Experts and Doctors on humans in Sendai, Miyagi, Japan

Summary

Locale: Sendai, Miyagi, Japan
Topic: humans

Top Publications

  1. Kikawa E, Nakazawa M, Chida Y, Shiono T, Tamai M. A novel mutation (Asn244Lys) in the peripherin/RDS gene causing autosomal dominant retinitis pigmentosa associated with bull's-eye maculopathy detected by nonradioisotopic SSCP. Genomics. 1994;20:137-9 pubmed
  2. Yoshinari M, Imaizumi M, Eguchi M, Ogasawara M, Saito T, Suzuki H, et al. Establishment of a novel cell line (TS-2) of pre-B acute lymphoblastic leukemia with a t(1;19) not involving the E2A gene. Cancer Genet Cytogenet. 1998;101:95-102 pubmed
    ..3 distinct from the E2A gene and, therefore, may be useful for investigating the heterogeneity of molecular pathogenesis in leukemias with t(1;19)(q23;p13) translocation. ..
  3. Yang X, Aoki Y, Li X, Sakamoto O, Hiratsuka M, Kure S, et al. Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiency. Hum Genet. 2001;109:526-34 pubmed
  4. Saito H, Yasumoto K, Takeda K, Takahashi K, Yamamoto H, Shibahara S. Microphthalmia-associated transcription factor in the Wnt signaling pathway. Pigment Cell Res. 2003;16:261-5 pubmed
    ..MITF-M therefore plays dual roles in the Wnt signaling pathway; MITF-M represents a downstream target and a nuclear mediator of Wnt signals in melanocytes. ..
  5. Sagai S, Suetake M, Yano H, Yoshida M, Ohyama K, Endo H, et al. Relationship between respiratory syncytial virus infection and acute otitis media in children. Auris Nasus Larynx. 2004;31:341-5 pubmed
    ..However, there are only a few reports about AOM associated with RSV infection...
  6. Hashimoto J, Hirayama H, Hanasawa T, Watabe D, Asayama K, Metoki H, et al. Efficacy of combination antihypertensive therapy with low-dose indapamide: assessment by blood pressure self-monitoring at home. Clin Exp Hypertens. 2005;27:331-41 pubmed
    ..95 for SBP and 0.85 for DBP. Low-dose indapamide used in combination can provide additional anti-hypertensive efficacy lasting for 24 h. The added effect of indapamide may be more prominent on ARBs than on CCBs. ..
  7. Kure S, Kato K, Dinopoulos A, Gail C, DeGrauw T, Christodoulou J, et al. Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia. Hum Mutat. 2006;27:343-52 pubmed
    ..Multiple origins of the exon 1 deletion were suggested by haplotype analysis with four GLDC polymorphisms. This study provides a comprehensive picture of the genetic background of NKH as it is known to date...
  8. Jingu K, Nemoto K, Matsushita H, Takahashi C, Ogawa Y, Sugawara T, et al. Results of radiation therapy combined with nedaplatin (cis-diammine-glycoplatinum) and 5-fluorouracil for postoperative locoregional recurrent esophageal cancer. BMC Cancer. 2006;6:50 pubmed
    ..Radiotherapy combined with nedaplatin and 5-FU is a safe and effective salvage treatment for postoperative locoregional recurrent esophageal cancer. ..
  9. Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre J, Caprioli R, et al. Epididymis-specific lipocalin promoters. Asian J Androl. 2007;9:515-21 pubmed
    ..Our approach provides a basic strategy for further analysis of the epididymal lipocalin gene regulation and flexible control of epididymal function. ..

More Information

Publications245 found, 100 shown here

  1. Ishida M, Sunamura M, Furukawa T, Akada M, Fujimura H, Shibuya E, et al. Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis. World J Gastroenterol. 2007;13:4593-7 pubmed
    ..However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. ..
  2. Hwang G, Hayashi T, Kita K, Takahashi T, Kuge S, Naganuma A. siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells. J Toxicol Sci. 2007;32:581-3 pubmed
    ..Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells. ..
