Experts and Doctors on signal transduction in Yokohama, Kanagawa, Japan

Summary

Locale: Yokohama, Kanagawa, Japan
Topic: signal transduction

Top Publications

  1. Labrousse Arias D, Martínez Alonso E, Corral Escariz M, Bienes Martínez R, Berridy J, Serrano Oviedo L, et al. VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1. J Cell Biol. 2017;216:835-847 pubmed publisher
  2. Koshida S, Hirai Y. Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis. Biochem Biophys Res Commun. 1997;234:522-5 pubmed
    ..These results not only revealed a part of the functional mechanism of epimorphin but also demonstrated that cell/ epimorphin interaction through the NL-peptide sequence is a critical step for lung epithelial morphogenesis. ..
  3. Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, et al. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010;285:24248-59 pubmed publisher
    ..Because the disruption of Epac exerted a protective effect on neuronal apoptosis in vivo, the inhibition of Epac may be a consideration in designing a therapeutic strategy for the treatment of neurodegenerative diseases. ..
  4. Yokoyama U, Ishiwata R, Jin M, Kato Y, Suzuki O, Jin H, et al. Inhibition of EP4 signaling attenuates aortic aneurysm formation. PLoS ONE. 2012;7:e36724 pubmed publisher
    ..An EP4 antagonist that prevents the activation of MMP and thereby inhibits the degradation of aortic elastic fiber may serve as a new strategy for medical treatment of AAA. ..
  5. Ono Minagi H, Sarper S, Kurosaka H, Kuremoto K, Taniuchi I, Sakai T, et al. Runx1 mediates the development of the granular convoluted tubules in the submandibular glands. PLoS ONE. 2017;12:e0184395 pubmed publisher
    ..Furthermore, RUNX1 could also be involved in the membrane trafficking of the AQP5 protein of the acinar cells in the SMG in order to allow for the proper secretion of saliva. ..
  6. Kataoka T, Tschopp J. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol. 2004;24:2627-36 pubmed
    ..Thus, our present results demonstrate that FLIP(p43) processed by caspase 8 specifically interacts with TRAF2 and subsequently induces activation of the NF-kappaB signaling pathway. ..
  7. Nishiyama T, Kii I, Kudo A. Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion. J Biol Chem. 2004;279:47311-9 pubmed
  8. Takeshita F, Ishii K, Kobiyama K, Kojima Y, Coban C, Sasaki S, et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur J Immunol. 2005;35:2477-85 pubmed
    ..These results suggest that TRAF4 participates in the molecular mechanism underlying silencing of TLR-mediated signaling through the interaction with molecules harboring phagosome/endosome membrane. ..
  9. Ihara A, Wada K, Yoneda M, Fujisawa N, Takahashi H, Nakajima A. Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. J Pharmacol Sci. 2007;103:24-32 pubmed
    ..These results indicate that the blockade of the LTB(4)-signaling pathway induces apoptosis via the inhibition of ERK activation in colon cancer cells. The LTB(4)-signaling pathway might be a new therapeutic target for colon cancer. ..

More Information

Publications239 found, 100 shown here

  1. Ko D, Kang J, Kiba T, Park J, Kojima M, Do J, et al. Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin. Proc Natl Acad Sci U S A. 2014;111:7150-5 pubmed publisher
    ..Our results provide molecular evidence for the long-distance transport of cytokinin and show that this transport is necessary for normal shoot development. ..
  2. Nakakuki T, Yumoto N, Naka T, Shirouzu M, Yokoyama S, Hatakeyama M. Topological analysis of MAPK cascade for kinetic ErbB signaling. PLoS ONE. 2008;3:e1782 pubmed publisher
    ..Such characteristics of the signaling cause the preferential binding of the Grb2-SOS complex to heterodimer-mediated signaling molecules. ..
