Experts and Doctors on spinal cord in Tokyo, Japan


Locale: Tokyo, Japan
Topic: spinal cord

Top Publications

  1. Momose Sato Y, Honda Y, Sasaki H, Sato K. Optical imaging of large-scale correlated wave activity in the developing rat CNS. J Neurophysiol. 2005;94:1606-22 pubmed
    ..These characteristics of the wave activity are similar to those of the depolarization wave reported in the chick embryo, suggesting that the large-scale depolarization wave is globally generated across different species. ..
  2. Urase K, Soyama A, Fujita E, Momoi T. Expression of RA175 mRNA, a new member of the immunoglobulin superfamily, in developing mouse brain. Neuroreport. 2001;12:3217-21 pubmed
    ..5 and in the central nervous system at E14.5-E18.5, but its expression decreased after birth and was undetectable in the adult mouse brain. ..
  3. Xie L, Li X, Funeshima Fuji N, Kimura H, Matsumoto Y, Isaka Y, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol. 2009;9:575-81 pubmed publisher
  4. Takei T, Seki K. Spinal interneurons facilitate coactivation of hand muscles during a precision grip task in monkeys. J Neurosci. 2010;30:17041-50 pubmed publisher
    ..These results suggest that spinal interneurons contribute to the control of hand grasping in primates by combining and coordinating multiple finger muscles. ..
  5. Iseki M, Morita Y, Nakamura Y, Ifuku M, Komatsu S. Efficacy of limited-duration spinal cord stimulation for subacute postherpetic neuralgia. Ann Acad Med Singapore. 2009;38:1004-6 pubmed
    ..The authors believe that limited-duration SCS for subacute postherpetic neuralgia is a useful treatment approach that may prevent the pain from progressing to chronic postherpetic neuralgia. ..
  6. Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, et al. Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain. 2013;136:828-43 pubmed publisher
  7. Hayata T, Uochi T, Asashima M. Molecular cloning of XNLRR-1, a Xenopus homolog of mouse neuronal leucine-rich repeat protein expressed in the developing Xenopus nervous system. Gene. 1998;221:159-66 pubmed
    ..The similarity of the XNLRR-1 gene to other known cell adhesion molecules, together with the expression pattern, suggests that XNLRR-1 is involved in interactions at the neuronal cell surface. ..
  8. Sakuma H, Kohyama K, Jee Y, Matsumoto Y. Tracking of V beta 8.2-positive encephalitogenic T cells by complementarity-determining region 3 spectratyping and subsequent Southern blot hybridization in Lewis rats after neuroantigen sensitization. J Immunol. 2004;173:4516-22 pubmed
    ..Analysis of pathogenic T cells at the clonal level provides useful information for designing effective immunotherapy. ..
  9. Inui K, Mitsumori K, Harada T, Maita K. Quantitative analysis of neuronal damage induced by tri-ortho-cresyl phosphate in Wistar rats. Fundam Appl Toxicol. 1993;20:111-9 pubmed
    ..Morphometric examinations on semi-thin sections and frozen sections stained with Nauta's method were demonstrated to be useful for objective evaluation of OPIDN in the rat. ..

More Information


  1. Seki K, Fetz E. Gating of sensory input at spinal and cortical levels during preparation and execution of voluntary movement. J Neurosci. 2012;32:890-902 pubmed publisher
    ..This suppression could be induced by a top-down gating mechanism to facilitate the preparation and execution of upcoming movement. ..
  2. Nagata N, Iwasaki T, Ami Y, Tano Y, Harashima A, Suzaki Y, et al. Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation. J Gen Virol. 2004;85:2981-9 pubmed
    ..Thus, intravenous inoculation with EV71 is an excellent model to study the neuropathology of EV71 and to evaluate candidate vaccines and potential antiviral agents. ..
  3. Iizuka M, Onimaru H, Izumizaki M. Distribution of respiration-related neuronal activity in the thoracic spinal cord of the neonatal rat: An optical imaging study. Neuroscience. 2016;315:217-27 pubmed publisher
    ..These results suggest that the inspiratory interneurons in the thoracic spinal cord play a role in the generation of the rostrocaudal gradient in the inspiratory intercostal muscle activity. ..