  3. Suzuki K, Takamatsu K, Takano T, Tanabe Y, Fujiyama K, Matsuoka H. Safety of electroconvulsive therapy in psychiatric patients shortly after the occurrence of pulmonary embolism. J ECT. 2008;24:286-8 pubmed publisher
  4. Nakagawa K, Kiko T, Hatade K, Asai A, Kimura F, Sookwong P, et al. Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: application to clinical studies. Anal Biochem. 2008;381:129-34 pubmed publisher
    ..3-70.2 nmol/L packed cells), and polar oxygenated carotenoids (xanthophylls) were predominant in RBCs. The HPLC-DAD-APCI/MS method would be a useful tool for clinical studies for evaluating the bioavailability of RBC carotenoids. ..
  5. Nishiyama S, Ito T, Misu T, Takahashi T, Kikuchi A, Suzuki N, et al. A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. Neurology. 2009;72:1960-1 pubmed publisher
  6. Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De Angelis S, et al. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int J Oncol. 2009;35:867-72 pubmed
    ..These results indicate that GO-Y030 is a potent inhibitor of cell viability and STAT3 activation, and may thus have potential as a therapeutic agent for cancers expressing high levels of activated STAT3. ..
  7. Murakami Y, Honda Y, Anada T, Shimauchi H, Suzuki O. Comparative study on bone regeneration by synthetic octacalcium phosphate with various granule sizes. Acta Biomater. 2010;6:1542-8 pubmed publisher
    ..It seems likely that the enhancement of bone formation by OCP is accompanied by simultaneous activation of osteoclastic resorption of OCP. ..
  8. Hattori T, Umetsu M, Nakanishi T, Togashi T, Yokoo N, Abe H, et al. High affinity anti-inorganic material antibody generation by integrating graft and evolution technologies: potential of antibodies as biointerface molecules. J Biol Chem. 2010;285:7784-93 pubmed publisher
    ..We show the availability of the construction of antibodies by integrating graft and evolution technology for various inorganic materials and the potential of high affinity material-binding antibodies in biointerface applications. ..
  9. Namiki S, Carlile R, Namiki T, Fukagai T, Takegami M, Litwin M, et al. Racial differences in sexuality profiles among American, Japanese, and Japanese American men with localized prostate cancer. J Sex Med. 2011;8:2625-31 pubmed publisher
    ..We found significant interethnic variations among CA, JP, and JA with prostate cancer in terms of their sexual profiles. Ethnicity and/or country appear to modify some of these variables. ..
  10. Kakazu E, Ueno Y, Kondo Y, Inoue J, Ninomiya M, Kimura O, et al. Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis. PLoS ONE. 2011;6:e23402 pubmed publisher
    ..The aim of this study is to investigate the influence of the plasma L-Cys/L-Glu imbalance observed in patients with advanced cirrhosis on the function of circulating monocytes...
  11. Saitoh H, Ashino Y, Chagan Yasutan H, Niki T, Hirashima M, Hattori T. Rapid decrease of plasma galectin-9 levels in patients with acute HIV infection after therapy. Tohoku J Exp Med. 2012;228:157-61 pubmed
    ..In conclusion, the plasma levels of Gal-9 may be predictive of a severe inflammation status during the acute phase of HIV-1 infection and could be a potential biomarker during acute infection. ..
  12. Kuroda Y, Wakao S, Kitada M, Murakami T, Nojima M, Dezawa M. Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells. Nat Protoc. 2013;8:1391-415 pubmed publisher
    ..Under both spontaneous and induced differentiation conditions, they show triploblastic differentiation. It takes 4-6 h to collect and 2 weeks to confirm the differentiation and self-renewal capacity of Muse cells. ..
  13. Zhang J, Yamada O, Kida S, Matsushita Y, Hattori T. Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-β. Cell Oncol (Dordr). 2016;39:119-28 pubmed publisher
    ..Our results indicate that the OPN gene is a direct target of Smad-mediated TGF-β signaling, implying that OPN expression inhibition serves as a novel mechanism underlying the cytostatic activity of TGF-β. ..
  14. Ninomiya M, Kondo Y, Kimura O, Funayama R, Nagashima T, Kogure T, et al. The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen. J Viral Hepat. 2016;23:330-9 pubmed publisher
    ..This study indicated that expression of miR-125b-5p was related to the etiology of chronic hepatitis B infection and regulated the expression of HBsAg. ..
  15. Ito R, Sato I, Tsujita T, Yokoyama A, Sugawara A. A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis. Biochem Biophys Res Commun. 2017;489:21-28 pubmed publisher
    ..Taken together, these results suggest the possibility of developing novel antihypertensive drugs that prevent CYP11B2 expression. ..