  3. Fukamatsu Y, Yabe N, Hasunuma K. Arabidopsis NDK1 is a component of ROS signaling by interacting with three catalases. Plant Cell Physiol. 2003;44:982-9 pubmed
    ..Transgenic plants expressing AtNDK1 under control of the CaMV 35S promoter exhibited tolerance to paraquat and high ability to eliminate exogenous H2O2. These results indicate that AtNDK1 has a role in ROS response. ..
  4. Fujimoto M, Takatsu H, Ohno H. CMRF-35-like molecule-5 constitutes novel paired receptors, with CMRF-35-like molecule-1, to transduce activation signal upon association with FcRgamma. Int Immunol. 2006;18:1499-508 pubmed
    ..Taken together, these characteristics suggest that CLM-1 and CLM-5 constitute novel PIRs and that CLM-5 may transduce activation signals as the activating receptor in myeloid cells. ..
  5. Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, et al. SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc Natl Acad Sci U S A. 2008;105:294-9 pubmed publisher
    ..These results together indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders. ..
  6. Sawane M, Kajiya K. Ultraviolet light-induced changes of lymphatic and blood vasculature in skin and their molecular mechanisms. Exp Dermatol. 2012;21 Suppl 1:22-5 pubmed publisher
    ..We also discuss potential strategies to block photoageing of skin by inhibiting angiogenesis and/or promoting lymphatic vascular function. ..
  7. Yamane A, Takahashi K, Mayo M, Vo H, Shum L, Zeichner David M, et al. Induced expression of myoD, myogenin and desmin during myoblast differentiation in embryonic mouse tongue development. Arch Oral Biol. 1998;43:407-16 pubmed
  8. Suzuki N, Saito T. IRAK-4--a shared NF-kappaB activator in innate and acquired immunity. Trends Immunol. 2006;27:566-72 pubmed
    ..Here, we discuss the impact of these evolutionarily conserved molecules on innate and acquired immunity, and their potential as drug targets for the simultaneous modulation of both immunities. ..
  9. Moriyama A, Kii I, Sunabori T, Kurihara S, Takayama I, Shimazaki M, et al. GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. Genesis. 2007;45:90-100 pubmed
    ..e., the liver and spleen, as novel organs in which the Wnt canonical signal is in motion in the adult. These transgenic lines will provide us broader opportunities to investigate the function of the Wnt canonical pathway in vivo. ..
  10. Nagashima T, Ushikoshi Nakayama R, Suenaga A, Ide K, Yumoto N, Naruo Y, et al. Mutation of epidermal growth factor receptor is associated with MIG6 expression. FEBS J. 2009;276:5239-51 pubmed publisher
    ..Taking all the above together, an EGFR mutation can cause transcriptional changes to accommodate the activation potency of the original signaling pathway at the cellular level. ..
  11. Yoshimoto K, Jikumaru Y, Kamiya Y, Kusano M, Consonni C, Panstruga R, et al. Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell. 2009;21:2914-27 pubmed publisher
    ..We also show that autophagy is induced by the SA agonist. These findings imply that plant autophagy operates a novel negative feedback loop modulating SA signaling to negatively regulate senescence and immunity-related PCD. ..
  12. Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, et al. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. J Immunol. 2010;184:3341-5 pubmed publisher
    ..Our results show that IKKalpha is a unique molecule involved in TLR7/9-MyD88-dependent type I IFN production through DC subset-specific mechanisms. ..
  13. Hirata K, Miyashiro M, Ogawa H, Taki H, Tobe K, Sugita T. Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells. Biol Pharm Bull. 2010;33:1233-7 pubmed
    ..These results improve understanding of TNFalpha regulatory mechanisms and might provide a new therapeutic strategy against inflammatory diseases. ..
  14. Abo T, Iida R, Kaneko S, Suga T, Yamada H, Hamada Y, et al. IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a ??-adrenergic agonist. Cell Biochem Funct. 2012;30:671-6 pubmed publisher
    ..These results suggest that myostatin functions as a negative regulator in the later stages in the hypertrophy of rat masseter muscle induced by clenbuterol, whereas IGF works as a positive regulator in the earlier stages. ..
