Experts and Doctors on cell nucleus in Sapporo, Hokkaido, Japan


Locale: Sapporo, Hokkaido, Japan
Topic: cell nucleus

Top Publications

  1. Nakatani T, Ueno S, Mori N, Matsuoka I. Role of NRSF/REST in the molecular mechanisms regulating neural-specific expression of trkC/neurotrophin-3 receptor gene. Brain Res Mol Brain Res. 2005;135:249-59 pubmed
    ..From these observations, molecular mechanisms regulating the expression of neuron-specific genes via NRSE during neuronal differentiation are discussed. ..
  2. Shaheen S, Akita H, Yamashita A, Katoono R, Yui N, Biju V, et al. Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET. Nucleic Acids Res. 2011;39:e48 pubmed publisher
    ..This represents the first demonstration of the successful control of condensation/decondensation in specific nuclear sub-domain via the use of an artificial DNA condenser. ..
  3. Silva M, Smith A, Friesen V, Bried J, Hasegawa O, Coelho M, et al. Mechanisms of global diversification in the marine species Madeiran Storm-petrel Oceanodroma castro and Monteiro's Storm-petrel O. monteiroi: Insights from a multi-locus approach. Mol Phylogenet Evol. 2016;98:314-23 pubmed publisher
    ..In view of the predicted climate change impacts, future changes in the demography and evolutionary dynamics of marine populations might be expected. ..
  4. Higashino F, Aoyagi M, Takahashi A, Ishino M, Taoka M, Isobe T, et al. Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism. J Cell Biol. 2005;170:15-20 pubmed
    ..Moreover, inhibition of the CRM1-dependent export pathway failed to block the export of ARE-mRNAs mediated by E4orf6. Thus, E4orf6 interacts with pp32/LANP to modulate the fate of ARE-mRNAs by altering the CRM1-dependent export pathway. ..
  5. Serizawa K, Suzuki H, Tsuchiya K. A phylogenetic view on species radiation in Apodemus inferred from variation of nuclear and mitochondrial genes. Biochem Genet. 2000;38:27-40 pubmed
    ..These results may have a correlation with the notion that deciduous broadleaf forests remained in Central East Asia through the late Tertiary to the present, while those in Europe to a large extent had disappeared by the Pliocene. ..
  6. Suzuki H, Shimada T, Terashima M, Tsuchiya K, Aplin K. Temporal, spatial, and ecological modes of evolution of Eurasian Mus based on mitochondrial and nuclear gene sequences. Mol Phylogenet Evol. 2004;33:626-46 pubmed
    ..The temporal pattern of evolution among Eurasian Mus is more complex than that within the Eurasian temperate genus Apodemus. ..
  7. Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000;485:53-6 pubmed
    ..These findings indicate that MAIL is one of the nuclear I kappa B proteins and an activator of IL-6 production. ..
  8. Tosa N, Iwai A, Tanaka T, Kumagai T, Nitta T, Chiba S, et al. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Biochem Biophys Res Commun. 2010;395:356-60 pubmed publisher
    ..10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77. ..
  9. Takekawa M, Adachi M, Nakahata A, Nakayama I, Itoh F, Tsukuda H, et al. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 2000;19:6517-26 pubmed
    ..These results suggest that p53-dependent expression of Wip1 mediates a negative feedback regulation of p38-p53 signaling and contributes to suppression of the UV-induced apoptosis. ..

More Information


  1. Nunome M, Ishimori C, Aplin K, Tsuchiya K, Yonekawa H, Moriwaki K, et al. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol Ecol. 2010;19:2474-89 pubmed publisher
    ..Intact'domesticus and castaneus haplotypes in other Japanese wild mice imply ongoing stowaway introductions. The method has general utility for assessing the history of genetic admixture and for disclosing ongoing genetic contamination...
  2. Okui T, Endoh D, Kon Y, Hayashi M. Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation. Radiat Res. 2002;157:553-61 pubmed
    ..Since the nucleotide sequences of the G22p1 and Xrcc5 genes of the LEC rats coincided with those of the control rats, the deficiency in nuclear accumulation may not be caused by mutations of the G22p1 and Xrcc5 proteins. ..
  3. Kagawa H, Shino Y, Kobayashi D, Demizu S, Shimada M, Ariga H, et al. A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1. PLoS ONE. 2011;6:e18638 pubmed publisher
  4. Katagiri C, Masuda K, Urano T, Yamashita K, Araki Y, Kikuchi K, et al. Phosphorylation of Ser-446 determines stability of MKP-7. J Biol Chem. 2005;280:14716-22 pubmed
    ..These results indicate that activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation. ..
