Genomes and Genes
Experts and Doctors on spinal cord in Tokyo, Japan
Locale: Tokyo, Japan
Topic: spinal cord
- Seki K, Fetz E. Gating of sensory input at spinal and cortical levels during preparation and execution of voluntary movement. J Neurosci. 2012;32:890-902 pubmed publisher..This suppression could be induced by a top-down gating mechanism to facilitate the preparation and execution of upcoming movement. ..
- Nagata N, Iwasaki T, Ami Y, Tano Y, Harashima A, Suzaki Y, et al. Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation. J Gen Virol. 2004;85:2981-9 pubmed..Thus, intravenous inoculation with EV71 is an excellent model to study the neuropathology of EV71 and to evaluate candidate vaccines and potential antiviral agents. ..
- Iizuka M, Onimaru H, Izumizaki M. Distribution of respiration-related neuronal activity in the thoracic spinal cord of the neonatal rat: An optical imaging study. Neuroscience. 2016;315:217-27 pubmed publisher..These results suggest that the inspiratory interneurons in the thoracic spinal cord play a role in the generation of the rostrocaudal gradient in the inspiratory intercostal muscle activity. ..
- Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, et al. Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. Anesthesiology. 2010;112:418-31 pubmed publisher..These findings indicate that spinally released dynorphin A (1-17) by noxious stimuli leads to the direct activation of ascending pain transmission. ..
- Okuda T, Okamura M, Kaitsuka C, Haga T, Gurwitz D. Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. J Biol Chem. 2002;277:45315-22 pubmed..This polymorphism in the allelic CHT1 gene may represent a predisposing factor for cholinergic dysfunction. ..
- Arita M, Shimizu H, Nagata N, Ami Y, Suzaki Y, Sata T, et al. Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys. J Gen Virol. 2005;86:1391-401 pubmed..These results indicate that EV71 and PV1 share common genetic determinants of neurovirulence in monkeys, despite the distinct properties in their original pathogenesis. ..
- Hiraki K, Park I, Kohyama K, Matsumoto Y. Characterization of CD8-positive macrophages infiltrating the central nervous system of rats with chronic autoimmune encephalomyelitis. J Neurosci Res. 2009;87:1175-84 pubmed publisher..Analysis of CD8+ monocytes/macrophages may provide useful information to permit further dissect the pathomechanisms of multiple sclerosis and to develop effective immunotherapies against autoimmune diseases in the CNS. ..
- Niimi N, Kohyama K, Matsumoto Y. Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases. Neuropathology. 2013;33:612-20 pubmed publisher..Thus, MMP-targeted therapies should be designed after the mechanisms of candidate drugs have been considered. ..
- Tsuruoka M, Hitoto T, Hiruma Y, Matsui Y. Neurochemical evidence for inflammation-induced activation of the coeruleospinal modulation system in the rat. Brain Res. 1999;821:236-40 pubmed..The result suggests that unilateral hindpaw inflammation produces excitation of descending NA-containing neurons from the LC, resulting in an increase of the NA level in the dorsal horn ipsilateral to the site of inflammation. ..
- Jee Y, Kim G, Tanuma N, Matsumoto Y. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol. 2001;114:40-7 pubmed..Taken together, these findings suggest that STAT3 and STAT4 play an important role in the formation of, and recovery from, autoimmune inflammation in the CNS. ..
- Satoh J, Yukitake M, Kurohara K, Takashima H, Kuroda Y. Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis. J Neurol Sci. 2003;212:11-20 pubmed
- Sakitama K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats. Jpn J Pharmacol. 1993;63:369-76 pubmed
- Meng H, Bai R, Sato H, Imagawa M, Sasaki M, Uchino Y. Otolith-activated vestibulothalamic neurons in cats. Exp Brain Res. 2001;141:415-24 pubmed..Only three UT-activated and two SAC-activated neurons sent descending collaterals to the spinal cord. ..
