Genomes and Genes
Experts and Doctors on caenorhabditis elegans proteins in Kobe, Hyōgo, Japan
Locale: Kobe, Hyōgo, Japan
Topic: caenorhabditis elegans proteins
- Ide N, Hirao K, Hata Y, Takeuchi M, Irie M, Yao I, et al. Molecular cloning and characterization of rat lin-10. Biochem Biophys Res Commun. 1998;243:634-8 pubmed..These results suggest that rat lin-10 is involved at least in synaptic functions in brain. ..
- Furuya M, Qadota H, Chisholm A, Sugimoto A. The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6. Dev Biol. 2005;286:452-63 pubmed..Thus, eya-1 appears to play a partially redundant role with pax-6 during C. elegans embryogenesis. ..
- Takeshita H, Sawa H. Asymmetric cortical and nuclear localizations of WRM-1/beta-catenin during asymmetric cell division in C. elegans. Genes Dev. 2005;19:1743-8 pubmed..Our results indicate that Wnt signals release cortical WRM-1 from the posterior cortex to generate cortical asymmetry that may control WRM-1 asymmetric nuclear localization by regulating cell polarity. ..
- Liao Y, Kariya K, Hu C, Shibatohge M, Goshima M, Okada T, et al. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. J Biol Chem. 1999;274:37815-20 pubmed..On the other hand, Ce-RA-GEF associated with and stimulated GDP/GTP exchange of both Ras and Rap1A. These results indicate that Ce-RA-GEF and Hs-RA-GEF define a novel class of Rap1A GEF molecules, which are conserved through evolution. ..
- Ide N, Hata Y, Hirao K, Irie M, Deguchi M, Yao I, et al. Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin. Biochem Biophys Res Commun. 1998;244:258-62 pubmed..We discuss the physiological significance of the interaction of rat lin-10 with neurabin-II/spinophilin. ..
- Fujita M, Takasaki T, Nakajima N, Kawano T, Shimura Y, Sakamoto H. MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans. Mech Dev. 2002;114:61-9 pubmed..These results suggest that MRG-1 is required maternally to form normal PGCs with the potential to start mitotic proliferation during post-embryonic development. ..
- Kitagawa H, Egusa N, Tamura J, Kusche Gullberg M, Lindahl U, Sugahara K. rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. J Biol Chem. 2001;276:4834-8 pubmed..These findings suggest that the biosynthetic mechanism of heparan sulfate in C. elegans is distinct from that reported for the mammalian system. ..
- Kitagawa H, Izumikawa T, Mizuguchi S, Dejima K, Nomura K, Egusa N, et al. Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. J Biol Chem. 2007;282:8533-44 pubmed..These findings also show that heparan sulfate is essential for post-gastrulation morphogenic movement of embryonic cells and is indispensable for ensuring the normal spatial organization of differentiated tissues and organs. ..
- Mizumoto K, Sawa H. Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans. Dev Cell. 2007;12:287-99 pubmed..Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well. ..
- Irie M, Hata Y, Deguchi M, Ide N, Hirao K, Yao I, et al. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Oncogene. 1999;18:2811-7 pubmed..The mammalian homologues of lin-7 may be implicated in the formation of cell-cell junctions. ..
- Tamai K, Nishiwaki K. bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans. Dev Biol. 2007;308:562-71 pubmed
- Oishi K, Okano H, Sawa H. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J Cell Biol. 2007;179:1149-62 pubmed..Human homologues of RMD-1 could also bind microtubules, which would suggest a function for these proteins in chromosome segregation during mitosis in other organisms as well. ..
- Konishi T, Uodome N, Sugimoto A. The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types. Dev Dyn. 2008;237:2367-77 pubmed publisher..We speculate that DDX-23 functions with the three MOG proteins in the same pathway to regulate tissue differentiation, robust germline proliferation, and the sperm/oocyte switch through modulations of ribonucleoprotein complexes. ..
- Toya M, Iida Y, Sugimoto A. Imaging of mitotic spindle dynamics in Caenorhabditis elegans embryos. Methods Cell Biol. 2010;97:359-72 pubmed publisher..In particular, we present the use of double- or triple-labeled fluorescent strains for high-resolution two-dimensional and three-dimensional live imaging to analyze dynamic behaviors of mitotic spindles. ..
- Arata Y, Lee J, Goldstein B, Sawa H. Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo. Development. 2010;137:3337-45 pubmed publisher..Our findings suggest that Src functions as an evolutionarily conserved molecular link that coordinates extrinsic cues with PAR protein localization. ..
- Ohta A, Kuhara A. Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature response circuit of Caenorhabditis elegans. Neurosci Res. 2013;76:119-24 pubmed publisher..Most significantly, trimetric G proteincoupled thermosensation, single sensory neuron-based memory, and the orchestrated synaptic transmission system have been elucidated. ..
- Takasaki T, Liu Z, Habara Y, Nishiwaki K, Nakayama J, Inoue K, et al. MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans. Development. 2007;134:757-67 pubmed..We discuss how an autosome-enriched protein might repress genes on the X chromosome, promote PGC proliferation and survival, and influence the germ versus soma distinction. ..
- Ihara S, Nishiwaki K. Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans. EMBO J. 2007;26:2607-20 pubmed
- Fujita M, Hawkinson D, King K, Hall D, Sakamoto H, Buechner M. The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals. Dev Biol. 2003;256:290-301 pubmed..These data imply that EXC-7 protein may affect expression of sma-1 and other genes to effect proper development of the excretory canals. ..
- Kubota Y, Sano M, Goda S, Suzuki N, Nishiwaki K. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Development. 2006;133:263-73 pubmed..Furthermore, COGC-3 requires MIG-17 activity for its action in DTC migration. Our findings demonstrate that COG complex-dependent glycosylation of an ADAM protease plays a crucial role in determining organ shape. ..
- Kubota Y, Tsuyama K, Takabayashi Y, Haruta N, Maruyama R, Iida N, et al. The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans. Dev Biol. 2014;391:43-53 pubmed publisher..Thus, although the PAF1C is universally expressed in C. elegans embryos, its epidermal function is crucial for the viability of this animal. ..