Experts and Doctors on middle aged in Tokyo, Japan


Locale: Tokyo, Japan
Topic: middle aged

Top Publications

  1. Tatsuguchi A, Miyake K, Gudis K, Futagami S, Tsukui T, Wada K, et al. Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. Am J Gastroenterol. 2004;99:2121-7 pubmed
    ..pylori infection affected ghrelin expression. After H. pylori eradication, gastric tissue ghrelin concentration increased significantly. This could lead to the increased appetite and weight gain seen following H. pylori eradication. ..
  2. Toda J, Fukushima H, Kato S. Injection of triamcinolone acetonide into the posterior sub-tenon capsule for treatment of diabetic macular edema. Retina. 2007;27:764-9 pubmed
    ..1 +/- 186.3 microm (P=0.052, paired t-test) and 478.3 +/- 269.1 microm (P=0.65, paired t-test). Injection of 20 mg of TA into the posterior sub-Tenon capsule effectively reduces macular thickening due to DME, at least in the short term. ..
  3. Arai S, Matsunaga Y, Takasaki T, Tanaka Taya K, Taniguchi K, Okabe N, et al. Japanese encephalitis: surveillance and elimination effort in Japan from 1982 to 2004. Jpn J Infect Dis. 2008;61:333-8 pubmed
    ..Although JE cases have been reported in single figures since 1992, the risk of JE virus infection is still present. Thus, high immunization rates of JE vaccine should be maintained in Japan. ..
  4. Fukada J, Shigematsu N, Takeda A, Ohashi T, Tomita T, Shiotani A, et al. Weekly low-dose docetaxel-based chemoradiotherapy for locally advanced oropharyngeal or hypopharyngeal carcinoma: a retrospective, single-institution study. Int J Radiat Oncol Biol Phys. 2010;76:417-24 pubmed publisher
    ..To retrospectively assess the efficacy, toxicity, and prognostic factors of weekly low-dose docetaxel-based chemoradiotherapy for Stage III/IV oropharyngeal or hypopharyngeal carcinoma...
  5. Shimada K, Shimazu A, Bakker A, Demerouti E, Kawakami N. Work-family spillover among Japanese dual-earner couples: a large community-based study. J Occup Health. 2010;52:335-43 pubmed
    ..Gender had a moderating effect on the relationship between negative spillover and psychological distress. ..
  6. Yamashita H, Ogiya A, Shien T, Horimoto Y, Masuda N, Inao T, et al. Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer. Breast Cancer. 2016;23:830-843 pubmed
    ..Predictors of early and late distant recurrence might differ according to menopausal status and age. ..
  7. Tsunoda A, Yasuda N, Yokoyama N, Kamiyama G, Kusano M. Delorme's procedure for rectal prolapse: clinical and physiological analysis. Dis Colon Rectum. 2003;46:1260-5 pubmed
    ..Improved anal sphincter and rectal sensation were associated with a reduced incidence of defecatory problems after Delorme's procedure. ..
  8. Yanagawa T, Araki A, Sasamoto K, Shirabe S, Yamanouchi T. Effect of antidiabetic medications on microalbuminuria in patients with type 2 diabetes. Metabolism. 2004;53:353-7 pubmed
  9. Takehara A, Eguchi H, Ohigashi H, Ishikawa O, Kasugai T, Hosokawa M, et al. Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Sci. 2006;97:1191-7 pubmed
    ..These findings indicate that REG4 is a promising tumor marker to screen early-stage PDAC, and also that neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC. ..

More Information

Publications1400 found, 100 shown here

  1. Okubo K, Nakashima M, Miyake N, Komatsubara M, Okuda M. Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis. Allergy Asthma Proc. 2009;30:84-94 pubmed publisher
    ..FFNS was well tolerated. Treatment with once-daily FFNS was effective and noninferior to twice-daily FPNS in reducing nasal symptoms. Faster onset of action for FFNS was observed. ..