  15. Murayama M, Hayashi S, Nishimura N, Ishide M, Kobayashi K, Yagi Y, et al. Isolation of Arabidopsis ahg11, a weak ABA hypersensitive mutant defective in nad4 RNA editing. J Exp Bot. 2012;63:5301-10 pubmed publisher
    ..Presumably, partial impairment of mitochondrial function caused by an amino acid conversion in one of the complex I components induces redox imbalance which, in turn, confers an abnormal response to the plant hormone. ..
  16. Nguyen H, Umemura K, Kawano T. Indole-3-acetic acid-induced oxidative burst and an increase in cytosolic calcium ion concentration in rice suspension culture. Biosci Biotechnol Biochem. 2016;80:1546-54 pubmed publisher
    ..The IAA-induced [Ca(2+)]c elevation was inhibited by Ca(2+) channel blockers and a Ca(2+) chelator. Furthermore, ROS scavengers effectively blocked the action of IAA on [Ca(2+)]c elevation. ..
  17. Suzuki A, Akimoto K, Ohno S. Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem. 2003;133:9-16 pubmed
  18. Kakui N, Kitamura K. Direct evidence that stimulation of neuropeptide Y Y5 receptor activates hypothalamo-pituitary-adrenal axis in conscious rats via both corticotropin-releasing factor- and arginine vasopressin-dependent pathway. Endocrinology. 2007;148:2854-62 pubmed
  19. Tsuchida Mayama T, Sakai T, Hanada A, Uehara Y, Asami T, Yamaguchi S. Role of the phytochrome and cryptochrome signaling pathways in hypocotyl phototropism. Plant J. 2010;62:653-62 pubmed publisher
  20. Iida R, Kanko S, Suga T, Morito M, Yamane A. Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging. Mol Cell Biochem. 2011;348:89-98 pubmed publisher
    ..Thus, the deficiency of amino acid by the active movement of the masseter and tongue seems to stimulate the autophagic-lysosomal pathway via the down-regulation of mTOR signalling pathway. ..
  21. Fukada T, Kambe T. Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics. 2011;3:662-74 pubmed publisher
  22. Nishiyama R, Watanabe Y, Fujita Y, Le D, Kojima M, Werner T, et al. Analysis of cytokinin mutants and regulation of cytokinin metabolic genes reveals important regulatory roles of cytokinins in drought, salt and abscisic acid responses, and abscisic acid biosynthesis. Plant Cell. 2011;23:2169-83 pubmed publisher
  23. Shimizu K, Asakura M, Shinga J, Sato Y, Kitahara S, Hoshino K, et al. Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. J Immunol. 2013;190:5609-19 pubmed publisher
    ..These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy. ..
  24. Kobayashi K, Sawada K, Yamamoto H, Wada S, Saiga H, Nishida H. Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos. Development. 2003;130:5179-90 pubmed
    ..A zygotic event involving snail expression downstream of maternal macho-1 mediates the suppression of notochord induction in mesenchyme precursors. ..
  25. Maruyama Nakashita A, Nakamura Y, Yamaya T, Takahashi H. A novel regulatory pathway of sulfate uptake in Arabidopsis roots: implication of CRE1/WOL/AHK4-mediated cytokinin-dependent regulation. Plant J. 2004;38:779-89 pubmed
    ..Our results suggested that two different modes of regulation, represented as the -S induction and the cytokinin-dependent repression of sulfate transporters, independently control the uptake of sulfate in Arabidopsis roots. ..
  26. Kanazawa A, Tsukada S, Kamiyama M, Yanagimoto T, Nakajima M, Maeda S. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2005;330:505-10 pubmed
    ..These findings indicate that Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt/beta-catenin pathway. ..
  27. Hossain M, Sakemura R, Fujii M, Ayusawa D. G-protein gamma subunit GNG11 strongly regulates cellular senescence. Biochem Biophys Res Commun. 2006;351:645-50 pubmed
    ..Furthermore, overexpression of GNG11 activated ERK1/2 of the MAP kinase family, but did not Ras. Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues. ..
