Experts and Doctors on schizosaccharomyces pombe proteins in Saitama, Japan

Summary

Locale: Saitama, Japan
Topic: schizosaccharomyces pombe proteins

Top Publications

  1. Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, et al. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 1994;13:1831-43 pubmed
    ..All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer. ..
  2. Hirota K, Hoffman C, Shibata T, Ohta K. Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot. Genetics. 2003;165:505-15 pubmed
    ..These observations suggest that these fission yeast Tup1-like corepressors repress chromatin remodeling at CRE-related sequences and that Rst2 antagonizes this function. ..
  3. Hirota K, Hasemi T, Yamada T, Mizuno K, Hoffman C, Shibata T, et al. Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses. Nucleic Acids Res. 2004;32:855-62 pubmed
    ..Such a role for these proteins may serve as a paradigm for the regulation of stress response in higher eukaryotes. ..
  4. Hirota K, Miyoshi T, Kugou K, Hoffman C, Shibata T, Ohta K. Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs. Nature. 2008;456:130-4 pubmed publisher
    ..Our results demonstrate that transcription through the promoter region is required to make DNA sequences accessible to transcriptional activators and to RNAPII. ..
  5. Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A, et al. Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling. Nat Chem Biol. 2010;6:519-26 pubmed publisher
    ..Theonellamides thus represent a new class of sterol-binding molecules that induce membrane damage and activate Rho1-mediated 1,3-beta-D-glucan synthesis...
  6. Morita T, Yamada T, Yamada S, Matsumoto K, Ohta K. Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Genes Cells. 2011;16:217-30 pubmed publisher
  7. Hirota K, Hoffman C, Ohta K. Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling. Eukaryot Cell. 2006;5:1980-9 pubmed
    ..This notion provides new insights into the molecular mechanisms of the Tup family corepressors in gene regulation. ..
  8. Hirota K, Mizuno K, Shibata T, Ohta K. Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26. Mol Biol Cell. 2008;19:1162-73 pubmed publisher
    ..Thus, we propose that multiple chromatin modulators regulate chromatin structure reversibly and participate in the regulation of both meiotic recombination and stress-induced transcription around CRE-like sequences. ..