Experts and Doctors on heat shock proteins in Sapporo, Hokkaido, Japan


Locale: Sapporo, Hokkaido, Japan
Topic: heat shock proteins

Top Publications

  1. Ohkawara T, Takeda H, Kato K, Miyashita K, Kato M, Iwanaga T, et al. Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice. Scand J Gastroenterol. 2005;40:1321-7 pubmed
    ..Polaprezinc could be useful in the treatment of inflammatory bowel diseases. ..
  2. Yokota S, Fujii N. Immunomodulatory activity of extracellular heat shock proteins and their autoantibodies. Microbiol Immunol. 2010;54:299-307 pubmed publisher
    ..In addition, anti-HSP autoantibodies are frequently found in patients with autoimmune diseases and inflammatory disorders, and these autoantibodies can modulate the "danger signal" triggered by extracellular HSP. ..
  3. Juni N, Awasaki T, Yoshida K, Hori S. The Om (1E) mutation in Drosophila ananassae causes compound eye overgrowth due to tom retrotransposon-driven overexpression of a novel gene. Genetics. 1996;143:1257-70 pubmed
    ..These findings suggest that the Om(1E) gene is involved in a variety of developmental processes. ..
  4. Koike M, Takezawa D, Arakawa K, Yoshida S. Accumulation of 19-kDa plasma membrane polypeptide during induction of freezing tolerance in wheat suspension-cultured cells by abscisic acid. Plant Cell Physiol. 1997;38:707-16 pubmed
    ..2). Expression of WPM-1 mRNA was dramatically induced by 50 microM ABA within a few hours. These results suggest that the AWPM-19 might be closely associated with the ABA-induced increase in freezing tolerance in wheat cultured cells...
  5. Ukaji N, Kuwabara C, Takezawa D, Arakawa K, Fujikawa S. Cold acclimation-induced WAP27 localized in endoplasmic reticulum in cortical parenchyma cells of mulberry tree was homologous to group 3 late-embryogenesis abundant proteins. Plant Physiol. 2001;126:1588-97 pubmed
    ..The role of WAP27 in the ER is discussed in relation to acquisition of freezing tolerance of cortical parenchyma cells in mulberry tree during winter. ..
  6. Tomita Y, Mizuno T, Diez J, Naito S, Ahlquist P, Ishikawa M. Mutation of host DnaJ homolog inhibits brome mosaic virus negative-strand RNA synthesis. J Virol. 2003;77:2990-7 pubmed
  7. Qi X, Okuma Y, Hosoi T, Kaneko M, Nomura Y. Induction of murine HRD1 in experimental cerebral ischemia. Brain Res Mol Brain Res. 2004;130:30-8 pubmed
    ..These findings suggest that hypoxia-ischemia triggers ER dysfunction and mHRD1 may play a role in ischemia-induced ER dysfunction. ..
  8. Nakanishi K, Kamiguchi K, Torigoe T, Nabeta C, Hirohashi Y, Asanuma H, et al. Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. Cell Stress Chaperones. 2004;9:253-64 pubmed
    ..These data suggest that ERdj3 might have diverse roles in the ER, including that of the molecular cochaperone of BiP and an as yet unknown protective action against vero toxin. ..
  9. Chiba S, Yokota S, Yonekura K, Tanaka S, Furuyama H, Kubota H, et al. Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis. J Neurol Sci. 2006;241:39-43 pubmed

More Information


  1. Nishitani Y, Matsumoto H. Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH. FEBS Lett. 2006;580:9-14 pubmed
    ..Ethanol loading with ADH inhibition causes down-regulation of GRP78 mRNA levels. Therefore, these findings suggest first revelation that inhibition of ethanol metabolism complicates oxidative and ER stresses produced by ethanol. ..
  2. Tashiro J, Kikuchi S, Shinpo K, Kishimoto R, Tsuji S, Sasaki H. Role of p53 in neurotoxicity induced by the endoplasmic reticulum stress agent tunicamycin in organotypic slice cultures of rat spinal cord. J Neurosci Res. 2007;85:395-401 pubmed
    ..This difference might be a clue to the mechanism of the stress-response pathway and might also contribute to the potential application of p53 inhibitors for the treatment of spinal cord diseases, including amyotrophic lateral sclerosis. ..
  3. Kim M, Sasaki K, Imai R. Cold shock domain protein 3 regulates freezing tolerance in Arabidopsis thaliana. J Biol Chem. 2009;284:23454-60 pubmed publisher
    ..Overexpression of AtCSP3 in transgenic plants conferred enhanced freezing tolerance over wild-type plants. Together, the data demonstrated an essential role of RNA chaperones for cold adaptation in higher plants. ..
  4. Torigoe T, Tamura Y, Sato N. Heat shock proteins and immunity: application of hyperthermia for immunomodulation. Int J Hyperthermia. 2009;25:610-6 pubmed publisher
    ..In the present review, we present novel aspects of the roles of HSPs in immunity and discuss the therapeutic application of hyperthermia for immunomodulation. ..
  5. Yokota S, Yokosawa N, Kubota T, Okabayashi T, Arata S, Fujii N. Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1. J Biol Chem. 2003;278:41654-60 pubmed
    ..The lack of thermotolerance should allow the infected cells to be eliminated by apoptosis and might be a host defense against viral infection. ..