Experts and Doctors on mutation in Kobe, Hyōgo, Japan


Locale: Kobe, Hyōgo, Japan
Topic: mutation

Top Publications

  1. Matsuoka D, Nanmori T, Sato K, Fukami Y, Kikkawa U, Yasuda T. Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro and in vivo: analysis of active mutants expressed in E. coli and generation of the active form in stress response in seedlings. Plant J. 2002;29:637-47 pubmed
    ..These data indicate that the AtMEK1 becomes an active form through phosphorylation and activates its downstream target ATMPK4 in stress response in Arabidopsis. ..
  2. Maeda T, Sugiura R, Kita A, Saito M, Deng L, He Y, et al. Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasis. Genes Cells. 2004;9:71-82 pubmed
    ..These results suggest that Pmr1 and Pdt1 cooperatively regulate cell morphogenesis through the control of Mn2+ homeostasis, and that calcineurin functions as a Mn2+ sensor as well as a Mn2+ homeostasis regulator. ..
  3. Hirano M, Kiyonari H, Inoue A, Furushima K, Murata T, Suda Y, et al. A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. Dev Dyn. 2006;235:2229-37 pubmed
    ..Concomitantly, its null mutant exhibits omphalocele with a failure in closure of the secondary body wall. There are no apparent gross morphological defects in brain, however, despite the unique Omphk1 expression in this tissue. ..
  4. Ding D, Sakurai N, Katou Y, Itoh T, Shirahige K, Haraguchi T, et al. Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. J Cell Biol. 2006;174:499-508 pubmed
  5. Tamai K, Nishiwaki K. bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans. Dev Biol. 2007;308:562-71 pubmed
  6. Habara Y, Doshita M, Hirozawa S, Yokono Y, Yagi M, Takeshima Y, et al. A strong exonic splicing enhancer in dystrophin exon 19 achieve proper splicing without an upstream polypyrimidine tract. J Biochem. 2008;143:303-10 pubmed
    ..This compensation was only seen in living cells but not in 'in vitro splicing'. This suggests the possibility that the previous splicing experiments using an in vitro splicing system could underestimate the activity of ESEs. ..
  7. Yutori H, Semba S, Komori T, Yokozaki H. Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells. Cancer Sci. 2008;99:524-30 pubmed publisher
    ..These findings suggest that Fhit plays a key role in the regulation of the ataxia telangiectasia mutated-Chk2 DNA damage response during oral carcinogenesis. ..
  8. Jin Z, Mandai M, Homma K, Ishigami C, Hirami Y, Nao I N, et al. Allelic copy number variation in FSCN2 detected using allele-specific genotyping and multiplex real-time PCRs. Invest Ophthalmol Vis Sci. 2008;49:3799-805 pubmed publisher
    ..It is not likely that the FSCN2 gene is imprinted differentially. The real-time PCR-based genotyping method developed in this study is useful for investigations of allelic asymmetries within genomic regions with CNVs. ..
  9. Semba S, Yasujima H, Takano T, Yokozaki H. Autopsy case of the neonatal form of carnitine palmitoyltransferase-II deficiency triggered by a novel disease-causing mutation del1737C. Pathol Int. 2008;58:436-41 pubmed publisher
    ..Eventually, laboratory and autopsy findings led to diagnosis of the neonatal form of CPT-II deficiency. TMS can be expected to be widely used to detect metabolic disorders in neonates. ..

More Information

Publications115 found, 100 shown here

  1. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..Our data provide a platform for future studies of zebrafish cerebellar development. ..
  2. Imagawa K, Fang Y, Sugiura R, Zhou X, Ma Y, Kuno T. Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis. Kobe J Med Sci. 2009;55:E30-5 pubmed
  3. Mukai M, Kato H, Hira S, Nakamura K, Kita H, Kobayashi S. Innexin2 gap junctions in somatic support cells are required for cyst formation and for egg chamber formation in Drosophila. Mech Dev. 2011;128:510-23 pubmed publisher
    ..Inx2 gap junctions may mediate the transfer of nutrients and signal molecules between germ cells and somatic support cells, as well as play a role in the regulation of cell adhesion. ..
