Experts and Doctors on gene expression in Sendai, Miyagi, Japan


Locale: Sendai, Miyagi, Japan
Topic: gene expression

Top Publications

  1. Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K. Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization. J Clin Invest. 1995;96:657-64 pubmed
    ..The present study will provide important insights into the etiology and pathophysiology of renal diseases with relation to TX metabolism. ..
  2. Ohbo K, Takasawa N, Ishii N, Tanaka N, Nakamura M, Sugamura K. Functional analysis of the human interleukin 2 receptor gamma chain gene promoter. J Biol Chem. 1995;270:7479-86 pubmed
    ..These results suggest that expression of the gamma chain is regulated at the transcription level by extracellular stimuli and may be implicated in immune response. ..
  3. Fujita H, Kondo M, Taketani S, Nomura N, Furuyama K, Akagi R, et al. Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria. Hum Mol Genet. 1994;3:1807-10 pubmed
  4. Koyama T, Gotoh Y, Nishino T. Intersubunit location of the active site of farnesyl diphosphate synthase: reconstruction of active enzymes by hybrid-type heteromeric dimers of site-directed mutants. Biochemistry. 2000;39:463-9 pubmed
    ..Commun. 212, 681-686], respectively. These results suggest that the subunits of the FPP synthase interact with each other to form a shared active site in the homodimer structure rather than an independent active site in each subunit. ..
  5. Kimura Y, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Darnel A, et al. Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart. J Clin Endocrinol Metab. 2002;87:340-6 pubmed
    ..Endogenously produced Ucn may therefore exert its effects mostly through CRF-R2 in an autocrine and/or paracrine manner in the human heart. ..
  6. Fukushima K, Ogawa H, Takahashi K, Naito H, Funayama Y, Kitayama T, et al. Non-pathogenic bacteria modulate colonic epithelial gene expression in germ-free mice. Scand J Gastroenterol. 2003;38:626-34 pubmed
    ..The present study provides a basis for the functional study of each molecule in symbiosis with luminal bacteria in healthy and diseased colon. ..
  7. Yonekura S, Senoo T, Kobayashi Y, Yonezawa T, Katoh K, Obara Y. Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells. Gen Comp Endocrinol. 2003;133:165-72 pubmed
    ..These findings indicate that acetate and butyrate enhance leptin expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses OB-Ra expression in both rat and bovine pituitaries. ..
  8. Yoshida H, Kobayashi D, Ohkubo S, Nakahata N. ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. Eur J Pharmacol. 2006;540:1-9 pubmed
    ..These results suggest that 1) ATP is released from HaCaT cells upon physical stimulation and may act as an autocrine molecule, and 2) the stimulation of P2Y receptors causes IL-6 production via mRNA expression through [Ca2+]i elevation. ..
  9. Fujimura Y, Iwashita M, Matsuzaki F, Yamamoto T. MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains. Brain Res. 2006;1101:12-9 pubmed
    ..Interestingly, MDGA1 also interacts with differentiating muscle through its N-terminal region, which contains Ig domains. These results suggest that MDGA1 functions in MDGA1-expressing nerves en route to and at their target site. ..

More Information

Publications115 found, 100 shown here

  1. Sasaki M, Sukegawa J, Miyosawa K, Yanagisawa T, Ohkubo S, Nakahata N. Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes. Prostaglandins Other Lipid Mediat. 2007;83:237-49 pubmed
    ..These results suggest that TP beta binds to alpha 7 and PA28 gamma, and the cell-surface expression of TP beta is lower than that of TP alpha through the negative regulation of its membrane traffic by proteasomes. ..
  2. Asano R, Sone Y, Ikoma K, Hayashi H, Nakanishi T, Umetsu M, et al. Preferential heterodimerization of a bispecific diabody based on a humanized anti-EGFR antibody 528. Protein Eng Des Sel. 2008;21:597-603 pubmed publisher
    ..We suggest that the preparation of hEx3 from bacterial insoluble material by means of in vitro refolding would be useful for industrial-scale production of the diabody for its potential use in clinical studies. ..
  3. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008;31:1727-32 pubmed
    ..In conclusion, H. erinaceus contains active compounds that stimulate NGF synthesis via activation of the JNK pathway; these compounds are not hericenones. ..
