Experts and Doctors on pulmonary alveoli in Sapporo, Hokkaido, Japan
Locale: Sapporo, Hokkaido, Japan
Topic: pulmonary alveoli
Jesmin S, Gando S, Zaedi S, Sakuraya F. Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury. Inflammation. 2007;30:14-27 pubmed
..The differential expression patterns (over a time course) and distribution of PAR isoforms suggests a distinct role for each isoform in the pathogenesis of LPS-induced ALI. ..
Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, et al
. Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. Inhal Toxicol. 2008;20:349-59 pubmed
..These findings suggest the association of downregulation of bronchiolar VEGF and its receptors with cigarette smoking and COPD. ..
Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, et al
. Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects. Hum Mol Genet. 2008;17:3075-83 pubmed publisher
..Our HI model mice reproduce the human HI skin phenotype soon after the initiation of fetal skin keratinization and provide evidence that ABCA12 plays pivotal roles in lung and skin barrier functions...
Seki S, Kobayashi M, Itagaki S, Hirano T, Iseki K. Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells. Biochim Biophys Acta. 2009;1788:911-7 pubmed publisher
..These results indicate that AMD uptake mediated by carriers, including OATP2B1, might lead to accumulation of AMD in the lung and AMD-induced pulmonary toxicity (AIPT). ..
Togami K, Yamaguchi K, Chono S, Tada H. Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-Î²1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosi. J Pharmacol Toxicol Methods. 2017;86:19-27 pubmed publisher
..Therefore, our results indicate that TGF-Î²1-treated NCI-H441 cell monolayers may serve as a useful in vitro model of respiratory epithelial cells for IPF. ..