  4. Ito Y, Shibata N, Saito K, Kobayashi M, Osawa M. New insights into the pathogenesis of spinal muscular atrophy. Brain Dev. 2011;33:321-31 pubmed publisher
  5. Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, et al. Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. Anesthesiology. 2010;112:418-31 pubmed publisher
    ..These findings indicate that spinally released dynorphin A (1-17) by noxious stimuli leads to the direct activation of ascending pain transmission. ..
  6. Okuda T, Okamura M, Kaitsuka C, Haga T, Gurwitz D. Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. J Biol Chem. 2002;277:45315-22 pubmed
    ..This polymorphism in the allelic CHT1 gene may represent a predisposing factor for cholinergic dysfunction. ..
  7. Arita M, Shimizu H, Nagata N, Ami Y, Suzaki Y, Sata T, et al. Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys. J Gen Virol. 2005;86:1391-401 pubmed
    ..These results indicate that EV71 and PV1 share common genetic determinants of neurovirulence in monkeys, despite the distinct properties in their original pathogenesis. ..
  8. Hiraki K, Park I, Kohyama K, Matsumoto Y. Characterization of CD8-positive macrophages infiltrating the central nervous system of rats with chronic autoimmune encephalomyelitis. J Neurosci Res. 2009;87:1175-84 pubmed publisher
    ..Analysis of CD8+ monocytes/macrophages may provide useful information to permit further dissect the pathomechanisms of multiple sclerosis and to develop effective immunotherapies against autoimmune diseases in the CNS. ..
  9. Niimi N, Kohyama K, Matsumoto Y. Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases. Neuropathology. 2013;33:612-20 pubmed publisher
    ..Thus, MMP-targeted therapies should be designed after the mechanisms of candidate drugs have been considered. ..
  10. Tsuruoka M, Hitoto T, Hiruma Y, Matsui Y. Neurochemical evidence for inflammation-induced activation of the coeruleospinal modulation system in the rat. Brain Res. 1999;821:236-40 pubmed
    ..The result suggests that unilateral hindpaw inflammation produces excitation of descending NA-containing neurons from the LC, resulting in an increase of the NA level in the dorsal horn ipsilateral to the site of inflammation. ..
  11. Jee Y, Kim G, Tanuma N, Matsumoto Y. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol. 2001;114:40-7 pubmed
    ..Taken together, these findings suggest that STAT3 and STAT4 play an important role in the formation of, and recovery from, autoimmune inflammation in the CNS. ..
  12. Satoh J, Yukitake M, Kurohara K, Takashima H, Kuroda Y. Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis. J Neurol Sci. 2003;212:11-20 pubmed
  13. Sakitama K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats. Jpn J Pharmacol. 1993;63:369-76 pubmed
  14. Meng H, Bai R, Sato H, Imagawa M, Sasaki M, Uchino Y. Otolith-activated vestibulothalamic neurons in cats. Exp Brain Res. 2001;141:415-24 pubmed
    ..Only three UT-activated and two SAC-activated neurons sent descending collaterals to the spinal cord. ..
  15. Sasaki S. Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2011;70:349-59 pubmed publisher
    ..Thus, autophagy seems to be activated and upregulated in the cytoplasm of motor neurons and may be involved in the mechanisms of neurodegeneration of motor neurons in sporadic ALS. ..
  16. Warabi Y, Matsumoto Y, Hayashi H. Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination. J Neurol Sci. 2007;252:57-61 pubmed
    ..The present study strongly suggests that these patients should be diagnosed as having NMO. ..
  17. Sakuma H, Kohyama K, Park I, Miyakoshi A, Tanuma N, Matsumoto Y. Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats. Brain. 2004;127:2201-13 pubmed
    ..Further analysis will provide useful information to elucidate the pathogenesis and to develop immunotherapy for neuromyelitis optica and multiple sclerosis. ..
  18. Mizutani T, Sakamaki S, Tsuchiya N, Kamei S, Kohzu H, Horiuchi R, et al. Amyotrophic lateral sclerosis with ophthalmoplegia and multisystem degeneration in patients on long-term use of respirators. Acta Neuropathol. 1992;84:372-7 pubmed
  19. Tsuda M, Mizokoshi A, Shigemoto Mogami Y, Koizumi S, Inoue K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. 2004;45:89-95 pubmed
    ..Taken together, our results demonstrate that nerve injury-induced pain hypersensitivity depends on activation of the p38MAPK signaling pathway in hyperactive microglia in the dorsal horn following peripheral nerve injury. ..