  4. Moriyama T, Fujimitsu Y, Yoshikai Y, Sasano T, Yamada K, Murakami M, et al. SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells. Biochem Biophys Res Commun. 2014;447:419-24 pubmed publisher
    ..Our findings provide insights into the in vivo dynamics of TDG SUMOylation and further clarify the TDG-RNF4 interaction. ..
  5. Nakamura T, Tateishi K, Niwa T, Matsushita Y, Tamura K, Kinoshita M, et al. Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas. Neuropathol Appl Neurobiol. 2016;42:279-90 pubmed publisher
    ..These hotspot mutations may serve as a genetic hallmark for PCNSL serving as a genetic marker for diagnose and potential targets for molecular therapy. ..
  6. Masanari M, Fujii S, Kawahara K, Oki H, Tsujino H, Maruno T, et al. Comparative study on stabilization mechanism of monomeric cytochrome c5 from deep-sea piezophilic Shewanella violacea. Biosci Biotechnol Biochem. 2016;80:2365-2370 pubmed
    ..As SVcytc5 was isolated from a deep-sea piezophilic bacterium, the present comparative study indicates that adaptation of monomeric SVcytc5 to high pressure environments results in stabilization against heat. ..
  7. Nuvolone M, Paolucci M, Sorce S, Kana V, Moos R, Matozaki T, et al. Prion pathogenesis is unaltered in the absence of SIRP?-mediated "don't-eat-me" signaling. PLoS ONE. 2017;12:e0177876 pubmed publisher
    ..It will be important to search for additional candidates mediating prion phagocytosis, as this mechanism may represent an important target of antiprion therapies. ..
  8. Shima F, Okada T, Kido M, Sen H, Tanaka Y, Tamada M, et al. Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation. Mol Cell Biol. 2000;20:26-33 pubmed
    ..These results, taken together with those obtained with mammalian Raf, suggest the importance of the second Ras-binding site in effector regulation. ..
  9. Cortés J, Katoh Fukui R, Moto K, Ribas J, Ishiguro J. Schizosaccharomyces pombe Pmr1p is essential for cell wall integrity and is required for polarized cell growth and cytokinesis. Eukaryot Cell. 2004;3:1124-35 pubmed
    ..Disruption and complementation analyses suggest that Pmr1p shares its function with a vacuolar Ca2+-ATPase homologue, Pmc1p (SPAPB2B4.04c), to prevent lethal activation of calcineurin for cell growth. ..
  10. Furuya M, Qadota H, Chisholm A, Sugimoto A. The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6. Dev Biol. 2005;286:452-63 pubmed
    ..Thus, eya-1 appears to play a partially redundant role with pax-6 during C. elegans embryogenesis. ..
  11. He Y, Sugiura R, Ma Y, Kita A, Deng L, Takegawa K, et al. Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway. Genes Cells. 2006;11:207-21 pubmed
    ..These results suggest that Ryh1 is involved in the secretory pathway and may have a potential overlapping function with Ypt3 in addition to its role in recycling. ..
  12. Kakihara K, Shinmyozu K, Kato K, Wada H, Hayashi S. Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila. Mech Dev. 2008;125:325-36 pubmed
  13. Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, et al. Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice. Mech Dev. 2008;125:832-42 pubmed publisher
    ..We also present genetic evidence for the context-dependent functional relationship between Tsg and Cv2 during mouse development. ..
  14. Ohtani Y, Harada T, Funasaka Y, Nakao K, Takahara C, Abdel Daim M, et al. Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. Oncogene. 2008;27:7162-70 pubmed publisher
    ..These findings suggest that growth of melanoma can be inhibited in vivo by eliminating only one of the multiple genetic anomalies involved in tumorigenesis. ..
  15. Kubota Y, Ohkura K, Tamai K, Nagata K, Nishiwaki K. MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans. Proc Natl Acad Sci U S A. 2008;105:20804-9 pubmed publisher
  16. Bungyoku Y, Shoji I, Makine T, Adachi T, Hayashida K, Nagano Fujii M, et al. Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells. J Gen Virol. 2009;90:1681-91 pubmed publisher
    ..The J6/JFH1-derived mutant viruses presented here would be a good tool for producing HCV particles with enhanced infectivity and for studying the molecular mechanism of HCV entry. ..