  16. Tanishima M, Takashima S, Honda A, Yasuda D, Tanikawa T, Ishii S, et al. Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling. J Biol Chem. 2017;292:17250-17257 pubmed publisher
    ..These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1β/LPS-induced NF-κB activation by preventing polyubiquitination of TRAF6. ..
  17. Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet. 2017;49:1458-1467 pubmed publisher
    ..18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity. ..
  18. Hishinuma T, Nakamura H, Itoh K, Ohyama Y, Ishibashi M, Mizugaki M. Microdetermination of the prostaglandin B1 in human plasma by gas chromatography/selected ion monitoring using [18O]prostaglandin B1 as an internal standard. Prostaglandins. 1995;49:239-46 pubmed
    ..3 for internal standard. A good linear response over the range of 10 pg to 100 ng was demonstrated. We detected PGB1 to a level of about 40 pg/mL in human plasma. This method can be used to determine PGB1 in biological samples. ..
  19. Ishimoto O, Saijo Y, Narumi K, Kimura Y, Ebina M, Matsubara N, et al. High level of vascular endothelial growth factor in hemorrhagic pleural effusion of cancer. Oncology. 2002;63:70-5 pubmed
    ..Our data suggest that VEGF secreted from tumor cells may be involved in the accumulation of pleural effusion in malignancy, and that increased levels of VEGF may induce hemorrhagic effusion. ..
  20. Abd Elaziz M, Akahira J, Moriya T, Suzuki T, Yaegashi N, Sasano H. Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome. Cancer Sci. 2003;94:980-5 pubmed
    ..In conclusion, DAX-1 immunoreactivity is considered to be a new independent marker of poor prognosis or adverse clinical outcome in patients with epithelial ovarian carcinoma, possibly through altering in situ steroids production. ..
  21. Fujimura T, Okuyama R, Ito Y, Aiba S. Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides. Br J Dermatol. 2008;158:1256-63 pubmed publisher
    ..The lower percentage of epidermal or dermal Foxp3+ cells in eczematous dermatitis or psoriasis vulgaris, respectively, might contribute to their pathogenesis. ..
  22. Kumabe T, Sohma Y, Yamamoto T. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. Nucleic Acids Res. 1992;20:2598 pubmed
  23. Tanaka N, Asao H, Ohtani K, Nakamura M, Sugamura K. A novel human tyrosine kinase gene inducible in T cells by interleukin 2. FEBS Lett. 1993;324:1-5 pubmed
    ..This gene was transcriptionally induced in normal T cells by interleukin 2 stimulation. These results suggest the crucial roles of this gene in T cell proliferation and differentiation. ..
  24. Terui T, Aiba S, Tagami H. Solitary subcutaneous mucinosis surrounded by bizarre-shaped, factor XIIIa-positive cells with intranuclear vacuoles. J Cutan Pathol. 1998;25:271-4 pubmed
    ..We think that this solitary subcutaneous mucinosis is a unique variant of cutaneous focal mucinosis, because neither a reticulin network nor reactivity to anti-smooth muscle A-actin antibody were demonstrable. ..
  25. Ohki K, Kumamoto H, Ichinohasama R, Suzuki M, Yamaguchi T, Echigo S, et al. Genetic analysis of DNA microsatellite loci in salivary gland tumours: comparison with immunohistochemical detection of hMSH2 and p53 proteins. Int J Oral Maxillofac Surg. 2001;30:538-44 pubmed
    ..These features suggest that the p53 gene plays an important role in malignant transformation of salivary gland tumours. The genetic characteristics of pleomorphic adenomas might reflect a low-grade potential for malignant progression. ..
  26. Uehara A, Sugawara S, Takada H. Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans. J Med Microbiol. 2002;51:626-34 pubmed
    ..These findings suggested that IFN-gamma primed oral epithelial cells to produce cytokines upon stimulation with various bacterial components by up-regulation of the TLR system. ..
  27. Ieiri N, Hotta O, Taguma Y. Resolution of typical lipoprotein glomerulopathy by intensive lipid-lowering therapy. Am J Kidney Dis. 2003;41:244-9 pubmed
    ..These findings suggest that typical LPG could be regressed if the abnormal lipoproteinemia is controlled sufficiently. ..
