Genomes and Genes
Experts and Doctors on rna binding proteins in Tokyo, Japan
Locale: Tokyo, Japan
Topic: rna binding proteins
- Matsumoto A, Mitchell A, Kurata H, Pyle L, Kondo K, Itakura H, et al. Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins. J Biol Chem. 1997;272:16778-82 pubmed
- Miyoshi K, Miyoshi T, Hartig J, Siomi H, Siomi M. Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila. RNA. 2010;16:506-15 pubmed publisher..These results suggest that the precursor RNA structure determines the biogenesis mechanism of esiRNAs and miRNAs, thereby implicating hairpin structures with long stems as intermediates in the evolution of Drosophila miRNA. ..
- Fukuda Y, Ishida R, Aoki K, Nakahara K, Takashi T, Mochida K, et al. Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation. Biol Pharm Bull. 2008;31:207-11 pubmed..Taken together, the results suggest that Translin contributes to hematopoietic regeneration by acting as a sensor protein for radiation-induced damage. ..
- Takahashi Y, Mizoi J, Toh e A, Kikuchi Y. Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J Biochem. 2000;128:723-5 pubmed..Gle1, another NPC-associating component, also interacted with Ulp1 in the two-hybrid system and co-immunoprecipitation experiment. Thus Ulp1 associates with nucleoporins and may interact with septin rings in the telophase. ..
- Mashima R, Hishida Y, Tezuka T, Yamanashi Y. The roles of Dok family adapters in immunoreceptor signaling. Immunol Rev. 2009;232:273-85 pubmed publisher..Here, we review the physiological roles and underlying mechanisms of Dok family proteins. ..
- Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, et al. Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). Biochem J. 2008;411:201-9 pubmed
- Wakiyama M, Honkura N, Miura K. Interference with interaction between eukaryotic translation initiation factor 4G and poly(A)-binding protein in Xenopus oocytes leads to inhibition of polyadenylated mRNA translation and oocyte maturation. J Biochem. 2001;130:737-40 pubmed..These results further support the idea that the eIF4G-PABP interaction is critical for translational regulation of maternal mRNAs in oocytes. ..
- Kofuji S, Sakuno T, Takahashi S, Araki Y, Doi Y, Hoshino S, et al. The decapping enzyme Dcp1 participates in translation termination through its interaction with the release factor eRF3 in budding yeast. Biochem Biophys Res Commun. 2006;344:547-53 pubmed..These results suggest that the decapping enzyme Dcp1p may have an additional role in the translation termination through its interaction with eRF3p. ..
- Yano M, Okano H, Okano H. Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation. J Biol Chem. 2005;280:12690-9 pubmed
- Kurimoto K, Fukai S, Nureki O, Muto Y, Yokoyama S. Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase. Structure. 2001;9:1253-63 pubmed..The clefts between the trimers may provide spaces sufficient to accommodate the RNA bases. ..
- Watanabe Y, Yokobori S, Inaba T, Yamagishi A, Oshima T, Kawarabayasi Y, et al. Introns in protein-coding genes in Archaea. FEBS Lett. 2002;510:27-30 pubmed
- Shinohara H, Yasuda T, Yamanashi Y. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells. 2004;9:601-7 pubmed..Thus, Dok-1 probably recruits as yet unidentified molecule(s), which, in concert with rasGAP, negatively regulate Ras-Erk signalling. ..
- Mori D, Sasagawa N, Kino Y, Ishiura S. Quantitative analysis of CUG-BP1 binding to RNA repeats. J Biochem. 2008;143:377-83 pubmed..This is the first report of a binding constant for CUG-BP1 calculated in vitro. ..
- Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci U S A. 2006;103:11329-33 pubmed..Thus, we show that SRPK, a well known kinase in the cellular RNA-processing machinery, is used by at least some viruses for propagation and hence suggest that SRPIN340 or its derivatives may be useful for curbing viral diseases. ..
- Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M. C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development. Dev Biol. 2006;295:689-99 pubmed..Taken together, CPEB appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression. ..