  2. Shirakawa H, Ishida H, Shimizu T, Omoto K, Iida S, Toki D, et al. The low dose of rituximab in ABO-incompatible kidney transplantation without a splenectomy: a single-center experience. Clin Transplant. 2011;25:878-84 pubmed publisher
    ..The patients in Group II showed excellent results similar to Group I. These results suggest that the low dose of rituximab (200 mg/body) is the sufficient dose in ABO-i kidney transplantation. ..
  3. Maeda S, Koya D, Araki S, Babazono T, Umezono T, Toyoda M, et al. Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol. 2011;15:381-390 pubmed publisher
    ..0028). These results indicate that SIRT1 may play a role in susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. ..
  4. Takao M, Miyamoto W, Matsui K, Sasahara J, Matsushita T. Functional treatment after surgical repair for acute lateral ligament disruption of the ankle in athletes. Am J Sports Med. 2012;40:447-51 pubmed publisher
    ..There have been several reports showing 20% to 40% failure after nonoperative functional treatment for acute lateral ligament disruption of the ankle...
  5. Baba H, Nakano Y, Maeshima H, Satomura E, Kita Y, Suzuki T, et al. Metabolism of amyloid-? protein may be affected in depression. J Clin Psychiatry. 2012;73:115-20 pubmed publisher
    ..Our findings suggest that A? metabolism may be affected in depression; these findings also possibly answer the question of why even early-onset depression is a risk factor for developing Alzheimer's disease. ..
  6. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18:378-81 pubmed publisher
  7. Teramoto T, Shirai K, Daida H, Yamada N. Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study. Cardiovasc Diabetol. 2012;11:29 pubmed publisher
    ..We investigated glycemic control, relationship between lipid metabolism and HbA1c, and safety in diabetic patients treated with bezafibrate...
  8. Nakayama T, Kashiwagi Y, Kawashima H, Kumagai T, Ishii K, Ihara T. Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) enhanced inflammatory cytokine productions. Vaccine. 2012;30:3885-90 pubmed publisher
  9. Tsubokura M, Takita M, Matsumura T, Hara K, Tanimoto T, Kobayashi K, et al. Changes in metabolic profiles after the Great East Japan Earthquake: a retrospective observational study. BMC Public Health. 2013;13:267 pubmed publisher
    ..A natural disaster could affect metabolic profiles, and careful follow-up for survivors should be planned. ..
  10. Odawara M, Miyagawa J, Iwamoto N, Takita Y, Imaoka T, Takamura T. Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide significantly decreases glycated haemoglobin compared with once-daily liraglutide in Japanese patients with type 2 diabetes: 52 weeks of treatment in a randomized phase III study. Diabetes Obes Metab. 2016;18:249-57 pubmed publisher
    ..Monotherapy with once-weekly dulaglutide 0.75 mg was effective and safe in Japanese patients with T2D, with better glycaemic control compared with once-daily liraglutide 0.9 mg. ..
  11. Ebihara I, Nakamura T, Shimada N, Koide H. Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus. Am J Kidney Dis. 1998;32:544-50 pubmed
    ..01). However, serum MMP-1 and tissue inhibitor of MMP-1 showed no change during the study period. These data suggest that plasma MMP-9 concentrations preceded and may predict the development of microalbuminuria in NIDDM. ..
  12. Ochiai T, Morishima T, Hao T, Takayama A. Bullous amyloidosis: the mechanism of blister formation revealed by electron microscopy. J Cutan Pathol. 2001;28:407-11 pubmed
    ..Trauma or rubbing of her hands and feet appears to act as the localized precipitating factor of blister formation in bullous amyloidosis. ..
  13. Oishi M, Mochizuki Y, Suzuki Y, Ogawa K, Naganuma T, Nishijo Y, et al. Current perception threshold and sympathetic skin response in diabetic and alcoholic polyneuropathies. Intern Med. 2002;41:819-22 pubmed
    ..Correlation between current perception threshold and sympathetic skin response was investigated in patients with diabetic or alcoholic polyneuropathy...
