Experts and Doctors on transcription factors in Tokyo, Japan


Locale: Tokyo, Japan
Topic: transcription factors

Top Publications

  1. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, et al. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J Biol Chem. 1999;274:17003-10 pubmed
  2. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami Murofushi K, et al. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999;274:27776-85 pubmed
  3. Miyazono K. TGF-beta signaling by Smad proteins. Cytokine Growth Factor Rev. 2000;11:15-22 pubmed
    ..Through interaction with different transcription factors and transcriptional co-activators or co-repressors, Smads may exhibit specific effects in various cell types. ..
  4. Murakami T, Haga K, Takeuchi M, Sato T. Analysis of the Bacillus subtilis spoIIIJ gene and its Paralogue gene, yqjG. J Bacteriol. 2002;184:1998-2004 pubmed
    ..This localization of SpoIIIJ at the sporulation-specific septa may be important for the role of spoIIIJ during sporulation. ..
  5. Arai A, Kanda E, Miura O. Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway. Oncogene. 2002;21:2641-51 pubmed
    ..Together, these results indicate that Rac is activated by Epo or IL-3 at downstream of the Ras/PI3K pathway in parallel with Akt and plays a role in activation of the Erk/Elk-1 signaling pathway in hematopoietic cells. ..
  6. Ma K, Araki K, Ichwan S, Suganuma T, Tamamori Adachi M, Ikeda M. E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. Mol Cancer Res. 2003;1:438-44 pubmed
    ..The ectopic expression of E2FBP1/DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53. ..
  7. Matsuda S, Koyasu S. Regulation of MAPK signaling pathways through immunophilin-ligand complex. Curr Top Med Chem. 2003;3:1358-67 pubmed
    ..Here we discuss the action of immunophilin-ligand complexes on JNK and p38 activation pathways. We also argue the possibility of immunotherapeutic application targeting at JNK and p38 signaling pathways. ..
  8. Tomita K, Azuma T, Kitamura N, Nishida J, Tamiya G, Oka A, et al. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology. 2004;126:873-85 pubmed
    ..Pioglitazone activates c-Met and VLDL-dependent lipid retrieval and suppresses triglyceride synthesis and thereby serves as a potentially useful stratagem to attenuate ethanol-induced hepatic steatosis. ..
  9. Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, et al. Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci U S A. 2004;101:8017-21 pubmed
    ..These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling. ..

More Information

Publications256 found, 100 shown here

  1. Saito T, Tojo K, Kuriyama G, Murakawa Y, Fujimoto K, Taniguchi K, et al. A case of acquired deficiency of pituitary GH, PRL and TSH, associated with type 1 diabetes mellitus. Endocr J. 2004;51:287-93 pubmed
    ..We report here a rare case of SPIDDM with CPHD which might be caused by lymphocytic hypophysitis. ..
  2. Unoki M, Nishidate T, Nakamura Y. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene. 2004;23:7601-10 pubmed
    ..The data reported here suggest that ICBP90 is involved in cell proliferation by way of methylation-mediated regulation of certain genes. ..
  3. Ikuzawa M, Kobayashi K, Yasumasu S, Iuchi I. Expression of CCAAT/enhancer binding protein delta is closely associated with degeneration of surface mucous cells of larval stomach during the metamorphosis of Xenopus laevis. Comp Biochem Physiol B Biochem Mol Biol. 2005;140:505-11 pubmed
    ..The result suggests a possibility that Xenopus C/EBP delta plays a role in apoptotic cell death of larval-type epithelium during the stomach remodeling. ..
  4. Kawazu M, Asai T, Ichikawa M, Yamamoto G, Saito T, Goyama S, et al. Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development. J Immunol. 2005;174:3526-33 pubmed
    ..These results suggest that the activation domain is essential for Runx1 to establish thymocyte development and that Runx1 has both TLE-dependent and TLE-independent functions in thymocyte development. ..
