Experts and Doctors on trophoblasts in Ōsaka, Japan
Locale: Ōsaka, Japan
Kumazaki K, Nakayama M, Yanagihara I, Suehara N, Wada Y. Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Hum Pathol. 2004;35:47-54 pubmed
..Elucidation of biological functions of placental TLR4 under physiological conditions requires further investigation. ..
Fujita D, Tanabe A, Sekijima T, Soen H, Narahara K, Yamashita Y, et al
. Role of extracellular signal-regulated kinase and AKT cascades in regulating hypoxia-induced angiogenic factors produced by a trophoblast-derived cell line. J Endocrinol. 2010;206:131-40 pubmed publisher
..Our results suggest that both the phosphatidylinositol 3-kinase-AKT-MTOR-HIF-1alpha and ERK-HIF-1alpha signaling pathways are crucial for increasing VEGF and endoglin expression in response to hypoxia in BeWo cells. ..
Okamoto Y, Sakata M, Ogura K, Yamamoto T, Yamaguchi M, Tasaka K, et al
. Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Am J Physiol Cell Physiol. 2002;282:C196-204 pubmed
..Our results suggest that the heterodimer of 4F2hc and hLAT1 may play an important role in placental amino acid transport system L...
Terao Y, Kumano S, Takatsu Y, Hattori M, Nishimura A, Ohtaki T, et al
. Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. Biochim Biophys Acta. 2004;1678:102-10 pubmed
..These results suggest that metastin/OT7T175 signaling may participate in implantation of the mammalian embryo, placenta formation, and maintenance of pregnancy. ..
Minekawa R, Sakata M, Okamoto Y, Hayashi M, Isobe A, Takeda T, et al
. Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1. Endocrinology. 2007;148:5803-10 pubmed
..Taken together, these findings suggest that RAI may be involved in the regulation of trophoblast differentiation via interaction with Sp1. ..
Muto M, Fujihara Y, Tobita T, Kiyozumi D, Ikawa M. Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice. Biol Reprod. 2016;94:6 pubmed publisher
..Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration. Its proper expression is required for normal placentation and fetal development. ..
Nishimoto F, Sakata M, Minekawa R, Okamoto Y, Miyake A, Isobe A, et al
. Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells. Endocrinology. 2009;150:1801-8 pubmed publisher
..Taken together, these findings suggest that MTF-1 is involved in hypoxia-dependent regulation of PlGF in trophoblast-derived cells. ..