  14. Ohtsuka T, Tanaka M, Nakajima J, Takamoto S. Videoscopic supradiaphragmatic thoracic duct division using ultrasonic coagulator. Eur J Cardiothorac Surg. 2002;22:828-30 pubmed
    ..No mortality, morbidity or recurrence occurred during follow-up periods of 27, 17 and 9 months. The Harmonic Scalpel with a hook blade can facilitate supradiaphragmatic exposure of the thoracic duct. ..
  15. Yamaguchi H, Shrivastav R, Andrews M, Niimi S. A comparison of voice quality ratings made by Japanese and American listeners using the GRBAS scale. Folia Phoniatr Logop. 2003;55:147-57 pubmed
    ..Despite these discrepancies, the GRBAS scale may be an excellent tool for perceptual evaluation of voice quality by linguistically diverse groups. ..
  16. Shoji J, Kato H, Kitazawa M, Inada N, Sawa M. Evaluation of staphylococcal enterotoxin-specific IgE antibody in tears in allergic keratoconjunctival disorders. Jpn J Ophthalmol. 2003;47:609-11 pubmed
    ..Our data strongly suggested that staphylococcal enterotoxin may cause type I allergy, and may be an exacerbating factor for vernal keratoconjunctivitis and atopic keratoconjunctivitis. ..
  17. Ishikawa K, Funayama T, Ohtake Y, Tanino T, Kurosaka D, Suzuki K, et al. Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. J Glaucoma. 2004;13:466-71 pubmed
    ..9% of our Japanese POAG patients. The use of pooled DNAs with DHPLC analysis is a time- and labor-saving technique. All mutations detected appear to be specific to Japanese patients. ..
  18. Tsukino H, Hanaoka T, Otani T, Iwasaki M, Kobayashi M, Hara M, et al. hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations. Cancer Sci. 2004;95:977-83 pubmed
    ..The results of the present study suggest that patients with atrophic gastritis in conjunction with the hOGG1 Cys allele might have a higher susceptibility to gastric cancer. ..
  19. Waragai M, Wei J, Fujita M, Nakai M, Ho G, Masliah E, et al. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem Biophys Res Commun. 2006;345:967-72 pubmed
    ..001 by ANOVA with post hoc Bonferroni's test), suggesting a protective role of DJ-1 against oxidative stress during the early stage. Thus, we propose that CSF DJ-1 could be a possible biomarker for early sporadic PD. ..
  20. Izumizaki M, Kakizaki F, Tanaka K, Homma I. Immediate effects of thixotropy conditioning of inspiratory muscles on chest-wall volume in chronic obstructive pulmonary disease. Respir Care. 2006;51:750-7 pubmed
    ..Thixotropy conditioning of inspiratory muscles, at a reduced chest-wall volume, decreased end-expiratory chest-wall volume in the 5 subsequent breaths in patients with chronic obstructive pulmonary disease. ..
  21. Kouno T, Ando M, Yonemori K, Matsumoto K, Shimizu C, Katsumata N, et al. Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Eur Urol. 2007;52:1115-22 pubmed
    ..Toxicities were mild except one toxic death due to neutropenic sepsis. Weekly paclitaxel plus carboplatin was a manageable, active second-line treatment for advanced transitional cell cancer after failure of platinum-based therapy. ..
  22. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, et al. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet. 2008;82:1122-9 pubmed publisher
    ..Our data indicate that regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH. ..
  23. Chin K, Baba S, Hosaka H, Ishiyama A, Mizunuma N, Shinozaki E, et al. Irinotecan plus cisplatin for therapy of small-cell carcinoma of the esophagus: report of 12 cases from single institution experience. Jpn J Clin Oncol. 2008;38:426-31 pubmed publisher
    ..The combination of CPT-11 and CDDP appears to be effective therapy of this disease with acceptable toxicity profile. We believe that this regimen is one of the options to be considered for treatment of esophageal small-cell carcinoma. ..
  24. Sakamaki H, Ishizawa K, Taniwaki M, Fujisawa S, Morishima Y, Tobinai K, et al. Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Int J Hematol. 2009;89:332-341 pubmed publisher
    ..Dasatinib therapy resulted in high rates of hematologic and cytogenetic response, suggesting that dasatinib is promising as a new treatment for Japanese CML and Ph(+) ALL patients resistant or intolerant to imatinib. ..