  5. Matoba S, Kanai Y, Kidokoro T, Kanai Azuma M, Kawakami H, Hayashi Y, et al. A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation. J Cell Sci. 2005;118:1449-59 pubmed
    ..To the best of our knowledge, this is a novel Sry-downstream cellular event which preserves this readily available energy source in Sertoli cells for testis-specific morphogenesis and hormone production. ..
  6. Shibuya K, Kudoh J, Okui M, Shimizu N. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q. Biochem Biophys Res Commun. 2005;332:557-68 pubmed
    ..Interestingly, this gene crosses over a clone gap (GAP2) remaining in the band 21q22.3. We obtained the DNA fragments corresponding to GAP2 using ZNF298 cDNA sequence as anchor primers for PCR and determined its genomic DNA sequence. ..
  7. Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka Saito N, et al. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Nat Genet. 2006;38:101-6 pubmed
    ..This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development...
  8. Okuwaki M, Takada T, Iwayanagi Y, Koh S, Kariya Y, Fujii H, et al. LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR. Pharm Res. 2007;24:390-8 pubmed
    ..It was concluded that LXRalpha/RXRalpha transcriptionally regulate mouse Ostalpha/beta via IR-1 elements shared with FXR/RXRalpha. Exposure to FXR/LXRalpha modulators may affect the disposition of Ostalpha/beta substrates. ..
  9. Seki A, Hanaoka M, Akimoto Y, Masuda S, Iwasaki H, Tanaka K. Induction of a group 2 sigma factor, RPOD3, by high light and the underlying mechanism in Synechococcus elongatus PCC 7942. J Biol Chem. 2007;282:36887-94 pubmed
    ..Thus, we have concluded that phosphorylated RpaB are repressing the rpoD3 and hliA transcription under normal growth conditions, and the RpaB dephosphorylation induced by high light stress results in transcriptional derepression. ..
  10. Miura S, Kai Y, Kamei Y, Ezaki O. Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise. Endocrinology. 2008;149:4527-33 pubmed publisher
    ..These data indicate that AR activation is a major mechanism of an increase in PGC-1alpha expression in skeletal muscles, and the increase in PGC-1alpha mRNAs was isoform specific. ..
  11. Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, et al. Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008;135:3511-9 pubmed publisher
    ..These results demonstrate that there is significant evolutionary conservation of Mesp regulatory mechanisms between fish and mice...
  12. Saito S, Furuno A, Sakurai J, Sakamoto A, Park H, Shin ya K, et al. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res. 2009;69:4225-34 pubmed publisher
    ..Our findings show that disrupting the UPR during glucose deprivation could be an attractive approach for selective cancer cell killing and could provide a chemical genomic basis for developing UPR-targeting drugs against solid tumors. ..
  13. Fukunishi N, Katoh I, Tomimori Y, Tsukinoki K, Hata R, Nakao A, et al. Induction of ?Np63 by the newly identified keratinocyte-specific transforming growth factor ? Signaling Pathway with Smad2 and I?B Kinase ? in squamous cell carcinoma. Neoplasia. 2010;12:969-79 pubmed
    ..This study indicates that p63 is a target gene of the proposed keratinocyte-specific TGF-? signal pathway for suppression of the malignant conversion of SCC. ..
  14. Shono T, Kurokawa D, Miyake T, Okabe M. Acquisition of glial cells missing 2 enhancers contributes to a diversity of ionocytes in zebrafish. PLoS ONE. 2011;6:e23746 pubmed publisher
    ..Our results suggest that an acquisition of enhancers for the expression of gcm2 contributes to a diversity of ionocytes in zebrafish during evolution. ..
  15. Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T, et al. DNA hypomethylation at the ZNF206-exon 5 CpG island associated with neuronal differentiation in mice and development of neuroblastoma in humans. Int J Oncol. 2012;40:31-9 pubmed publisher
    ..Even though the function of ZNF206 and its expression regulation in neuroblastoma remain elusive, ZNF206 might be a candidate differentiation suppressor and prognosis marker in neuroblastoma. ..