- Hidai C, Ohno M, Kazama H, Ikeda H, Kasanuki H, Kokubun S, et al. Specific regulation of nucleocytoplasmic distribution of poly(C)-binding protein gene mRNA in mouse development. Biochem Biophys Res Commun. 2003;309:339-43 pubmed..These results suggest that the intracellular distribution of alphaCP2 mRNA is developmentally regulated in a gene and/or cell specific manner. ..
- Komatsu M, Kominami E, Arahata K, Tsukahara T. Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones. Genes Cells. 1999;4:593-606 pubmed..NSSR 1 and 2 were cloned from mouse cDNA libraries. Results indicate that NSSR 1 may play a crucial role in the regulation of alternative splicing in neurones. ..
- Sakai K. [Paraneoplastic cerebellar degeneration]. Brain Nerve. 2010;62:357-64 pubmed..The effect of immunotherapy is unclear in most PCD cases. Clarification of the relevant clinical-immunological associations is crucial for the developent of new therapeutic strategies for PCD...
- Okubo K, Mitani H, Naruse K, Kondo M, Shima A, Tanaka M, et al. Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes. Biochem Biophys Res Commun. 2002;293:327-31 pubmed
- Otori M, Karashima T, Yamamoto M. The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch. Mol Biol Cell. 2006;17:3147-55 pubmed..Conversely, a mutation in gld-3, a gene that functionally counteracts FBF, could partially restore oogenesis in the daz-1 mutant. Together, we propose that daz-1 plays a role upstream of the pathway for germ cell sex determination. ..
- Kino Y, Mori D, Oma Y, Takeshita Y, Sasagawa N, Ishiura S. Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats. Hum Mol Genet. 2004;13:495-507 pubmed..It was also found that MBNL1 can bind to repetitive motifs in ZNF9, which contain a minimal length of CCUG repeats with non-CCUG insertions. ..
- Nagata H, Akiba Y, Suzuki H, Okano H, Hibi T. Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution. FEBS Lett. 2006;580:27-33 pubmed..We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation. ..
- Shinohara H, Inoue A, Toyama Sorimachi N, Nagai Y, Yasuda T, Suzuki H, et al. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med. 2005;201:333-9 pubmed..Thus, Dok-1 and Dok-2 are essential negative regulators downstream of TLR4, implying a novel PTK-dependent pathway in innate immunity. ..
- Takahashi S, Araki Y, Ohya Y, Sakuno T, Hoshino S, Kontani K, et al. Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA. 2008;14:1950-8 pubmed publisher..These results suggest that Upf1 may serve as an E3 ubiquitin ligase upon its association with Upf3 and play an important role in signaling to the NMD pathway. ..
- Morozumi Y, Takizawa Y, Takaku M, Kurumizaka H. Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities. Nucleic Acids Res. 2009;37:4296-307 pubmed publisher..These results suggest that PSF may have dual functions in homologous recombination and RNA processing through its N-terminal and central regions, respectively. ..
- Nakazawa Y, Hiraguri A, Moriyama H, Fukuhara T. The dsRNA-binding protein DRB4 interacts with the Dicer-like protein DCL4 in vivo and functions in the trans-acting siRNA pathway. Plant Mol Biol. 2007;63:777-85 pubmed..These results indicate that DRB4, together with DCL4, functions in the ta-siRNA biogenesis. ..
- Kuroyanagi H. Fox-1 family of RNA-binding proteins. Cell Mol Life Sci. 2009;66:3895-907 pubmed publisher..Further systematic elucidation of target genes of the Fox-1 family and other splicing regulators in various tissues will lead to a comprehensive understanding of splicing regulatory networks...
- Nishitsuji H, Hayashi T, Takahashi T, Miyano M, Kannagi M, Masuda T. Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection. PLoS ONE. 2009;4:e7825 pubmed publisher..Taken together, SIP1 appears to stabilize functional multimer forms of IN, thereby promoting the assembly of IN and RT on viral RNA to allow efficient reverse transcription, which is a prerequisite for efficient HIV-1 infection. ..
