Experts and Doctors on viral matrix proteins in Hiroshima, Japan
Locale: Hiroshima, Japan
Topic: viral matrix proteins
Sakaguchi T, Uchiyama T, Huang C, Fukuhara N, Kiyotani K, Nagai Y, et al
. Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cysteine residues of the matrix protein. J Virol. 2002;76:1682-90 pubmed
..Cysteine-dependent conformation of the M protein was not due to disulfide bond formation, since the cysteines were shown to be free throughout the viral life cycle. ..
Watanabe H, Tanaka Y, Shimazu Y, Sugahara F, Kuwayama M, Hiramatsu A, et al
. Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors. Microbiol Immunol. 2005;49:835-44 pubmed
..Effects of proteasome inhibitors on virus maturation are thus highly cell-specific and partly virus-specific. ..
Irie T, Shimazu Y, Yoshida T, Sakaguchi T. The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein. J Virol. 2007;81:2263-73 pubmed publisher
..Our results suggest that the interaction of multiple viral proteins with Alix/AIP1 may enhance the efficiency of the utilization of cellular MVB sorting machinery for efficient SeV budding...
Irie T, Inoue M, Sakaguchi T. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection. Virology. 2010;405:334-41 pubmed publisher
..The results indicate that the YLDL motif is essential for efficient budding in the context of virus infection and suggest involvement of Alix/AIP1 in SeV budding. ..
Irie T, Liu Y, Drolet B, Carnero E, Garcia Sastre A, Harty R. Cytopathogenesis of vesicular stomatitis virus is regulated by the PSAP motif of M protein in a species-dependent manner. Viruses. 2012;4:1605-18 pubmed publisher
..These findings indicate that the PSAP motif plays a direct role in regulating cytopathogenicity in a species-dependent manner, and suggest that the intact PSAP motif may be important for maintaining persistence of VSV in an insect host. ..