  20. Shibuta K, Suzuki I, Shinoda M, Tsuboi Y, Honda K, Shimizu N, et al. Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain. Brain Res. 2012;1451:74-86 pubmed publisher
  21. Miura H, Oda K, Endo C, Yamazaki K, Shibasaki H, Kikuchi T. Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy. Neuropathol Appl Neurobiol. 1993;19:41-51 pubmed
  22. Sasaki S, Warita H, Abe K, Iwata M. Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene. Acta Neuropathol. 2004;107:452-60 pubmed
  23. Kawahara Y, Ito K, Sun H, Kanazawa I, Kwak S. Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain. Eur J Neurosci. 2003;18:23-33 pubmed
    ..These results suggest that Q/R site of GluRs editing is regulated in a regional, and hence presumably cell-specific, manner and that the GluR2 Q/R site editing is critically regulated by ADAR2 in human brain. ..
  24. Hayashi M, Araki S, Arai N, Kumada S, Itoh M, Tamagawa K, et al. Oxidative stress and disturbed glutamate transport in spinal muscular atrophy. Brain Dev. 2002;24:770-5 pubmed
    ..These data suggest that oxidative stress and disturbed glutamate transport can partly be involved in the motor neuron devastation and/or latent thalamic degeneration in SMA type 1. ..
  25. Onimaru H, Kumagawa Y, Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J Neurophysiol. 2006;96:55-61 pubmed
    ..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations. ..
  26. Nakamura M, Tsuji O, Bregman B, Toyama Y, Okano H. Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells. PLoS ONE. 2011;6:e20717 pubmed publisher
    ..These findings suggest that endogenous CNTF and exogenous BDNF and NT-3 play roles in the differentiation of embryonic spinal cord derived progenitor cells into astrocytes, neurons and oligodendrocytes, respectively. ..
  27. Ichihara N, Wu J, Chui D, Yamazaki K, Wakabayashi T, Kikuchi T. Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse. Brain Res. 1995;695:173-8 pubmed
  28. Sasaki S. Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2010;69:346-55 pubmed publisher
  29. Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, et al. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. Ann Neurol. 2012;72:739-49 pubmed publisher
    ..MS785 is the first molecular mechanism-based antibody that was shown to be able to distinguish ALS-linked toxic SOD1 mutants from both wild-type and nontoxic mutants. MS785 may thus become an innovative tool for the diagnosis of ALS. ..
  30. Ohno T, Maeda H, Murabe N, Kamiyama T, Yoshioka N, Mishina M, et al. Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses. Proc Natl Acad Sci U S A. 2010;107:15252-7 pubmed publisher
  31. Ito D, Fujisawa T, Iida H, Suzuki N. Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. Neurobiol Dis. 2008;31:266-77 pubmed publisher
    ..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases. ..
  32. Suzuki H, Kanekura K, Levine T, Kohno K, Olkkonen V, Aiso S, et al. ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. J Neurochem. 2009;108:973-985 pubmed publisher
    ..These results lead us to hypothesize that the total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis. ..
  33. Sengoku R, Saito Y, Ikemura M, Hatsuta H, Sakiyama Y, Kanemaru K, et al. Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J Neuropathol Exp Neurol. 2008;67:1072-83 pubmed publisher
    ..These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease. ..
  34. Mishima T, Hamada T, Ui Tei K, Takahashi F, Miyata Y, Imaki J, et al. Expression of DDAH1 in chick and rat embryos. Brain Res Dev Brain Res. 2004;148:223-32 pubmed
    ..The DDAH1 expression patterns were completely different from nNOS expression patterns. Our study suggests that DDAH1 plays an important role in development. ..