  17. Nozu K, Iijima K, Kawai K, Nozu Y, Nishida A, Takeshima Y, et al. In vivo and in vitro splicing assay of SLC12A1 in an antenatal salt-losing tubulopathy patient with an intronic mutation. Hum Genet. 2009;126:533-8 pubmed publisher
    ..These analytical assays could be adapted for all inherited kidney diseases. ..
  18. Jin Z, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, et al. Modeling retinal degeneration using patient-specific induced pluripotent stem cells. PLoS ONE. 2011;6:e17084 pubmed publisher
    ..Our results demonstrate that the use of patient-derived iPS cells will help to elucidate the pathogenic mechanisms caused by genetic mutations in RP. ..
  19. Ohmura T, Shioi G, Hirano M, Aizawa S. Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012;241:1350-64 pubmed publisher
    ..In the double mutant neural plate, phosphorylated myosin light chain 2, F-actin, and cortactin did not concentrate efficiently in apical surfaces, and acetylated ?-tubulin-positive microtubules did not develop significantly. ..
  20. Ishiguro J, Shibahara K, Ueda Y, Nakamura K. Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress. Mol Genet Genomics. 2013;288:63-75 pubmed publisher
    ..This finding may shed light on our understanding of a new stress-responsive mechanism in TOR signaling in higher organisms. ..
  21. Matsumoto M, Ogawa W, Hino Y, Furukawa K, Ono Y, Takahashi M, et al. Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. J Biol Chem. 2001;276:14400-6 pubmed
    ..These results suggest that epsilonKD inhibits the insulin-induced phosphorylation and activation of Akt by interfering with the ability of PDK1 to phosphorylate Akt. ..
  22. Jin T, Satoh T, Liao Y, Song C, Gao X, Kariya K, et al. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem. 2001;276:30301-7 pubmed
    ..These results suggest a pivotal role of the CDC25 homology domain in amplifying Rap1-dependent signal transduction, including the activation of PLCepsilon itself, at specific subcellular locations such as the Golgi apparatus. ..
  23. Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, et al. Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development. 2005;132:2535-46 pubmed
    ..These results suggest that Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1. ..
  24. Ishiguro J, Saitou A, Duran A, Ribas J. cps1+, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersensitivity to cyclosporin A and papulacandin B. J Bacteriol. 1997;179:7653-62 pubmed
    ..Thus, the cps1+ product might be a catalytic or an associated copurifying subunit of the fission yeast 1,3-beta-D-glucan synthase that plays an essential role in cell wall synthesis. ..
  25. Nakayashiki H, Awa T, Tosa Y, Mayama S. The C-terminal chromodomain-like module in the integrase domain is crucial for high transposition efficiency of the retrotransposon MAGGY. FEBS Lett. 2005;579:488-92 pubmed
    ..Our results indicate that the CLM may confer high transposition activity to the element. ..
  26. Adachi Yamada T, Harumoto T, Sakurai K, Ueda R, Saigo K, O Connor M, et al. Wing-to-Leg homeosis by spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein. Mol Cell Biol. 2005;25:3140-50 pubmed
    ..These data support a mechanism in which the lack of some membrane proteins helps to recognize the presence of different cell types and direct these cells to an apoptotic fate in order to exclude them from the normal developing field. ..
  27. Herini E, Gunadi -, van Kempen M, Yusoff S, Sutaryo -, Sunartini -, et al. Novel SCN1A mutations in Indonesian patients with severe myoclonic epilepsy in infancy. Pediatr Int. 2010;52:234-9 pubmed publisher
    ..The first cases of SMEI and SMEB are reported in South-East Asian populations. Two novel SCN1A mutations are also identified in these patients, p.V1612I and p.C1756G, which may lead to neuronal excitability or convulsions. ..
  28. Ryuko S, Ma Y, Ma N, Sakaue M, Kuno T. Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast. Mol Genet Genomics. 2012;287:651-62 pubmed publisher
    ..Altogether, our genome-wide study demonstrates for the first time the mechanisms of cobalt homeostasis, particularly its uptake and detoxification in fission yeast. ..