  28. Hojyo S, Fukada T, Shimoda S, Ohashi W, Bin B, Koseki H, et al. The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS ONE. 2011;6:e18059 pubmed publisher
    ..Our data highlight SLC39A14 as an important novel player in GPCR-mediated signaling. In addition, the Slc39a14-KO mice may be useful for studying the GPCR-associated regulation of mammalian systemic growth. ..
  29. Diaz C, Kusano M, Sulpice R, Araki M, Redestig H, Saito K, et al. Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes. BMC Syst Biol. 2011;5:192 pubmed publisher
    ..Taken together, our findings indicate that 14-3-3 proteins play roles as crucial tuners of multiple primary metabolic processes including TCA cycle and the shikimate pathway. ..
  30. Yamasaki S, Hasegawa A, Hojyo S, Ohashi W, Fukada T, Nishida K, et al. A novel role of the L-type calcium channel ?1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave. PLoS ONE. 2012;7:e39654 pubmed publisher
    ..These findings indicated that the LTCC ?(1D) subunit located on the ER membrane has a novel function as a gatekeeper for the Zn wave, which is involved in regulating NF-?B signaling and the delayed-type allergic reaction. ..
  31. Li Y, Drnevich J, Akraiko T, Band M, Li D, Wang F, et al. Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells. Genomics. 2013;102:456-67 pubmed publisher
    ..Finally, forced activation of Gli2 in mESCs increased their proliferation rate. Collectively, it is suggested with these results that Gli2 may play a novel role in the self-renewal of pluripotent stem cells. ..
  32. Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
    ..Thus, ILCs integrate stromal and myeloid signals to orchestrate innate-like antibody production at the interface between the immune system and circulatory system. ..
  33. Shoji S, Hanada K, Ohsawa N, Shirouzu M. Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation. Biochem J. 2017;474:3207-3226 pubmed publisher
    ..Here, we propose a model for the oligomeric ubiquitylation process, controlled by the RNF52 domain, which is not a sequential assembly process involving monomers. ..
  34. Nakano K, Yamauchi J, Nakagawa K, Itoh H, Kitamura N. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. J Biol Chem. 2000;275:20533-9 pubmed
    ..These results suggest that NESK, a novel activator of the JNK pathway, functions in coupling TRAF2 to the MEKK1 --> MKK4 --> JNK kinase cascade during the late stages of mammalian embryogenesis. ..
  35. Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L. Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol Cell Biol. 2000;20:4658-65 pubmed
    ..Taken together, our data indicate that Ras and Ral regulate the chemotactic migration of skeletal muscle progenitors. ..
  36. Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells. 2003;8:131-44 pubmed
    ..These results indicate that p38 comprises the senescence-executing pathway in response to diverse stimuli. ..
  37. Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, et al. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood. 2007;110:3591-660 pubmed
    ..We propose that human DCs use unique and flexible developmental programs that cannot be categorized into the conventional myeloid or lymphoid pathway. ..
  38. Okumura S, Vatner D, Kurotani R, Bai Y, Gao S, Yuan Z, et al. Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation. 2007;116:1776-83 pubmed
  39. Hashimoto Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W, Saito T. T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering. Mol Cell Biol. 2010;30:3421-9 pubmed publisher
  40. Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano Satoh A, et al. An essential developmental checkpoint for production of the T cell lineage. Science. 2010;329:93-6 pubmed publisher
    ..Our study thus identifies the earliest checkpoint during T cell development and shows that it is Bcl11b-dependent. ..
  41. Ohnuki Y, Umeki D, Mototani Y, Shiozawa K, Nariyama M, Ito A, et al. Role of phosphodiesterase 4 expression in the Epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol. Physiol Rep. 2016;4: pubmed publisher
  42. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron. 2002;35:907-20 pubmed
    ..The sema3A gene shows strong interaction with fyn for apical dendrite guidance in the cerebral cortex. We propose a signal transduction pathway in which Fyn and Cdk5 mediate neuronal guidance regulated by Sema3A. ..