  4. Nedachi T, Fujita H, Kanzaki M. Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle. Am J Physiol Endocrinol Metab. 2008;295:E1191-204 pubmed publisher
    ..Utilizing this model, we identified contraction-inducible myokines potentially linked to the metabolic alterations, immune responses, and angiogenesis induced by exercise. ..
  5. Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E, et al. Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats. Exp Eye Res. 2010;90:429-36 pubmed publisher
    ..Expression of ChR2V was observed mainly in the retinal ganglion cells. These findings demonstrate that visual function can be restored in blind rats by transducing the ChR2V gene into retinal ganglion cells...
  6. Shibata A, Nakagawa K, Kawakami Y, Tsuzuki T, Miyazawa T. Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. J Agric Food Chem. 2010;58:7013-20 pubmed publisher
    ..These results suggest T3 has potential use to protect against UVB-induced skin inflammation. ..
  7. Egawa R, Hososhima S, Hou X, Katow H, Ishizuka T, Nakamura H, et al. Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion. PLoS ONE. 2013;8:e59179 pubmed publisher
  8. Fujita R, Takayama Tsujimoto M, Satoh H, Gutierrez L, Aburatani H, Fujii S, et al. NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013;33:2659-70 pubmed publisher
    ..By activating genes in megakaryocytes that mediate platelet production and function, p45 determines the quantity and quality of platelets. ..
  9. Burdeos G, Nakagawa K, Watanabe A, Kimura F, Miyazawa T. ?-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. J Nutr Sci Vitaminol (Tokyo). 2013;59:148-51 pubmed
    ..Therefore, T3 is a potential lipid-lowering compound candidate with realistic prospects for its use as a therapy for lipid-related diseases in humans. ..
  10. Takagi K, Moriguchi T, Miki Y, Nakamura Y, Watanabe M, Ishida T, et al. GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor. Cancer Sci. 2014;105:600-7 pubmed publisher
  11. Fujita M, Kusajima M, Okumura Y, Nakajima M, Minamisawa K, Nakashita H. Effects of colonization of a bacterial endophyte, Azospirillum sp. B510, on disease resistance in tomato. Biosci Biotechnol Biochem. 2017;81:1657-1662 pubmed publisher
    ..These indicate that endophytic colonization with Azospirillum sp. B510 is able to activate the innate immune system also in tomato, which does not seem to be systemic acquired resistance. ..
  12. Sakagami H, Kondo H. Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells. Brain Res Mol Brain Res. 1993;19:215-8 pubmed
    ..By in situ hybridization histochemistry, we demonstrated the differential gene expression for alpha and beta polypeptides of CaM kinase IV in mature and developing rat brains using oligonucleotide probes specific for each polypeptide. ..
  13. Suzuki G, Kai N, Hirose T, Fukui K, Nishio T, Takayama S, et al. Genomic organization of the S locus: Identification and characterization of genes in SLG/SRK region of S(9) haplotype of Brassica campestris (syn. rapa). Genetics. 1999;153:391-400 pubmed
    ..The small cysteine-rich protein was similar to a pollen coat protein, named PCP-A1, which had previously been shown to bind SLG...
  14. Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, Aigaki T, et al. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A. 2002;99:13705-10 pubmed
    ..Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity. ..
  15. Tomita H, Sugano E, Yawo H, Ishizuka T, Isago H, Narikawa S, et al. Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer. Invest Ophthalmol Vis Sci. 2007;48:3821-6 pubmed
    ..These results suggest that the transduction of Chop2 would provide a new strategy to treat some retinitis pigmentosa (RP) symptoms independent of their etiology. ..
  16. Fujiki N, Konno H, Kaneko Y, Gohno T, Hanamura T, Imami K, et al. Estrogen response element-GFP (ERE-GFP) introduced MCF-7 cells demonstrated the coexistence of multiple estrogen-deprivation resistant mechanisms. J Steroid Biochem Mol Biol. 2014;139:61-72 pubmed publisher
    ..This finding also implies that breast cancers with different resistance mechanisms can concomitantly occur and mingle in an individual patient, and may be a cause of the recurrence of cancer. ..