  29. Hinata N, Shirakawa T, Zhang Z, Matsumoto A, Fujisawa M, Okada H, et al. Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53-mutated bladder cancer cells. Urol Res. 2003;31:387-96 pubmed
    ..It was demonstrated that ionizing radiation induces p53-dependent cell apoptosis in bladder cancer cells with wt- p53 but not in those with mutated p53. ..
  30. Shimizu T, Yabe T, Muraoka O, Yonemura S, Aramaki S, Hatta K, et al. E-cadherin is required for gastrulation cell movements in zebrafish. Mech Dev. 2005;122:747-63 pubmed
    ..These data suggest that E-cadherin-mediated cell adhesion between the DC and EVL plays a role in the epiboly movement in zebrafish. ..
  31. Ito M, Fukuzawa K, Mochizuki Y, Nakano T, Tanaka S. Ab initio fragment molecular orbital study of molecular interactions between liganded retinoid X receptor and its coactivator; part II: influence of mutations in transcriptional activation function 2 activating domain core on the molecular interactio. J Phys Chem A. 2008;112:1986-98 pubmed
    ..Our findings suggest that the inhibitions of the local RXR-SRC1 interaction via AF2C and of the local CT from RXR to SRC1 via AF2C would be the possible causes for the marked decrease in the transcriptional activity of RXR. ..
  32. Watanabe T, Hosoya H, Yonemura S. Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells. Mol Biol Cell. 2007;18:605-16 pubmed
    ..We further found that myosin phosphatase or Zipper-interacting protein kinase localizes to stress fibers depending on the activity of myosin II ATPase. ..
  33. Takami Y, Takeshima Y, Awano H, Okizuka Y, Yagi M, Matsuo M. High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy. Pediatr Neurol. 2008;39:399-403 pubmed publisher
    ..The disease can be divided into two types: age-dependent and age-independent. Deep Q-waves and low RV5 + SV1 are proposed as markers of age-dependent cardiac complications. ..
  34. Shirai Y, Morioka S, Sakuma M, Yoshino K, Otsuji C, Sakai N, et al. Direct binding of RalA to PKC? and its crucial role in morphological change during keratinocyte differentiation. Mol Biol Cell. 2011;22:1340-52 pubmed publisher
    ..These results provide a new insight into the molecular mechanism of cytoskeletal regulation leading to drastic change of cell shape. ..
  35. Nishida Y, Shima F, Sen H, Tanaka Y, Yanagihara C, Yamawaki Kataoka Y, et al. Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with adenylyl cyclase is sufficient for its function in Saccharomyces cerevisiae ras pathway. J Biol Chem. 1998;273:28019-24 pubmed
    ..These results indicate the coiled-coil mechanism as a basis of the CAP-adenylyl cyclase interaction. ..
  36. Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, et al. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes. 2002;51:1672-80 pubmed
    ..These results suggest that the IRS-1-PI 3-kinase pathway is essential for insulin-induced expression of SREBP-1c and glucokinase genes. ..
  37. Kubota Y, Sano M, Goda S, Suzuki N, Nishiwaki K. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Development. 2006;133:263-73 pubmed
    ..Furthermore, COGC-3 requires MIG-17 activity for its action in DTC migration. Our findings demonstrate that COG complex-dependent glycosylation of an ADAM protease plays a crucial role in determining organ shape. ..
  38. Yokoi N, Hayashi C, Fujiwara Y, Wang H, Seino S. Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat. Diabetes. 2007;56:506-12 pubmed
    ..The low incidence and delayed onset of the disease strongly suggest involvement of genetic modifiers; the congenic strain established in this study should be useful for the mapping and identification of such modifiers. ..
  39. Kitajima A, Fuse N, Isshiki T, Matsuzaki F. Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. Dev Biol. 2010;347:9-23 pubmed publisher
  40. Mizuno S, Nakazaki Y, Yoshida M, Watanabe Y. Orientation of the amino-terminal domain of ClpB affects the disaggregation of the protein. FEBS J. 2012;279:1474-84 pubmed publisher
    ..These results indicate that the NTD supports the substrate binding of ClpB and that its conformational shift assists the threading and disaggregation of substrate proteins...
