Experts and Doctors on animals in Obihiro, Hokkaido, Japan

Summary

Locale: Obihiro, Hokkaido, Japan
Topic: animals

Top Publications

  1. Yamagishi N, Kajiwara A, Shibano K, Aoki T, Itoh M, Hatate K, et al. Humeral fracture in a Japanese Black calf repaired by closed approach and two methods of external skeletal fixation. J Vet Med Sci. 2017;79:1056-1060 pubmed publisher
    ..This case suggests that recovery after closed repair with TPC for a humeral fracture in an active calf can be successfully managed on the farm. ..
  2. Karanis P, Thekisoe O, Kiouptsi K, Ongerth J, Igarashi I, Inoue N. Development and preliminary evaluation of a loop-mediated isothermal amplification procedure for sensitive detection of cryptosporidium oocysts in fecal and water samples. Appl Environ Microbiol. 2007;73:5660-2 pubmed
    ..This is the first demonstration of LAMP applied to detection of Cryptosporidium. Due to its specificity and simplicity, the method could become a useful diagnostic tool for epidemiologic studies of Cryptosporidium presence. ..
  3. Nishimura M, Kohara J, Hiasa J, Muroi Y, Yokoyama N, Kida K, et al. Tissue distribution of Neospora caninum in experimentally infected cattle. Clin Vaccine Immunol. 2013;20:309-12 pubmed publisher
    ..Our findings revealed that the most appropriate brain areas for researching N. caninum pathogenesis were the amygdala and hippocampus for qPCR and the corpus striatum and diencephalon for histopathology. ..
  4. Tagawa M, Yamamoto Y, Shimbo G, Iguchi A, Xuan X, Tomihari M, et al. Gene and protein expression of a soluble form of CTLA-4 in a healthy dog. J Vet Med Sci. 2017;79:871-875 pubmed publisher
    ..Immunoprecipitation and western blotting of dog serum revealed a band of approximately 23-kDa, which is consistent with the predicted size, based on the amino acid sequence of the canine sCTLA-4 obtained in this study. ..
  5. Jia H, Terkawi M, Aboge G, Goo Y, Luo Y, Li Y, et al. Characterization of a leucine aminopeptidase of Babesia gibsoni. Parasitology. 2009;136:945-52 pubmed publisher
    ..These results indicated that BgLAP played an important role in free amino acid regulation...
  6. Kawazu S, Takemae H, Komaki Yasuda K, Kano S. Target proteins of the cytosolic thioredoxin in Plasmodium falciparum. Parasitol Int. 2010;59:298-302 pubmed publisher
  7. Murao T, Omata Y, Kano R, Murata S, Okada T, Konnai S, et al. Serological survey of Toxoplasma gondii in wild waterfowl in Chukotka, Kamchatka, Russia and Hokkaido, Japan. J Parasitol. 2008;94:830-3 pubmed publisher
    ..No specific bands were noted in samples for which antibody activity was not detected. These results suggest that wild waterfowl inhabiting Hokkaido, Chukotka, and Kamchatka may be exposed to T. gondii...
  8. Murayama C, Miyazaki H, Miyamoto A, Shimizu T. Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells. Mol Cell Biochem. 2008;314:51-8 pubmed publisher
    ..Such an essential pathway for steroid production might indicate the importance of theca cell function in bovine ovary...
  9. Doi Y, Shinzawa N, Fukumoto S, Okano H, Kanuka H. ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development. Biochem Biophys Res Commun. 2010;397:668-72 pubmed publisher
    ..However, both the ookinete-to-oocyst and sporozoite-to-EEF transformations showed significant defects. These results indicated that Plasmodium ADF2 plays a pivotal role in transformation in the malaria parasite life cycle. ..

More Information

Publications62

  1. Nishimoto H, Matsutani R, Yamamoto S, Takahashi T, Hayashi K, Miyamoto A, et al. Gene expression of glucose transporter (GLUT) 1, 3 and 4 in bovine follicle and corpus luteum. J Endocrinol. 2006;188:111-9 pubmed
    ..These results indicate that GLUT1 and 3 act as major transporters of glucose while GLUT4 may play a supporting role in the bovine follicle and CL. ..