  16. Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, et al. Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects. Circ J. 2012;76:1703-11 pubmed
    ..Our results provide the first demonstration of MEF2C mutation and suggest that disturbances in the regulatory circuits involving these cardiac transcription factors may cause a subset of non-syndromic and non-familial CHDs. ..
  17. Yamamura Y, Senda H, Noda M, Ikawa Y. Activation of the JAK1-STAT5 pathway by binding of the Friend virus gp55 glycoprotein to the erythropoietin receptor. Leukemia. 1997;11 Suppl 3:432-4 pubmed
    ..These results indicate that JAK1 is involved in the gp55/EPOR signaling but STAT5 is not playing an essential role in the growth of those erythroid cells. ..
  18. Nishizawa M, Kawasumi M, Fujino M, Toh e A. Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation. Mol Biol Cell. 1998;9:2393-405 pubmed
    ..Pho85 and other G1 Cdks appear to phosphorylate Sic1 at different sites in vivo. Thus at least two distinct Cdks can participate in phosphorylation of Sic1 and may therefore regulate progression through G1. ..
  19. Yanagisawa S. Dof1 and Dof2 transcription factors are associated with expression of multiple genes involved in carbon metabolism in maize. Plant J. 2000;21:281-8 pubmed
    ..Speculation raised by these results concerning the evolution of the C4pepc gene is also discussed. ..
  20. Udagawa Y, Hanai J, Tada K, Grieder N, Momoeda M, Taketani Y, et al. Schnurri interacts with Mad in a Dpp-dependent manner. Genes Cells. 2000;5:359-69 pubmed
    ..Finally, we found that Shn interacts with Mad in a Dpp-dependent manner. The present results argue that Shn may act as a nuclear component of the Dpp signalling pathway through direct interaction with Mad. ..
  21. Lee H, Miyauchi K, Nagata Y, Fukuda R, Sasagawa S, Endoh H, et al. Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters. J Biochem. 2002;131:399-405 pubmed
  22. Yoshida K, Inoue I. Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. Oncogene. 2004;23:6250-60 pubmed
    ..Our data suggest a model in which UV irradiation-induced DNA damage depends, at least in part, on the accumulation of the E2F4 transcription factor on the MCM10 and TopBP1 promoters, which results in suppression of DNA replication. ..
  23. Nakamura Y, Hayashi T, Kozaki K, Kubo A, Omoto S, Watanabe A, et al. Enhanced S-cone syndrome in a Japanese family with a nonsense NR2E3 mutation (Q350X). Acta Ophthalmol Scand. 2004;82:616-22 pubmed
    ..The clinical findings for this patient suggest that his left eye, with its functional L/M- and S-cones, was at an earlier stage of the syndrome than his right eye. ..
  24. Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, et al. Expression of DGAT2 in white adipose tissue is regulated by central leptin action. J Biol Chem. 2005;280:3331-7 pubmed
    ..We propose the hypothesis that leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis. ..
  25. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, et al. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 2005;1:27-39 pubmed
    ..KLF5, in turn, acts in concert with C/EBPbeta/delta to activate the PPARgamma2 promoter. This study establishes KLF5 as a key component of the transcription factor network controlling adipocyte differentiation. ..
  26. Tomono A, Tsai Y, Yamazaki H, Ohnishi Y, Horinouchi S. Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol. 2005;187:5595-604 pubmed
    ..Consistent with this, expression of strR under the control of a constitutively expressed promoter in an adpA null mutant caused the host to produce streptomycin. ..
  27. Tsuda M, Langmann C, Harden N, Aigaki T. The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep. 2005;6:1082-7 pubmed
    ..We show that POSH binds to and degrades TAK1, a crucial activator of both the JNK and the Relish signalling pathways. These results establish a novel role for POSH in the Drosophila immune system. ..
