Experts and Doctors on viral proteins in Hiroshima, Japan


Locale: Hiroshima, Japan
Topic: viral proteins

Top Publications

  1. Irie T, Kiyotani K, Igarashi T, Yoshida A, Sakaguchi T. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J Virol. 2012;86:7136-45 pubmed publisher
    ..These results indicate that IRF3 is important as an alternative target of paramyxovirus V proteins. ..
  2. Oda K, Matoba Y, Kumagai T, Noda M, Sugiyama M. Crystallographic study to determine the substrate specificity of an L-serine-acetylating enzyme found in the D-cycloserine biosynthetic pathway. J Bacteriol. 2013;195:1741-9 pubmed publisher
    ..In contrast, the side chain of the last residue in the turn of DcsE may need to form an extensive hydrogen-bonding network on the turn, which interferes with the binding of l-homoserine. ..
  3. Irie T, Okamoto I, Yoshida A, Nagai Y, Sakaguchi T. Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity. J Virol. 2014;88:690-8 pubmed publisher
    ..A series of promoter-swapped SeV recombinants suggested the importance of the primary as well as secondary structures of the promoters in this trans-regulation. ..
  4. Sumi S, Tsuneyoshi T, Furutani H. Novel rod-shaped viruses isolated from garlic, Allium sativum, possessing a unique genome organization. J Gen Virol. 1993;74 ( Pt 9):1879-85 pubmed
    ..The results suggest that the garlic viruses described here belong to an unclassified and new virus group closely related to the carlaviruses. ..
  5. Irie T, Shimazu Y, Yoshida T, Sakaguchi T. The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein. J Virol. 2007;81:2263-73 pubmed publisher
    ..Our results suggest that the interaction of multiple viral proteins with Alix/AIP1 may enhance the efficiency of the utilization of cellular MVB sorting machinery for efficient SeV budding...
  6. Irie T, Nagata N, Yoshida T, Sakaguchi T. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles. Virology. 2008;374:495-505 pubmed publisher
    ..Our results demonstrate for the first time that the C proteins regulate balance of viral genome and antigenome RNA synthesis for efficient production of infectious virus particles in the course of virus infection. ..
  7. Nakaune R, Toda S, Mochizuki M, Nakano M. Identification and characterization of a new vitivirus from grapevine. Arch Virol. 2008;153:1827-32 pubmed publisher
    ..We propose to name this virus grapevine virus E (GVE). ..
  8. Irie T, Nagata N, Igarashi T, Okamoto I, Sakaguchi T. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses. PLoS ONE. 2010;5:e10719 pubmed publisher
  9. Adachi T, Wang X, Murata T, Obara M, Akutsu H, Machida M, et al. Production of a non-triple helical collagen alpha chain in transgenic silkworms and its evaluation as a gelatin substitute for cell culture. Biotechnol Bioeng. 2010;106:860-70 pubmed publisher
    ..These results show that the recombinant human alpha1(I) chain is a promising candidate biomaterial as a high-quality and safe gelatin substitute for cell culture. ..

More Information


  1. Irie T, Inoue M, Sakaguchi T. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection. Virology. 2010;405:334-41 pubmed publisher
    ..The results indicate that the YLDL motif is essential for efficient budding in the context of virus infection and suggest involvement of Alix/AIP1 in SeV budding. ..
  2. Sakaguchi T, Irie T, Kuwayama M, Ueno T, Yoshida A, Kawabata R. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5. Microbiol Immunol. 2011;55:760-7 pubmed publisher
    ..Viral pathogenicity of SeV is related to the inhibitory effect of the V protein on MDA5, but is not always related to the binding of V protein with MDA5. ..
  3. Yamaki M, Shinozaki K, Sakaguchi T, Meseck M, Ebert O, Ohdan H, et al. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer. Int J Mol Med. 2013;31:299-306 pubmed publisher
    ..001), none of the rats achieved long-term survival. VSV virotherapy has potential for CRC liver and lung metastases, although systemic venous delivery is much less effective than locoregional delivery such as hepatic arterial infusion...
  4. Irie T, Yoshida A, Sakaguchi T. Clustered basic amino acids of the small sendai virus C protein Y1 are critical to its RAN GTPase-mediated nuclear localization. PLoS ONE. 2013;8:e73740 pubmed publisher
    ..These results suggest that nuclear localization of the Y1 protein might be important for the inhibitory effect on type-I IFN-stimulated gene expression. ..
  5. Kiyotani K, Sakaguchi T, Kato A, Nagai Y, Yoshida T. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice. Virology. 2007;359:82-91 pubmed
    ..These results indicate that SeV V protein counteracts IRF-3-mediated innate antiviral immunity for efficient virus replication and pathogenesis in mice, but it is not IFN...
  6. Yoshida A, Sakaguchi T, Irie T. Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome. PLoS ONE. 2012;7:e49968 pubmed publisher
    ..These results suggest that a lack of C proteins could lead unexpectedly to strong selective pressures, and that the C proteins might play more critical roles in SeV replication than ever reported. ..