Genomes and Genes
Experts and Doctors on neurons in Kyoto, Japan
Locale: Kyoto, Japan
Publications164 found, 100 shown here
- Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, et al. PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity. Biochem Biophys Res Commun. 2010;391:1240-5 pubmed publisher..Since PS1/gamma-secretase is deeply involved in the production of Abeta protein, a deeper knowledge into its metabolism could contribute to a better elucidation of AD pathogenesis. ..
- Tatebe H, Watanabe Y, Kasai T, Mizuno T, Nakagawa M, Tanaka M, et al. Extracellular neurosin degrades ?-synuclein in cultured cells. Neurosci Res. 2010;67:341-6 pubmed publisher..These findings suggest that neurosin targets the extracellular alpha-synuclein. ..
- Komada M, Fujiyama F, Yamada S, Shiota K, Nagao T. Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly in mouse embryos. Birth Defects Res B Dev Reprod Toxicol. 2010;89:213-22 pubmed publisher..Our data suggest that prenatal exposure to MNU induces the excessive cell death of neural precursor/stem cells, and the defective development of the cerebral cortex, resulting in microcephalic abnormalities. ..
- Nakamura K, Morrison S. Central efferent pathways for cold-defensive and febrile shivering. J Physiol. 2011;589:3641-58 pubmed publisher..These results provide the interesting notion that, under the demand for increasing levels of heat production, parallel central efferent pathways control the somatic and sympathetic motor systems to drive thermogenesis. ..
- Matsui R, Tanabe Y, Watanabe D. Avian adeno-associated virus vector efficiently transduces neurons in the embryonic and post-embryonic chicken brain. PLoS ONE. 2012;7:e48730 pubmed publisher..Thus, the A3V technology complements current gene transfer techniques in chicken studies and will contribute to better understanding of the functional organization of neural circuits. ..
- Miyama A, Saito Y, Yamanaka K, Hayashi K, Hamakubo T, Noguchi N. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS ONE. 2011;6:e27883 pubmed publisher..Collectively, these results suggest that electrophilic p-quinone formed from 6-OHDA induces DJ-1 oxidation by decreasing intracellular GSH. ..
- Minami C, Shimizu T, Mitani A. Neural activity in the prelimbic and infralimbic cortices of freely moving rats during social interaction: Effect of isolation rearing. PLoS ONE. 2017;12:e0176740 pubmed publisher..The differential influence of isolation rearing on neural activity in the PL and IL may be one of the neural bases of isolation rearing-induced behavior...
- Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, et al. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007;53:519-33 pubmed..Taken together, these data show that Sept4 may be involved in PD as a dual susceptibility factor, as its insufficiency can diminish dopaminergic neurotransmission and enhance alpha-synuclein neurotoxicity. ..
- Hamamoto A, Yamato S, Katoh Y, Nakayama K, Yoshimura K, Takeda S, et al. Modulation of primary cilia length by melanin-concentrating hormone receptor 1. Cell Signal. 2016;28:572-84 pubmed publisher..Therefore, further characterization of MCHR1 as a ciliary GPCR will provide a potential molecular mechanism to link cilia length control with obesity. ..
- Tomita K, Moriyoshi K, Nakanishi S, Guillemot F, Kageyama R. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 2000;19:5460-72 pubmed..These results indicated that Mash1 and Math3 direct neuronal versus glial fate determination in the CNS and raised the possibility that downregulation of these bHLH genes is one of the mechanisms to initiate gliogenesis. ..
- Hirata H, Tomita K, Bessho Y, Kageyama R. Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001;20:4454-66 pubmed..These results indicate that Hes1 and Hes3 prevent premature differentiation and maintain the organizer activity of the isthmic cells, thereby regulating the development of the midbrain and anterior hindbrain. ..
- Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, et al. Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. Eur J Pharmacol. 2002;455:91-100 pubmed..These results suggest that direct interaction with NMDA receptors but not sigma receptors is crucial to the neuroprotective effects of sigma receptor ligands with affinity for NMDA receptors...
- Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A. Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. Eur J Neurosci. 2005;21:2329-35 pubmed..Thus, with strict structural specificity, PS but not pregnenolone or PHS attenuates AMPA cytotoxicity, probably by inhibiting activities of AMPA receptor-associated channels. ..