  28. Inoue O, Kanno E, Kasai K, Ukai H, Okamoto S, Ikeda M. Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. Toxicol Lett. 2004;147:177-86 pubmed
    ..Overall, therefore, it appeared reasonable to conclude that BMA is superior to hippuric acid and o-cresol as a marker of occupational exposure to toluene. ..
  29. Torisawa Y, Takagi A, Nashimoto Y, Yasukawa T, Shiku H, Matsue T. A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip. Biomaterials. 2007;28:559-66 pubmed
    ..Our spheroid culture system facilitated the understanding of spheroid formation, culture, and viability assay on a single chip, thus functioning as a useful drug-screening device for cancer and liver cells. ..
  30. Hagiwara Y, Hatori M, Moriya T, Terada Y, Yaegashi N, Ehara S, et al. Inguinal endometriosis attaching to the round ligament. Australas Radiol. 2007;51:91-4 pubmed
    ..Worth mentioning is that MRI clearly showed the change of tumour size depending on the menstrual cycle, which aided in arriving at the correct diagnosis of endometriosis in an unusual location. ..
  31. Kouadio I, Koffi A, Attoh Toure H, Kamigaki T, Oshitani H. Outbreak of measles and rubella in refugee transit camps. Epidemiol Infect. 2009;137:1593-601 pubmed publisher
    ..Supplemental immunization with a measles-mumps-rubella (MMR) vaccine was conducted during week 20. This study illustrates the importance of testing for both measles and rubella in outbreaks of rash and fever in refugee settings. ..
  32. Ohkawa M, Ohno Y, Masuko K, Takeuchi A, Suda K, Kubo A, et al. Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy. Biochem Biophys Res Commun. 2011;406:649-55 pubmed publisher
    ..All these results indicate essential roles of LAT1 in the cell proliferation and occurrence of malignant phenotypes and that LAT1 is a promising candidate as a molecular target of human cancer therapy. ..
  33. Watanabe R, Hayashi R, Kimura Y, Tanaka Y, Kageyama T, Hara S, et al. A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation. Tissue Eng Part A. 2011;17:2213-9 pubmed publisher
    ..These results indicate that the gelatin hydrogel sheet is a promising material to transport corneal endothelial cells during transplantation. ..
  34. Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, et al. Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. Cancer Sci. 2012;103:760-6 pubmed publisher
    ..The prognostic impact of p62 status was pronounced in adenocarcinoma patients, suggesting that molecular mechanisms underlying cancer evolution differ between adenocarcinoma and squamous cell carcinoma. ..
  35. Nakagawa T, Mondal K, Swanson P. VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases. BMC Mol Biol. 2013;14:22 pubmed publisher
    ..Taken together, these studies provide important insights and raise interesting new questions regarding the mechanisms that regulate or subvert VprBP function in the context of both the CRL4 and EDD/UBR5 E3 ligases. ..
  36. Miyata K, Yotsumoto F, Fukagawa S, Kiyoshima C, Ouk N, Urushiyama D, et al. Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer. Anticancer Res. 2017;37:3955-3960 pubmed
    ..In addition, serum HB-EGF levels increased as the cancer advanced. These data suggest that serum HB-EGF may be a target for the design of novel therapies for ovarian cancer. ..
  37. Ogawa A, Yoshimoto T, Sakurai Y. Clinical analysis of STA-SCA bypass for vertebrobasilar occlusive disease. Tohoku J Exp Med. 1991;164:183-90 pubmed
    ..Favorable outcomes were obtained for the remaining cases. The present study suggests that, STA-SCA bypass, can be performed without surgical and systemic complications and used as an effective therapy for vertebrobasilar ischemia. ..
  38. Sato M, Mori Y, Sakurada A, Fujimura S, Horii A. The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum Genet. 1998;103:96-101 pubmed
    ..These results suggest that a combination of deletion and hypermethylation causes inactivation of the CDH13 gene in a considerable number of human lung cancers. ..
  39. Baik U, Suzuki M, Ikeda K, Sugawara J, Mitani H. Relationship between cephalometric characteristics and obstructive sites in obstructive sleep apnea syndrome. Angle Orthod. 2002;72:124-34 pubmed
    ..All of the groups shared the characteristic of having an inferior position of the hyoid bone. Based on the results of the current study, we conclude that many features of OSAS are specifically related to each obstructive type of OSAS. ..
