Experts and Doctors on zebrafish proteins in Fukuoka, Japan
Locale: Fukuoka, Japan
Topic: zebrafish proteins
Yoshimura Y, Tani M, Okino N, Iida H, Ito M. Molecular cloning and functional analysis of zebrafish neutral ceramidase. J Biol Chem. 2004;279:44012-22 pubmed
..These results indicate that znCD is essential for the metabolism of ceramide and the early development of zebrafish. ..
Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, et al
. Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. J Biol Chem. 2007;282:30889-900 pubmed
..GlcCer was found to fit well the cleft of the crystal structure of KLrP. Collectively, KLrP was identified as a cytosolic neutral glycosylceramidase that could be involved in a novel nonlysosomal catabolic pathway of GlcCer. ..
Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D. Cold exposure down-regulates zebrafish hematopoiesis. Biochem Biophys Res Commun. 2010;394:859-64 pubmed publisher
..We propose that this zebrafish model is useful to identify novel genes for hematopoiesis, particularly erythropoiesis. ..
Tsukada Y, Ishitani T, Nakayama K. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010;24:432-7 pubmed publisher
..Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development...
Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T. NLK positively regulates Wnt/?-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 2012;31:1904-15 pubmed publisher
..Furthermore, we demonstrate that NLK functions downstream of Dishevelled (Dvl) in the Wnt/?-catenin signalling pathway. Our findings reveal a novel role of NLK in the activation of the Wnt/?-catenin signalling pathway. ..