- Abe K, Takeichi M. NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron. 2007;53:387-97 pubmed..These findings reveal another pathway for beta-catenin-dependent signaling, in addition to the canonical Wnt-beta-catenin pathway, and suggest that this other pathway could play an important role in activity-dependent gene expression. ..
- Fujimoto S, Negishi M, Katoh H. RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex. Mol Biol Cell. 2009;20:4941-50 pubmed publisher..Taken together, these results indicate that RhoG promotes NPC proliferation through PI3K in cortical development. ..
- Nishinaka Y, Mori H, Endo N, Miyoshi T, Yamashita K, Adachi S, et al. Edaravone directly reacts with singlet oxygen and protects cells from attack. Life Sci. 2010;86:808-13 pubmed publisher..Since 1O2 is possibly involved in post-ischemic neuronal damage, the clinically approved curative effects of edaravone on acute brain infarction might be attributed to its potent 1O2 scavenging activity. ..
- Iijima N, Matsumoto Y, Yano T, Tanaka M, Yamamoto T, Kakihara K, et al. A novel function of prolactin-releasing peptide in the control of growth hormone via secretion of somatostatin from the hypothalamus. Endocrinology. 2001;142:3239-43 pubmed..From these findings it was strongly suggested that SOM-neurons respond to PrRP and secrete SOM into the portal vessels and thus inhibit GH secretion from the anterior pituitary. ..
- Nishi M, Tanaka M, Matsuda K, Sunaguchi M, Kawata M. Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer. J Neurosci. 2004;24:4918-27 pubmed..These results obtained with FRET analyses give new insights into the sites, time course, and effects of ligand concentration on heterodimersization of the GR and MR. ..
- Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, et al. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci. 2007;10:691-701 pubmed
- Kuba H, Ohmori H. Roles of axonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick. J Physiol. 2009;587:87-100 pubmed publisher..Thus the axonal Na(+) channel distribution is effectively coupled with synaptic inputs, allowing these neurons to convey auditory information in the timing of firing. ..
- Imura T, Wang X, Noda T, Sofroniew M, Fushiki S. Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus. Stem Cells. 2010;28:2053-2064 pubmed publisher..stem cells 2010;28:2053-2064. ..
- Wakabayashi Y, Tsujimura A, Matsuda K, Yoshimura N, Kawata M. Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons. Arch Histol Cytol. 2008;71:23-36 pubmed..These results suggest that LFA-1 plays some mechanisms in synaptic contacts and synaptogenesis of hippocampal neurons. ..
- Koike N, Kassai Y, Kouta Y, Miwa H, Konishi M, Itoh N. Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. J Biol Chem. 2007;282:15843-50 pubmed..Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. The present findings indicate that Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions. ..
- Kataoka K, Kanje M, Dahlin L. Induction of activating transcription factor 3 after different sciatic nerve injuries in adult rats. Scand J Plast Reconstr Surg Hand Surg. 2007;41:158-66 pubmed..These findings have clinical implications on when it is worthwhile to reconstruct nerve injuries. ..
- Yamada N, Katsuura G, Tatsuno I, Kawahara S, Ebihara K, Saito Y, et al. Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures. Neurosci Lett. 2009;450:132-5 pubmed publisher..The mRNA expression of BDNF was significantly increased only by orexin-B at 1microM. These findings suggest that orexins, but not MCH, may be an inducer of NT-3 in the cerebral cortex. ..
- Nakagawa T, Suzuki Y, Nagayasu K, Kitaichi M, Shirakawa H, Kaneko S. Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures. PLoS ONE. 2011;6:e24865 pubmed publisher..This in vitro sensitization model provides a unique approach for studying mechanisms underlying behavioral sensitization to drugs of abuse. ..
- Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, et al. Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A. 2002;99:1580-5 pubmed..The SDIA method provides an unlimited source of primate cells for the study of pathogenesis, drug development, and transplantation in degenerative diseases such as Parkinson's disease and retinitis pigmentosa. ..
- Hanafusa H, Torii S, Yasunaga T, Nishida E. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol. 2002;4:850-8 pubmed..Our findings suggest that Spry functions in a negative feedback mechanism in which its inhibitor activity is controlled rapidly and reversibly by post-translational mechanisms. ..
- Kuramoto E, Fujiyama F, Unzai T, Nakamura K, Hioki H, Furuta T, et al. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. J Comp Neurol. 2007;500:908-22 pubmed..These findings indicate that the mGluR4-positive terminals of MSN axon collaterals selectively form synapses with neostriatal cholinergic interneurons. ..