- Kim I, Muto Y, Inoue M, Watanabe S, Kitamura A, Yokoyama S, et al. NMR analysis of the hydrogen bonding interactions of the RNA-binding domains of the Drosophila sex-lethal protein with target RNA fragments with site-specific [3-15N]uridine substitutions. Nucleic Acids Res. 1997;25:1565-9 pubmed..All these results indicate that the A/G, U1, U2, U5 and U6 residues in the target sequence of (G/A)UUUUUUUU are specifically recognized by the two RNA-binding domains of the Sxl protein. ..
- Kato T, Hayama S, Yamabuki T, Ishikawa N, Miyamoto M, Ito T, et al. Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clin Cancer Res. 2007;13:434-42 pubmed..These results suggest that IMP-1 expression is likely to play important roles in lung cancer development and progression, and that IMP-1 is a prognostic biomarker and a promising therapeutic target for lung cancer. ..
- Ichikawa H, Shimizu K, Hayashi Y, Ohki M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 1994;54:2865-8 pubmed..Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma. ..
- Ichimura Y, Kumanomidou T, Sou Y, Mizushima T, Ezaki J, Ueno T, et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem. 2008;283:22847-57 pubmed publisher..These results demonstrate that the intracellular level of p62 is tightly regulated by autophagy through the direct interaction of LC3 with p62 and reveal that selective turnover of p62 via autophagy controls inclusion body formation. ..
- Watanabe T, Takagi A, Sasagawa N, Ishiura S, Nakase H. Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA-RNA interaction. Neurosci Res. 2004;49:47-54 pubmed..These results suggest that the CUG expansion may bind to complementary sequences within the CUGBP1 mRNA and that this molecular interaction may affect CUGBP1 mRNA expression in DM1. ..
- Nakamura N, Hirata A, Ohsumi Y, Wada Y. Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J Biol Chem. 1997;272:11344-9 pubmed..These results showed that Vam2p and Vam6p execute their function in the vacuolar assembly as the components of a protein complex reside on the vacuolar membranes. ..
- Yoshida T, Sato Y, Morita I, Abe M. Pigpen, a nuclear coiled body component protein, is involved in angiogenesis. Cancer Sci. 2010;101:1170-6 pubmed publisher..These data indicate that Pigpen is involved in angiogenesis and that pigpen may be a target for blocking tumor angiogenesis. ..
- Sasaki T, Toh e A, Kikuchi Y. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. Mol Cell Biol. 2000;20:7971-9 pubmed..These data lead us to conclude that Krr1p physically and functionally interacts with Kri1p to form a complex which is required for 40S ribosome biogenesis in the nucleolus. ..
- Sakai K, Ueno Y, Ueda S, Yada K, Fukushi S, Saijo M, et al. Novel reovirus isolation from an Ostrich (Struthio camelus) in Japan. Vet Microbiol. 2009;134:227-32 pubmed publisher..To our knowledge, this is the first genetic report of an orthoreovirus isolated from an ostrich...
- Saijo M, Niikura M, Morikawa S, Ksiazek T, Meyer R, Peters C, et al. Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins. J Clin Microbiol. 2001;39:1-7 pubmed publisher..The results indicate that ELISA systems prepared with the recombinant NPs of EBO and MBG are valuable tools for the diagnosis of EBO and MBG infections and for seroepidemiological field studies...
- Ae K, Kobayashi N, Sakuma R, Ogata T, Kuroda H, Kawaguchi N, et al. Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells. Oncogene. 2002;21:3112-20 pubmed..The results support the hypothesis that ini1 is a tumor suppressor gene and suggest a novel link between human SWI/SNF chromatin remodeling complex and apoptosis. ..
- Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Nat Methods. 2006;3:909-15 pubmed..This transgenic reporter system can be a powerful experimental tool for the comprehensive study of expression profiles and regulation mechanisms of alternative splicing in metazoans. ..
- Sun G, Kobayashi T, Abe M, Tada N, Adachi H, Shiota A, et al. The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation. Biochem Biophys Res Commun. 2007;360:181-7 pubmed..Additionally, suppression of NIBAN expression in HeLa cells promoted apoptosis. Together these results suggest that Niban is involved in the ER stress response, and that Niban can modulate cell death signaling by regulating translation. ..
- Tsukahara K, Yamamoto H, Okayama H. An RNA binding protein negatively controlling differentiation in fission yeast. Mol Cell Biol. 1998;18:4488-98 pubmed..We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation. ..
