Experts and Doctors on opsin in Tokyo, Japan
Locale: Tokyo, Japan
Terao K, Mikami A, Saito A, Itoh S, Ogawa H, Takenaka O, et al
. Identification of a protanomalous chimpanzee by molecular genetic and electroretinogram analyses. Vision Res. 2005;45:1225-35 pubmed
..Unlike in humans, a polymorphic difference in the copy number of the genes and a polymorphic base substitution at amino acid position 180 were not frequently observed in chimpanzees. ..
Kasahara T, Okano T, Haga T, Fukada Y. Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock. J Neurosci. 2002;22:7321-5 pubmed
..Together, our results demonstrate the existence of a G11-mediated opsin-signaling pathway contributing to the photic entrainment of the circadian clock. ..
Yanagi Y, Takezawa S, Kato S. Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci. 2002;43:3489-94 pubmed
..Thus, our results partly disclosed the molecular mechanism of cone photoreceptor development, highlighting the distinct functions of PNR and TRbeta2. ..
Hayashi T, Kitahara K. Optical coherence tomography in enhanced S-cone syndrome: large macular retinoschisis with disorganized retinal lamination. Eur J Ophthalmol. 2005;15:643-6 pubmed
..The purpose of the current study was to describe the patient's optical coherence tomography (OCT) findings...
Hayashi T, Gekka T, Goto Omoto S, Takeuchi T, Kubo A, Kitahara K. Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity. Ophthalmology. 2005;112:2115 pubmed
..This may be explained by the possibility that the heterodimers encoded by the 2 mutant alleles retain certain NR2E3 functions through the respective intact DBD and LBD. ..
Wada Y, Sugiyama J, Okano T, Fukada Y. GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones. J Neurochem. 2006;98:824-37 pubmed
..The reinforced activity of the cone kinase should provide a strengthened shutoff mechanism of the light-signaling in the cone and contribute to the characteristics of the cone responses by reducing signal amplification efficiency. ..
Torii M, Kojima D, Okano T, Nakamura A, Terakita A, Shichida Y, et al
. Two isoforms of chicken melanopsins show blue light sensitivity. FEBS Lett. 2007;581:5327-31 pubmed
..The melanopsin isoforms found in this study may function as pineal circadian photoreceptors...