  35. Ikeda K, Iwasaki Y, Tagaya N, Shiojima T, Kinoshita M. Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor on wobbler murine motor neuron disease. Muscle Nerve. 1995;18:1344-7 pubmed
  36. Sakitama K, Ozawa Y, Aoto N, Tomita H, Ishikawa M. Effects of a new centrally acting muscle relaxant, NK433 (lanperisone hydrochloride) on spinal reflexes. Eur J Pharmacol. 1997;337:175-87 pubmed
    ..LPS-9 could contribute to the potent activity of NK433 after oral administration. ..
  37. Misawa H, Nakata K, Toda K, Matsuura J, Oda Y, Inoue H, et al. VAChT-Cre. Fast and VAChT-Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset. Genesis. 2003;37:44-50 pubmed
    ..The use of VAChT-Cre mice should allow us to deliver Cre to a subset of postnatal motor neurons, thereby bypassing lethality and facilitating analysis of gene function in adult motor neurons. ..
  38. Hideyama T, Yamashita T, Aizawa H, Tsuji S, Kakita A, Takahashi H, et al. Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons. Neurobiol Dis. 2012;45:1121-8 pubmed publisher
    ..These results indicate that ADAR2 downregulation is a profound pathological change relevant to death of motor neurons in ALS. ..
  39. Nomura Kitabayashi A, Takahashi Y, Kitajima S, Inoue T, Takeda H, Saga Y. Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Development. 2002;129:2473-81 pubmed
    ..These results suggest that the Mesp family of transcription factors is involved in both segment border formation and establishment of RC polarity through different genetic cascades. ..
  40. Shibata N, Kakita A, Takahashi H, Ihara Y, Nobukuni K, Fujimura H, et al. Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis. Acta Neuropathol. 2010;119:345-54 pubmed publisher
  41. Narita M, Usui A, Narita M, Niikura K, Nozaki H, Khotib J, et al. Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. J Neurosci. 2005;25:10000-9 pubmed
    ..These data provide novel evidence that PAR-1 and PDGF-A-mediated signaling pathway within spinal cord neurons may be directly implicated in neuropathic pain after nerve injury in mice. ..
  42. Yamazaki K, Moriya H, Ichihara N, Mitsushio H, Inagaki S, Kikuchi T. Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouse. Mol Chem Neuropathol. 1993;20:1-20 pubmed
  43. Sasaki S, Aoki M, Nagai M, Kobayashi M, Itoyama Y. Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene. J Neuropathol Exp Neurol. 2009;68:365-73 pubmed publisher
  44. Tsuruoka M, Wang D, Tamaki J, Inoue T. Descending influence from the nucleus locus coeruleus/subcoeruleus on visceral nociceptive transmission in the rat spinal cord. Neuroscience. 2010;165:1019-24 pubmed publisher
    ..Considering a role of muscular defense, the presence of the LC/SC-unaffected neurons may be advantageous for the individual under an abnormal pain state, such as inflammation. ..
  45. Katayama Y, Yamamoto T, Kobayashi K, Kasai M, Oshima H, Fukaya C. Motor cortex stimulation for phantom limb pain: comprehensive therapy with spinal cord and thalamic stimulation. Stereotact Funct Neurosurg. 2001;77:159-62 pubmed
    ..One patient of them reported better pain control by MCS than by DBS, whereas two reported the opposite results. There is no evidence at present for an advantage of MCS over SCS and DBS of the VC in controlling phantom limb pain...
  46. Sasaki S, Warita H, Komori T, Murakami T, Abe K, Iwata M. Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 2006;1083:196-203 pubmed
  47. Guan J, Wang Q, Shioda S. Immunoelectron microscopic examination of orexin-like immunoreactive fibers in the dorsal horn of the rat spinal cord. Brain Res. 2003;987:86-92 pubmed
  48. Mukaino M, Nakamura M, Yamada O, Okada S, Morikawa S, Renault Mihara F, et al. Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. Exp Neurol. 2010;224:403-14 pubmed publisher
    ..Our findings indicate that the functional improvement elicited by MR16-1 involves microglial functions, and provide new insights into the role of IL-6 signaling in the pathology of SCI. ..
  49. Makino A, Sakai A, Ito H, Suzuki H. Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice. J Nippon Med Sch. 2012;79:129-38 pubmed
    ..These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in CAIA. ..
  50. Kimura N. Fictive lung ventilation in the isolated brainstem preparation of the aquatic frog, Xenopus laevis. Adv Exp Med Biol. 2010;669:9-12 pubmed publisher
    ..These results suggest that Xenopus is capable of oscillating buccal rhythm within the brainstem. ..