  25. Ikeda M, Hasegawa K, Sano K, Imamura H, Beck Y, Sugawara Y, et al. The vessel sealing system (LigaSure) in hepatic resection: a randomized controlled trial. Ann Surg. 2009;250:199-203 pubmed publisher
  26. Tani S, Nagao K, Anazawa T, Kawamata H, Furuya S, Takahashi H, et al. Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease. Am J Cardiol. 2010;105:144-8 pubmed publisher
    ..0023). In conclusion, our results have indicated that the decrease in the apoB/apoA-I ratio is a simple predictor for coronary atherosclerotic regression: the lower the apoB/apoA-I ratio, the lower the risk of coronary atherosclerosis. ..
  27. Nakauchi Y, Takase H, Sugita S, Mochizuki M, Shibata S, Ishiwata Y, et al. Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. Int J Hematol. 2010;92:179-85 pubmed publisher
    ..Grade 3 adverse event, leukocytopenia, was observed in only 1 patient. No grade 4 event was observed. Although further evaluation is required, concurrent sMTX and vMTX may be effective for IOL with CNS involvement. ..
  28. Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, et al. Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment. Intervirology. 2012;55:417-25 pubmed publisher
    ..This study identified genetic variation near IL28B gene and aa substitution of the core region as predictors of viral dynamics during triple therapy. ..
  29. Takayama T, Ebinuma H, Tada S, Yamagishi Y, Wakabayashi K, Ojiro K, et al. Prediction of effect of pegylated interferon alpha-2b plus ribavirin combination therapy in patients with chronic hepatitis C infection. PLoS ONE. 2011;6:e27223 pubmed publisher
    ..In conclusion, ANN was more accurate than MLRs in predicting the outcome of PEGIFN plus RBV therapy in patients with group 1b HCV. ..
  30. Tamai N, Matsuda K, Sumiyama K, Yoshida Y, Tajiri H. Glucagon facilitates colonoscopy and reduces patient discomfort: a randomized double-blind controlled trial with salivary amylase stress analysis. Eur J Gastroenterol Hepatol. 2013;25:575-9 pubmed publisher
    ..These results indicate that intravenous administration of glucagon can reduce patient discomfort and improve scope intubation during screening colonoscopy. ..
  31. Tanuma J, Sano K, Teruya K, Watanabe K, Aoki T, Honda H, et al. Pharmacokinetics of rifabutin in Japanese HIV-infected patients with or without antiretroviral therapy. PLoS ONE. 2013;8:e70611 pubmed publisher
    ..The results highlight the importance of monitoring rifabutin plasma concentration during ART. UMIN-CTR ( UMIN000001102. ..
  32. Iwamoto S, Takahashi T, Tamagawa H, Nakamura M, Munemoto Y, Kato T, et al. FOLFIRI plus bevacizumab as second-line therapy in patients with metastatic colorectal cancer after first-line bevacizumab plus oxaliplatin-based therapy: the randomized phase III EAGLE study. Ann Oncol. 2015;26:1427-33 pubmed publisher
    ..If bevacizumab is continued after first-line therapy in mCRC, a dose of 5 mg/kg is appropriate for use as second-line treatment. UMIN000002557. ..
  33. Kawamura Y, Arase Y, Ikeda K, Akuta N, Kobayashi M, Saitoh S, et al. Effects of Alcohol Consumption on Hepatocarcinogenesis in Japanese Patients With Fatty Liver Disease. Clin Gastroenterol Hepatol. 2016;14:597-605 pubmed publisher
    ..61 (95% CI, 5.68-28.00; P < .001). Based on a multicenter, retrospective analysis of almost 10,000 patients with FLD, ethanol consumption ≥40 g/day is an independent risk factor for HCC. ..
