Experts and Doctors on monophenol monooxygenase in Sendai, Miyagi, Japan


Locale: Sendai, Miyagi, Japan
Topic: monophenol monooxygenase

Top Publications

  1. Shibahara S, Okinaga S, Tomita Y, Takeda A, Yamamoto H, Sato M, et al. A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85. Eur J Biochem. 1990;189:455-61 pubmed
    ..We therefore suggest that a G----C transversion at nucleotide residue 387 of the tyrosinase gene could lead to the albino phenotype of BALB/c mouse...
  2. Yamamoto H, Takeuchi S, Kudo T, Sato C, Takeuchi T. Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA. Jpn J Genet. 1989;64:121-35 pubmed
    ..It seems possible that this region represents the regulatory element of the tyrosinase gene. Unusually long GA cluster at 5' upstream region was also found. ..
  3. Sato C, Ito S, Takeuchi T. Enhancement of pheomelanogenesis by L-dopa in the mouse melanocyte cell line, TM10, in vitro. J Cell Sci. 1987;87 ( Pt 4):507-12 pubmed
    ..2mM-L-dopa, an increase in the number of pheomelanosomes was observed in the cytoplasm of TM10 cells. Our results also suggest that the L-dopa treatment results in a decrease in tyrosinase activity per melanosome...
  4. Sato S, Miura H, Yamamoto H, Takeuchi T. Identification of nuclear factors that bind to the mouse tyrosinase gene regulatory region. Pigment Cell Res. 1994;7:279-84 pubmed
  5. Tomita Y. Tyrosinase gene mutations causing oculocutaneous albinisms. J Invest Dermatol. 1993;100:186S-190S pubmed
    ..Various combinations of these alleles result in tyrosinase-negative (t-/t-), yellow mutant (y/y, y/t-, y/ts), or temperature-sensitive (ts/t-, ts/ts) OCA. ..
  6. Yasumoto K, Yokoyama K, Takahashi K, Tomita Y, Shibahara S. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J Biol Chem. 1997;272:503-9 pubmed
    ..These results suggest that MITF is sufficient to direct pigment cell-specific transcription of the tyrosinase and TRP-1 genes but not the TRP-2 gene. ..
  7. Takeda K, Takemoto C, Kobayashi I, Watanabe A, Nobukuni Y, Fisher D, et al. Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum Mol Genet. 2000;9:125-32 pubmed
    ..These findings suggest that the Ser298 is important for MITF function and is phosphorylated probably by GSK3beta. ..
  8. Hasegawa T, Matsuzaki Kobayashi M, Takeda A, Sugeno N, Kikuchi A, Furukawa K, et al. Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease. FEBS Lett. 2006;580:2147-52 pubmed
    ..This cellular model may reconstitute the pathological metabolism of alpha-S in the synucleinopathy and provide a useful tool to explore possible pathomechanisms of nigral degeneration in PD. ..
  9. Itoh N, Kamitaka R, Takahashi K, Osada M. Identification and characterization of multiple beta-glucan binding proteins in the Pacific oyster, Crassostrea gigas. Dev Comp Immunol. 2010;34:445-54 pubmed publisher
    ..Cg-betaGBP-1 possibly evolved for hemocyte-related functions through integrin, and Cg-betaGBP-2 for the PO activation system...

More Information


  1. Tomita Y, Takeda A, Matsunaga J, Okinaga S, Shibahara S, Tagami H. Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene. Pigment Cell Res. 1992;Suppl 2:96-100 pubmed
    ..We therefore propose that these mutations in the tyrosinase genes lead to a phenotype of tyrosinase-negative OCA...
  2. Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016;291:1427-40 pubmed publisher
    ..These results collectively indicate that proper spatiotemporal regulation of Rab32/38 is essential for the trafficking of all three melanogenic enzymes in mouse melanocytes. ..