Experts and Doctors on ovarian neoplasms in Kanagawa, Japan
Locale: Kanagawa, Japan
Topic: ovarian neoplasms
Suzuki N, Tamada Y, Shigirahara K, Suzuki A, Susumu N, Ishida I, et al
. Human monoclonal antibody for ovarian clear cell carcinoma-2, a human monoclonal antibody with antitumor activity against ovarian cancer cells that recognizes CA125-like antigen. Int J Gynecol Cancer. 2008;18:996-1006 pubmed
..These findings suggest that it may have the potential to be employed clinically for molecular-targeting therapy. ..
Akizawa Y, Miyashita T, Sasaki R, Nagata R, Aoki R, Ishitani K, et al
. Gorlin syndrome with an ovarian leiomyoma associated with a PTCH1 second hit. Am J Med Genet A. 2016;170A:1029-34 pubmed publisher
..We anticipate that accumulation of more cases will clarify the importance of second hit mutations in ovarian tumor formation in GS. ..
Tazo Y, Yoshimura Y, Shoda T, Kyushima N, Okada T, Yamazaki H. Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports. J Med Case Rep. 2016;10:20 pubmed publisher
..The TNM classification and FIGO stage were T1aNXM0 and Ia, respectively. We report the usefulness of frozen section assessment during operation, as well as preoperative measurement of tumor marker levels. ..
Komiyama S, Katabuchi H, Mikami M, Nagase S, Okamoto A, Ito K, et al
. Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer. Int J Clin Oncol. 2016;21:435-46 pubmed publisher
Kino Y, Kojima F, Kiguchi K, Igarashi R, Ishizuka B, Kawai S. Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2. Prostaglandins Leukot Essent Fatty Acids. 2005;73:103-11 pubmed
..These findings suggest that COX-1 might be a major enzyme regulating PGE2 production in ovarian cancer cells. ..
Murakami M, Miyamoto T, Iida T, Tsukada H, Watanabe M, Shida M, et al
. Whole-body positron emission tomography and tumor marker CA125 for detection of recurrence in epithelial ovarian cancer. Int J Gynecol Cancer. 2006;16 Suppl 1:99-107 pubmed
..The sensitivity of the combination of PET and CA125 was 97.8% with only one false-negative case. The combination of FDG-PET and CA125 titer is useful for the accurate detection of recurrence. ..
Yoshioka N, Suzuki N, Uekawa A, Kiguchi K, Ishizuka B. POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. Hum Cell. 2009;22:94-100 pubmed publisher
..Clear cell adenocarcinoma of the ovary shows little response to standard therapy. The results of the present study suggest that the transcription factor POU6F1 could be a new molecular target for treatment of this cancer. ..
Suzuki N, Yoshioka N, Uekawa A, Matsumura N, Tozawa A, Koike J, et al
. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Int J Gynecol Cancer. 2010;20:212-9 pubmed publisher
..Clear cell adenocarcinoma shows little response to standard therapy. The results of this study suggested that the transcription factor POU6F1 could be a new molecular target for treatment of this cancer. ..
Miyazawa M, Yasuda M, Fujita M, Hirabayashi K, Hirasawa T, Kajiwara H, et al
. Granulosa cell tumor with activated mTOR-HIF-1alpha-VEGF pathway. J Obstet Gynaecol Res. 2010;36:448-53 pubmed publisher
..It was concluded that mTOR-targeted therapy may represent a promising strategy for some GCT with an activated mTOR-HIF-1alpha-VEGF pathway...