- Kawaoka S, Minami K, Katsuma S, Mita K, Shimada T. Developmentally synchronized expression of two Bombyx mori Piwi subfamily genes, SIWI and BmAGO3 in germ-line cells. Biochem Biophys Res Commun. 2008;367:755-60 pubmed publisher..Notably, developmental expression patterns of SIWI and BmAGO3 were remarkably similar. Collectively, our results suggest that SIWI and BmAGO3 may cooperate in an unknown pathway during the development of B. mori germ-line cells...
- Oki K, Kaneko N, Kanki H, Imai T, Suzuki N, Sawamoto K, et al. Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia. Neurosci Res. 2010;66:390-5 pubmed publisher..However, the difference in the distributions of Msi1 and Nestin suggests that some of their features may differ in reactive astrocytes. ..
- Nozawa M, Aotsuka T, Tamura K. A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex. Genetics. 2005;171:1719-27 pubmed publisher..The potential of retroposition to produce a copy of promoter and intron sequences in the context of gene overlapping was demonstrated...
- Ohno G, Hagiwara M, Kuroyanagi H. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes Dev. 2008;22:360-74 pubmed publisher..We propose that the developmental switching between alternative sequences of intron removal determines the ratio between the mature let-2 mRNA isoforms. ..
- Tsuchiya N, Fukuda H, Nakashima K, Nagao M, Sugimura T, Nakagama H. LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo. Biochem Biophys Res Commun. 2004;317:736-43 pubmed..Taking all these results together, it is suggested that LRP130, a novel type of RNA-binding protein, associates with mRNA/mRNP complexes at the outside of NE and ER, and plays a role in control of mRNA metabolisms. ..
- Kawakatsu T, Itoh J, Miyoshi K, Kurata N, Alvarez N, Veit B, et al. PLASTOCHRON2 regulates leaf initiation and maturation in rice. Plant Cell. 2006;18:612-25 pubmed publisher..Based on these analyses, we propose a model in which plastochron is determined by signals from immature leaves that act non-cell-autonomously in the shoot apical meristem to inhibit the initiation of new leaves...
- Honda A, Okamoto T, Ishihama A. Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes Cells. 2007;12:133-42 pubmed
- Adachi D, Oda T, Yagasaki H, Nakasato K, Taniguchi T, D Andrea A, et al. Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet. 2002;11:3125-34 pubmed..Reconstitution of the FA pathway by group II and III mutants closely correlated with cellular sensitivity to MMC. The different activation of the FA pathway may partly account for the phenotypic variation seen in FA patients. ..
- Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, et al. Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res. 2009;15:4009-16 pubmed publisher..This pattern may have clinical application as a biomarker for colorectal cancer development and might be emphasized by self-reinforcing regulatory systems integrated with the miR-21 gene, which has been previously shown in cell culture. ..
- Takada H, Kawana T, Ito Y, Kikuno R, Mamada H, Araki T, et al. The RNA-binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development. Development. 2009;136:2413-22 pubmed publisher..These data suggest that the 3'LCU-mediated fine-tuning system determines the appropriate level of mex3b expression, which in turn contributes to neural patterning through regulating FGF signaling. ..
- Siomi H, Siomi M. Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 2010;38:323-32 pubmed publisher..Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals. ..
- Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, et al. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010;67:407-21 pubmed publisher..Together, these findings indicate that Msi1-mediated posttranscriptional regulation of Robo3 controls midline crossing of precerebellar neurons...
- Shimizu S, Urano E, Futahashi Y, Miyauchi K, Isogai M, Matsuda Z, et al. Inhibiting lentiviral replication by HEXIM1, a cellular negative regulator of the CDK9/cyclin T complex. AIDS. 2007;21:575-82 pubmed..These data indicate that HEXIM1 is a host factor that negatively regulates lentiviral replication specifically. Elucidating the regulatory mechanism of HEXIM1 might lead to ways to control lentiviral replication. ..