  28. Yasuhiko Y, Haraguchi S, Kitajima S, Takahashi Y, Kanno J, Saga Y. Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc Natl Acad Sci U S A. 2006;103:3651-6 pubmed
    ..This finding uncovers an additional component of the interacting network of various signaling pathways that are involved in somitogenesis. ..
  29. Miyakawa K, Uchida A, Shiraki T, Teshima K, Takeshima H, Shibata S. ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle. Neuropharmacology. 2007;52:1055-64 pubmed
    ..The present results suggest that post-translational down-regulation of mPER2 protein in the shell region of mouse SCN may be involved in W-212393-induced non-photic phase advance. ..
  30. Sun G, Kobayashi T, Abe M, Tada N, Adachi H, Shiota A, et al. The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation. Biochem Biophys Res Commun. 2007;360:181-7 pubmed
    ..Additionally, suppression of NIBAN expression in HeLa cells promoted apoptosis. Together these results suggest that Niban is involved in the ER stress response, and that Niban can modulate cell death signaling by regulating translation. ..
  31. Inamura K, Togashi Y, Okui M, Ninomiya H, Hiramatsu M, Satoh Y, et al. HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. J Thorac Oncol. 2007;2:802-7 pubmed
    ..Confirmation with a larger number of samples is needed, with further research to clarify the molecular functions of HOXB2. ..
  32. Nakamura H, Ishii C, Suehiro M, Iguchi A, Kuroda K, Shimizu K, et al. The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB. Virus Res. 2008;131:170-9 pubmed
    ..These results suggest the possibility that Bcl-3 is involved in the pathogenesis of certain EBV-associated malignancies and lymphoproliferative disorders. ..
  33. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Watabe T, Miyazono K. Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci. 2008;121:3317-24 pubmed publisher
    ..These results indicate that Snail mediates the actions of endogenous TGFbeta signals that induce EndMT. ..
  34. Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, et al. Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem. 2008;283:31861-70 pubmed publisher
    ..This hyperactive mTOR mutant will be a valuable tool for establishing physiological consequences of mTOR activation in cells as well as in organisms. ..
  35. Kuroda R, Endo B, Abe M, Shimizu M. Chiral blastomere arrangement dictates zygotic left-right asymmetry pathway in snails. Nature. 2009;462:790-4 pubmed publisher
    ..Similar chiral blastomere configuration mechanisms may also operate upstream of the Nodal pathway in left-right patterning of deuterostomes/vertebrates...
  36. Azuma M, Osanai T, Hirai M, Tanaka K. A response regulator Rre37 and an RNA polymerase sigma factor SigE represent two parallel pathways to activate sugar catabolism in a cyanobacterium Synechocystis sp. PCC 6803. Plant Cell Physiol. 2011;52:404-12 pubmed publisher
    ..These findings substantiated a regulatory network of sugar catabolic genes in this cyanobacterium...
  37. Wagatsuma A, Kotake N, Mabuchi K, Yamada S. Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle. J Physiol Biochem. 2011;67:359-70 pubmed publisher
    ..In addition, other PGC-1 family of transcriptional coactivators and DNA binding transcription factors may also contribute to mitochondrial adaptation after early response to denervation. ..
  38. Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, et al. Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. Mol Vis. 2011;17:1222-30 pubmed
    ..Furthermore, TGF-? induced relocalization of Snail to the nucleus in RPE cells. The current data indicate that Snail is a major transcriptional factor for EMT changes of RPE cells in human CNV. ..
  39. Mizoi J, Shinozaki K, Yamaguchi Shinozaki K. AP2/ERF family transcription factors in plant abiotic stress responses. Biochim Biophys Acta. 2012;1819:86-96 pubmed publisher
    ..This article is part of a Special Issue entitled: Plant gene regulation in response to abiotic stress. ..
  40. Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, et al. Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. EMBO J. 2012;31:2541-52 pubmed publisher
    ..Therefore, the V-shaped form of HHM may represent an autoinhibited state, and the dynamic conformational equilibrium may control the target specificity. ..
  41. Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, et al. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Exp Cell Res. 2013;319:931-45 pubmed publisher
    ..In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. ..