  43. Takase T, Nakazawa M, Ishikawa A, Manabe K, Matsui M. DFL2, a new member of the Arabidopsis GH3 gene family, is involved in red light-specific hypocotyl elongation. Plant Cell Physiol. 2003;44:1071-80 pubmed
    ..DFL2 promoter activity was observed in the hypocotyl. Our results suggest that DFL2 is located downstream of red light signal transduction and determines the degree of hypocotyl elongation. ..
  44. Fujita T, Otsu K, Oshikawa J, Hori H, Kitamura H, Ito T, et al. Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner. J Cell Mol Med. 2006;10:216-24 pubmed
    ..Our findings suggest that caveolin exhibits growth inhibition in a Ca2+-dependent manner, most likely through PKC, in cardiac myoblasts...
  45. Katagiri C, Negishi K, Hibino T. c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. J Dermatol Sci. 2006;43:171-9 pubmed
    ..In addition, recombinant SCCA1 suppressed kinase activity of JNK1 but did not affect JNK2 or JNK3 kinase activity. JNK1 is associated with UV signal transduction in human epidermis and SCCA1 is a suppressor of this process. ..
  46. Maemura M, Yoshimoto A, Tsukada Y, Morishita Y, Miyazawa K, Tanaka T, et al. Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line. Cancer Sci. 2006;97:1343-50 pubmed
  47. Shirako E, Hirayama N, Tsukada Y, Tanaka T, Kitamura N. Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation. J Cell Biochem. 2008;104:176-88 pubmed
  48. Kawamura I, Yoshida H, Ikeda Y, Yamaguchi S, Tuzi S, Saito H, et al. Dynamics change of phoborhodopsin and transducer by activation: study using D75N mutant of the receptor by site-directed solid-state 13C NMR. Photochem Photobiol. 2008;84:921-30 pubmed publisher
  49. Hara M, Mori M, Wada T, Tachibana K, Kishimoto T. Start of the embryonic cell cycle is dually locked in unfertilized starfish eggs. Development. 2009;136:1687-96 pubmed publisher
    ..Release from such a 'dual-lock' by fertilization results in the start of the embryonic cell cycle...
  50. Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, et al. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased ? cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem. 2011;286:25467-76 pubmed publisher
    ..In conclusion, SL exacerbated ? cell apoptosis in diabetic Gck(+/-) mice but not in euglycemic wild-type mice, and DPP-4 inhibition protected against these effects. ..
  51. Minato A, Ise H, Goto M, Akaike T. Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides. Biomaterials. 2012;33:515-23 pubmed publisher
    ..These findings suggest that substrate immobilization of soluble factors is a useful technique for differentiation of ESCs in regenerative medicine and tissue engineering. ..
  52. Nishii T, Tanabe M, Tanaka R, Matsuzawa T, Okudela K, Nozawa A, et al. Unique mutation, accelerated mTOR signaling and angiogenesis in the pulmonary cysts of Birt-Hogg-Dubé syndrome. Pathol Int. 2013;63:45-55 pubmed publisher
    ..Collective data indicates that dysregulation of mTOR signaling facilitates S6-mediated protein synthesis and HIF-1?-mediated angiogenesis, which may contribute to the development of pulmonary cysts in this disorder...
  53. Kong K, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo Balancio A, et al. Protein kinase C-? controls CTLA-4-mediated regulatory T cell function. Nat Immunol. 2014;15:465-72 pubmed publisher
    ..These results reveal a CTLA-4-PKC-? signaling axis required for contact-dependent suppression and implicate this pathway as a potential cancer immunotherapy target. ..
  54. Matsuzawa M, Arai C, Nomura Y, Murata T, Yamakoshi Y, Oida S, et al. Periostin of human periodontal ligament fibroblasts promotes migration of human mesenchymal stem cell through the αvβ3 integrin/FAK/PI3K/Akt pathway. J Periodontal Res. 2015;50:855-63 pubmed publisher
    ..Periostin expression in hPDLFs promotes the migration of hMSCs through the αvβ3 integrin/FAK/PI3K/Akt pathway in vitro. ..