  17. Ueha S, Kitazawa H, Tomioka Y, Kawai Y, Saito T, Itoh T. cDNA cloning and expression of swine IL-7 from neonatal intestinal epithelium. Biochim Biophys Acta. 2001;1517:468-71 pubmed
    ..By RT-PCR using the constructed specific primers to sIL-7, sIL-7 mRNA was confirmed to be expressed in swine intestine, thymus, kidney and skin but not in the heart. ..
  18. Harigae H, Okitsu Y, Yokoyama H, Fujiwara T, Inomata M, Takahashi S, et al. Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells. Int J Hematol. 2006;84:38-42 pubmed
  19. Toyomizu M, Kikusato M, Kawabata Y, Azad M, Inui E, Amo T. Meat-type chickens have a higher efficiency of mitochondrial oxidative phosphorylation than laying-type chickens. Comp Biochem Physiol A Mol Integr Physiol. 2011;159:75-81 pubmed publisher
    ..The current results regarding a higher efficiency of oxidative phosphorylation and UCP content may partially support the high feed efficiency of meat-type chickens...
  20. Asami K, Inagaki A, Imura T, Sekiguchi S, Fujimori K, Masutani H, et al. Thioredoxin-1 attenuates early graft loss after intraportal islet transplantation in mice. PLoS ONE. 2013;8:e70259 pubmed publisher
    ..We therefore propose that a combination of TRX and other anti-inflammatory treatments represents a promising regimen for improving the efficacy of islet transplantation. ..
  21. Totsune K, Takahashi K, Mackenzie H, Murakami O, Arihara Z, Sone M, et al. Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure. Clin Sci (Lond). 2000;99:541-6 pubmed
    ..These findings suggest potential roles of locally-produced and locally-acting adrenomedullin in the failing heart. ..
  22. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Sato K, et al. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Hypertens Res. 2001;24:229-33 pubmed
    ..We therefore speculate that the strong transcriptional suppression of the TXR and AT1R genes by troglitazone may be mediated in part by its antioxidant effect. ..
  23. Kimura N, Konno Y, Miyoshi K, Matsumoto H, Sato E. Expression of hyaluronan synthases and CD44 messenger RNAs in porcine cumulus-oocyte complexes during in vitro maturation. Biol Reprod. 2002;66:707-17 pubmed
  24. Hoshida T, Sunamura M, Duda D, Egawa S, Miyazaki S, Shineha R, et al. Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor. Pancreas. 2002;25:111-21 pubmed
    ..These results indicate that antiangiogenic gene therapy using soluble flt-1 might be an effective approach for pancreatic cancer treatment. ..
  25. Sato S, Miura H, Yamamoto H, Takeuchi T. Identification of nuclear factors that bind to the mouse tyrosinase gene regulatory region. Pigment Cell Res. 1994;7:279-84 pubmed
  26. Hasegawa T, Matsuzaki Kobayashi M, Takeda A, Sugeno N, Kikuchi A, Furukawa K, et al. Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease. FEBS Lett. 2006;580:2147-52 pubmed
    ..This cellular model may reconstitute the pathological metabolism of alpha-S in the synucleinopathy and provide a useful tool to explore possible pathomechanisms of nigral degeneration in PD. ..
  27. Ito M, Prokop Z, Klvana M, Otsubo Y, Tsuda M, Damborsky J, et al. Degradation of beta-hexachlorocyclohexane by haloalkane dehalogenase LinB from gamma-hexachlorocyclohexane-utilizing bacterium Sphingobium sp. MI1205. Arch Microbiol. 2007;188:313-25 pubmed
    ..This cluster is identical to the one located on the exogenously isolated plasmid pLB1, suggesting that MI1205 had recruited the linB genes by a horizontal transfer event. ..
  28. Kaneko K, Yamada T, Tsukita S, Takahashi K, Ishigaki Y, Oka Y, et al. Obesity alters circadian expressions of molecular clock genes in the brainstem. Brain Res. 2009;1263:58-68 pubmed publisher
    ..These perturbations might contribute to neuronal dysfunction in obese states. This is the first report showing that obesity perturbs the circadian expressions of core clock genes in the CNS. ..
  29. Asano R, Ikoma K, Kawaguchi H, Ishiyama Y, Nakanishi T, Umetsu M, et al. Application of the Fc fusion format to generate tag-free bi-specific diabodies. FEBS J. 2010;277:477-87 pubmed publisher
    ..This approach may be used for industrial-scale production of functional tag-free small therapeutic antibodies. ..