  5. Furusawa M, Taira T, Iguchi Ariga S, Ariga H. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. J Biol Chem. 2002;277:50885-92 pubmed
    ..These findings suggest that AMY-1 is an important modulator of PKA. ..
  6. Kimura H, Ohtomo T, Yamaguchi M, Ishii A, Sugimoto K. Mouse MCM proteins: complex formation and transportation to the nucleus. Genes Cells. 1996;1:977-93 pubmed
    ..We conclude that in the mouse, six MCM proteins form a single protein complex of molecular weight 450-600 kDa, which may enter the nucleus by nuclear localization signals in the mMCM2 and mP1MCM3 subunits. ..
  7. Kuroda T, Maita H, Tabata T, Taira T, Kitaura H, Ariga H, et al. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. Gene. 2004;340:83-98 pubmed
    ..These results suggest that PAPA-1 induces growth and cell cycle arrests at the G1 phase of the cell cycle. ..
  8. Okumura F, Okumura A, Matsumoto M, Nakayama K, Hatakeyama S. TRIM8 regulates Nanog via Hsp90?-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta. 2011;1813:1784-92 pubmed publisher
    ..These findings suggest that TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90? and consequently regulates transcription of Nanog in embryonic stem cells. ..
  9. Sagae S, Saito T, Satoh M, Ikeda T, Kimura S, Mori M, et al. The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading. Oncology. 2004;67:344-50 pubmed
    ..We analyzed this system for predicting the prognosis, with respect to inter- and intraobserver reproducibility and treatment modalities...
  10. Yamamoto T, Sekine Y, Kashima K, Kubota A, Sato N, Aoki N, et al. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun. 2002;297:811-7 pubmed
    ..Endogenous TC-PTP complexed with STAT3 in the nucleus of M1 cells. These results strongly suggest that the nuclear isoform of TC-PTP may serve as a negative regulator of IL-6-mediated signaling pathway. ..
  11. Hayashi N, Shirakura H, Uehara T, Nomura Y. Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells. Neurosci Lett. 2006;397:5-9 pubmed
    ..These findings suggest that SUMO-1 modification in caspase-7 may be linked to specific its localization in the nucleus and may therefore contribute to the cleavage of nuclear substrates during neuronal apoptosis. ..
  12. Maruyama Y, Yamoto N, Suzuki Y, Chiba Y, Yamazaki K, Sato T, et al. The Arabidopsis transcriptional repressor ERF9 participates in resistance against necrotrophic fungi. Plant Sci. 2013;213:79-87 pubmed publisher
    ..These results indicate that the transcriptional repressor ERF9 participates in plant defense mechanisms against necrotic fungi mediated by the DEAR1-dependent ethylene/JA signaling pathway...
  13. Sato N, Tsuruma R, Imoto S, Sekine Y, Muromoto R, Sugiyama K, et al. Nuclear retention of STAT3 through the coiled-coil domain regulates its activity. Biochem Biophys Res Commun. 2005;336:617-24 pubmed
    ..These data demonstrate that Arg-214/215 are involved in CRM1-mediated STAT3 nuclear export and the regulation of STAT3 activity. ..
  14. Iki S, Yokota S, Okabayashi T, Yokosawa N, Nagata K, Fujii N. Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus. Virology. 2005;343:106-15 pubmed
    ..These results indicate that PML isoforms which are expressed in a serum-dependent manner suppress the propagation of influenza virus at an early stage of infection. ..
  15. Kitamura A, Yuno S, Muto H, Kinjo M. Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43 kDa. Genes Cells. 2017;22:521-534 pubmed publisher
    ..Moreover, the structure of ordered oligomers as well as nuclear sequestration may be important in mediating cytotoxicity in ALS pathology. ..
  16. Imoto S, Ohbayashi N, Ikeda O, Kamitani S, Muromoto R, Sekine Y, et al. Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling. Biochem Biophys Res Commun. 2008;370:359-65 pubmed publisher
    ..These results suggest that PIASy regulates TGF-beta/Smad3-mediated signaling by stimulating sumoylation and nuclear export of Smad3. ..
  17. Kubota S, Ohara M. The evolution of self-compatible and self-incompatible populations in a hermaphroditic perennial, Trillium camschatcense (Melanthiaceae). J Plant Res. 2009;122:497-507 pubmed publisher
    ..camschatcense. The plausibility of each scenario was evaluated based on the reproductive and geographical features of the mating systems...