  2. Altangerel K, Sivakumar T, Battsetseg B, Battur B, Ueno A, Igarashi I, et al. Phylogenetic relationships of Mongolian Babesia bovis isolates based on the merozoite surface antigen (MSA)-1, MSA-2b, and MSA-2c genes. Vet Parasitol. 2012;184:309-16 pubmed publisher
    ..Our findings indicate that effective preventative and control strategies are essential to control B. bovis infection in Mongolian cattle populations, and suggest that a careful approach must be adopted when using immunization techniques...
  3. Lee I, Yamagishi N, Oboshi K, Ayukawa Y, Sasaki N, Yamada H. Comparison of xylazine, lidocaine and the two drugs combined for modified dorsolumbar epidural anaesthesia in cattle. Vet Rec. 2004;155:797-9 pubmed
    ..2 mg/kg lidocaine alone ( < 0.01). After the treatment with 0-025 mg/kg xylazine and 0.1 mg/kg lidocaine, flank surgery was performed successfully without additional line block or side effects. ..
  4. Sivakumar T, Tagawa M, Yoshinari T, Ybañez A, Igarashi I, Ikehara Y, et al. PCR detection of Babesia ovata from cattle reared in Japan and clinical significance of coinfection with Theileria orientalis. J Clin Microbiol. 2012;50:2111-3 pubmed publisher
    ..Our findings indicate that while B. ovata infection might not be the primary cause of anemia in the cattle, it may contribute to the clinical development of anemia in animals coinfected with both B. ovata and T. orientalis...
  5. Bannai H, Sakurai T, Inoue N, Sugimoto C, Igarashi I. Cloning and sxpression of mitochondrial heat shock protein 70 of Trypanosoma congolense and potential use as a diagnostic antigen. Clin Diagn Lab Immunol. 2003;10:926-33 pubmed
    ..Thus, MTP may be useful as an antigen for the serodiagnosis of primary T. congolense infection...
  6. Bochimoto H, Matsuno N, Ishihara Y, Shonaka T, Koga D, Hira Y, et al. The ultrastructural characteristics of porcine hepatocytes donated after cardiac death and preserved with warm machine perfusion preservation. PLoS ONE. 2017;12:e0186352 pubmed publisher
    ..In addition, temperature condition of the machine perfusion preservation may also affect the condition of the hepatic graft attributed to autophagy systems, and consequently alleviate the damage of the hepatocytes...
  7. Shimizu T. Promotion of ovarian follicular development by injecting vascular endothelial growth factor (VEGF) and growth differentiation factor 9 (GDF-9) genes. J Reprod Dev. 2006;52:23-32 pubmed
    ..This technique may be an innovative technique for enhanced induction of follicular development in the ovary through gene and hormonal treatment, which may lead to prevention of infertility caused by ovarian dysfunction. ..
  8. Shirasuna K, Shimizu T, Hayashi K, Nagai K, Matsui M, Miyamoto A. Positive association, in local release, of luteal oxytocin with endothelin 1 and prostaglandin F2alpha during spontaneous luteolysis in the cow: a possible intermediatory role for luteolytic cascade within the corpus luteum. Biol Reprod. 2007;76:965-70 pubmed
    ..05). In conclusion, intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the CL, and thus might be one of the luteal mediators of spontaneous luteolysis in the cow...
  9. Shirasuna K, Kobayashi A, Nitta A, Nibuno S, Sasahara K, Shimizu T, et al. Possible action of vasohibin-1 as an inhibitor in the regulation of vascularization of the bovine corpus luteum. Reproduction. 2012;143:491-500 pubmed publisher
    ..The results indicate that VASH1 has the potential to act as a negative feedback regulator of angiogenesis and lymphangiogenesis in the CL in cows. ..
  10. Uchida M, Harada T, Enkhtuya J, Kusumoto A, Kobayashi Y, Chiba S, et al. Protective effect of Bacillus anthracis surface protein EA1 against anthrax in mice. Biochem Biophys Res Commun. 2012;421:323-8 pubmed publisher
    ..e., before massive multiplication and toxin production by vegetative cells. These results suggest that EA1 is a novel candidate for anthrax vaccine and provides a more effective protection when used in combination with PA...
  11. Kishimoto M, Pae S, Muroya N, Watarai H, Anzai H, Lee K, et al. The relationship between the size of caudolateral curvilinear osteophyte of the canine femoral neck and the radiographic view. J Vet Sci. 2010;11:89-91 pubmed
    ..Hence, radiographic-CCO findings should be used cautiously in hip evaluation of Border Collies...