- Wang P, Niidome T, Akaike A, Kihara T, Sugimoto H. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. J Neurosci Res. 2009;87:2105-14 pubmed publisher..Taken together, our results suggest that Rac1 regulates transcription of the APP gene in primary hippocampal neurons. ..
- Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Hisa Y. Brainstem vocalization area in guinea pigs. Neurosci Res. 2010;66:359-65 pubmed publisher..We thus concluded that guinea pigs can be utilized in studies of brainstem vocal mechanism. ..
- Sowa Y, Imura T, Numajiri T, Nishino K, Fushiki S. Adipose-derived stem cells produce factors enhancing peripheral nerve regeneration: influence of age and anatomic site of origin. Stem Cells Dev. 2012;21:1852-62 pubmed publisher..These results suggest that ADSCs promote peripheral nerve regeneration partly through paracrine secretion of trophic factors and regardless of donor age or anatomic site of origin. ..
- Katsuki H, Tomita M, Takenaka C, Shirakawa H, Shimazu S, Ibi M, et al. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity. J Neurochem. 2001;76:1336-45 pubmed
- Yodoya E, Wada M, Shimada A, Katsukawa H, Okada N, Yamamoto A, et al. Functional and molecular identification of sodium-coupled dicarboxylate transporters in rat primary cultured cerebrocortical astrocytes and neurons. J Neurochem. 2006;97:162-73 pubmed..These transporters might play important roles in the trafficking of tricarboxylic acid cycle intermediates and related metabolites between glia and neurons. ..
- Tsuchiya D, Kitamura Y, Takata K, Sugisaki T, Taniguchi T, Uemura K, et al. Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus. Neurosci Res. 2006;56:459-69 pubmed..Taken together, N-WASP, WAVE and their related proteins may participate in normal brain development and synaptic plasticity by regulating the actin cytoskeleton. ..
- Takahashi A, Islam M, Abe H, Okubo K, Akazome Y, Kaneko T, et al. Morphological analysis of the early development of telencephalic and diencephalic gonadotropin-releasing hormone neuronal systems in enhanced green fluorescent protein-expressing transgenic medaka lines. J Comp Neurol. 2016;524:896-913 pubmed publisher
- Zhou L, Furuta T, Kaneko T. Neurokinin B-producing projection neurons in the lateral stripe of the striatum and cell clusters of the accumbens nucleus in the rat. J Comp Neurol. 2004;480:143-61 pubmed
- Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, et al. Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS ONE. 2008;3:e3322 pubmed publisher..We propose that Meltrin beta stabilizes the interaction between ephrin-A5 and EphA4 by regulating endocytosis of the ephrinA5-EphA complex negatively, which would contribute to the fine-tuning of the NMJ during development. ..
- Kitaoka R, Fujikawa T, Miyaki T, Matsumura S, Fushiki T, Inoue K. Increased noradrenergic activity in the ventromedial hypothalamus during treadmill running in rats. J Nutr Sci Vitaminol (Tokyo). 2010;56:185-90 pubmed..Given the known effects of NA in the VMH on energy metabolism, our results suggest that the increase in noradrenergic activity in the VMH is related to the enhancement of fat oxidation during exercise...
- Tamamaki N, Fujimori K, Nojyo Y, Kaneko T, Takauji R. Evidence that Sema3A and Sema3F regulate the migration of GABAergic neurons in the developing neocortex. J Comp Neurol. 2003;455:238-48 pubmed..Finally, the semaphorin-neuropilin interactions sorted GABAergic inteneurons into the CP and white matter neurons into the IZ. ..
- Zhou L, Furuta T, Kaneko T. Chemical organization of projection neurons in the rat accumbens nucleus and olfactory tubercle. Neuroscience. 2003;120:783-98 pubmed
- Uemura K, Lill C, Banks M, Asada M, Aoyagi N, Ando K, et al. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J Neurochem. 2009;108:350-60 pubmed publisher..These results indicate that N-cadherin-mediated synaptic adhesion may modulate Abeta secretion as well as the Abeta(42/40) ratio via PS1/N-cadherin interactions. ..
- Segi Nishida E, Sukeno M, Imoto Y, Kira T, Sakaida M, Tsuchiya S, et al. Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. Neuropharmacology. 2013;71:164-73 pubmed publisher..Our data show an effect of ECS on increased expression of anorexigenic factors in the VMH, and suggest a role in the regulation of energy homeostasis by ECS. ..