  40. Ito C. The role of the central histaminergic system on schizophrenia. Drug News Perspect. 2004;17:383-7 pubmed
    ..Therefore, the dysfunction of the histamine neuron system may participate in the extradopaminergic brain dysfunction of schizophrenia, and histamine agents may improve the refractory schizophrenia. ..
  41. Ding Y, Zhang Y, Furuyama K, Ogawa K, Igarashi K, Shibahara S. Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. FEBS J. 2006;273:5333-46 pubmed
    ..These results suggest that HO-2 may down-regulate the expression of HO-1, thereby directing the co-ordinated expression of HO-1 and HO-2. ..
  42. Takeyama J, Saito T, Itagaki T, Abukawa D. Vanishing bile duct syndrome with a history of erythema multiforme. Pediatr Int. 2006;48:651-3 pubmed
  43. Kikuchi H. [Novel biologically active compounds isolated from unexploited organisms, cellular sime molds]. Yakugaku Zasshi. 2007;127:1431-9 pubmed
    ..In addition, brefelamide inhibited the cellular proliferation of 1321N1 human astrocytoma cells. These results show that cellular slime molds are promising sources in natural product chemistry...
  44. Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S. Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception. Neurogastroenterol Motil. 2007;19:831-8 pubmed
    ..These findings lead us to possible new treatment for control of visceral perception. ..
  45. Tanabe K, Utsunomiya H, Tamura M, Niikura H, Takano T, Yoshinaga K, et al. Expression of retinoic acid receptors in human endometrial carcinoma. Cancer Sci. 2008;99:267-71 pubmed publisher
    ..AM580 might therefore be considered as a potential treatment for endometrial carcinoma. ..
  46. Suzuki T, Miki Y, Akahira J, Moriya T, Ohuchi N, Sasano H. Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations. Endocr J. 2008;55:455-63 pubmed
    ..Aromatase inhibitors may thus have additional antiproliferative effects through increasing local DHT concentration with estrogen deprivation. ..
  47. Okada Y, Kondo T. Preservation solution for lung transplantation. Gen Thorac Cardiovasc Surg. 2009;57:635-9 pubmed publisher
    ..This review summarizes the experimental and clinical studies on lung preservation, particularly focusing attention on the preservation solution being employed for clinical lung transplantation. ..
  48. Otani H, Kikuya M, Hara A, Terata S, Ohkubo T, Kondo T, et al. Association of kidney dysfunction with silent lacunar infarcts and white matter hyperintensity in the general population: the Ohasama study. Cerebrovasc Dis. 2010;30:43-50 pubmed publisher
    ..CCr is closely associated with lacunar infarcts, suggesting that kidney dysfunction in the elderly is an independent risk factor or predictor for silent lacunar infarcts. ..
  49. Deguchi T, Kurosaka H, Oikawa H, Kuroda S, Takahashi I, Yamashiro T, et al. Comparison of orthodontic treatment outcomes in adults with skeletal open bite between conventional edgewise treatment and implant-anchored orthodontics. Am J Orthod Dentofacial Orthop. 2011;139:S60-8 pubmed publisher
    ..In addition, since a significant amount of tooth movement occurs with miniscrews, careful attention is required during the retention phase. ..
  50. Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Wang L, Chan M, et al. Increased 5?-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation. Horm Cancer. 2011;2:73-81 pubmed publisher
    ..These results suggest that increased 5?Red2 and AR following AI treatment may partly contribute to reduce the tumor cell proliferation through increasing intratumoral androgen concentrations and its receptor. ..
  51. Kubo H. Tissue engineering for pulmonary diseases: insights from the laboratory. Respirology. 2012;17:445-54 pubmed publisher
    ..These results give us a greater understanding of the possibilities and the limitations of tissue engineering for pulmonary diseases. ..
  52. Hidaka M, Koga T, Gotoh A, Sanada M, Hirose K, Uchida T. Alzheimer's disease-related protein hGas7b interferes with kinesin motility. J Biochem. 2012;151:593-8 pubmed publisher
    ..Excess hGas7b interferes with kinesin motility on microtubules. These results suggest that regulation to maintain an appropriate concentration of hGas7b is required for healthy neurotransmission. ..
  53. Tsuji K, Copeland N, Jenkins N, Obinata M. Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. Biochem J. 1995;307 ( Pt 2):377-81 pubmed
    ..Sequence comparisons with recently cloned mammalian Aop1 homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation and antioxidant functions. ..