  51. Obata H, Sekiguchi H, Nakazawa K, Ohtsuki T. Enhanced excitability of the corticospinal pathway of the ankle extensor and flexor muscles during standing in humans. Exp Brain Res. 2009;197:207-13 pubmed publisher
  52. Fujii K, Nagata N, Sato Y, Ong K, Wong K, Yamayoshi S, et al. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci U S A. 2013;110:14753-8 pubmed publisher
    ..These results suggest that this Tg mouse could represent a useful animal model for the study of EV71 infection. ..
  53. Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, et al. Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J Neurosci Res. 2010;88:2736-46 pubmed publisher
    ..These results suggest that the activated and aggregated microglia represent phagocytic features in response to early changes in motoneurons and possibly play an important role in ALS disease progression during the presymptomatic stage. ..
  54. Suzuki H, Ahuja C, Salewski R, Li L, Satkunendrarajah K, Nagoshi N, et al. Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury. PLoS ONE. 2017;12:e0182339 pubmed publisher
    ..This represents important proof-of-concept data that the chronically injured spinal cord can be 'unlocked' by ChABC pretreatment to produce a microenvironment conducive to regenerative iPS-NSC therapy. ..
  55. Hattori T, Takei N, Mizuno Y, Kato K, Kohsaka S. Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain. Neurosci Res. 1995;21:191-8 pubmed
    ..The existence of specific binding of NSE to cultured neurons suggests the possibility that receptor-like or carrier-like molecules on the neuronal surface are involved in the neurotrophic activity of NSE. ..
  56. Noma N, Tsuboi Y, Kondo M, Matsumoto M, Sessle B, Kitagawa J, et al. Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats. J Comp Neurol. 2008;507:1428-40 pubmed publisher
  57. Yato Y, Fujimura Y, Nakamura M, Watanabe M, Yabe Y. Decreased choline acetyltransferase activity in the murine spinal cord motoneurons under chronic mechanical compression. Spinal Cord. 1997;35:729-34 pubmed
    ..Thus, our findings indicate that an occupation rate of about 20% may be the critical level for functional changes in the spinal motoneurons. ..
  58. Katayama Y, Yamamoto T, Kobayashi K, Kasai M, Oshima H, Fukaya C. Motor cortex stimulation for post-stroke pain: comparison of spinal cord and thalamic stimulation. Stereotact Funct Neurosurg. 2001;77:183-6 pubmed
    ..This may be one of the reasons why satisfactory pain control was obtained more frequently as the stimulation site was moved to higher levels...
  59. Nasu Tada K, Koizumi S, Tsuda M, Kunifusa E, Inoue K. Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Glia. 2006;53:769-75 pubmed
    ..Taken together, our results suggest that spinal fibronectin is elevated after the peripheral nerve injury and it may be involved in the upregulation of the P2X4 receptor in microglia, which leads to the induction of neuropathic pain. ..
  60. Aoyama R, Okada Y, Yokota S, Yasui Y, Fukuda K, Shinozaki Y, et al. Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn. Pain. 2011;152:2085-97 pubmed publisher
    ..Astrocytes are involved in sensitization of sensory network activity more importantly in the superficial than in the deep layer. ..
  61. Iida A, Takahashi A, Kubo M, Saito S, Hosono N, Ohnishi Y, et al. A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Hum Mol Genet. 2011;20:3684-92 pubmed publisher
    ..Our results strongly suggest that ZNF512B is an important positive regulator of TGF-? signaling and that decreased ZNF512B expression increases susceptibility to ALS. ..
  62. Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, et al. PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain. J Dent Res. 2011;90:777-81 pubmed publisher
    ..Taken together, these findings suggest that PKC? expression in the Vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury...
  63. Kuwana S, Okada Y, Sugawara Y, Tsunekawa N, Obata K. Disturbance of neural respiratory control in neonatal mice lacking GABA synthesizing enzyme 67-kDa isoform of glutamic acid decarboxylase. Neuroscience. 2003;120:861-70 pubmed
    ..We suggest that GABAergic transmission is not essential for basic respiratory rhythm generation but plays an important role in the maintenance of regular respiratory rhythm and normal inspiratory pattern in neonatal mice. ..