- Miyata S, Taguchi K, Maekawa S. Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons. Neuroscience. 2003;122:169-81 pubmed..Moreover, the subcellular localization of OBCAM is changed in an activity-dependent manner. ..
- Uno T, Koike S, Bamba H, Hirota R, Hisa Y. Capsaicin receptor expression in rat laryngeal innervation. Ann Otol Rhinol Laryngol. 2004;113:356-8 pubmed..These findings suggest that these capsaicin receptors play an important role in the nociception of the laryngeal innervation. ..
- Arai J, Katai N, Kuida K, Kikuchi T, Yoshimura N. Decreased retinal neuronal cell death in caspase-1 knockout mice. Jpn J Ophthalmol. 2006;50:417-425 pubmed publisher..Retinal neuronal apoptosis was less prominent in Casp1-/- mice after excessive light exposure and ischemia-reperfusion injury. These data indicate that caspase-1 plays a role in retinal neuronal apoptosis. ..
- Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, et al. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:1674-85 pubmed publisher..These results suggest that TIMP-1 inhibits MMP-9 activity and can play a neuroprotective role in cerebral ischemia. ..
- Hashimoto T, Yamada M, Maekawa S, Nakashima T, Miyata S. IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res. 2008;1224:1-11 pubmed publisher..These results demonstrate the alteration of modulatory function of Kilon for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. ..
- Komai T, Iwanari H, Mochizuki Y, Hamakubo T, Shinkai Y. Expression of the mouse PR domain protein Prdm8 in the developing central nervous system. Gene Expr Patterns. 2009;9:503-14 pubmed publisher..These results show that Prdm8 expression is tightly regulated in a spatio-temporal manner during neural development and mainly restricted to postmitotic neurons, except in the spinal cord. ..
- Ando K, Uemura K, Kuzuya A, Maesako M, Asada Utsugi M, Kubota M, et al. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem. 2011;286:7619-28 pubmed publisher..The dissociation of N-cadherin-mediated synaptic contact by A? may underlie the pathological basis of neurodegeneration such as neuronal death, synaptic loss, and Tau phosphorylation in Alzheimer disease brain. ..
- Enomoto K, Matsumoto N, Nakai S, Satoh T, Sato T, Ueda Y, et al. Dopamine neurons learn to encode the long-term value of multiple future rewards. Proc Natl Acad Sci U S A. 2011;108:15462-7 pubmed publisher..These findings demonstrate that dopamine neurons learn to encode the long-term value of multiple future rewards with distant rewards discounted. ..
- Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, et al. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem. 2001;276:13541-6 pubmed..These findings indicate that the alpha7 nicotinic receptor transduces signals to PI3K in a cascade, which ultimately contributes to a neuroprotective effect. This might form the basis of a new treatment for AD. ..
- Abe J, Hosokawa H, Okazawa M, Kandachi M, Sawada Y, Yamanaka K, et al. TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res. 2005;136:91-8 pubmed..These results suggest that TRPM8 protein is present in sensory lingual nerve fibers mainly projected from TG and might work as cold and l-menthol receptors on tongue. ..
- Himukashi S, Takeshima H, Koyanagi S, Shichino T, Fukuda K. The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide. Anesth Analg. 2006;103:738-41 pubmed..These results together suggest that the antinociceptive action of nitrous oxide is, at least partly, mediated by the nociceptin system. ..
- Miyoshi G, Bessho Y, Yamada S, Kageyama R. Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. J Neurosci. 2004;24:3672-82 pubmed..These results suggest that combinations of distinct bHLH factors promote formation of distinct neuronal subtypes, thereby increasing neuronal diversity. ..
- Saba R, Johnson J, Saito T. Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1. Development. 2005;132:2147-55 pubmed..These findings indicate that Mbh1 is necessary and sufficient for the specification of commissural neurons, as a direct downstream target of Math1. ..
- Kim T, Nakagawa T, Kita T, Higashi T, Takebayashi S, Matsumoto M, et al. Neural connections between embryonic stem cell-derived neurons and vestibular hair cells in vitro. Brain Res. 2005;1057:127-33 pubmed..These findings indicate that ESC-derived neurons have the potential to restore neural connections in the peripheral vestibular system. ..