  18. Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, et al. A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3. J Biol Chem. 2016;291:11161-71 pubmed publisher
    ..These results indicate that ARL3 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing its nuclear accumulation of STAT3. ..
  19. Aoyagi M, Higashino F, Yasuda M, Takahashi A, Sawada Y, Totsuka Y, et al. Nuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins. Oncogene. 2003;22:6919-27 pubmed
    ..These results suggest that E4orf6 is exported from the nucleus to the cytoplasm, enabling it to interact with BH3-only proteins, eventually leading to the inhibition of apoptotic activity. ..
  20. Sahara K, Marec F, Eickhoff U, Traut W. Moth sex chromatin probed by comparative genomic hybridization (CGH). Genome. 2003;46:339-42 pubmed
    ..mori appeared to lack the latter component. Our results show that CGH can be applied to obtain a first estimate of the sequence composition of sex chromosomes in species from which otherwise little is known on the molecular level...
  21. Nishihara H, Tanaka S, Tsuda M, Oikawa S, Maeda M, Shimizu M, et al. Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. Cancer Lett. 2002;180:55-61 pubmed
    ..The elevated expression levels of c-Crk-II might be related to the development of human cancers. ..
  22. Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, et al. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett. 2001;506:33-8 pubmed
  23. Kobayashi S, Suzuki T, Igarashi M, Orba Y, Ohtake N, Nagakawa K, et al. Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation. PLoS ONE. 2013;8:e76668 pubmed publisher
    ..These findings suggest that C80 of JCV Vp1 is required for Vp1 stability and pentamer formation, and C247 is involved in capsid assembly in the nucleus...
  24. Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, et al. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem. 2010;285:8375-82 pubmed publisher
    ..SIRT1 activators such as resveratrol could be novel therapeutic tools for the treatment of chronic heart failure. ..
  25. Yoshizawa K, Johnson K. How stable is the "Polyphyly of Lice" hypothesis (Insecta: Psocodea)?: a comparison of phylogenetic signal in multiple genes. Mol Phylogenet Evol. 2010;55:939-51 pubmed publisher
    ..These findings demonstrate that the increased support values provided by combined data set does not always indicate corroboration of the hypothesis. ..
  26. Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, et al. Physical and functional interactions between ZIP kinase and UbcH5. Biochem Biophys Res Commun. 2008;372:708-12 pubmed publisher
    ..These results suggest that UbcH5 regulates ZIPK accumulation in PML-NBs by interacting with ZIPK and stimulating its ubiquitination. ..
  27. Ohbayashi N, Taira N, Kawakami S, Togi S, Sato N, Ikeda O, et al. An RNA biding protein, Y14 interacts with and modulates STAT3 activation. Biochem Biophys Res Commun. 2008;372:475-9 pubmed publisher
    ..These results indicate that Y14 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing the tyrosine-phosphorylation of STAT3. ..
  28. Takahashi S, Shinzato K, Nakamura S, Domon T, Yamamoto T, Wakita M. The roles of apoptosis and mitosis in atrophy of the rat sublingual gland. Tissue Cell. 2002;34:297-304 pubmed
    ..In addition, it appears that the transition from acinar to duct cell and the necrosis of acinar cells play important roles in the atrophy of the sublingual gland...
  29. Shibata M, Sato T, Nukiwa R, Ariga T, Hatakeyama S. TRIM45 negatively regulates NF-?B-mediated transcription and suppresses cell proliferation. Biochem Biophys Res Commun. 2012;423:104-9 pubmed publisher
    ..Moreover, we found that TRIM45 overexpression suppresses cell growth. These findings suggest that TRIM45 acts as a repressor for the NF-?B signal and regulates cell growth. ..
  30. Muromoto R, Sugiyama K, Yamamoto T, Oritani K, Shimoda K, Matsuda T. Physical and functional interactions between Daxx and TSG101. Biochem Biophys Res Commun. 2004;316:827-33 pubmed
    ..These results provide the novel molecular interactions between Daxx and TSG101, which establish an efficient repressive transcription complex in the nucleus. ..
  31. Begum P, Fugetsu B. Induction of cell death by graphene in Arabidopsis thaliana (Columbia ecotype) T87 cell suspensions. J Hazard Mater. 2013;260:1032-41 pubmed publisher
    ..In conclusion, our results show that graphene induced cell death in T87 cells through mitochondrial damage mediated by ROS...
  32. Yasuda K, Kotani T, Ota R, Yamashita M. Transgenic zebrafish reveals novel mechanisms of translational control of cyclin B1 mRNA in oocytes. Dev Biol. 2010;348:76-86 pubmed publisher
    ..Our genetic approach in combination with real-time imaging of the translation site and timing provides a novel insight into the mechanisms of temporal control of translation...