  12. Sudo N, Shimizu T, Kawashima C, Kaneko E, Tetsuka M, Miyamoto A. Insulin-like growth factor-I (IGF-I) system during follicle development in the bovine ovary: relationship among IGF-I, type 1 IGF receptor (IGFR-1) and pregnancy-associated plasma protein-A (PAPP-A). Mol Cell Endocrinol. 2007;264:197-203 pubmed
    ..Therefore, we suggest that PAPP-A stimulated with FSH play a crucial role for IGF-I system in bovine follicular development. ..
  13. Kamikawa A, Ishikawa T. Functional expression of a Kir2.1-like inwardly rectifying potassium channel in mouse mammary secretory cells. Am J Physiol Cell Physiol. 2014;306:C230-40 pubmed publisher
    ..1-like channel is expressed in lactating mouse MS cells. We propose that the channel might be involved, at least in part, in secretion and/or preservation of ionic components of milk stored into the lumen of these cells. ..
  14. Miyamoto A, Shirasuna K, Shimizu T, Bollwein H, Schams D. Regulation of corpus luteum development and maintenance: specific roles of angiogenesis and action of prostaglandin F2alpha. Soc Reprod Fertil Suppl. 2010;67:289-304 pubmed
    ..The balance between luteotrophic and luteolytic factors as well as stimulation and inhibition of angiogenic factors during luteal formation, development and maintenance can have a profound effect on the fate of the CL...
  15. Yoshinari T, Sivakumar T, Asada M, Battsetseg B, Huang X, Lan D, et al. A PCR based survey of Babesia ovata in cattle from various Asian, African and South American countries. J Vet Med Sci. 2013;75:211-4 pubmed
    ..ovata AMA-1, and that amplicons from different geographical locations were conserved. Our findings highlight the importance of designing adequate strategies to control B. ovata infection in Japan, Mongolia, and Thailand...
  16. Murakami T, Kobayashi Y, Chiba S, Kurauchi Y, Sakamoto H, Sasaki M, et al. Humeral chondrosarcoma in a Hokkaido brown bear (Ursus arctos yesoensis). J Vet Med Sci. 2012;74:1195-7 pubmed
    ..The tumor cells were positively immunostained with vimentin and S-100 protein. Based on these findings, the tumors were diagnosed as chondrosarcoma. Metastases were found in the left axillary lymph node, lungs, liver and kidney. ..
  17. Namangala B, Inoue N, Sugimoto C. Preliminary studies on the effects of orally-administered Transforming Growth Factor-beta on protozoan diseases in mice. Jpn J Vet Res. 2009;57:101-8 pubmed
  18. Lee I, Yamagishi N, Oboshi K, Yamada H. Distribution of new methylene blue injected into the lumbosacral epidural space in cats. Vet Anaesth Analg. 2004;31:190-4 pubmed
    ..To determine the effects of injection volume and vertebral anatomy on the spread of new methylene blue (NMB) injected into the lumbosacral epidural space in cats...
  19. Perera N, Aonuma H, Yoshimura A, Teramoto T, Iseki H, Nelson B, et al. Rapid identification of virus-carrying mosquitoes using reverse transcription-loop-mediated isothermal amplification. J Virol Methods. 2009;156:32-6 pubmed publisher
    ..These observations suggest that RT-LAMP is more reliable and useful for routine diagnosis of vector mosquitoes in regions where the prevalence of vector-borne diseases such as West Nile fever or dengue fever are common. ..
  20. Battsetseg B, Matsuo T, Xuan X, Boldbaatar D, Chee S, Umemiya R, et al. Babesia parasites develop and are transmitted by the non-vector soft tick Ornithodoros moubata (Acari: Argasidae). Parasitology. 2007;134:1-8 pubmed
    ..gibsoni increased gradually. These results indicate that O. moubata may be a useful vector model for Babesia parasites and also a very important tool for studies on tick immunity against Babesia parasites and tick-Babesia interactions...
  21. Shirasuna K, Asaoka H, Acosta T, Wijayagunawardane M, Ohtani M, Hayashi M, et al. Real-time relationships in intraluteal release among Prostaglandin F2alpha, endothelin-1, and angiotensin II during spontaneous luteolysis in the cow. Biol Reprod. 2004;71:1706-11 pubmed
    ..The data suggest that these vasoactive substances may interact with each other in a local positive feedback manner to activate their secretion in the regressing CL, thus accelerating and completing luteolysis. ..