- Sasaki S. Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2011;70:349-59 pubmed publisher..Thus, autophagy seems to be activated and upregulated in the cytoplasm of motor neurons and may be involved in the mechanisms of neurodegeneration of motor neurons in sporadic ALS. ..
- Warabi Y, Matsumoto Y, Hayashi H. Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination. J Neurol Sci. 2007;252:57-61 pubmed..The present study strongly suggests that these patients should be diagnosed as having NMO. ..
- Sakuma H, Kohyama K, Park I, Miyakoshi A, Tanuma N, Matsumoto Y. Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats. Brain. 2004;127:2201-13 pubmed..Further analysis will provide useful information to elucidate the pathogenesis and to develop immunotherapy for neuromyelitis optica and multiple sclerosis. ..
- Mizutani T, Sakamaki S, Tsuchiya N, Kamei S, Kohzu H, Horiuchi R, et al. Amyotrophic lateral sclerosis with ophthalmoplegia and multisystem degeneration in patients on long-term use of respirators. Acta Neuropathol. 1992;84:372-7 pubmed
- Tsuda M, Mizokoshi A, Shigemoto Mogami Y, Koizumi S, Inoue K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. 2004;45:89-95 pubmed..Taken together, our results demonstrate that nerve injury-induced pain hypersensitivity depends on activation of the p38MAPK signaling pathway in hyperactive microglia in the dorsal horn following peripheral nerve injury. ..
- Miura H, Oda K, Endo C, Yamazaki K, Shibasaki H, Kikuchi T. Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy. Neuropathol Appl Neurobiol. 1993;19:41-51 pubmed
- Sasaki S, Warita H, Abe K, Iwata M. Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene. Acta Neuropathol. 2004;107:452-60 pubmed
- Kawahara Y, Ito K, Sun H, Kanazawa I, Kwak S. Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain. Eur J Neurosci. 2003;18:23-33 pubmed..These results suggest that Q/R site of GluRs editing is regulated in a regional, and hence presumably cell-specific, manner and that the GluR2 Q/R site editing is critically regulated by ADAR2 in human brain. ..
- Hayashi M, Araki S, Arai N, Kumada S, Itoh M, Tamagawa K, et al. Oxidative stress and disturbed glutamate transport in spinal muscular atrophy. Brain Dev. 2002;24:770-5 pubmed..These data suggest that oxidative stress and disturbed glutamate transport can partly be involved in the motor neuron devastation and/or latent thalamic degeneration in SMA type 1. ..
- Onimaru H, Kumagawa Y, Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J Neurophysiol. 2006;96:55-61 pubmed..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations. ..
- Nakamura M, Tsuji O, Bregman B, Toyama Y, Okano H. Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells. PLoS ONE. 2011;6:e20717 pubmed publisher..These findings suggest that endogenous CNTF and exogenous BDNF and NT-3 play roles in the differentiation of embryonic spinal cord derived progenitor cells into astrocytes, neurons and oligodendrocytes, respectively. ..
- Ichihara N, Wu J, Chui D, Yamazaki K, Wakabayashi T, Kikuchi T. Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse. Brain Res. 1995;695:173-8 pubmed
- Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, et al. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. Ann Neurol. 2012;72:739-49 pubmed publisher..MS785 is the first molecular mechanism-based antibody that was shown to be able to distinguish ALS-linked toxic SOD1 mutants from both wild-type and nontoxic mutants. MS785 may thus become an innovative tool for the diagnosis of ALS. ..
- Ito D, Fujisawa T, Iida H, Suzuki N. Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. Neurobiol Dis. 2008;31:266-77 pubmed publisher..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases. ..
- Suzuki H, Kanekura K, Levine T, Kohno K, Olkkonen V, Aiso S, et al. ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. J Neurochem. 2009;108:973-985 pubmed publisher..These results lead us to hypothesize that the total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis. ..
- Sengoku R, Saito Y, Ikemura M, Hatsuta H, Sakiyama Y, Kanemaru K, et al. Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J Neuropathol Exp Neurol. 2008;67:1072-83 pubmed publisher..These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease. ..
