Experts and Doctors on n acetylgalactosaminyltransferases in Tokyo, Japan
Locale: Tokyo, Japan
Topic: n acetylgalactosaminyltransferases
Dohi T, Yuyama Y, Natori Y, Smith P, Lowe J, Oshima M. Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer. Int J Cancer. 1996;67:626-31 pubmed
Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, et al
. Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. Clin Cancer Res. 2004;10:2090-9 pubmed
..This phenotype may serve as a unique biological feature associated with the malignant behavior. ..
Kawamura Y, Kawashima R, Fukunaga R, Hirai K, Toyama Sorimachi N, Tokuhara M, et al
. Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. Cancer Res. 2005;65:6220-7 pubmed
..In summary, forced expression of Sd(a) carbohydrate determinant caused remarkable elimination of carbohydrate ligands for selectin and reduced metastasis of human gastrointestinal tract cancer cells. ..
Kanoh A, Takeuchi H, Kato K, Waki M, Usami K, Irimura T. Interleukin-4 induces specific pp-GalNAc-T expression and alterations in mucin O-glycosylation in colonic epithelial cells. Biochim Biophys Acta. 2008;1780:577-84 pubmed
..The results indicated that IL-4-treated LS174T cells are able to produce mucins with a higher degree of O-glycosylation than untreated counterparts. ..
Kawamura Y, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, et al
. DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. Gastroenterology. 2008;135:142-151.e3 pubmed publisher
Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto Sasaki Y, Morimoto Tomita M, et al
. Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis. Glycoconj J. 2010;27:267-76 pubmed publisher
..These results strongly suggest that mGalNAc-T3 in colon 38 cells is involved in additional transfer of GalNAc residues to this peptide. ..