  41. Ma Y, Sugiura R, Zhang L, Zhou X, Takeuchi M, He Y, et al. Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase. Mol Genet Genomics. 2010;284:161-71 pubmed publisher
    ..In conclusion, Ric1 is a putative component of GEF for Ryh1 and might be regulated by Vps15. Further studies are needed to reveal the mechanism underlying the regulation. ..
  42. Kim S, El Shamy A, Imoto S, Kim K, Ide Y, Deng L, et al. Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load. J Gastroenterol. 2012;47:1143-51 pubmed publisher
    ..IL28B minor and platelets <15 × 10(4)/mm(3) were significantly associated with NVR. Certain combinations of these factors improved SVR and NVR predictability and could, therefore, be used to design therapeutic strategies. ..
  43. Zhou X, Ma Y, Kato T, Kuno T. A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities. J Biol Chem. 2012;287:23434-9 pubmed publisher
    ..Further genetic and biological analyses revealed that the residual activation is caused by the activation of the cell wall integrity Pmk1 MAPK pathway and a redox-mediated activation of Atf1. ..
  44. Watanabe Y, Nakazaki Y, Suno R, Yoshida M. Stability of the two wings of the coiled-coil domain of ClpB chaperone is critical for its disaggregation activity. Biochem J. 2009;421:71-7 pubmed publisher
  45. Aoyama S, Shirakawa O, Ono H, Hashimoto T, Kajimoto Y, Maeda K. Mutation and association analysis of the DAP-1 gene with schizophrenia. Psychiatry Clin Neurosci. 2003;57:545-7 pubmed
    ..The results do not provide evidence that the DAP-1 gene is involved in vulnerability to schizophrenia. ..
  46. Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, et al. Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy. Cell Rep. 2016;14:2209-2223 pubmed publisher
    ..These findings establish the molecular basis of mammalian Rbo5P glycosylation and provide insight into pathogenesis and therapeutic strategies in α-DG-associated diseases. ..
  47. Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, et al. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). J Biol Chem. 1999;274:20611-8 pubmed
    ..These data suggest that Akt, but not PKClambda, is required for insulin activation of glycogen synthase and for insulin-induced phosphorylation of 4E-BP1. ..
  48. Hanyu Nakamura K, Kobayashi S, Nakamura A. Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos. Development. 2004;131:4545-53 pubmed
    ..In somatic cells, Wun and Wun2 may provide a repulsive environment for pole cell migration by depleting this extracellular substrate. ..
  49. Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, et al. Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem. 2005;280:12867-75 pubmed
    ..Our observations thus demonstrate that KLF15 plays an essential role in adipogenesis in 3T3-L1 cells through its regulation of PPAR gamma expression. ..
  50. Gunadi -, Miura K, Ohta M, Sugano A, Lee M, Sato Y, et al. Two novel mutations in the ED1 gene in Japanese families with X-linked hypohidrotic ectodermal dysplasia. Pediatr Res. 2009;65:453-7 pubmed publisher
    ..Thus, we identified two novel mutations, p.L40fsX100 and p.G381R, in ED1 of two XLHED patients. Simulation analysis suggested that the p.G381R mutation hampers binding of EDA to its receptor via alteration of overall EDA structure. ..
  51. Fujimoto D, Tomii K, Otoshi T, Kawamura T, Tamai K, Takeshita J, et al. Preexisting interstitial lung disease is inversely correlated to tumor epidermal growth factor receptor mutation in patients with lung adenocarcinoma. Lung Cancer. 2013;80:159-64 pubmed publisher
    ..31; 95% CI, 2.12-5.20; P<0.001), and the absence of ILD (OR, 17.41; 95% CI, 3.54-315.34; P<0.001). This study showed that patients with pulmonary adenocarcinoma and ILD had a lower probability of carrying tumor EGFR mutations. ..
  52. Ikeda K, Van Vu B, Kadotani N, Tanaka M, Murata T, Shiina K, et al. Is the fungus Magnaporthe losing DNA methylation?. Genetics. 2013;195:845-55 pubmed publisher
    ..Overall, our data suggest that MoDMT1 is not essential for the natural life cycle of the fungus and raise the possibility that the genus Magnaporthe may be losing the mechanism of DNA methylation on the evolutionary time scale. ..