- Matsui A, Yanase M, Tomiya T, Ikeda H, Fujiwara K, Ogata I. Stabilization of RNA strands in protein synthesis by type I procollagen C-proteinase enhancer protein, a potential RNA-binding protein, in hepatic stellate cells. Biochem Biophys Res Commun. 2002;290:898-902 pubmed..PCPE may be involved in stabilization of RNA strands in noncollagenous protein synthesis as well as collagen synthesis. ..
- Matsuzaki F, Ohshiro T, Ikeshima Kataoka H, Izumi H. miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis. Development. 1998;125:4089-98 pubmed..Our observations suggest that the epithelial cell and neuroblast (both of epithelial origin) share the same molecular machinery for creating cellular asymmetry. ..
- Oneyama C, Nakano H, Sharma S. UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002;21:2037-50 pubmed..In vitro analyses suggested that UCS15A did not bind to the SH3 domain itself but rather may interact directly with the target proline-rich domains. ..
- Hanazawa M, Kawasaki I, Kunitomo H, Gengyo Ando K, Bennett K, Mitani S, et al. The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1. Mech Dev. 2004;121:213-24 pubmed
- Hayashi N, Sugimoto Y, Tsuchiya E, Ogawa M, Nakamura Y. Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem Biophys Res Commun. 1994;202:1426-30 pubmed..Five were deletions and 14 were missense mutations. These results suggest that inactivation of MTS1/CDK4l plays an important role during carcinogenesis of NSCLC. ..
- Terauchi M, Koi H, Hayano C, Toyama Sorimachi N, Karasuyama H, Yamanashi Y, et al. Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection. J Virol. 2003;77:8187-95 pubmed..In fibroblasts, these US proteins were localized at the ER before and after HCMV infection. These results suggest that the US gene products are not integrated into ER of HCMV-infected EVT and fail to downregulate class I MHC molecules. ..
- Sasagawa N, Ohno E, Kino Y, Watanabe Y, Ishiura S. Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins. J Neurosci Res. 2009;87:1090-7 pubmed publisher..The expression of GFP driven by the K02H8.1 promoter was absent in muscle; however, significant GFP expression was detected in the neurons around the pharynx. ..
- Suzuki H, Saba R, Sada A, Saga Y. The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. PLoS ONE. 2010;5:e9300 pubmed publisher..Our current study thus suggests that Nanos3-3'UTR has an essential role in translational control in the mouse embryo. ..
- Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T. The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. J Biol Chem. 1999;274:16677-80 pubmed..Thus, the present study is the first report showing that GSPT/eRF3 carries the translation termination signal to 3'-poly(A) tail ubiquitously present in eukaryotic mRNAs. ..
- Toda M, Iizuka Y, Yu W, Imai T, Ikeda E, Yoshida K, et al. Expression of the neural RNA-binding protein Musashi1 in human gliomas. Glia. 2001;34:1-7 pubmed..These results suggest that primary CNS tumors may share gene expression patterns with primitive, undifferentiated CNS cells and that Musashi1 may be a useful marker for the diagnosis of CNS tumors. ..
- Murakami K, Abe M, Kageyama T, Kamoshita N, Nomoto A. Down-regulation of translation driven by hepatitis C virus internal ribosomal entry site by the 3' untranslated region of RNA. Arch Virol. 2001;146:729-41 pubmed
- Mizutani T, Ito T, Nishina M, Yamamichi N, Watanabe A, Iba H. Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex. J Biol Chem. 2002;277:15859-64 pubmed..These results suggest that the Brm-containing SWI/SNF complex subfamily (trithorax-G) and a complex including YY1 and HDACs (Polycomb-G) counteract each other to maintain transcription of exogenously introduced genes. ..
- Tagami Y, Motose H, Watanabe Y. A dominant mutation in DCL1 suppresses the hyl1 mutant phenotype by promoting the processing of miRNA. RNA. 2009;15:450-8 pubmed publisher..Our results suggest significant roles of the helicase domain of DCL1, which remain unclear to date, possibly in relation with HYL1. ..
- Kihara T, Kano F, Murata M. Modulation of SRF-dependent gene expression by association of SPT16 with MKL1. Exp Cell Res. 2008;314:629-37 pubmed..These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex. ..