- Mishima T, Hamada T, Ui Tei K, Takahashi F, Miyata Y, Imaki J, et al. Expression of DDAH1 in chick and rat embryos. Brain Res Dev Brain Res. 2004;148:223-32 pubmed..The DDAH1 expression patterns were completely different from nNOS expression patterns. Our study suggests that DDAH1 plays an important role in development. ..
- Ikeda K, Iwasaki Y, Tagaya N, Shiojima T, Kinoshita M. Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor on wobbler murine motor neuron disease. Muscle Nerve. 1995;18:1344-7 pubmed
- Sakitama K, Ozawa Y, Aoto N, Tomita H, Ishikawa M. Effects of a new centrally acting muscle relaxant, NK433 (lanperisone hydrochloride) on spinal reflexes. Eur J Pharmacol. 1997;337:175-87 pubmed..LPS-9 could contribute to the potent activity of NK433 after oral administration. ..
- Misawa H, Nakata K, Toda K, Matsuura J, Oda Y, Inoue H, et al. VAChT-Cre. Fast and VAChT-Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset. Genesis. 2003;37:44-50 pubmed..The use of VAChT-Cre mice should allow us to deliver Cre to a subset of postnatal motor neurons, thereby bypassing lethality and facilitating analysis of gene function in adult motor neurons. ..
- Hideyama T, Yamashita T, Aizawa H, Tsuji S, Kakita A, Takahashi H, et al. Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons. Neurobiol Dis. 2012;45:1121-8 pubmed publisher..These results indicate that ADAR2 downregulation is a profound pathological change relevant to death of motor neurons in ALS. ..
- Nomura Kitabayashi A, Takahashi Y, Kitajima S, Inoue T, Takeda H, Saga Y. Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Development. 2002;129:2473-81 pubmed..These results suggest that the Mesp family of transcription factors is involved in both segment border formation and establishment of RC polarity through different genetic cascades. ..
- Narita M, Usui A, Narita M, Niikura K, Nozaki H, Khotib J, et al. Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. J Neurosci. 2005;25:10000-9 pubmed..These data provide novel evidence that PAR-1 and PDGF-A-mediated signaling pathway within spinal cord neurons may be directly implicated in neuropathic pain after nerve injury in mice. ..
- Yamazaki K, Moriya H, Ichihara N, Mitsushio H, Inagaki S, Kikuchi T. Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouse. Mol Chem Neuropathol. 1993;20:1-20 pubmed
- Tsuruoka M, Wang D, Tamaki J, Inoue T. Descending influence from the nucleus locus coeruleus/subcoeruleus on visceral nociceptive transmission in the rat spinal cord. Neuroscience. 2010;165:1019-24 pubmed publisher..Considering a role of muscular defense, the presence of the LC/SC-unaffected neurons may be advantageous for the individual under an abnormal pain state, such as inflammation. ..
- Katayama Y, Yamamoto T, Kobayashi K, Kasai M, Oshima H, Fukaya C. Motor cortex stimulation for phantom limb pain: comprehensive therapy with spinal cord and thalamic stimulation. Stereotact Funct Neurosurg. 2001;77:159-62 pubmed..One patient of them reported better pain control by MCS than by DBS, whereas two reported the opposite results. There is no evidence at present for an advantage of MCS over SCS and DBS of the VC in controlling phantom limb pain...
- Sasaki S, Warita H, Komori T, Murakami T, Abe K, Iwata M. Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 2006;1083:196-203 pubmed
- Guan J, Wang Q, Shioda S. Immunoelectron microscopic examination of orexin-like immunoreactive fibers in the dorsal horn of the rat spinal cord. Brain Res. 2003;987:86-92 pubmed
- Mukaino M, Nakamura M, Yamada O, Okada S, Morikawa S, Renault Mihara F, et al. Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. Exp Neurol. 2010;224:403-14 pubmed publisher..Our findings indicate that the functional improvement elicited by MR16-1 involves microglial functions, and provide new insights into the role of IL-6 signaling in the pathology of SCI. ..