  55. Draber P, Hálová I, Polakovičová I, Kawakami T. Signal transduction and chemotaxis in mast cells. Eur J Pharmacol. 2016;778:11-23 pubmed publisher
    ..This review will focus on recent progresses in FcεRI and KIT signaling and chemotaxis. ..
  56. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, et al. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017;214:1607-1618 pubmed publisher
    ..Our present study thus demonstrates that IL-22BP promotes bacterial uptake into PPs by influencing FAE gene expression and function. ..
  57. Camp J, Sekine K, Gerber T, Loeffler Wirth H, Binder H, Gac M, et al. Multilineage communication regulates human liver bud development from pluripotency. Nature. 2017;546:533-538 pubmed publisher
    ..Our molecular dissection reveals interlineage communication regulating organoid development, and illuminates previously inaccessible aspects of human liver development. ..
  58. Edamatsu H, Kaziro Y, Itoh H. Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells. FEBS Lett. 1998;440:231-4 pubmed
    ..Our findings suggest that Ras may play a critical role in the G alpha i2-induced transformation and G alpha i2 can transduce signals from the Gi-coupled receptor to JNK and ERK in certain types of mammalian cells. ..
  59. Suzuki S, Nagano T, Yamakoshi Y, Gomi K, Arai T, Fukae M, et al. Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta}. J Dent Res. 2005;84:510-4 pubmed
    ..These results indicate that Emd-Gel contains both TGF-beta- and BMP-like growth factors that contribute to the induction of biomineralization during periodontal regeneration. ..
  60. Tsurumi Y, Tamura K, Tanaka Y, Koide Y, Sakai M, Yabana M, et al. Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules. Kidney Int. 2006;69:488-94 pubmed
    ..Furthermore, this is the first report demonstrating a substantial colocalization of ATRAP and AT1 receptor in vivo. ..
  61. Umezawa T, Okamoto M, Kushiro T, Nambara E, Oono Y, Seki M, et al. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Plant J. 2006;46:171-82 pubmed
    ..Taken together, our results indicate that CYP707A3 plays an important role in determining threshold levels of ABA during dehydration and after rehydration. ..
  62. Nakatani Y, Nishidate M, Fujita M, Kawakami A, Kudo A. Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration. Dev Growth Differ. 2008;50:71-83 pubmed
    ..From these data, we propose a model in which distinct signals that direct the cell cycle activation, mesenchymal cell migration and epidermal remodeling coordinate together to accomplish the correct blastema formation and regeneration. ..
  63. Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, et al. Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator. J Biol Chem. 2011;286:17766-76 pubmed publisher
    ..These findings indicate that TFE3 and Gα(16) are up-regulated under pathologic conditions and are involved in a novel mechanism of transcriptional regulation via the relocalization and activation of Gα(16). ..
  64. Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, et al. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab. 2012;16:44-54 pubmed publisher
    ..Our results indicate that obesity-induced leptin plays a crucial role in NASH progression via enhanced responsivity to endotoxin, and we propose a mechanism of bacteria-mediated progression of NASH. ..
  65. Osugi A, Kojima M, Takebayashi Y, Ueda N, Kiba T, Sakakibara H. Systemic transport of trans-zeatin and its precursor have differing roles in Arabidopsis shoots. Nat Plants. 2017;3:17112 pubmed publisher
  66. Kimura M, Manabe K, Abe T, Yoshida S, Matsui M, Yamamoto Y. Analysis of hydrogen peroxide-independent expression of the high-light-inducible ELIP2 gene with the aid of the ELIP2 promoter-luciferase fusions. Photochem Photobiol. 2003;77:668-74 pubmed
  67. Oshikawa J, Otsu K, Toya Y, Tsunematsu T, Hankins R, Kawabe J, et al. Insulin resistance in skeletal muscles of caveolin-3-null mice. Proc Natl Acad Sci U S A. 2004;101:12670-5 pubmed
    ..Our findings suggest that Cav3 is an enhancer of insulin signaling in skeletal muscles but does not act as a scaffolding molecule for insulin receptors. ..