- Hiraguri A, Itoh R, Kondo N, Nomura Y, Aizawa D, Murai Y, et al. Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana. Plant Mol Biol. 2005;57:173-88 pubmed..The presented data suggest that each member of the HYL1/DRB protein family may individually modulate Dicer function through heterodimerization with a Dicer-like protein in vivo. ..
- Kurihara Y, Takashi Y, Watanabe Y. The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis. RNA. 2006;12:206-12 pubmed..These results indicate that HYL1 has a function in assisting efficient and precise cleavage of pri-miRNA through interaction with DCL1. ..
- Suzuki H, Tsuda M, Kiso M, Saga Y. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol. 2008;318:133-42 pubmed publisher..Our findings thus suggest that heterogeneity exists in the PGC populations and that Nanos3 maintains the germ cell lineage by suppressing both Bax-dependent and Bax-independent apoptotic pathways. ..
- Masumi A, Fukazawa H, Shimazu T, Yoshida M, Ozato K, Komuro K, et al. Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncogene. 2006;25:5113-24 pubmed..We conclude that nucleolin is recruited to acetylated IRF-2, thereby contributing to gene regulation crucial for the control of cell growth. ..
- Nagaoka K, Suzuki T, Kawano T, Imakawa K, Sakai S. Stability of casein mRNA is ensured by structural interactions between the 3'-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex. Biochim Biophys Acta. 2006;1759:132-40 pubmed..Collectively, our results suggest that beta-casein mRNA is protected from degradation by virtue of the structural interaction between the 3'-UTR and poly(A) tail via a protein complex of HuR and PABP. ..
- Takahashi S, Kontani K, Araki Y, Katada T. Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly. Nucleic Acids Res. 2007;35:1187-97 pubmed..Taken together, these results suggest a novel function of Caf1 as a key regulator in the stress-induced RNR activation. ..
- Inoue A, Yasuda T, Yamamoto T, Yamanashi Y. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J Biochem. 2007;142:257-63 pubmed..Furthermore, mice lacking Dok-1 showed an impaired IgE response to thymus-dependent antigen. Thus, Dok-1 is a positive regulator of IL-4 signalling and IgE response. ..
- Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M. Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. Genomics. 1997;43:237-41 pubmed..In situ hybridization and physical mapping of somatic cell hybrids allowed localization of the gene to human chromosome 2q21.1. ..
- Yasuda J, Mashiyama S, Makino R, Ohyama S, Sekiya T, Hayashi K. Cloning and characterization of rat cellular nucleic acid binding protein (CNBP) cDNA. DNA Res. 1995;2:45-9 pubmed..The recombinant GST-CNBP fusion protein produced in Escherichia coli bound to a G-rich single-stranded RNA and DNA in a sequence-specific manner. ..
- Sato M, Watanabe Y, Akiyoshi Y, Yamamoto M. 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p. Curr Biol. 2002;12:141-5 pubmed..This model will explain, at least partly, why phosphorylation by Pat1 kinase inhibits the meiosis-inducing activity of Mei2p. ..
- Sekizaki H, Takahashi S, Tanegashima K, Onuma Y, Haramoto Y, Asashima M. Tracing of Xenopus tropicalis germ plasm and presumptive primordial germ cells with the Xenopus tropicalis DAZ-like gene. Dev Dyn. 2004;229:367-72 pubmed publisher..These results indicate that Xtdazl mRNA is the first specific marker of germ plasm and pPGCs in Xenopus tropicalis and is very useful to trace Xenopus tropicalis pPGCs, including germ plasm until the early tadpole stage...
- Ueno T, Tokunaga K, Sawa H, Maeda M, Chiba J, Kojima A, et al. Nucleolin and the packaging signal, psi, promote the budding of human immunodeficiency virus type-1 (HIV-1). Microbiol Immunol. 2004;48:111-8 pubmed..Our results suggest that an empty particle which contains neither nucleolin nor the genomic RNA is eliminated during the budding process, and this mechanism is beneficial for escape from the host immune response against HIV-1. ..
- Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, et al. The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A. 2005;102:4625-30 pubmed..Taken together, the results suggest that HuD is required at multiple points during neuronal development, including negative regulation of proliferative activity and neuronal cell-fate acquisition of neural stem/progenitor cells. ..