  54. Kim D, Magoori K, Inoue T, Mao C, Kim H, Suzuki H, et al. Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene. J Biol Chem. 1997;272:8498-504 pubmed
    ..Sequence inspection of the 5'-flanking region revealed potential DNA elements: AP-2, GC factor, PEA3, and Sp1. The minimal promoter region and a region required for nerve growth factor inducibility in PC12 cells were also determined. ..
  55. Endo C, Sagawa M, Sato M, Chen Y, Sakurada A, Aikawa H, et al. Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung. Br J Cancer. 1998;78:612-5 pubmed
    ..These results suggest that several tumour-suppressor genes are associated with lung cancer progression and that genetic changes on 3p21, 5q21 and 17p13 are early events. ..
  56. Kawabe Y, Seki M, Seki T, Wang W, Imamura O, Furuichi Y, et al. Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1. J Biol Chem. 2000;275:20963-6 pubmed
    ..Finally, we confirmed by immunoblotting with an anti-SUMO-1 antibody that Wrn was covalently attached with SUMO-1. ..
  57. Iijima K, Fyfe V, McColl K. Studies of nitric oxide generation from salivary nitrite in human gastric juice. Scand J Gastroenterol. 2003;38:246-52 pubmed
    ..Saliva contains substantial concentrations of nitrite derived from the enterosalivary recirculation of dietary nitrate...
  58. Moriya T, Kasajima A, Ishida K, Kariya Y, Akahira J, Endoh M, et al. New trends of immunohistochemistry for making differential diagnosis of breast lesions. Med Mol Morphol. 2006;39:8-13 pubmed
    ..Some of the lobular carcinomas are positive for 34betaE12, but they are consistently negative for CK5/6. Comparison with histopathological findings of hematoxylin and eosin is essential to make proper diagnosis in the individual case. ..
  59. Nakashima I, Fujinoki M, Fujihara K, Kawamura T, Nishimura T, Nakamura M, et al. Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis. Ann Neurol. 2007;62:197-200; discussion 205 pubmed
    ..Enzyme-linked immunosorbent assay showed that the cystatin C levels tended to be lower in multiple sclerosis and NMO. Alterations of cystatin C may relate to the pathogeneses of demyelinating diseases. ..
  60. Nakajima S, Lan L, Kanno S, Usami N, Kobayashi K, Mori M, et al. Replication-dependent and -independent responses of RAD18 to DNA damage in human cells. J Biol Chem. 2006;281:34687-95 pubmed
    ..These data indicate that RAD18 responds to DNA damage in two distinct ways, one replication-dependent and one replication-independent, involving the SAP and zinc finger motifs, respectively. ..
  61. Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, et al. Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol. 2008;180:4067-74 pubmed
    ..neoformans. ..
  62. Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y, et al. Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. Cancer Sci. 2009;100:1996-8 pubmed publisher
    ..The infrequency of IDH1 mutation in primary glioblastomas revealed that these subtypes are genetically distinct entities from other glial tumors. ..
  63. Ohsaki Y, Shirakawa H, Miura A, Giriwono P, Sato S, Ohashi A, et al. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor ?B through the repression of IKK?/? phosphorylation. J Nutr Biochem. 2010;21:1120-6 pubmed publisher
    ..These results clearly show that the anti-inflammatory activity of vitamin K is mediated via the inactivation of the NF?B signaling pathway. ..
  64. Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, et al. Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-? secretion activity. J Gastroenterol. 2011;46:232-41 pubmed publisher
    ..Lymphotropic HCV replication suppressed proliferation and development, including that towards Th1 commitment, in human primary naïve CD4(+) cells. ..
  65. Harigae H. [Recent progress in iron metabolism and iron-related anemia]. Rinsho Byori. 2010;58:1211-8 pubmed
    ..However, there are still significant numbers of cases with genetically undefined, inherited sideroblastic anemia. Molecular analysis of these cases will contribute to the understanding of mitochondrial iron metabolism. ..
  66. Kanazawa M, Watanabe S, Tana C, Komuro H, Aoki M, Fukudo S. Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2011;23:754-e332 pubmed publisher
    ..These findings suggest that mosapride may have the potential to treat IBS patients with constipation and/or functional constipation. Further clinical trials are warranted to confirm the efficacy of this agent. ..