- Okano T, Nakagawa T, Endo T, Kim T, Kita T, Tamura T, et al. Engraftment of embryonic stem cell-derived neurons into the cochlear modiolus. Neuroreport. 2005;16:1919-22 pubmed..These findings support the hypothesis that transplantation of embryonic stem cell-derived neural progenitors can contribute to the functional restoration of spiral ganglion neurons. ..
- Daijo H, Kai S, Tanaka T, Wakamatsu T, Kishimoto S, Suzuki K, et al. Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a ?-opioid receptor-dependent manner. Eur J Pharmacol. 2011;667:144-52 pubmed publisher..In this report, we describe for the first time that fentanyl, both in vitro and in vivo, induces HIF-1 activation under non-hypoxic conditions, leading to increases in expression of genes associated with adaptation to hypoxia. ..
- Tanaka T, Nishida S, Aso T, Ogawa T. Visual response of neurons in the lateral intraparietal area and saccadic reaction time during a visual detection task. Eur J Neurosci. 2013;37:942-56 pubmed publisher..Thus, the present results reveal how visually responsive LIP neurons contribute to saccade generation in visual detection. ..
- Funahashi S, Takeda K, Watanabe Y. Neural mechanisms of spatial working memory: contributions of the dorsolateral prefrontal cortex and the thalamic mediodorsal nucleus. Cogn Affect Behav Neurosci. 2004;4:409-20 pubmed..These results indicate that, although the MD participates in working memory, the way it participates in this process is different between these two areas, in that the MD participates more in motor control aspects than the DLPFC does. ..
- Tsuchiya H, Oka T, Nakamura K, Ichikawa A, Saper C, Sugimoto Y. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. J Biol Chem. 2008;283:11064-71 pubmed publisher..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever. ..
- Shirakawa H, Yamaoka T, Sanpei K, Sasaoka H, Nakagawa T, Kaneko S. TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons. Biochem Biophys Res Commun. 2008;377:1211-5 pubmed publisher..Together, these data indicate that TRPV1 activation triggers apoptotic cell death of rat cortical cultures via L-type Ca(2+) channel opening, Ca(2+) influx, ERK phosphorylation, and reactive oxygen species production. ..
- Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, et al. Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology. 2011;152:2634-43 pubmed publisher..Thus, depression associated with obesity is due, at least in part, to impaired leptin activity in the hippocampus. ..
- Mizunuma M, Norimoto H, Tao K, Egawa T, Hanaoka K, Sakaguchi T, et al. Unbalanced excitability underlies offline reactivation of behaviorally activated neurons. Nat Neurosci. 2014;17:503-5 pubmed publisher..During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition. ..
- Iwai Y, Hirota Y, Ozaki K, Okano H, Takeichi M, Uemura T. DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses. Mol Cell Neurosci. 2002;19:375-88 pubmed..These results suggest that the cadherin adhesion system is required for interaction between pre- and postsynaptic terminals and for generation of the mature synaptic structures. ..
- Nakayama Y, Miyake A, Nakagawa Y, Mido T, Yoshikawa M, Konishi M, et al. Fgf19 is required for zebrafish lens and retina development. Dev Biol. 2008;313:752-66 pubmed..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish. ..
- Higuchi M, Suzuki Y, Yatani Y, Kitagawa Y, Nagayasu K, Shirakawa H, et al. Augmentation of serotonin release by sustained exposure to MDMA and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons. J Neurochem. 2008;106:2410-20 pubmed publisher..The in vitro model system could help to elucidate the mechanisms underlying drug addiction. ..
- Tan S, Ohtsuka T, Gonzalez A, Kageyama R. MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain. Genes Cells. 2012;17:952-61 pubmed publisher..These results indicate that miR-9 regulates the proliferation and differentiation of neural stem cells by controlling the dynamics of Hes1 expression in the developing brain. ..
- Oinuma I, Katoh H, Negishi M. R-Ras controls axon specification upstream of glycogen synthase kinase-3beta through integrin-linked kinase. J Biol Chem. 2007;282:303-18 pubmed..In addition, membrane targeting of ILK was sufficient to inactivate GSK-3beta and to form multiple axons. Our study demonstrates a novel role of R-Ras and ILK upstream of GSK-3beta in the regulation of neuronal polarity. ..