  68. Yuasa K, Toyooka K, Fukuda H, Matsuoka K. Membrane-anchored prolyl hydroxylase with an export signal from the endoplasmic reticulum. Plant J. 2005;41:81-94 pubmed publisher
    ..Analysis of this protein fused to green fluorescent protein indicated that basic amino acids in the cytoplasmic, N-terminal region of the PH play a role in its export from the ER...
  69. Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, et al. Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem. 2009;284:27393-401 pubmed publisher
    ..These results suggest that Fyn-dependent phosphorylation of CRMP2 at Tyr(32) is involved in Sema3A signaling. ..
  70. Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, et al. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells. 2010;15:339-49 pubmed publisher
    ..These findings suggest that UBR1 and UBR2 are negative regulators of the leucine-mTOR signaling pathway. Leucine might activate this pathway in part through inhibition of their ubiquitin ligase activity. ..
  71. Denda K, Nakao Wakabayashi K, Okamoto N, Kitamura N, Ryu J, Tagawa Y, et al. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor. J Biol Chem. 2011;286:28802-10 pubmed publisher
    ..We thus provide evidence for a novel labor-inducing fetoplacental signal that depends on the X chromosome and possibly arises from the placenta. ..
  72. Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, et al. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011;333:769-73 pubmed publisher
    ..A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation. ..
  73. Kajiya K, Kidoya H, Sawane M, Matsumoto Okazaki Y, Yamanishi H, Furuse M, et al. Promotion of lymphatic integrity by angiopoietin-1/Tie2 signaling during inflammation. Am J Pathol. 2012;180:1273-82 pubmed publisher
    ..Overall, our data strongly support the idea that Ang1/Tie2 signaling promotes lymphatic integrity by modulating tight junction molecule expression during inflammation. ..
  74. Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, et al. Functional variants in NFKBIE and RTKN2 involved in activation of the NF-?B pathway are associated with rheumatoid arthritis in Japanese. PLoS Genet. 2012;8:e1002949 pubmed publisher
    ..These results suggest that the NF-?B pathway plays a role in pathogenesis and would be a rational target for treatment of rheumatoid arthritis. ..
  75. Araki Y, Ku W, Akioka M, May A, Hayashi Y, Arisaka F, et al. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol. 2013;203:299-313 pubmed publisher
    ..These data suggest that the homodimer of Atg38 functions as a physical linkage between the Vps15-Vps34 and Atg14-Vps30 subcomplexes to facilitate complex I formation...
  76. Kim J, To T, Matsui A, Tanoi K, Kobayashi N, Matsuda F, et al. Acetate-mediated novel survival strategy against drought in plants. Nat Plants. 2017;3:17097 pubmed publisher
    ..Our findings highlight a radically new survival strategy that exploits an epigenetic switch of metabolic flux conversion and hormone signalling by which plants adapt to drought. ..
  77. Matsuura A, Naito T, Ishikawa F. Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics. 1999;152:1501-12 pubmed
    ..Our results demonstrate a novel role of the S. pombe ATM homologues that is independent of chk1(+) and cds1(+). ..
  78. Kaji K, Katogi R, Azuma Y, Naito A, Inoue J, Kudo A. Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6. J Bone Miner Res. 2001;16:1593-9 pubmed
    ..Thus, we have provided the first evidence showing that TRAF6 is involved in TNF-alpha-induced osteoclastogenesis. ..
  79. Aiba Y, Oh Hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, et al. Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004;101:16612-7 pubmed
    ..Hence, our data suggest that PKC, after being activated by diacylglycerol, phosphorylates RasGRP3, thereby contributing to its full activation. ..
