spatiotemporally restricted expression patterns suggested that PLD4 might play a role in common function(s) among microglia during early postnatal brain development and splenic marginal zone cells. ..
  20. Sasaki N, Kurisu J, Kengaku M. Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation. Mol Cell Neurosci. 2010;45:335-44 pubmed publisher
    ..Shh induces remodeling of the actin cytoskeleton independently of transcriptional activation in mouse embryonic fibroblasts. These findings demonstrate a novel Shh pathway that regulates the actin cytoskeleton via Tiam1-Rac1 activation. ..
  21. Matsunaga E, Nambu S, Oka M, Okanoya K, Iriki A. Comparative analysis of protocadherin-11 X-linked expression among postnatal rodents, non-human primates, and songbirds suggests its possible involvement in brain evolution. PLoS ONE. 2013;8:e58840 pubmed publisher
    ..Our results suggest that the enriched expression of protocadherin-11 X-linked is involved in primate brain evolution and that some similarity exists between songbirds and primates regarding the neural basis for vocalization. ..
  22. Aoki T, Kinoshita M, Aoki R, Agetsuma M, Aizawa H, Yamazaki M, et al. Imaging of neural ensemble for the retrieval of a learned behavioral program. Neuron. 2013;78:881-94 pubmed publisher
    ..Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning. ..
  23. Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, et al. Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. J Biol Chem. 2014;289:10785-96 pubmed publisher
    ..Furthermore, this mouse model for cellular inositol depletion could be beneficial for understanding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated skeletal development. ..
  24. Susaki E, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe T, et al. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Cell. 2014;157:726-39 pubmed publisher
    ..CUBIC enables time-course expression profiling of whole adult brains with single-cell resolution. ..
  25. Ohnishi T, Ohba H, Seo K, Im J, Sato Y, Iwayama Y, et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007;282:637-46 pubmed
    ..These data suggest that IMPA2 has a separate function in vivo from that of IMPA1. ..
  26. Sadakata T, Mizoguchi A, Sato Y, Katoh Semba R, Fukuda M, Mikoshiba K, et al. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci. 2004;24:43-52 pubmed
    ..Thus, we suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development. ..
  27. Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti J, et al. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. J Neurosci. 2000;20:6540-50 pubmed
    ..The expression pattern of netrin-G1 and its predicted neuronal membrane localization suggest it may also have novel signaling functions in nervous system development. ..
  28. Nekooki Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, Tanaka M. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proc Natl Acad Sci U S A. 2009;106:9679-84 pubmed publisher
    ..Thus, the amyloid conformation of thtt may be a critical determinant of cytotoxicity in HD. ..
  29. Nakayama T, Ogiwara I, Ito K, Kaneda M, Mazaki E, Osaka H, et al. Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome. Hum Mutat. 2010;31:820-9 pubmed publisher
  30. Sadakata T, Furuichi T. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Neurosci Lett. 2006;405:217-22 pubmed
    ..High mRNA levels of d1401/Ogdh were observed in the olfactory bulb, hippocampus, cerebellum, and pons, whereas those of d1501 were detected in the granule cells of the olfactory bulb, dentate gyrus, and cerebellum. ..
  31. Meerabux J, Ohba H, Fukasawa M, Suto Y, Aoki Suzuki M, Nakashiba T, et al. Human netrin-G1 isoforms show evidence of differential expression. Genomics. 2005;86:112-6 pubmed
    ..There is also evidence of developmental regulation of these isoforms between fetal and adult brain. In conclusion, NTNG1 may use alternative splicing to diversify its function in a developmentally and tissue-specific manner. ..
  32. Nakahara H, Kaveri S. Internal-time temporal difference model for neural value-based decision making. Neural Comput. 2010;22:3062-106 pubmed publisher
    ..We also relate the internal TD formulation to research on interval timing and subjective time. ..
  33. Furuya S, Watanabe M. Novel neuroglial and glioglial relationships mediated by L-serine metabolism. Arch Histol Cytol. 2003;66:109-21 pubmed
    ..A transient capillary expression of ASCT1 in fetal and neonatal brains further suggests that, in addition to the glia-borne L-serine, an active transport of blood-borne L-serine would play an essential role in neural development. ..
