Experts and Doctors on lymphocyte activation in Kitakyushu, Fukuoka, Japan
Locale: Kitakyushu, Fukuoka, Japan
Topic: lymphocyte activation
Ichiki Y, Takenoyama M, Mizukami M, So T, Sugaya M, Yasuda M, et al
. Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer. J Immunol. 2004;172:4844-50 pubmed
..This approach may allow us to better understand the mechanisms of T and B cell immunity against the same tumor Ag in cancer patients. ..
Nakano K, Saito K, Mine S, Matsushita S, Tanaka Y. Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death. Apoptosis. 2007;12:45-54 pubmed
..We therefore propose that the engagement of CD44 on T cells can eliminate autoreactive T cells by expression of FasL and FasL-mediated AICD. ..
Izu K, Hino R, Isoda H, Nakashima D, Kabashima K, Tokura Y. Photocontact dermatitis to ketoprofen presenting with erythema multiforme. Eur J Dermatol. 2008;18:710-3 pubmed publisher
..The presence of circulating photoantigen-reactive T cells seemed to induce erythema multiforme as an unusual manifestation in this patient. ..
Wang S, Iwata S, Nakayamada S, Sakata K, Yamaoka K, Tanaka Y. Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro. Ann Rheum Dis. 2014;73:2213-5 pubmed publisher
Sugita K, Kabashima K, Atarashi K, Shimauchi T, Kobayashi M, Tokura Y. Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin. Clin Exp Immunol. 2007;147:176-83 pubmed
..This also implies that innate immunity evoked by TLR ligation of keratinocytes enhances acquired immunity comprising LCs and T cells. ..
Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y. CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun. 2007;361:1012-6 pubmed
..These findings suggest that CXCL12-CXCR4 engagement enhances DC maturation and survival to initiate acquired immune response. ..