  22. Hakimi H, Asada M, Angeles J, Kawai S, Inoue N, Kawazu S. Plasmodium vivax and Plasmodium knowlesi: cloning, expression and functional analysis of 1-Cys peroxiredoxin. Exp Parasitol. 2013;133:101-5 pubmed publisher
    ..Using specific polyclonal antibodies, it was indicated that Pv1-Cys-Prx and Pk1-Cys-Prx are expressed in the cytoplasm of the parasite. Altogether, the results suggested that 1-Cys-Prxs protect the parasites from oxidative damages. ..
  23. Inoue M, Xuan X, Fujisaki K, Igarashi I, Suzuki H. Short report: role of type I/II scavenger receptors in malarial infection in C57BL/6J mice. Am J Trop Med Hyg. 2006;75:178-81 pubmed
  24. Yamashita H, Murayama C, Takasugi R, Miyamoto A, Shimizu T. BMP-4 suppresses progesterone production by inhibiting histone H3 acetylation of StAR in bovine granulosa cells in vitro. Mol Cell Biochem. 2011;348:183-90 pubmed publisher
    ..Our data suggested that theca cell-derived BMP-4 is important as a regulator of steroid hormone synthesis in granulosa cells during follicular development in the mammalian ovary. ..
  25. Magata F, Shirasuna K, Strüve K, Herzog K, Shimizu T, Bollwein H, et al. Gene expressions in the persistent corpus luteum of postpartum dairy cows: distinct profiles from the corpora lutea of the estrous cycle and pregnancy. J Reprod Dev. 2012;58:445-52 pubmed
    ..The results suggest that the persistent CL may survive for a long period without changes in local immune tolerance but develops several major systems required for CL maintenance similar to the CL of pregnancy...
  26. Herbas M, Suzuki H. Vitamin C deficiency fails to protect mice from malaria. Exp Anim. 2010;59:239-43 pubmed
    ..The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice. ..
  27. Goo Y, Ueno A, Terkawi M, Aboge G, Junya Y, Igarashi M, et al. Actin polymerization mediated by Babesia gibsoni aldolase is required for parasite invasion. Exp Parasitol. 2013;135:42-9 pubmed publisher
    ..gibsoni. This study is the first molecular approach to determine the invasion mechanisms of Babesia species. ..
  28. Jiemtaweeboon S, Shirasuna K, Nitta A, Kobayashi A, Schuberth H, Shimizu T, et al. Evidence that polymorphonuclear neutrophils infiltrate into the developing corpus luteum and promote angiogenesis with interleukin-8 in the cow. Reprod Biol Endocrinol. 2011;9:79 pubmed publisher
    ..We therefore hypothesized that neutrophils infiltrate in the developing CL from just after ovulation and may play a role in angiogenesis of the CL...
  29. Usui M, Fukumoto S, Inoue N, Kawazu S. Improvement of the observational method for Plasmodium berghei oocysts in the midgut of mosquitoes. Parasit Vectors. 2011;4:118 pubmed publisher
    ..This technique was evaluated for its accuracy and suitability in observing the oocyst development...
  30. Watanabe H, Fukui Y. Effects of dithiothreitol and boar on pronuclear formation and embryonic development following intracytoplasmic sperm injection in pigs. Theriogenology. 2006;65:528-39 pubmed
    ..Furthermore, the rate of blastocyst formation of oocytes injected with spermatozoa differed among boars...
  31. Bork S, Okamura M, Matsuo T, Kumar S, Yokoyama N, Igarashi I. Host serum modifies the drug susceptibility of Babesia bovis in vitro. Parasitology. 2005;130:489-92 pubmed
    ..Therefore, the serum-free culture system is useful for standardizing drug test protocols and understanding the roles of serum factors in the drug test...
  32. Badral D, Odonbayar B, Murata T, Munkhjargal T, Tuvshintulga B, Igarashi I, et al. Flavonoid and Galloyl Glycosides Isolated from Saxifraga spinulosa and Their Antioxidative and Inhibitory Activities against Species That Cause Piroplasmosis. J Nat Prod. 2017;80:2416-2423 pubmed publisher
    ..The results indicated that several of these compounds showed growth-inhibitory effects on such organisms that cause piroplasmosis...
  33. Nozaki H, Matsuzawa T, Nakamura T, Arai I, Urashima T. Are there two forms of beta 2-N-acetylglucosaminyltransferase I in rat testicular and epididymal fluids?. Biochim Biophys Acta. 2003;1649:140-5 pubmed
    ..These data suggest that two forms of GnT I exist in the testicular and epididymal fluids. ..