- Nishimoto T, Kihara T, Akaike A, Niidome T, Sugimoto H. AMPA reduces surface expression of NR1 through regulation of GSK3beta. Neuroreport. 2009;20:161-5 pubmed publisher..Our data suggest that AMPA reduces the cell surface expression of NMDA receptors through the regulation of GSK3beta and, consequently, reduces the amount of intracellular Ca2+. ..
- Hikida T, Morita M, Macpherson T. Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning. Neurosci Res. 2016;108:1-5 pubmed publisher..These basal ganglia neural mechanisms will give us new insights into the pathophysiology of neuropsychiatric diseases. ..
- Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K, Kaneko T. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol. 2003;467:60-79 pubmed..4% of the GFP-positive cells. They accounted for 6.5% in layer I. In accord with unidentified GFP-positive cells, many medium-sized spherical somata emitting intense GFP fluorescence were observed in layer I. ..
- Niidome T, Takahashi K, Goto Y, Goh S, Tanaka N, Kamei K, et al. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport. 2007;18:813-6 pubmed
- Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron. 2008;58:52-64 pubmed publisher..These results suggest that Hes1 oscillation regulates Ngn2 and Dll1 oscillations, which in turn lead to maintenance of neural progenitors by mutual activation of Notch signaling. ..
- Takada Takatori Y, Kume T, Izumi Y, Ohgi Y, Niidome T, Fujii T, et al. Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biol Pharm Bull. 2009;32:318-24 pubmed..This review summarizes recent findings on the roles of the nicotinic receptor in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. ..
- Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria R, et al. Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. Brain Res. 2009;1294:202-10 pubmed publisher..Taken together, chronic cerebral hypoperfusion increased Abeta fibrils and induced Abeta deposition in the intracellular compartment and, therefore, may accelerate the pathological changes of Alzheimer's disease. ..
- Yamada Goto N, Katsuura G, Ebihara K, Inuzuka M, Ochi Y, Yamashita Y, et al. Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice. Diabetes. 2013;62:1500-4 pubmed publisher..These results indicated that intracerebroventricular administration of CNP induces an anorexigenic action, in part, via activation of the melanocortin system. ..
- Ohishi A, Keno Y, Marumiya A, Sudo Y, Uda Y, Matsuda K, et al. Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons. Neuroscience. 2016;319:35-45 pubmed publisher..Overall, we reveal that neuronal vulnerability to ATP depends on the expression level of P2X7R, and co-existence of astrocytes exacerbates ATP-induced neuronal death. ..
- Kageyama R, Ohtsuka T, Shimojo H, Imayoshi I. Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat Neurosci. 2008;11:1247-51 pubmed publisher..This dynamic mode of gene expression would require a revision of the traditional view of how Notch-mediated lateral inhibition operates in the developing mammalian nervous system. ..
- Niidome T, Goto Y, Kato M, Wang P, Goh S, Tanaka N, et al. Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity. Biochem Biophys Res Commun. 2009;386:734-8 pubmed publisher..Our results suggest that non-fibrillar Abeta42 protects hippocampal neurons from glutamate-induced neurotoxicity through regulation of the NMDA receptor. ..
- Furuta T, Deschenes M, Kaneko T. Anisotropic distribution of thalamocortical boutons in barrels. J Neurosci. 2011;31:6432-9 pubmed publisher..The actual significance of the direction-dependent segregation of thalamocortical terminals in barrels may only come to light in the context of active sensing...
- Nomura T, Gotoh H, Ono K. Changes in the regulation of cortical neurogenesis contribute to encephalization during amniote brain evolution. Nat Commun. 2013;4:2206 pubmed publisher..In addition, the temporal regulation for making cortical neuronal subtypes has evolved in a common ancestor(s) of amniotes. ..
- Honjo Y, Horibe T, Torisawa A, Ito H, Nakanishi A, Mori H, et al. Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease. J Alzheimers Dis. 2014;38:601-9 pubmed publisher..The accumulation of misfolded proteins induces ER stress and may cause apoptosis of neuronal cells through S-nitrosylation and down-regulation of PDI and P5 in AD. ..
- Furuta T, Koyano K, Tomioka R, Yanagawa Y, Kaneko T. GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex. J Comp Neurol. 2004;473:43-58 pubmed
- Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y, Takai Y. MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. J Biol Chem. 2005;280:26499-507 pubmed..Taken together, these results suggest that Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system. ..
- Kakimoto T, Katoh H, Negishi M. Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination. J Biol Chem. 2006;281:29042-53 pubmed..These results suggest that a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP. ..