Experts and Doctors on repressor proteins in Kumamoto, Japan


Locale: Kumamoto, Japan
Topic: repressor proteins

Top Publications

  1. Namba T, Tanaka K, Ito Y, Hoshino T, Matoyama M, Yamakawa N, et al. Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. Cell Death Differ. 2010;17:1882-95 pubmed publisher
  2. Watanabe T, Ishihara K, Hirosue A, Watanabe S, Hino S, Ojima H, et al. Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol. 2012;32:1529-41 pubmed publisher
    ..These results suggest that insulators mediate the spatiotemporal control of enhancer-promoter associations in the TNF/LT gene cluster. ..
  3. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, et al. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci U S A. 2016;113:3054-9 pubmed publisher
    ..The presence of an ectopic CTCF-BS introduced by the retrovirus in tens of thousands of genomic locations has the potential to cause widespread abnormalities in host cell chromatin structure and gene expression. ..
  4. Kawakami S, Mitsunaga K, Kikuti Y, Ando A, Inoko H, Yamamura K, et al. Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Mamm Genome. 1998;9:874-80 pubmed
    ..Mouse Tctex3 gene was mapped adjacent to Tsc2 gene on mouse Chromosome (Chr) 17, and HUTEX3 was located closely to HSET gene in the HLA class II region of chromosome 6. ..
  5. Fujita N, Shimotake N, Ohki I, Chiba T, Saya H, Shirakawa M, et al. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol Cell Biol. 2000;20:5107-18 pubmed
    ..Based on these findings we have concluded that MBD1 acts as a transcriptional regulator depending on the density of methyl-CpG pairs through the cooperation of MBD, CXXC, and TRD sequences. ..
  6. Onogi T, Yamazoe M, Ichinose C, Niki H, Hiraga S. Null mutation of the dam or seqA gene suppresses temperature-sensitive lethality but not hypersensitivity to novobiocin of muk null mutants. J Bacteriol. 2000;182:5898-901 pubmed
    ..Null mutation of either dam or seqA suppressed partially the temperature-sensitive lethality but failed to suppress the anucleate cell production and the hypersensitivity to novobiocin caused by muk null mutations. ..
  7. Takizawa T, Ochiai W, Nakashima K, Taga T. Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res. 2003;31:5723-31 pubmed
    ..These data suggest a novel functional cooperation between Notch signaling and BMP signaling. ..
  8. Oda H, Fushimi F, Kato M, Kitagawa M, Araki K, Seki N, et al. Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells. Biochem Biophys Res Commun. 2005;335:458-68 pubmed
    ..These results suggest that NDRF or its related bHLH proteins may act upstream of these genes in a subset of developing neurons. ..
  9. Mishiro T, Ishihara K, Hino S, Tsutsumi S, Aburatani H, Shirahige K, et al. Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J. 2009;28:1234-45 pubmed publisher

More Information


  1. Kawano Y, Fujiwara S, Wada N, Izaki M, Yuki H, Okuno Y, et al. Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide. Int J Oncol. 2012;41:876-84 pubmed publisher
    ..Establishment of a treatment strategy for MM cells expressing low levels of CD138 is needed to improve their poor outcome...
  2. Yamazoe M, Onogi T, Sunako Y, Niki H, Yamanaka K, Ichimura T, et al. Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli. EMBO J. 1999;18:5873-84 pubmed
    ..This suggests that Ca(2+) or Mg(2+) may be required for the formation of a complex consisting of the three Muk proteins, and thus may participate in a particular step during chromosome partitioning. ..
  3. Ohsumi K, Yamazoe M, Hiraga S. Different localization of SeqA-bound nascent DNA clusters and MukF-MukE-MukB complex in Escherichia coli cells. Mol Microbiol. 2001;40:835-45 pubmed
    ..We discuss the reorganization and proper arrangement of folded sister chromosome in the cell quarter positions, which are performed after release from the long-time cohesion of sister chromosomes. ..
  4. Fujita N, Watanabe S, Ichimura T, Ohkuma Y, Chiba T, Saya H, et al. MCAF mediates MBD1-dependent transcriptional repression. Mol Cell Biol. 2003;23:2834-43 pubmed
    ..These data provide a mechanistic basis for direct inhibition of gene expression via methylation-dependent and histone deacetylation-resistant processes. ..
  5. Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, et al. MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. Ann Surg Oncol. 2012;19 Suppl 3:S656-64 pubmed publisher
    ..miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer. ..
  6. Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, et al. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis. 2017;76:1150-1158 pubmed publisher
    ..Enrichment analysis suggested the importance of CD4-naïve primary T cell. GSDMA and PRDM1 are associated with SSc. These findings provide enhanced insight into the genetic and biological basis of SSc. ..