  34. Pyarokhil A, Ishihara M, Sasaki M, Kitamura N. The developmental plasticity of colocalization pattern of peptide YY and glucagon-like peptide-1 in the endocrine cells of bovine rectum. Biomed Res. 2012;33:35-8 pubmed
    ..The present results suggest the developmental plasticity of the colocalization pattern of gut hormones with nutritional transition. ..
  35. Lee K, Kishimoto M, Shimizu J, Iwasaki T, Miyake Y, Yamada K. Effect of a saline chaser for contrast enhancement of computed tomographic angiography in cattle. Vet Rec. 2010;166:137-9 pubmed publisher
    ..45 +/- 36.19 v 202.20 +/- 27.07, P<0.05) and dorsal sagittal sinus (241.2 +/- 31.51 v 198.88 +/- 21.09, P<0.05). These results indicate that a contrast injection followed by saline chaser increased uptake in contrast-enhanced CT...
  36. Matsuo T, Okoda Y, Badgar B, Inoue N, Xuan X, Taylor D, et al. Fate of GFP-expressing Escherichia coli in the midgut and response to ingestion in a tick, Ornithodoros moubata (Acari: Argasidae). Exp Parasitol. 2004;108:67-73 pubmed
    ..The results obtained here help to clarify that digestion enzymes is an important function of the tick midgut to protect against invading molecules and organisms...
  37. Sivakumar T, Altangerel K, Battsetseg B, Battur B, Aboulaila M, Munkhjargal T, et al. Genetic detection of Babesia bigemina from Mongolian cattle using apical membrane antigen-1 gene-based PCR assay. Vet Parasitol. 2012;187:17-22 pubmed publisher
    ..Furthermore, our findings also indicate that the AMA-1 nPCR assay may be a useful diagnostic tool for the specific detection of B. bigemina...
  38. Shimizu T, Hirai Y, Miyamoto A. Expression of cyclins and cyclin-dependent kinase inhibitors in granulosa cells from bovine ovary. Reprod Domest Anim. 2013;48:e65-9 pubmed publisher
    ..Taken together, our study suggested that cyclins and their inhibitors are associated with granulosa cell proliferation at specific follicular developmental stages. ..
  39. Nishimura M, Umeda K, Suwa M, Furuoka H, Nishikawa Y. CCR5 Is Involved in Interruption of Pregnancy in Mice Infected with Toxoplasma gondii during Early Pregnancy. Infect Immun. 2017;85: pubmed publisher
    ..These results suggested that CCR5 signaling is involved in embryo loss in T. gondii infection during early pregnancy and that apoptosis is associated with embryo loss rather than direct damage to the fetoplacental tissues. ..
  40. Mousa A, Roche D, Terkawi M, Kameyama K, Kamyingkird K, Vudriko P, et al. Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules. PLoS ONE. 2017;12:e0185372 pubmed publisher
    ..In conclusion, the TSP1 domain mimicry might help in studying the mechanisms of parasite-induced thrombocytopenia, with the TSP1-free truncate of the protein representing a potential safe candidate for future vaccine studies. ..
  41. Goo Y, Lee N, Terkawi M, Luo Y, Aboge G, Nishikawa Y, et al. Development of a rapid immunochromatographic test using a recombinant thrombospondin-related adhesive protein of Babesia gibsoni. Vet Parasitol. 2012;190:595-8 pubmed publisher
    ..The developed ICT showed high sensitivity, specificity, and kappa value with a reference test (100%, 93.78%, and 0.8976, respectively), indicating that the ICT could be a new practical diagnostic test for B. gibsoni infection...
  42. Shimizu T, Kayamori T, Murayama C, Miyamoto A. Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC. Biochem Biophys Res Commun. 2012;417:869-73 pubmed publisher
    ..Our data show that BMP-4 and BMP-7 are associated with granulosa cell survival via several non-Smad specific pathways: BMP-4 via the PI3K/PDK-1/PKC and BMP-7 via the PI3K/PDK-1/Akt. ..
  43. Senda A, Hatakeyama E, Kobayashi R, Fukuda K, Uemura Y, Saito T, et al. Chemical characterization of milk oligosaccharides of an African lion (Panthera leo) and a clouded leopard (Neofelis nebulosa). Anim Sci J. 2010;81:687-93 pubmed publisher
    ..These milks contained 3'-NGc-SL and A-tetrasaccharide, while spotted hyena colostrum did not; however, it contained Neu5Ac(?2-3)Gal(?1-4)Glc (3'-NAc-SL) and Gal(?1-3)[Fuc(?1-2)]Gal(?1-4)Glc (B-tetrasaccharide)...