  33. Fujino K, Hashida S, Ogawa T, Natsume T, Uchiyama T, Mikami T, et al. Temperature controls nuclear import of Tam3 transposase in Antirrhinum. Plant J. 2011;65:146-155 pubmed publisher
    ..NLID in Tam3 TPase is considered to interact with Antirrhinum-specific factor(s). The host-specific regulation of the nuclear localization of transposase represents a new repertoire controlling class-II TEs...
  34. Inaba J, Kim B, Shimura H, Masuta C. Virus-induced necrosis is a consequence of direct protein-protein interaction between a viral RNA-silencing suppressor and a host catalase. Plant Physiol. 2011;156:2026-36 pubmed publisher
  35. Ito T, Yu C, Nakamura K, Chung K, Yang Q, Fu C, et al. Unique parallel radiations of high-mountainous species of the genus Sedum (Crassulaceae) on the continental island of Taiwan. Mol Phylogenet Evol. 2017;113:9-22 pubmed publisher
    ..We suggest that these parallel radiations may be attributable to the geographical dynamics of Taiwan and specific biological features of Sedum that allow them to adapt to new ecological niches. ..
  36. Ohshima I, Yoshizawa K. Differential introgression causes genealogical discordance in host races of Acrocercops transecta (Insecta: Lepidoptera). Mol Ecol. 2010;19:2106-19 pubmed publisher
    ..Thus, the results show that a low level of gene flow coupled with the inflexible female host preference differentiates histories of divergence between maternally and biparentally inherited genes in this host race system. ..
  37. Murata Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, et al. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene. 2007;26:4617-26 pubmed
    ..pylori CagA plays an important role in the development of intestinal metaplasia, a premalignant transdifferentiation of gastric epithelial cells from which intestinal-type gastric adenocarcinoma arises. ..
  38. Kim M, Sasaki K, Imai R. Cold shock domain protein 3 regulates freezing tolerance in Arabidopsis thaliana. J Biol Chem. 2009;284:23454-60 pubmed publisher
    ..Overexpression of AtCSP3 in transgenic plants conferred enhanced freezing tolerance over wild-type plants. Together, the data demonstrated an essential role of RNA chaperones for cold adaptation in higher plants. ..
  39. Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, et al. CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB. Oncogene. 2009;28:2643-53 pubmed publisher
  40. Hirano T, Hoshino Y. Detection of changes in the nuclear phase and evaluation of male germ units by flow cytometry during in vitro pollen tube growth in Alstroemeria aurea. J Plant Res. 2009;122:225-34 pubmed publisher
    ..Therefore, the second change in the nuclear phase, which results in an increase in 2C nuclei, is possibly related to the formation of MGUs...
  41. Jin H, Yamashita T, Ochiai K, Haller O, Watanabe T. Characterization and expression of the Mx1 gene in wild mouse species. Biochem Genet. 1998;36:311-22 pubmed
    ..RT-PCR and immunofluorescence staining demonstrated that the Mx1 transcripts and proteins were induced by IFN-alpha/beta in macrophages from wild mouse species. ..
  42. Muromoto R, Sekine Y, Imoto S, Ikeda O, Okayama T, Sato N, et al. BART is essential for nuclear retention of STAT3. Int Immunol. 2008;20:395-403 pubmed publisher
    ..These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2. ..
  43. Maita C, Tsuji S, Yabe I, Hamada S, Ogata A, Maita H, et al. Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci Lett. 2008;431:86-9 pubmed
    ..There was no significant difference between the levels of secreted DJ-1 in two groups, and correlations of levels of secreted DJ-1 with age, clinical severity of PD and level of oxidative stress were not found. ..
  44. Kimura H, Nozaki N, Sugimoto K. DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period. EMBO J. 1994;13:4311-20 pubmed
    ..This is the first direct observation of a protein whose behavior is consistent with that of a hypothetical factor which restricts the chromatin to replicate once per cell cycle in higher eukaryotes. ..
  45. Masuda K, Shima H, Watanabe M, Kikuchi K. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. J Biol Chem. 2001;276:39002-11 pubmed
    ..Co-immunoprecipitation experiments and histological analysis suggested that MKP-7 determines the localization of MAPKs in the cytoplasm. ..