  30. Torii S, Kurihara A, Li X, Yasumoto K, Sogawa K. Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression. J Biochem. 2011;149:171-6 pubmed publisher
    ..These results demonstrate that selection of the culture medium must be considered with caution in cell culture experiments using CoCl(2) as a hypoxia-mimetic reagent...
  31. Ji Z, Ito S, Honjoh T, Ohta H, Ishizuka T, Fukazawa Y, et al. Light-evoked somatosensory perception of transgenic rats that express channelrhodopsin-2 in dorsal root ganglion cells. PLoS ONE. 2012;7:e32699 pubmed publisher
    ..This light-evoked somatosensory perception should facilitate study of how the complex tactile sense emerges in the brain. ..
  32. Nagatomo H, Kohri N, Akizawa H, Hoshino Y, Yamauchi N, Kono T, et al. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development. Anim Sci J. 2016;87:457-61 pubmed publisher
    ..These results suggest that NASP mRNA expression is required for preimplantation development into the blastocyst stage in cattle. ..
  33. Terauchi Y, Kim Y, Tanaka T, Nanatani K, Takahashi T, Abe K. Asp30 of Aspergillus oryzae cutinase CutL1 is involved in the ionic interaction with fungal hydrophobin RolA. Biosci Biotechnol Biochem. 2017;81:1363-1368 pubmed publisher
    ..Our results indicate that D30 is a novel residue involved in the ionic interaction between RolA and CutL1. ..
  34. Nakabayashi O, Nomura O, Nishimori K, Mizuno S. The cDNA cloning and transient expression of a chicken gene encoding a 3 beta-hydroxysteroid dehydrogenase/delta 5-->4 isomerase unique to major steroidogenic tissues. Gene. 1995;162:261-5 pubmed
    ..Among the Km values determined for the three substrates, that for dehydroepiandrosterone was the lowest, which was different from the case for human 3 beta-HSD. ..
  35. Sasano Y, Zhu J, Tsubota M, Takahashi I, Onodera K, Mizoguchi I, et al. Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb. J Histochem Cytochem. 2002;50:325-32 pubmed
    ..Furthermore, the expression of MMP8 is much broader than that of MMP13, for which expression is confined to differentiated phenotypes of osteoblastic and chondrocytic lineage. ..
  36. Mayanagi T, Maeda Y, Hirose S, Arakane T, Araki T, Amagai A. Cloning, sequencing, and expression of the genomic DNA encoding the protein phosphatase cdc25 in Dictyostelium discoideum. Dev Genes Evol. 2004;214:510-4 pubmed
    ..The Western blot analysis also revealed marked changes in the phosphorylated state of the Dd-cdc25, coupling with cellular development. ..
  37. Satouh Y, Padma P, Toda T, Satoh N, Ide H, Inaba K. Molecular characterization of radial spoke subcomplex containing radial spoke protein 3 and heat shock protein 40 in sperm flagella of the ascidian Ciona intestinalis. Mol Biol Cell. 2005;16:626-36 pubmed
    ..Immunoelectron microscopy indicates that Hsp40 is localized in the distal portion of spoke stalk, possibly at the junction between spoke head and the stalk. ..
  38. Ito J, Nakagawa K, Kato S, Miyazawa T, Kimura F, Miyazawa T. The combination of maternal and offspring high-fat diets causes marked oxidative stress and development of metabolic syndrome in mouse offspring. Life Sci. 2016;151:70-75 pubmed publisher
    ..The present findings in offspring from infancy to adulthood may be useful for better understanding the cause-and-effect relationships between oxidative stress and metabolic syndrome development. ..
  39. Motohashi H, Igarashi K, Onodera K, Takahashi S, Ohtani H, Nakafuku M, et al. Mesodermal- vs. neuronal-specific expression of MafK is elicited by different promoters. Genes Cells. 1996;1:223-38 pubmed
  40. Masamune A, Sakai Y, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro. Pancreas. 2002;25:78-85 pubmed
    ..Our results suggest that activated PSCs express ICAM-1 mainly through the activation of NF-kappa B, thus playing a role in the pathogenesis of pancreatic inflammation. ..