  44. Shiozuka C, Taguchi A, Matsuda J, Noguchi Y, Kunieda T, Uchio Yamada K, et al. Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem. 2011;149:161-70 pubmed publisher
    ..These data indicated that the TgG3S(+/-) M(+/-)/KO mouse was suitable for studying ASSC therapy for Fabry disease, and that the TgG3S mouse would be useful for studying the effect of high Gb3 levels in mouse organs. ..
  45. Thekisoe O, Rodriguez C, Rivas F, Coronel Servian A, Fukumoto S, Sugimoto C, et al. Detection of Trypanosoma cruzi and T. rangeli infections from Rhodnius pallescens bugs by loop-mediated isothermal amplification (LAMP). Am J Trop Med Hyg. 2010;82:855-60 pubmed publisher
    ..rangeli-positive by LAMP and PCR, respectively. Further evaluation of these LAMP assays is needed, especially with specimens collected from human patients as well as blood kept for transfusion purposes...
  46. Aboulaila M, Sivakumar T, Yokoyama N, Igarashi I. Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. Parasitol Int. 2010;59:278-82 pubmed publisher
    ..05) inhibited the growth of B. microti at the dosage of 10 and 100mg/kg BW, while the inhibition was low compared with the high doses used. Therefore, nerolidol could not be used as a chemotherapeutic drug for babesiosis...
  47. Sakamoto L, Ohbayashi T, Matsumoto K, Kobayashi Y, Inokuma H. Serum thymidine kinase activity as a useful marker for bovine leukosis. J Vet Diagn Invest. 2009;21:871-4 pubmed
    ..Sensitivity and specificity of measuring serum TK activity as a diagnostic tool for bovine leukosis was 95.0% and 95.9%, respectively. Results indicate that serum TK activity may be a marker for bovine leukosis. ..
  48. Thekisoe O, Rambritch N, Nakao R, Bazie R, Mbati P, Namangala B, et al. Loop-mediated isothermal amplification (LAMP) assays for detection of Theileria parva infections targeting the PIM and p150 genes. Int J Parasitol. 2010;40:55-61 pubmed publisher
    ..With the advantages of simplicity, rapidity and cost effectiveness, these LAMP assays are good candidates for molecular epidemiology studies and for monitoring control programs in ECF-endemic, resource poor countries...
  49. Ibrahim H, Bannai H, Xuan X, Nishikawa Y. Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner. Infect Immun. 2009;77:3686-95 pubmed publisher
    ..In conclusion, T. gondii possesses sophisticated mechanisms to manipulate host cell responses in a TgCyp18-mediated process...
  50. Kishimoto M, Yamada K, Pae S, Muroya N, Watarai H, Anzai H, et al. Quantitative evaluation of hip joint laxity in 22 Border Collies using computed tomography. J Vet Med Sci. 2009;71:247-50 pubmed
    ..We consider CT evaluation in a weight-bearing position to be a useful method for multidirectional evaluation of hips...
  51. Watanabe H, Hirai S, Tateno H, Fukui Y. Variation of cholesterol contents in porcine cumulus-oocyte complexes is a key factor in regulation of fertilizing capacity. Theriogenology. 2013;79:680-6 pubmed publisher
    ..We concluded that ovarian cholesterogenesis depended on sexual maturity of the donor and that variation in cholesterol content in COCs during in vitro maturation of porcine oocytes affected their ability to be fertilized. ..
  52. Erdenebaatar J, Bayarsaikhan B, Watarai M, Makino S, Shirahata T. Enzyme-linked immunosorbent assay to differentiate the antibody responses of animals infected with Brucella species from those of animals infected with Yersinia enterocolitica O9. Clin Diagn Lab Immunol. 2003;10:710-4 pubmed
    ..A field trial in Mongolia showed cattle, sheep, goat, reindeer, camel, and human sera without infection could be distinguished from Brucella-infected animals by conventional serological tests. ..
  53. Nishikawa Y, Tragoolpua K, Inoue N, Makala L, Nagasawa H, Otsuka H, et al. In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages. Clin Diagn Lab Immunol. 2001;8:811-6 pubmed
    ..The present study indicates that early IFN-gamma production has a crucial role in the activation of peritoneal macrophages for the induction of protective immune responses against N. caninum. ..