  67. Looi C, Imanishi M, Takaki S, Sato M, Chiba N, Sasahara Y, et al. Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis. PLoS ONE. 2011;6:e23640 pubmed publisher
    ..WT Lnk R8 protein delivery may provide a safer and more practical approach to inhibit leukemic cell growth worthy of further development. ..
  68. Inoue A, Arima N, Ishiguro J, Prestwich G, Arai H, Aoki J. LPA-producing enzyme PA-PLA?? regulates hair follicle development by modulating EGFR signalling. EMBO J. 2011;30:4248-60 pubmed publisher
    ..These data demonstrate that a PA-PLA(1)?-LPA-P2Y5 axis regulates differentiation and maturation of hair follicles via a TACE-TGF?-EGFR pathway, thus underscoring the physiological importance of LPA-induced EGFR transactivation. ..
  69. Chida T, Ando M, Matsuki T, Masu Y, Nagaura Y, Takano Yamamoto T, et al. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Biochem J. 2013;449:741-9 pubmed publisher
    ..Taken together, the results of the present study suggest that N-myristoylation of PPM1A and PPM1B plays a key role in recognition of their physiological substrates in cells. ..
  70. Kato Y, Natsume A, Kaneko M. A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation. Biochem Biophys Res Commun. 2013;432:564-7 pubmed publisher
    ..This is the first report to establish anti-IDH1-R132G-specific mAbs, which is useful in immunohistochemistry of IDH1-R132G-bearing tumors. ..
  71. Takagi K, Miki Y, Tanaka S, Hashimoto C, Watanabe M, Sasano H, et al. Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration. Endocr J. 2016;63:287-99 pubmed publisher
    ..These findings possibly suggested that NUCB2 and/or nesfatin-1 had pivotal roles in the progression of endometrial carcinomas. Immunohistochemical NUCB2 status may therefore serve as a potent biomarker for endometrial carcinomas. ..
  72. Iwasaki H, Chagan Yasutan H, Leaño P, Koizumi N, Nakajima C, Taurustiati D, et al. Combined antibody and DNA detection for early diagnosis of leptospirosis after a disaster. Diagn Microbiol Infect Dis. 2016;84:287-91 pubmed publisher
    ..5% were positive by DNA detection. These findings indicate that the leptospirosis detection rate is increased by combining antibody and DNA detection, providing a new tool for timely diagnosis of infection. ..
  73. Chiba H, Endo K, Fujishima F, Ohtsuka H, Naitoh T, Kuroha M, et al. A case of a ruptured submucosal aneurysm of the small intestine identified using double-balloon enteroscopy. Clin J Gastroenterol. 2016;9:49-54 pubmed publisher
    ..Only a few reports have described their endoscopic findings. Our experience indicates that small bowel enteroscopy may be useful for managing ruptured submucosal aneurysms of the small intestine. ..
  74. Shimizu T, Uchida C, Shimizu R, Motohashi H, Uchida T. Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau. Biochem Biophys Res Commun. 2017;493:946-951 pubmed publisher
    ..Pin1 bound tau and promoted microtubule polymerization. Our results show that Pin1 serves as a positive regulatory molecule of proplatelet formation of MKs by enhancing the function of phosphorylated tau. ..
  75. Suzuki T, Yanai M, Yamaya M, Satoh Nakagawa T, Sekizawa K, Ishida S, et al. Erythromycin and common cold in COPD. Chest. 2001;120:730-3 pubmed
    ..007). Significantly more patients were hospitalized due to exacerbations in the control group than in the erythromycin group (p = 0.0007). Erythromycin therapy has beneficial effects on the prevention of exacerbations in COPD patients. ..
  76. Shintaku I, Satoh M, Okajima E, Fujimoto H, Kamoto T, Ogawa O, et al. Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan. Jpn J Clin Oncol. 2008;38:281-7 pubmed publisher
    ..Since the IGCC classification was based on patients treated between 1975 and 1990, we aimed to investigate whether survival has improved for more recently treated Japanese patients...
  77. Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, et al. Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes. J Infect Dis. 2010;202:202-13 pubmed publisher
    ..Entecavir treatment suppressed the frequency and function of T(reg) cells; this might contribute to the persistence of HBV infection. ..
  78. Tatsuta T, Hosono M, Miura Y, Sugawara S, Kariya Y, Hakomori S, et al. Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs. Int J Oncol. 2013;43:1799-808 pubmed publisher
    ..It is noteworthy that SBL can induce cancer-selective apoptosis by multiple apoptotic signaling pathways, and it can serve as a candidate molecule for anticancer drugs in a novel field. ..