  41. Sato K, Fukao K, Seki Y, Akiba Y. Expression of the chicken peroxisome proliferator-activated receptor-gamma gene is influenced by aging, nutrition, and agonist administration. Poult Sci. 2004;83:1342-7 pubmed
  42. Takahashi S. Identification of Flt3 internal tandem duplications downstream targets by high-throughput immunoblotting protein array system. Am J Hematol. 2006;81:717-9 pubmed
    ..As a result, c-Jun and c-Raf were markedly induced, suggesting that these factors are functional downstream targets of Flt3-ITD. ..
  43. Harigae H. GATA transcription factors and hematological diseases. Tohoku J Exp Med. 2006;210:1-9 pubmed
    ..Based on these lines of evidence, some types of hematological diseases may be defined as transcription factor diseases. ..
  44. Iida S, Miki Y, Ono K, Akahira J, Nakamura Y, Suzuki T, et al. Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine tumors: a potential mechanism of therapeutic limitation of mTOR inhibitor. Mol Cell Endocrinol. 2012;350:99-106 pubmed publisher
    ..These results suggest the potential therapeutic efficacy of the combined therapy of mTOR and MEK inhibitors or a dual inhibitor for the treatment of NET patients. ..
  45. Kato S, Terasawa T, Kobayashi T, Ohnishi M, Sasahara Y, Kusuda K, et al. Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4). Arch Biochem Biophys. 1995;318:387-93 pubmed
    ..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions. ..
  46. Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A, et al. Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. Oncol Rep. 2000;7:1339-42 pubmed
    ..Mutation analysis in 38 primary EC tissues and six EC cell lines disclosed no genetic alterations. The genomic structure of hBRAG elucidated in this study should contribute to the future analysis of the hBRAG gene. ..
  47. Yamada M, Takeshita T, Miura S, Murata K, Kimura Y, Ishii N, et al. Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1. Mol Cell Biol. 2001;21:3807-19 pubmed
    ..These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons. ..
  48. Matsui A, Yokoyama R, Seki M, Ito T, Shinozaki K, Takahashi T, et al. AtXTH27 plays an essential role in cell wall modification during the development of tracheary elements. Plant J. 2005;42:525-34 pubmed
    ..These findings indicate that AtXTH27 plays an essential role during the generation of tracheary elements in the rosette leaves of Arabidopsis. ..
  49. Nonogaki K, Nozue K, Oka Y. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology. 2007;148:4658-66 pubmed
    ..Thus, social isolation can be included in the environmental factors that contribute to the development of obesity and type 2 diabetes. ..
  50. Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, et al. Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production. J Mol Endocrinol. 2011;46:37-49 pubmed publisher
    ..A CaMK inhibitor KN-93 attenuated pioglitazone-mediated CYP11B2 transrepression. PPAR? suppresses CYP11B2 expression and aldosterone secretion...
  51. Yasuda T, Saegusa C, Kamakura S, Sumimoto H, Fukuda M. Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression. Mol Biol Cell. 2012;23:3229-39 pubmed publisher
    ..Because both Slp2-a and claudin-2 are highly expressed in mouse renal proximal tubules, Slp2-a is likely to regulate claudin-2 expression through trafficking of podocalyxin to the apical surface in mouse renal tubule epithelial cells. ..
  52. Saito K, Mori S, Date F, Ono M. Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. Autoimmunity. 2013;46:231-7 pubmed publisher
    ..These results suggest that GITRL and 4-1BBL may be effective targets for the development of therapies for Sjögren's syndrome. ..
  53. Igarashi K, Itoh K, Motohashi H, Hayashi N, Matuzaki Y, Nakauchi H, et al. Activity and expression of murine small Maf family protein MafK. J Biol Chem. 1995;270:7615-24 pubmed
    ..mRNA for MafK is expressed in fractions enriched for hematopoietic stem cells as well as erythroid cells, suggesting that MafK plays an important regulatory role in hematopoiesis. ..
  54. Furuchi T, Masuko K, Nishimune Y, Obinata M, Matsui Y. Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Development. 1996;122:1703-9 pubmed
    ..These observations indicate that spermatogonial apoptosis is part of the normal program of mammalian spermatogenesis and is regulated by a pathway affected by Bcl-2. ..