  53. Masago K, Fujita S, Hata A, Okuda C, Kaji R, Katakami N, et al. PD-L1 Expression in Patients with Non-small Cell Lung Cancer. Anticancer Res. 2017;37:2269-2274 pubmed
    ..We showed that tumor PD-L1 expression decreased in patients with NSCLC who received chemoradiotherapy and radiation resistance might be due to pre-treatment PD-L1 expression. ..
  54. Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, et al. Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol. 1998;18:6971-82 pubmed
  55. Hiraoka Y, Ding D, Yamamoto A, Tsutsumi C, Chikashige Y. Characterization of fission yeast meiotic mutants based on live observation of meiotic prophase nuclear movement. Chromosoma. 2000;109:103-9 pubmed
  56. Tanaka M, Nagano Fujii M, Deng L, Ishido S, Sada K, Hotta H. Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem Biophys Res Commun. 2006;340:792-9 pubmed
  57. Okada K, Tonaka N, Moriya Y, Norioka N, Sawamura Y, Matsumoto T, et al. Deletion of a 236 kb region around S 4-RNase in a stylar-part mutant S 4sm-haplotype of Japanese pear. Plant Mol Biol. 2008;66:389-400 pubmed publisher
    ..Genomic PCR with a primer pair designed from the deletion junctions yielded a product specific for the S(4)sm-haplotype. The product could be useful as a maker for early selection of SC cultivars harboring the S(4)sm-haplotype...
  58. Izumikawa T, Koike T, Shiozawa S, Sugahara K, Tamura J, Kitagawa H. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. J Biol Chem. 2008;283:11396-406 pubmed publisher
    ..Based on these results, we renamed CSGlcA-T chondroitin synthase-3 (ChSy-3). ..
  59. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177-89 pubmed publisher
    ..These results suggest that Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in mouse development. ..
  60. Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010;139:381-93 pubmed publisher
    ..These findings unveil the presence of distinct posttranscriptional regulations in PGCs soon after their specification, for which RNA-binding proteins such as NANOS3 and TIAL1 would play critical functions. ..
  61. Okizuka Y, Takeshima Y, Itoh K, Zhang Z, Awano H, Maruyama K, et al. Low incidence of limb-girdle muscular dystrophy type 2C revealed by a mutation study in Japanese patients clinically diagnosed with DMD. BMC Med Genet. 2010;11:49 pubmed publisher
    ..8 per million. To the best of our knowledge, this is the first study to demonstrate a low incidence of LGMD2C in the Japanese population. ..
  62. Ishiuchi T, Takeichi M. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat Cell Biol. 2011;13:860-6 pubmed publisher
    ..Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology...
  63. Yamaoka M, Osawa S, Morinaga T, Takenaka S, Yoshida K. A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease. Microb Cell Fact. 2011;10:69 pubmed publisher
    ..However, this compound is relatively rare in nature, whereas another stereoisomer of inositol, myo-inositol, is abundantly available...
  64. Pujol F, Hodgson T, Martínez Corral I, Prats A, Devenport D, Takeichi M, et al. Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1732-1735 pubmed publisher
    ..Our data demonstrate that Fat4 and Dachsous1 are critical regulators of valve morphogenesis. This study highlights that valve defects may contribute to lymphedema in Hennekam syndrome caused by Fat4 mutations. ..
  65. Hu C, Kariya K, Okada T, Qi X, Song C, Kataoka T. Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation. J Biol Chem. 1999;274:48-51 pubmed
  66. Okada T, Hu C, Jin T, Kariya K, Yamawaki Kataoka Y, Kataoka T. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases. Mol Cell Biol. 1999;19:6057-64 pubmed
    ..These results indicate that the strength of interaction with Ras and Rap1A at its CRD may be a critical determinant of regulation of the Raf kinase activity by the Ras family small GTPases. ..
  67. Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem. 1999;274:34493-8 pubmed
  68. Liao Y, Satoh T, Gao X, Jin T, Hu C, Kataoka T. RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. J Biol Chem. 2001;276:28478-83 pubmed
  69. Fujita M, Hawkinson D, King K, Hall D, Sakamoto H, Buechner M. The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals. Dev Biol. 2003;256:290-301 pubmed
    ..These data imply that EXC-7 protein may affect expression of sma-1 and other genes to effect proper development of the excretory canals. ..
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