  79. Uchida H, Morita T, Niizuma K, Kushida Y, Kuroda Y, Wakao S, et al. Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation. Stem Cells. 2016;34:160-73 pubmed publisher
    ..Human fibroblast-derived Muse cells pose as a novel source of transplantable stem cells, circumventing the need for gene manipulations, especially when contemplating autologous cell therapy for stroke. ..
  80. Kobayashi S, Endo W, Inui T, Wakusawa K, Tanaka S, Onuma A, et al. The lack of antiepileptic drugs and worsening of seizures among physically handicapped patients with epilepsy during the Great East Japan Earthquake. Brain Dev. 2016;38:623-7 pubmed publisher
    ..Even if the stock of antiepileptic drugs is sufficient, stress could cause worsening of seizures. Specialized support is required after a disaster among physically handicapped patients with epilepsy. ..
  81. Yamazaki H, Kanno S, Abdjul D, Namikoshi M. A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2017;27:2207-2209 pubmed publisher
    ..The results obtained in this study suggest that compound 1 activates the insulin signaling pathway by inhibiting PTP1B activity. ..
  82. Abe T, Tominaga Y, Kikuchi T, Watanabe A, Satoh K, Watanabe Y, et al. Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung. Am J Respir Crit Care Med. 1997;156:1235-40 pubmed
    ..These facts suggested the local regulation of the SLPI gene expression in vivo in response to inflammatory stimuli at the site of inflammation. ..
  83. Sakurada A, Suzuki A, Sato M, Yamakawa H, Orikasa K, Uyeno S, et al. Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary. Jpn J Cancer Res. 1997;88:1025-8 pubmed
    ..Our results suggest that mutation of the PTEN/MMAC1 gene does not play a major role in carcinogenesis, at least in the tumor types from Japanese patients analyzed in this study. ..
  84. Furuyama K, Uno R, Urabe A, Hayashi N, Fujita H, Kondo M, et al. R411C mutation of the ALAS2 gene encodes a pyridoxine-responsive enzyme with low activity. Br J Haematol. 1998;103:839-41 pubmed
    ..These findings suggest that the R411C mutation accounts for low ALAS activity and a partial pyridoxine-responsiveness of the disease in the patient. ..
  85. Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, et al. STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett. 2000;477:55-61 pubmed
  86. Takahashi N. Acid-neutralizing activity during amino acid fermentation by Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Oral Microbiol Immunol. 2003;18:109-13 pubmed
  87. Shimada N, Suzuki T, Inoue S, Kato K, Imatani A, Sekine H, et al. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. Mol Cell Endocrinol. 2004;218:147-53 pubmed
    ..Therefore, these results indicate that Efp is widely expressed and may play important roles in various human tissues possibly through ERs. ..
  88. Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, et al. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res. 2005;65:6450-8 pubmed
    ..Therefore, progesterone therapy may be clinically effective in suppressing development of progesterone receptor-positive NSCLC patients. ..
  89. Dohi O, Hatori M, Ichinohasama R, Hosaka M, Hashimoto S, Kokubun S. Diffuse large B-cell lymphoma arising in a patient with neurofibromatosis type I and in a patient with neurofibromatosis type II. Tohoku J Exp Med. 2006;208:169-76 pubmed
    ..It is important to be aware of possibility of association of malignant tumors not only of the nervous system but also of unrelated to the nervous system when tumors appear in neurofibromatosis patients. ..
  90. Namai A, Sakurai M, Fujiwara H. Five cases of blunt traumatic cardiac rupture: success and failure in surgical management. Gen Thorac Cardiovasc Surg. 2007;55:200-4 pubmed
    ..We believe that patients with cardiac rupture who are alive when they reach hospital can often be saved by prompt diagnosis and immediate, adequate surgical repairs...
  91. Suzuki T, Inoue A, Miki Y, Moriya T, Akahira J, Ishida T, et al. Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor. Endocr Relat Cancer. 2007;14:279-92 pubmed
    ..These results suggest that EGR3 plays an important role in estrogen-meditated invasion and is an independent prognostic factor in breast carcinoma. ..
  92. Akahira J, Suzuki F, Suzuki T, Miura I, Kamogawa N, Miki Y, et al. Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation. Pathol Int. 2007;57:725-33 pubmed
    ..Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation. ..