- Makino A, Sakai A, Ito H, Suzuki H. Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice. J Nippon Med Sch. 2012;79:129-38 pubmed..These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in CAIA. ..
- Kimura N. Fictive lung ventilation in the isolated brainstem preparation of the aquatic frog, Xenopus laevis. Adv Exp Med Biol. 2010;669:9-12 pubmed publisher..These results suggest that Xenopus is capable of oscillating buccal rhythm within the brainstem. ..
- Fujii K, Nagata N, Sato Y, Ong K, Wong K, Yamayoshi S, et al. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci U S A. 2013;110:14753-8 pubmed publisher..These results suggest that this Tg mouse could represent a useful animal model for the study of EV71 infection. ..
- Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, et al. Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J Neurosci Res. 2010;88:2736-46 pubmed publisher..These results suggest that the activated and aggregated microglia represent phagocytic features in response to early changes in motoneurons and possibly play an important role in ALS disease progression during the presymptomatic stage. ..
- Suzuki H, Ahuja C, Salewski R, Li L, Satkunendrarajah K, Nagoshi N, et al. Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury. PLoS ONE. 2017;12:e0182339 pubmed publisher..This represents important proof-of-concept data that the chronically injured spinal cord can be 'unlocked' by ChABC pretreatment to produce a microenvironment conducive to regenerative iPS-NSC therapy. ..
- Hattori T, Takei N, Mizuno Y, Kato K, Kohsaka S. Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain. Neurosci Res. 1995;21:191-8 pubmed..The existence of specific binding of NSE to cultured neurons suggests the possibility that receptor-like or carrier-like molecules on the neuronal surface are involved in the neurotrophic activity of NSE. ..
- Yato Y, Fujimura Y, Nakamura M, Watanabe M, Yabe Y. Decreased choline acetyltransferase activity in the murine spinal cord motoneurons under chronic mechanical compression. Spinal Cord. 1997;35:729-34 pubmed..Thus, our findings indicate that an occupation rate of about 20% may be the critical level for functional changes in the spinal motoneurons. ..
- Katayama Y, Yamamoto T, Kobayashi K, Kasai M, Oshima H, Fukaya C. Motor cortex stimulation for post-stroke pain: comparison of spinal cord and thalamic stimulation. Stereotact Funct Neurosurg. 2001;77:183-6 pubmed..This may be one of the reasons why satisfactory pain control was obtained more frequently as the stimulation site was moved to higher levels...
- Nasu Tada K, Koizumi S, Tsuda M, Kunifusa E, Inoue K. Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Glia. 2006;53:769-75 pubmed..Taken together, our results suggest that spinal fibronectin is elevated after the peripheral nerve injury and it may be involved in the upregulation of the P2X4 receptor in microglia, which leads to the induction of neuropathic pain. ..
- Aoyama R, Okada Y, Yokota S, Yasui Y, Fukuda K, Shinozaki Y, et al. Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn. Pain. 2011;152:2085-97 pubmed publisher..Astrocytes are involved in sensitization of sensory network activity more importantly in the superficial than in the deep layer. ..
- Iida A, Takahashi A, Kubo M, Saito S, Hosono N, Ohnishi Y, et al. A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Hum Mol Genet. 2011;20:3684-92 pubmed publisher..Our results strongly suggest that ZNF512B is an important positive regulator of TGF-? signaling and that decreased ZNF512B expression increases susceptibility to ALS. ..
- Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, et al. PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain. J Dent Res. 2011;90:777-81 pubmed publisher..Taken together, these findings suggest that PKC? expression in the Vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury...
- Kuwana S, Okada Y, Sugawara Y, Tsunekawa N, Obata K. Disturbance of neural respiratory control in neonatal mice lacking GABA synthesizing enzyme 67-kDa isoform of glutamic acid decarboxylase. Neuroscience. 2003;120:861-70 pubmed..We suggest that GABAergic transmission is not essential for basic respiratory rhythm generation but plays an important role in the maintenance of regular respiratory rhythm and normal inspiratory pattern in neonatal mice. ..