  80. Kabe Y, Ohmori M, Shinouchi K, Tsuboi Y, Hirao S, Azuma M, et al. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. J Biol Chem. 2006;281:31729-35 pubmed
    ..This is the first report of a putative mechanism for accumulation of porphyrins in the mitochondrial inner membrane. ..
  81. Umezawa K. Inhibition of tumor growth by NF-kappaB inhibitors. Cancer Sci. 2006;97:990-5 pubmed
    ..It inhibited both canonical and non-canonical NF-kappaB activating pathways. It inhibited various carcinomas and leukemias in animal models without any toxicity, and might be useful as an anticancer agent. ..
  82. Aiba Y, Kameyama M, Yamazaki T, Tedder T, Kurosaki T. Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood. 2008;111:1497-503 pubmed
    ..Together, our data suggest that BCAP and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development. ..
  83. Fukada T, Civic N, Furuichi T, Shimoda S, Mishima K, Higashiyama H, et al. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS ONE. 2008;3:e3642 pubmed publisher
    ..The Slc39a13-KO mouse represents a novel animal model linking zinc metabolism, BMP/TGF-beta signaling and connective tissue dysfunction. ..
  84. Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, et al. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem. 2009;284:31431-40 pubmed publisher
    ..Under hypoxic stress, this unrecognized response program plays a critical role in the fate of NCM. ..
  85. Kiba T, Kudo T, Kojima M, Sakakibara H. Hormonal control of nitrogen acquisition: roles of auxin, abscisic acid, and cytokinin. J Exp Bot. 2011;62:1399-409 pubmed publisher
    ..In this review, the evidence is summarized, mostly focusing on examples related to nitrogen acquisition. ..
  86. Takahashi H, Kopriva S, Giordano M, Saito K, Hell R. Sulfur assimilation in photosynthetic organisms: molecular functions and regulations of transporters and assimilatory enzymes. Annu Rev Plant Biol. 2011;62:157-84 pubmed publisher
  87. Kuromori T, Sugimoto E, Shinozaki K. Arabidopsis mutants of AtABCG22, an ABC transporter gene, increase water transpiration and drought susceptibility. Plant J. 2011;67:885-94 pubmed publisher
    ..Also, the atabcg22 mutation enhanced the phenotype of nced3 mutants, which were defective in ABA biosynthesis. Accordingly, the additive roles of AtABCG22 functions in ABA signalling and ABA biosynthesis are discussed...
  88. Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, et al. The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Gastroenterology. 2011;141:621-32 pubmed publisher
    ..The AP-1B-mediated protein sorting machinery is required for maintenance of immune homeostasis and prevention of excessive inflammation. ..
  89. Kishimoto T. A primer on meiotic resumption in starfish oocytes: the proposed signaling pathway triggered by maturation-inducing hormone. Mol Reprod Dev. 2011;78:704-7 pubmed publisher
    ..Mitotic kinases including Aurora, Plk1 and Greatwall are activated downstream of cyclin B-Cdc2. The starfish oocyte thus provides a simple model system for the study of meiotic resumption...
  90. Izumi N, Yamashita A, Hirano H, Ohno S. Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex. Cancer Sci. 2012;103:50-7 pubmed publisher
  91. Yokosuka T, Takamatsu M, Kobayashi Imanishi W, Hashimoto Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med. 2012;209:1201-17 pubmed publisher
    ..This inhibitory mechanism also functions in PD-1(hi) T cells generated in vivo and can be overridden by a neutralizing anti-PD-L1 antibody. Therefore, PD-1 microcluster formation is important for regulation of T cell activation. ..
  92. Nam Y, Tran L, Kojima M, Sakakibara H, Nishiyama R, Shin R. Regulatory roles of cytokinins and cytokinin signaling in response to potassium deficiency in Arabidopsis. PLoS ONE. 2012;7:e47797 pubmed publisher
    ..From these results, we conclude that a reduction in CK levels subsequently allows fast and effective stimulation of low K-induced ROS accumulation, root hair growth and HAK5 expression, leading to plant adaptation to low K conditions. ..