  42. Kobayashi K, Sasaki D, Noguchi K, Fujinuma D, Komatsu H, Kobayashi M, et al. Photosynthesis of root chloroplasts developed in Arabidopsis lines overexpressing GOLDEN2-LIKE transcription factors. Plant Cell Physiol. 2013;54:1365-77 pubmed publisher
    ..Moreover, GLK overexpression increased CO? fixation and promoted phototrophic performance of the root, showing the potential of root photosynthesis to improve effective carbon utilization in plants. ..
  43. Matsushita M, Nakatake Y, Arai I, Ibata K, Kohda K, Goparaju S, et al. Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors. Biochem Biophys Res Commun. 2017;490:296-301 pubmed publisher
    ..These results indicate that over-expression of each of these five TFs can override the pluripotency-specific gene network and force hESCs to differentiate into neurons. ..
  44. Hakura A, Morimoto K, Sofuni T, Nohmi T. Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase. J Bacteriol. 1991;173:3663-72 pubmed
    ..The low ability of AdaST to function as a positive regulator could account for the apparent lack of an adaptive response to alkylation damage in S. typhimurium. ..
  45. Nose K, Ohba M. Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide. Biochem J. 1996;316 ( Pt 2):381-3 pubmed
    ..However, with appropriate concentrations of active oxygen, its capacity to bind a specific DNA sequence and to enhance the transcriptional activity of target genes is thought to be elevated. ..
  46. Liu Y, Watanabe H, Nifuji A, Yamada Y, Olson E, Noda M. Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J Biol Chem. 1997;272:29880-5 pubmed
    ..These results indicate that overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression via binding to the E-box-containing AgE sequence in ROS17/2.8 cells. ..
  47. Tahara S, Tanaka K, Yuasa Y, Okayama H. Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start". Mol Biol Cell. 1998;9:1577-88 pubmed
    ..The functional essentiality of these domains is also demonstrated by their requirement for rescue of the cold-sensitive rep2 deletion mutant of fission yeast. ..
  48. Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc Natl Acad Sci U S A. 1999;96:14535-40 pubmed
    ..These findings suggest that AF5q31 and AF4 might define a new family particularly involved in the pathogenesis of 11q23-associated-ALL. ..
  49. Sakashita C, Fukuda T, Okabe S, Kobayashi H, Hirosawa S, Tokuhisa T, et al. Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. Biochem Biophys Res Commun. 2002;291:567-73 pubmed
    ..These expression patterns of BAZF mRNA suggest that BAZF may regulate differentiation in stages or lineages that are different from those regulated by BCL6. ..
  50. Shibata K, Takase M, Nakamura M. The Dmrt1 expression in sex-reversed gonads of amphibians. Gen Comp Endocrinol. 2002;127:232-41 pubmed
    ..Taken together, the results suggest that Dmrt1 is closely implicated in testicular, but not ovarian differentiation in amphibians. ..
  51. Zhang L, Onda K, Imai R, Fukuda R, Horiuchi H, Ohta A. Growth temperature downshift induces antioxidant response in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2003;307:308-14 pubmed
    ..However, deletion of YAP1 did not reduce the elevated mRNA levels of the antioxidant genes. This suggests that the temperature downshift-induced increase in the mRNA level of anti-oxidant genes is YAP1-independent. ..
  52. Arimatsu Y, Ishida M, Kaneko T, Ichinose S, Omori A. Organization and development of corticocortical associative neurons expressing the orphan nuclear receptor Nurr1. J Comp Neurol. 2003;466:180-96 pubmed
    ..These results raise the possibility that Nurr1 plays a role in the establishment and maintenance of normal corticocortical circuitry and function. ..
  53. Sekimizu K, Nishioka N, Sasaki H, Takeda H, Karlstrom R, Kawakami A. The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development. 2004;131:2521-32 pubmed
    ..Taken together, our studies show that Igu/Dzip1 functions as a permissive factor that is required for the proper regulation of Hh target genes in response to Hh signals. ..