- Qi M, Wakabayashi Y, Enomoto M, Shinomiya K. Changes in neurocan expression in the distal spinal cord stump following complete cord transection: a comparison between infant and adult rats. Neurosci Res. 2003;45:181-8 pubmed..Combined with the different regenerative capacity of infant and adult rats, the present results suggest that neurocan inhibits spinal cord regeneration. ..
- Liu M, Matsuura S, Shinoda M, Honda K, Suzuki I, Shibuta K, et al. Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 2012;9:258 pubmed publisher..This tongue-inflamed model might be useful for future studies to further elucidate molecular and cellular mechanisms of pathological tongue pain such as burning mouth syndrome. ..
- Yajima Y, Narita M, Narita M, Matsumoto N, Suzuki T. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Brain Res. 2002;958:338-46 pubmed..These findings suggest the possibility that the binding of BDNF to full-length TrkB and subsequent its activation may play a critical role in the development of neuropathic pain-like thermal hyperalgesia induced by nerve injury in mice. ..
- Narita M, Miyoshi K, Narita M, Suzuki T. Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Neurosci Lett. 2007;414:21-5 pubmed..These findings support the idea that the activation and hypertrophy of microglia in the spinal cord may be, at least in part, associated with in the induction of ethanol-dependent neuropathic pain-like state...
- Tokuda E, Okawa E, Ono S. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. J Neurochem. 2009;111:181-91 pubmed publisher..These results indicate that the nature of mutant SOD1 toxicity might involve the dysregulation of the copper trafficking pathway, resulting in the disruption of intracellular copper homeostasis. ..
- Matsumura T, Sakai A, Nagano M, Sawada M, Umino M, Suzuki H. Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state. Br J Pharmacol. 2008;155:767-74 pubmed publisher..The present results suggest that HK-1 expression is increased at least partly in activated microglial cells after nerve injury and is clearly involved in the early phase of neuropathic pain. ..
- Ogura T, Yokoyama T, Fujisawa H, Kurashima Y, Esumi H. Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system. Biochem Biophys Res Commun. 1993;193:1014-22 pubmed..Generation of diversity of n-NOS is probably related to diversity of its biological functions. ..
- Hamada T, Ui Tei K, Miyata Y. A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. FEBS Lett. 2000;475:97-102 pubmed..Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord. ..
- Takei T, Seki K. Spinal premotor interneurons mediate dynamic and static motor commands for precision grip in monkeys. J Neurosci. 2013;33:8850-60 pubmed publisher..05), suggesting that they contributed to force maintenance. These results indicated that the neural pathway mediated by the spinal PreM-INs makes a significant contribution to the control of precision grip in primates. ..
- Tsuda M, Shigemoto Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter M, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424:778-83 pubmed..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury. ..
- Qi M, Wakabayashi Y, Haro H, Shinomiya K. Changes in FGF-2 expression in the distal spinal cord stump after complete cord transection: a comparison between infant and adult rats. Spine (Phila Pa 1976). 2003;28:1934-40 pubmed..After complete spinal cord transection, the expression of FGF-2 in the distal cord of infant rats was high compared with that of adults. This may provide neurotrophic support for axonal extension and functional recovery. ..
- Cacabelos D, Ayala V, Granado Serrano A, JovÃ© M, Torres P, Boada J, et al. Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis. 2016;88:148-60 pubmed publisher..Later on, this allostatic overload could exacerbate cell stress by contributing to TDP-43 aggregation. This, at its turn, could blunt this protective response, overall leading to DHA depletion and neuronal dysfunction. ..
- Fujikawa A, Tsuchiya K, Takeuchi S, Hachiya J. Diffusion-weighted MR imaging in acute spinal cord ischemia. Eur Radiol. 2004;14:2076-8 pubmed..DW imaging of the spinal cord can contribute to the early detection of spinal cord vascular compromise...