  55. Oda N, Abe M, Sato Y. ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3. J Cell Physiol. 1999;178:121-32 pubmed
    ..These results indicate that ETS-1 is a principal regulator that converts ECs to the angiogenic phenotype. ..
  56. Kumamoto H, Ohki K, Ooya K. Expression of Sonic hedgehog (SHH) signaling molecules in ameloblastomas. J Oral Pathol Med. 2004;33:185-90 pubmed
  57. Sakamoto K, Komatsu T, Kobayashi T, Rose M, Aso H, Hagino A, et al. Growth hormone acts on the synthesis and secretion of alpha-casein in bovine mammary epithelial cells. J Dairy Res. 2005;72:264-70 pubmed
  58. Tokuoka M, Tanaka M, Ono K, Takagi S, Shintani T, Gomi K. Codon optimization increases steady-state mRNA levels in Aspergillus oryzae heterologous gene expression. Appl Environ Microbiol. 2008;74:6538-46 pubmed publisher
    ..oryzae results in elimination of cryptic polyadenylation signals in native Der f 7, thereby circumventing the production of truncated transcripts and resulting in an increase in steady-state mRNA levels...
  59. Shimada M, Kameo S, Sugawara N, Yaginuma Sakurai K, Kurokawa N, Mizukami Murata S, et al. Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls. Arch Toxicol. 2010;84:271-86 pubmed publisher
    ..These results suggest that co-exposure does not simply exacerbate the toxicity of MeHg alone or PCB alone, but stimulates a protection system. ..
  60. Yoshida T, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, et al. Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores. PLoS Genet. 2010;6:e1000910 pubmed publisher
    ..This association is shown to have modulating effects on gene expression. ..
  61. Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler T, et al. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. Free Radic Biol Med. 2012;53:817-27 pubmed publisher
  62. Yamaguchi Y, Okada K, Mizuno T, Ota T, Yamada H, Doi M, et al. Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats. J Biol Rhythms. 2016;31:108-11 pubmed publisher
    ..Studies of in vivo transcriptional states of clock genes in freely moving animals should improve our understanding of how clock gene expression is reflected in behavior. ..
  63. Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, et al. Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. J Immunol. 1994;153:1310-7 pubmed
    ..These findings indicate that the gamma-chain gene mutations that accompany XSCID induce loss of the gamma-chain function, possibly resulting in stagnation of the differentiation and development of T cells. ..
  64. Iino K, Sasano H, Oki Y, Andoh N, Shin R, Kitamoto T, et al. Urocortin expression in human pituitary gland and pituitary adenoma. J Clin Endocrinol Metab. 1997;82:3842-50 pubmed
    ..The results described above indicated that urocortin is synthesized in human anterior pituitary cells and may play an important role in biological features of normal pituitary gland, possibly as an autocrine or a paracrine regulator ..
  65. Abe H, Takeshita T, Nagata K, Arita T, Endo Y, Fujita T, et al. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. Gene. 1999;227:71-7 pubmed
    ..Expression was also observed in liver, lung, kidney, brain, heart, thymus, and spleen. These results suggest that mouse CRTH2 functions in a variety of cells, making the effects of CRTH2 pleiotropic. ..
  66. Toshima J, Toshima J, Amano T, Yang N, Narumiya S, Mizuno K. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell. 2001;12:1131-45 pubmed
    ..We propose that TESK1 and LIM-kinases commonly phosphorylate cofilin but are regulated in different ways and play distinct roles in actin reorganization in living cells. ..
  67. Masamune A, Satoh K, Sakai Y, Yoshida M, Satoh A, Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. Pancreas. 2002;24:130-8 pubmed
  68. Katagiri H, Asano T, Yamada T, Aoyama T, Fukushima Y, Kikuchi M, et al. Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif. Mol Endocrinol. 2002;16:1049-59 pubmed
  69. Sato N, Ito K, Onogawa T, Akahira J, Unno M, Abe T, et al. Expression of organic cation transporter SLC22A16 in human endometria. Int J Gynecol Pathol. 2007;26:53-60 pubmed
    ..Our findings also suggest that it may be possible to use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens. ..
  70. Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, et al. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem Biophys Res Commun. 2012;421:98-104 pubmed publisher
    ..We found inactivating mutations in RDLD-1 and RTFK-1 and decreased expression of DCK in RMKN-28. These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance. ..
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