  54. Kato H, Tamamizu Kato S, Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004;279:41966-74 pubmed
    ..Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha ..
  55. Gohda J, Akiyama T, Koga T, Takayanagi H, Tanaka S, Inoue J. RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J. 2005;24:790-9 pubmed
    ..These results suggest that RANK may harbor a specific domain that amplifies TRAF6 signaling. ..
  56. Yousefi B, Jingu H, Ohta M, Umezu M, Koibuchi N. Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex. Thyroid. 2005;15:314-9 pubmed
    ..By Western blotting, SRC-1 protein level was greatest at P15, at which time TH action may be obvious. Taken together, the differential expression of SRC-1 may be crucial in mediating TH action during cerebellar development. ..
  57. Kobayashi D, Jindo T, Naruse K, Takeda H. Development of the endoderm and gut in medaka, Oryzias latipes. Dev Growth Differ. 2006;48:283-95 pubmed
    ..Our results therefore describe both molecular and morphological aspects of medaka digestive system development that will be necessary for the characterization of medaka mutants. ..
  58. Ishikawa H, Tachikawa H, Miura Y, Takahashi N. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. FEBS Lett. 2006;580:4784-92 pubmed
    ..These results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling. ..
  59. Yasunaga K, Saigo K, Kojima T. Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. Mech Dev. 2006;123:893-906 pubmed
    ..Our analysis also indicates that, in adults and pupae, the anterior-posterior boundary, dividing roughly equally the outer surface of the distiproboscis, runs along the outer circumference of the inner surface of distiproboscis. ..
  60. Izumi K, Aramaki M, Kimura T, Naito Y, Udaka T, Uchikawa M, et al. Identification of a prosencephalic-specific enhancer of SALL1: comparative genomic approach using the chick embryo. Pediatr Res. 2007;61:660-5 pubmed
    ..This report identifies, for the first time, an enhancer element of SALL1. ..
  61. Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, et al. Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun. 2007;357:383-90 pubmed
    ..Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors. ..
  62. Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, et al. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes. 2008;57:2083-91 pubmed publisher
    ..Our results indicate that the reduction of ROS is a potential therapeutic target of liver insulin resistance, at least partly by the reduced expression of PGC-1alpha. ..
  63. Hirakawa K, Kobayashi S, Inoue T, Endoh Yamagami S, Fukuda R, Ohta A. Yas3p, an Opi1 family transcription factor, regulates cytochrome P450 expression in response to n-alkanes in Yarrowia lipolytica. J Biol Chem. 2009;284:7126-37 pubmed publisher
    ..In contrast, YAS3 deletion did not affect the mRNA level of an INO1 ortholog in Y. lipolytica, indicating functional diversity of Opi1 family transcription factors. ..
  64. Goyama S, Kurokawa M. Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies. Cancer Sci. 2009;100:990-5 pubmed publisher
  65. Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, et al. The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009;76:1360-9 pubmed publisher
    ..Thus, the repressor function of DEC1 and DEC2 may be extended to other RXR heterodimer nuclear receptors. ..
  66. Endo K, Karim M, Taniguchi H, Krejci A, Kinameri E, Siebert M, et al. Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci. 2011;15:224-33 pubmed publisher
    ..Hamlet directs locus-specific modifications of histone methylation and histone density and controls accessibility of the DNA-binding protein Suppressor of Hairless at the Notch target promoter. ..
  67. Tohmonda T, Yoda M, Mizuochi H, Morioka H, Matsumoto M, Urano F, et al. The IRE1?-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis. J Biol Chem. 2013;288:1691-5 pubmed publisher
    ..Thus, the present study reveals potential involvement of the IRE1?-XBP1 pathway in PTH-induced osteoclastogenesis through the regulation of PTH1R expression. ..