- Onimaru H, Homma I. Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol (1985). 2006;100:2094-5 pubmed
- Nakamura Y, Otake K, Tokuno H. The parafascicular nucleus relays spinal inputs to the striatum: an electron microscope study in the rat. Neurosci Res. 2006;56:73-9 pubmed..We concluded that information from the spinal cord was transmitted to the striatum, being relayed by parafascicular nucleus neurons. ..
- Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, et al. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med. 2006;12:1380-9 pubmed..Thus, Sema3A is essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury (SCI). These results support the possibility of using Sema3A inhibitors in the treatment of human SCI. ..
- Guan J, Wang Q, Hori T, Takenoya F, Kageyama H, Shioda S. Ultrastructure of orexin-1 receptor immunoreactivities in the spinal cord dorsal horn. Peptides. 2004;25:1307-11 pubmed
- Kato T, Haro H, Komori H, Shinomiya K. Evaluation of hyaluronic acid sheet for the prevention of postlaminectomy adhesions. Spine J. 2005;5:479-88 pubmed..In an experimental laminectomy model, HA sheet formed a solid interpositional membrane barrier and exhibited anti-inflammatory activity. Further investigations will be needed for HA sheet to be used clinically. ..
- Shimizu K, Nakamura M, Nishikawa Y, Hijikata S, Chiba K, Toyama Y. Spinal kyphosis causes demyelination and neuronal loss in the spinal cord: a new model of kyphotic deformity using juvenile Japanese small game fowls. Spine (Phila Pa 1976). 2005;30:2388-92 pubmed..Histologic changes in the spinal cord caused by progressive spinal kyphosis were assessed using a new animal model...
- Kitagawa J, Tsuboi Y, Ogawa A, Ren K, Hitomi S, Saitoh K, et al. Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats. J Neurophysiol. 2005;94:4178-87 pubmed..The present findings suggest that the hyperexcitability of GN neurons could be involved in abnormal noxious pain sensations with advancing age. ..
- Nomura H, Sakai A, Nagano M, Umino M, Suzuki H. Expression changes of cation chloride cotransporters in the rat spinal cord following intraplantar formalin. Neurosci Res. 2006;56:435-40 pubmed..These results suggest that KCC2, rather than NKCC1, mainly contributes to modulating excitability of the dorsal spinal cord neurons in the initial stage of formalin-evoked hyperalgesia. ..
- Ishiura H, Morikawa M, Hamada M, Watanabe T, Kako S, Chiba S, et al. Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone. Arch Neurol. 2008;65:662-5 pubmed publisher..Because central nervous system (CNS) involvement of LYG has been known to show poor prognosis, the establishment of an effective treatment for CNS LYG with mild adverse effects is desired...
- Kihara Y, Yanagida K, Masago K, Kita Y, Hishikawa D, Shindou H, et al. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. J Immunol. 2008;181:5008-14 pubmed..These data suggest that PAF accumulation in the SC of EAE mice is profoundly dependent on the group IVA cytosolic PLA(2)/LysoPAFAT axis present in the infiltrating macrophages and activated microglia. ..
- Yoshii Y, Otomo A, Pan L, Ohtsuka M, Hadano S. Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS. Neurosci Res. 2011;70:321-9 pubmed publisher..Our findings in a mouse model of ALS may have implication that GFAP is not necessary for the initiation of disease, but it rather plays some modulatory roles in the progression of ALS/MND. ..
- Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, et al. Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. J Neurochem. 2005;94:1297-305 pubmed
- Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, et al. Molecular analysis and biochemical classification of TDP-43 proteinopathy. Brain. 2012;135:3380-91 pubmed publisher..These results suggest a new clinicopathological classification of TAR DNA-binding protein 43 proteinopathies based on their molecular properties. ..
- Oyanagi K, Yamazaki M, Takahashi H, Watabe K, Wada M, Komori T, et al. Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum. Neuropathol Appl Neurobiol. 2008;34:650-8 pubmed publisher..In relation to these features, although the possibility of ER stress has been reported in motor neurones of the brainstem and spinal cord of ALS patients, the rER itself has not been a main target of ultrastructural investigation...