Experts and Doctors on gene expression regulation in Matsumoto, Nagano, Japan


Locale: Matsumoto, Nagano, Japan
Topic: gene expression regulation

Top Publications

  1. Tanaka M, Gombart A, Koeffler H, Shiohara M. Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon. Int J Hematol. 2007;85:304-11 pubmed
    ..Expression of BPI in human cord blood cells was increased by incubation with 10-7 MATRA for 48 hours. These results demonstrate the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo. ..
  2. Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa Shindo Y, Kawate H, et al. Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis. Am J Pathol. 2013;182:2380-90 pubmed publisher
    ..In conclusion, the ADM-RAMP2 system is crucially involved in retinal angiogenesis. ADM and its receptor system are potential therapeutic targets for controlling pathological retinal angiogenesis. ..
  3. Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, et al. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010;31:671-5 pubmed publisher
    ..In summary, chronic moderate exercise appears to attenuate the age-dependent decrease in ASC methylation, implying suppression of excess pro-inflammatory cytokines through reduction of ASC expression. ..
  4. Ogawa T, Homma T, Igawa Y, Seki S, Ishizuka O, Imamura T, et al. CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. J Urol. 2010;183:1206-12 pubmed publisher
    ..These genes may be potential interstitial cystitis biomarkers. ..
  5. Ikomi F, Kawai Y, Nakayama J, Ogiwara N, Sasaki K, Mizuno R, et al. Critical roles of VEGF-C-VEGF receptor 3 in reconnection of the collecting lymph vessels in mice. Microcirculation. 2008;15:591-603 pubmed publisher
    ..These results suggest that activation of VEGF-C-VEGF receptor 3 has critical roles in reconnection of the collecting lymph vessels in adult mice. ..
  6. Komatsu D, Kato M, Nakayama J, Miyagawa S, Kamata T. NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene. 2008;27:4724-32 pubmed publisher
    ..We propose that Nox1 mediates oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1. ..
  7. Tanabe T, Fujimoto K, Yasuo M, Tsushima K, Yoshida K, Ise H, et al. Modulation of mucus production by interleukin-13 receptor alpha2 in the human airway epithelium. Clin Exp Allergy. 2008;38:122-34 pubmed
    ..The soluble form of IL-13Ralpha(2) may therefore modulate mucus overproduction by IL-13 through the pathway including IL-13Ralpha(1) in NHBECs. ..
  8. Itoh Y, Soldati L, Stalon V, Falmagne P, Terawaki Y, Leisinger T, et al. Anabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa: nucleotide sequence and transcriptional control of the argF structural gene. J Bacteriol. 1988;170:2725-34 pubmed
    ..In the argF promoter region no sequence homologous to the "arg box" (arginine operator module) of E. coli was found. The mechanism of arginine repression in P. aeruginosa thus appears to be different from that in E. coli. ..
  9. Oiwa A, Kakizawa T, Miyamoto T, Yamashita K, Jiang W, Takeda T, et al. Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1. Biochem Biophys Res Commun. 2007;353:895-901 pubmed
    ..The cyclic expression of mSHP may affect daily activity of other nuclear receptors and contribute to circadian liver functions. ..

More Information


  1. Nakamura Y, Wakitani S, Nakayama J, Wakabayashi S, Horiuchi H, Takaoka K. Temporal and spatial expression profiles of BMP receptors and noggin during BMP-2-induced ectopic bone formation. J Bone Miner Res. 2003;18:1854-62 pubmed
    ..The coordinate expression of these positive and negative regulators of BMP signaling points to a potential regulatory mechanism for bone induction. ..
  2. Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, et al. Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor. J Biol Chem. 2001;276:9720-5 pubmed
    ..The results suggest that the transcriptional activity of Oct-1 can be modulated by interaction through its POU domain by a silencing mediator SMRT resulting in the cross-talk between Oct-1 and nuclear receptors. ..
  3. Ikeo Y, Sakurai A, Suzuki R, Zhang M, Koizumi S, Takeuchi Y, et al. Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage. Lab Invest. 2000;80:797-804 pubmed
    ..This effect was not observed when cells were exposed to ultraviolet light. These results suggest that menin may negatively regulate cell cycle under certain DNA damage. ..
  4. Miyamoto T, Kakizawa T, Hashizume K. Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymerase. Mol Cell Biol. 1999;19:2644-9 pubmed
    ..Thus, PARP has transcriptional repressor activity when recruited to the promoter. These results indicates that poly(ADP-ribosyl)ation is a negative cofactor in gene transcription, regulating a member of the nuclear receptor superfamily. ..
  5. Nagumo H, Agematsu K, Shinozaki K, Hokibara S, Ito S, Takamoto M, et al. CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells. J Immunol. 1998;161:6496-502 pubmed
  6. Aoyama T, Peters J, Iritani N, Nakajima T, Furihata K, Hashimoto T, et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem. 1998;273:5678-84 pubmed
  7. Shang W, Adachi Y, Nakamura A, Copeland T, Kim S, Kamata T. Regulation of amphiphysin1 by mitogen-activated protein kinase: its significance in nerve growth factor receptor-mediated endocytosis. J Biol Chem. 2004;279:40890-6 pubmed
    ..This perhaps helps to regulate the availability of amphiphysin1-dynamin1 complexes for binding to the endocytic vesicle. ..
  8. Miki J, Fujimura Y, Koseki H, Kamijo T. Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3. Genes Cells. 2007;12:1371-82 pubmed
    ..Taken together, it seems that class II polycomb proteins and E2F3b dually control cellular senescence via the ARF/p53 pathway. ..
  9. Imai H, Ohta K, Yoshida A, Suzuki S, Hashizume K, Usami S, et al. {mu}-Crystallin, new candidate protein in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2010;51:3554-9 pubmed publisher
    ..Expression of the mRNA of IL-1alpha and -6 in the CRYM(-/-) mice was significantly lower than that in the CRYM(+/+) mice on day 5. CONCLUSIONS. CRYM plays an important role in the development of the second peak of murine EIU. ..
  10. Ohkawara T, Nagase H, Koh C, Nakayama K. The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis. Gene. 2011;475:1-9 pubmed publisher
    ..These results suggest that AICD induces dynamic changes in gene expression, which may be closely correlated with AICD-induced neuron-specific apoptosis. ..