  46. Murahashi H, Azuma H, Zamzami N, Furuya K, Ikebuchi K, Yamaguchi M, et al. Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat. J Leukoc Biol. 2003;73:399-406 pubmed
    ..In addition, reactive oxygen species generated by UVB might be involved in inducing the mitochondrio-nuclear translocation of AIF. ..
  47. Kase S, Yoshida K, Sakai M, Ohgami K, Shiratori K, Kitaichi N, et al. Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice. Acta Histochem. 2006;107:469-72 pubmed
    ..Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells. ..
  48. Kase S, Aoki K, Harada T, Harada C, Ohgami K, Shiratori K, et al. Activation of nuclear factor-kappa B in the conjunctiva with the epithelial scraping of the mouse cornea and human epidemic keratoconjunctivitis. Br J Ophthalmol. 2004;88:947-9 pubmed
    ..To examine the expression of p65, one of nuclear factor-kappa B (NF-kappa B), in the conjunctival epithelium of the C57Bl6 mouse and a patient with epidemic keratoconjunctivitis (EKC)...
  49. Maita H, Kitaura H, Ariga H, Iguchi Ariga S. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Exp Cell Res. 2005;303:375-87 pubmed
    ..These results indicate that CIR is a member of the family of SR-related proteins and that CIR plays a role in splicing regulation. ..
  50. Kitamura H, Torigoe T, Asanuma H, Hisasue S, Suzuki K, Tsukamoto T, et al. Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology. 2006;48:157-61 pubmed
    ..Cytosolic overexpression of p62 is a novel immunohistochemical characteristic in prostatic adenocarcinoma and high-grade PIN, suggesting that p62 might be a novel marker for prostatic malignancy. ..
  51. Maeno H, Sugimoto K, Nakajima N. Genomic structure of the mouse gene (Lmnb1) encoding nuclear lamin B1. Genomics. 1995;30:342-6 pubmed
    ..These data reveal the gene structure of the only remaining unanalyzed mouse somatic lamin gene. Gene structures of all the mouse somatic lamins are compared. ..
  52. Ono T, Kitaura H, Ugai H, Murata T, Yokoyama K, Iguchi Ariga S, et al. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem. 2000;275:31145-54 pubmed
    ..Furthermore, the results of three different types of experiments showed that TOK-1alpha enhanced the inhibitory activity of p21 toward histone H1 kinase activity of CDK2. TOK-1alpha is thus thought to be a new type of CDK2 modulator. ..
  53. Ogura J, Terada Y, Tsujimoto T, Koizumi T, Kuwayama K, Maruyama H, et al. The decrease in farnesoid X receptor, pregnane X receptor and constitutive androstane receptor in the liver after intestinal ischemia-reperfusion. J Pharm Pharm Sci. 2012;15:616-31 pubmed
    ..FXR, PXR and CAR expression levels are decreased in the liver after intestinal I/R. IL-6 is one of main causes the decreases in expressions of these receptors. ..
  54. Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, et al. Physical and functional interactions between Daxx and STAT3. Oncogene. 2006;25:2131-6 pubmed
    ..We further found that Daxx and STAT3 were co-localized in the nucleus. These results indicate that Daxx may serve as a transcriptional regulator of type I IFN-mediated suppression of the IL-6/STAT3 signaling pathway. ..
  55. Yamada K, Nakatsu Y, Onogi A, Ueda J, Watanabe T. Specific intracellular localization and antiviral property of genetic and splicing variants in bovine Mx1. Viral Immunol. 2009;22:389-95 pubmed publisher
    ..N-terminus-deleted Mx1B was only localized in the cytoplasm, and the deleted Mx1B-expressing cell lines showed significantly positive antiviral activities (p < 0.05) against VSVDeltaG*-G. ..
  56. Yanagisawa K, Yasuda S, Kai M, Imai S, Yamada K, Yamashita T, et al. Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation. Biochim Biophys Acta. 2007;1771:462-74 pubmed
    ..Together, these results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis. ..
  57. Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, et al. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci U S A. 2008;105:15599-604 pubmed publisher
    ..Our study indicated that SIRT1 is a player of repressing Notch1-Hes1 signaling pathway, and its transient translocation into the nucleus may have a role in the differentiation of NPCs. ..
  58. Iwata D, Kitaichi N, Miyazaki A, Iwabuchi K, Yoshida K, Namba K, et al. Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{kappa}B Inhibitor dehydroxy methyl epoxyquinomicin in mice. Invest Ophthalmol Vis Sci. 2010;51:2077-84 pubmed publisher
    ..DHMEQ-mediated regulation of NF-kappaB p65 could be a therapeutic target for the control of endogenous ocular inflammatory diseases. ..