  68. Suzuki M, Yamagata K, Shino M, Aikawa Y, Akashi K, Watanabe T, et al. Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia. Cancer Sci. 2014;105:315-23 pubmed publisher
    ..Furthermore, a fusion of AF10 with the minimal NES can immortalize bone-marrow cells and induce leukemia in mice. These results suggest that during leukemogenesis, CALM-AF10 plays its critical roles in the cytoplasm...
  69. Takahashi Y, Kou I, Takahashi A, Johnson T, Kono K, Kawakami N, et al. A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nat Genet. 2011;43:1237-40 pubmed publisher
    ..24 × 10(-19); odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1). The identification of this susceptibility locus provides new insights into the pathogenesis of adolescent idiopathic scoliosis. ..
  70. Tsuji Takechi K, Negishi Koga T, Sumiya E, Kukita A, Kato S, Maeda T, et al. Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development. Proc Natl Acad Sci U S A. 2012;109:2561-6 pubmed publisher
    ..Thus, this study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment. ..
  71. Goseki Sone M, Orimo H, Watanabe A, Hamatani R, Yokozeki M, Ohyama K, et al. Identification of a novel frameshift mutation (383insT) in the RUNX2 (PEBP2 alpha/CBFA1/AML3) gene in a Japanese patient with cleidocranial dysplasia. J Bone Miner Metab. 2001;19:263-6 pubmed
    ..We identified a 1-bp insertion (383insT) at codon 128 of the RUNX2 gene. The 383T insertion affects the conserved residue in the runt domain and results in premature termination in the runt domain...
  72. Hayashi T, Saigo K. Diversification of cell types in the Drosophila eye by differential expression of prepattern genes. Mech Dev. 2001;108:13-27 pubmed
  73. Horikawa K, Takatsu K. Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology. 2006;118:497-508 pubmed
    ..Taken together, preferential Aid and Blimp-1 expression plays a critical role in IL-5-induced immunoglobulin-secreting cell differentiation and micro to gamma 1 CSR in CD38-activated B cells. ..
  74. Kanai Azuma M, Kanai Y, Gad J, Tajima Y, Taya C, Kurohmaru M, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002;129:2367-79 pubmed
    ..Our findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endoderm formation is likely to be conserved among vertebrates. ..
  75. Wang G, Watanabe M, Imai Y, Hara K, Manabe I, Maemura K, et al. Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population. J Hum Genet. 2012;57:727-33 pubmed publisher
    ..In conclusion, polymorphisms on the MRF2/ARID5B gene were associated with susceptibility to T2D as well as adiponectin and other clinical factors, which was in a completely concordant way with their associations with CAD. ..
  76. Yoshida Y, Hosoda E, Nakamura T, Yamamoto T. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. Jpn J Cancer Res. 2001;92:592-6 pubmed
    ..Finally, in situ hybridization experiments revealed that expression of Caf1 overlaps at least in part with that of ANA. Thus, ANA could function through its interaction with Caf1. ..
  77. Toda T, Saito N, Ikarashi N, Ito K, Yamamoto M, Ishige A, et al. Intestinal flora induces the expression of Cyp3a in the mouse liver. Xenobiotica. 2009;39:323-34 pubmed publisher
    ..are known to alter intestinal flora. The present findings suggest that such changes also affect CYP and are one of the factors responsible for individual differences in pharmacokinetics. ..
  78. Takasawa K, Kashimada K, Pelosi E, Takagi M, Morio T, Asahara H, et al. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J. 2014;28:2020-8 pubmed publisher
    ..Our results support the hypothesis that FOXL2 negatively regulates Sf1 expression by antagonizing WT1-KTS during early ovarian development in mice. ..
  79. Tahara S, Kurotani R, Sanno N, Takumi I, Yoshimura S, Osamura R, et al. Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas. Mod Pathol. 2000;13:1097-108 pubmed
    ..The synergistic action with other transcription factors may be speculated to determine the specific production of the anterior pituitary hormones. ..
  80. Niho N, Takahashi M, Kitamura T, Shoji Y, Itoh M, Noda T, et al. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res. 2003;63:6090-5 pubmed
    ..Hyperlipidemia in these mice may thus be associated with their intestinal lesion development. ..