  34. Aoto K, Nishimura T, Eto K, Motoyama J. Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol. 2002;251:320-32 pubmed
    ..Together, our data reveal that GLI3 limits Fgf8-expression domains in multiple tissues, through a mechanism that may include the induction or maintenance of apoptosis. ..
  35. Takemura M, Gomi H, Colucci Guyon E, Itohara S. Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci. 2002;22:6972-9 pubmed
    ..The data further suggest that each of the phosphorylated sites has a distinct impact on the dynamics of GFAP. ..
  36. Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, et al. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. FASEB J. 2012;26:1204-17 pubmed publisher
    ..These findings implicate that calpain activation plays a pivotal role in the A?-triggered pathological cascade, highlighting a target for pharmacological intervention in the treatment of AD. ..
  37. Suzuki K, Matsunaga E, Kobayashi T, Okanoya K. Expression patterns of mineralocorticoid and glucocorticoid receptors in Bengalese finch (Lonchura striata var. domestica) brain suggest a relationship between stress hormones and song-system development. Neuroscience. 2011;194:72-83 pubmed publisher
    ..Thus, it appears that glucocorticoids are involved in song development directly by binding to receptors in song nuclei or indirectly by regulating sex hormones through hypothalamic hormones. ..
  38. Kizuka Y, Kitazume S, Yoshida M, Taniguchi N. Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications. J Biol Chem. 2011;286:31875-84 pubmed publisher
    ..This is the first report demonstrating a molecular mechanism at the chromatin level underlying tissue-specific glycan expression. ..
  39. Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, et al. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009;327:106-20 pubmed publisher
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis. ..
  40. Kato T, Ishiwata M, Yamada K, Kasahara T, Kakiuchi C, Iwamoto K, et al. Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder. Neurosci Res. 2008;61:143-58 pubmed publisher
    ..These findings may be relevant to the mood disorder observed in patients with Wolfram disease. ..
  41. Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, Furuichi T. Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol. 2004;473:582-99 pubmed
    ..These results demonstrate that Homer family members have distinct regional, cellular, and subcellular distributions in time and space during postnatal brain development. ..
  42. Shimizu M, Furuya S, Shinoda Y, Mitoma J, Okamura T, Miyoshi I, et al. Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain. J Neurosci Res. 2004;76:623-32 pubmed
    ..These observations suggest the presence of cis-acting elements that confer the cell type specificity of Phgdh transcription in the distal promoter region. ..
  43. Shimizu H, Iwayama Y, Yamada K, Toyota T, Minabe Y, Nakamura K, et al. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. Schizophr Res. 2006;84:244-52 pubmed
    ..These data suggest that the contribution of MAP6 to the processes that lead to schizophrenia should be further investigated. ..
  44. Sadakata T, Itakura M, Kozaki S, Sekine Y, Takahashi M, Furuichi T. Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. J Comp Neurol. 2006;495:735-53 pubmed
    ..These results demonstrate that the CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 is probably involved in BDNF secretion in many brain areas. ..
  45. Fukuda M. Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport. 2006;17:179-82 pubmed
    ..These findings suggest that synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles. ..
  46. Nakahara H. Multiplexing signals in reinforcement learning with internal models and dopamine. Curr Opin Neurobiol. 2014;25:123-9 pubmed publisher
    ..Even dopamine, a classic model-free signal, may work as multiplexed signals using model-based information and contribute to representational learning of reward structure...
  47. Matsuki T, Hori G, Furuichi T. Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system. Brain Res Mol Brain Res. 2005;136:231-54 pubmed
    ..Moreover, we identified a novel gene that encodes a putative protein kinase, Ebr kinase, which is differentially expressed in the developing brain. ..
  48. Yoshida Y, Kurosawa N, Kanematsu T, Kojima N, Tsuji S. Genomic structure and promoter activity of the mouse polysialic acid synthase gene (mST8Sia II). Brain-specific expression from a TATA-less GC-rich sequence. J Biol Chem. 1996;271:30167-73 pubmed
    ..Thus the TATA-less GC-rich minimal promoter region of mST8Sia II probably controls the cell type-specific expression of the mST8Sia II gene. ..