  64. Qi M, Wakabayashi Y, Enomoto M, Shinomiya K. Changes in neurocan expression in the distal spinal cord stump following complete cord transection: a comparison between infant and adult rats. Neurosci Res. 2003;45:181-8 pubmed
    ..Combined with the different regenerative capacity of infant and adult rats, the present results suggest that neurocan inhibits spinal cord regeneration. ..
  65. Liu M, Matsuura S, Shinoda M, Honda K, Suzuki I, Shibuta K, et al. Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 2012;9:258 pubmed publisher
    ..This tongue-inflamed model might be useful for future studies to further elucidate molecular and cellular mechanisms of pathological tongue pain such as burning mouth syndrome. ..
  66. Yajima Y, Narita M, Narita M, Matsumoto N, Suzuki T. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Brain Res. 2002;958:338-46 pubmed
    ..These findings suggest the possibility that the binding of BDNF to full-length TrkB and subsequent its activation may play a critical role in the development of neuropathic pain-like thermal hyperalgesia induced by nerve injury in mice. ..
  67. Narita M, Miyoshi K, Narita M, Suzuki T. Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Neurosci Lett. 2007;414:21-5 pubmed
    ..These findings support the idea that the activation and hypertrophy of microglia in the spinal cord may be, at least in part, associated with in the induction of ethanol-dependent neuropathic pain-like state...
  68. Tokuda E, Okawa E, Ono S. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. J Neurochem. 2009;111:181-91 pubmed publisher
    ..These results indicate that the nature of mutant SOD1 toxicity might involve the dysregulation of the copper trafficking pathway, resulting in the disruption of intracellular copper homeostasis. ..
  69. Matsumura T, Sakai A, Nagano M, Sawada M, Umino M, Suzuki H. Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state. Br J Pharmacol. 2008;155:767-74 pubmed publisher
    ..The present results suggest that HK-1 expression is increased at least partly in activated microglial cells after nerve injury and is clearly involved in the early phase of neuropathic pain. ..
  70. Ogura T, Yokoyama T, Fujisawa H, Kurashima Y, Esumi H. Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system. Biochem Biophys Res Commun. 1993;193:1014-22 pubmed
    ..Generation of diversity of n-NOS is probably related to diversity of its biological functions. ..
  71. Hamada T, Ui Tei K, Miyata Y. A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. FEBS Lett. 2000;475:97-102 pubmed
    ..Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord. ..
  72. Takei T, Seki K. Spinal premotor interneurons mediate dynamic and static motor commands for precision grip in monkeys. J Neurosci. 2013;33:8850-60 pubmed publisher
    ..05), suggesting that they contributed to force maintenance. These results indicated that the neural pathway mediated by the spinal PreM-INs makes a significant contribution to the control of precision grip in primates. ..
  73. Tsuda M, Shigemoto Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter M, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424:778-83 pubmed
    ..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury. ..
  74. Qi M, Wakabayashi Y, Haro H, Shinomiya K. Changes in FGF-2 expression in the distal spinal cord stump after complete cord transection: a comparison between infant and adult rats. Spine (Phila Pa 1976). 2003;28:1934-40 pubmed
    ..After complete spinal cord transection, the expression of FGF-2 in the distal cord of infant rats was high compared with that of adults. This may provide neurotrophic support for axonal extension and functional recovery. ..
  75. Cacabelos D, Ayala V, Granado Serrano A, Jové M, Torres P, Boada J, et al. Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis. 2016;88:148-60 pubmed publisher
    ..Later on, this allostatic overload could exacerbate cell stress by contributing to TDP-43 aggregation. This, at its turn, could blunt this protective response, overall leading to DHA depletion and neuronal dysfunction. ..
  76. Fujikawa A, Tsuchiya K, Takeuchi S, Hachiya J. Diffusion-weighted MR imaging in acute spinal cord ischemia. Eur Radiol. 2004;14:2076-8 pubmed
    ..DW imaging of the spinal cord can contribute to the early detection of spinal cord vascular compromise...
  77. Onimaru H, Homma I. Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol (1985). 2006;100:2094-5 pubmed
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