  81. Fujino T, Sato Y, Une M, Kanayasu Toyoda T, Yamaguchi T, Shudo K, et al. In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association. J Steroid Biochem Mol Biol. 2003;87:247-52 pubmed
    ..This method provides a rapid and reliable in vitro ligand assay for FXR. This kinetic analysis-featured technique may be applicable to mechanistic studies. ..
  82. Iwanaga R, Komori H, Ohtani K. Differential regulation of expression of the mammalian DNA repair genes by growth stimulation. Oncogene. 2004;23:8581-90 pubmed
  83. Shishido Hara Y, Higuchi K, Ohara S, Duyckaerts C, Hauw J, Uchihara T. Promyelocytic leukemia nuclear bodies provide a scaffold for human polyomavirus JC replication and are disrupted after development of viral inclusions in progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol. 2008;67:299-308 pubmed publisher
  84. Terada S, Tabata I. Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle. Am J Physiol Endocrinol Metab. 2004;286:E208-16 pubmed
    ..The number of factors involved (both AMPK and Ca2+, or Ca2+ only) in exercise-induced PGC-1alpha expression may differ among muscles. ..
  85. Marui T, Koishi S, Funatogawa I, Yamamoto K, Matsumoto H, Hashimoto O, et al. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. Neurosci Res. 2005;53:91-4 pubmed
    ..No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism. ..
  86. Kabashima A, Higuchi H, Takaishi H, Matsuzaki Y, Suzuki S, Izumiya M, et al. Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion. Int J Cancer. 2009;124:2771-9 pubmed publisher
    ..Because micro-invasion and metastasis are key mechanisms of cancer malignant potential, SP cells would be the attractive target for preventing cancer progression. ..
  87. Okano T, Yamamoto K, Okano K, Hirota T, Kasahara T, Sasaki M, et al. Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation. Genes Cells. 2001;6:825-36 pubmed
    ..The functional characterization of the chicken pineal clock molecules supports the key roles of BMAL1, BMAL2 and CLOCK which contribute to the E-box-dependent transcriptional regulation in the circadian clock system. ..
  88. Horiuchi T, Giniger E, Aigaki T. Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes Dev. 2003;17:2496-501 pubmed
    ..We demonstrate that at least one variable exon is transcribed from its own promoter,and trans-spliced to the constant exons transcribed separately. ..
  89. Hidai C, Ohno M, Kazama H, Ikeda H, Kasanuki H, Kokubun S, et al. Specific regulation of nucleocytoplasmic distribution of poly(C)-binding protein gene mRNA in mouse development. Biochem Biophys Res Commun. 2003;309:339-43 pubmed
    ..These results suggest that the intracellular distribution of alphaCP2 mRNA is developmentally regulated in a gene and/or cell specific manner. ..
  90. Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A. 2009;106:13974-9 pubmed publisher
    ..In contrast, the number of CD4(+)CD25(-)LAG3(+) Tregs is influenced by the presence of environmental microbiota. Thus, IL-10-secreting Egr-2(+)LAG3(+)CD4(+) Tregs can be exploited for the control of peripheral immunity. ..
  91. Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, et al. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013;48:1212-7 pubmed publisher
    ..Our observations provide new insights into the metabolic mechanisms of the retina and the sirtuins' regulatory systems. ..
  92. Fujii T, Abe H, Katsuma S, Shimada T. Identification and characterization of the fusion transcript, composed of the apterous homolog and a putative protein phosphatase gene, generated by 1.5-Mb interstitial deletion in the vestigial (Vg) mutant of Bombyx mori. Insect Biochem Mol Biol. 2011;41:306-12 pubmed publisher
    ..Moreover, an in-frame fusion transcript composed of the 5' part of Bmptp-Z and the 3' part of Bmap-A is generated specific to the Z(Vg) chromosome. Effects of the in-frame fusion transcript on the vestigial phenotype are discussed. ..