  34. Sezai A, Osaka S, Yaoita H, Arimoto M, Hata H, Shiono M, et al. Changeover Trial of Azilsartan and Olmesartan Comparing Effects on the Renin-Angiotensin-Aldosterone System in Patients with Essential Hypertension after Cardiac Surgery (CHAOS Study). Ann Thorac Cardiovasc Surg. 2016;22:161-7 pubmed publisher
    ..Accordingly, it may be effective in patients with increased renin-angiotensin-aldosterone system activity after cardiac surgery or patients with severe cardiac hypertrophy. ..
  35. Futagawa Y, Takano Y, Furukawa K, Kanehira M, Onda S, Sakamoto T, et al. Comparison of Outcomes with Hand-sewn Versus Stapler Closure of Pancreatic Stump in Distal Pancreatectomy. Anticancer Res. 2017;37:2515-2521 pubmed
    ..03). When indicating stapler closure, caution should be exercised for pancreatic consistency and thickness, device and cartridge type, and pancreatic duct ligation to more effectively control POPF rates. ..
  36. Naruke T, Tsuchiya R, Kondo H, Asamura H. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese experience. Ann Thorac Surg. 2001;71:1759-64 pubmed
    ..A new TNM staging system was proposed, and the previous system was revised in 1997...
  37. Katsube T, Ogawa K, Hamaguchi K, Murayama M, Konnno S, Shimakawa T, et al. Prevalence of Helicobacter pylori in the residual stomach after gastrectomy for gastric cancer. Hepatogastroenterology. 2002;49:128-32 pubmed
  38. Saito K, Yokoyama T, Yoshiike N, Date C, Yamamoto A, Muramatsu M, et al. Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure?. J Hypertens. 2003;21:1097-105 pubmed
    ..The alcohol-BP relationship was significantly stronger in men with ADH21/21 than in men with ADH21/22 or 22/22 in this Japanese rural population. This finding was exactly the opposite of what one previous study suggested. ..
  39. Tsuchida A, Kasuya K, Endo M, Saito H, Inoue K, Nagae I, et al. High risk of bile duct carcinogenesis after primary resection of a congenital biliary dilatation. Oncol Rep. 2003;10:1183-7 pubmed
  40. Aota Y, Sumi M, Iguchi T, Okabe S, Gotoh A, Ohyashiki K. Type I CD36 deficiency in hematologic disorder. Haematologica. 2004;89:EIM17 pubmed
  41. Otsubo T, Akimoto Y, Yamada H, Koda R, Aoyama H, Tanaka K, et al. A comparative study of the efficacy and safety profiles between fluvoxamine and nortriptyline in Japanese patients with major depression. Pharmacopsychiatry. 2005;38:30-5 pubmed
    ..The aim of this study was to compare the efficacy and safety profiles between fluvoxamine and nortriptyline in Japanese patients with major depression...
  42. Suzuki S, Shimoda M, Kawamura M, Sato H, Nogawa S, Tanaka K, et al. Myasthenia gravis accompanied by alopecia areata: clinical and immunogenetic aspects. Eur J Neurol. 2005;12:566-70 pubmed
    ..In conclusion, a subset of MG patients who have severe neuromuscular symptoms and thymoma develop AA several years after thymectomy. ..
  43. Watanabe M, Yoshida R, Ueoka K, Aoki K, Sasagawa I, Hasegawa T, et al. Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities. Hum Reprod. 2007;22:1279-84 pubmed
    ..Our results support the hypothesis that homozygosity for the specific ESR1 'AGATA' haplotype may increase the susceptibility to the development of male genital abnormalities in response to estrogenic EEDs. ..
  44. Minematsu N, Nakamura H, Furuuchi M, Nakajima T, Takahashi S, Tsujimura S, et al. Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema. Respirology. 2008;13:498-504 pubmed publisher
    ..Novel functional polymorphisms were identified in the cathepsin S gene, which has a possible association with pulmonary emphysema in the Japanese population. ..
  45. Niki Y, Mochizuki T, Momohara S, Saito S, Toyama Y, Matsumoto H. Is minimally invasive surgery in total knee arthroplasty really minimally invasive surgery?. J Arthroplasty. 2009;24:499-504 pubmed publisher
    ..Consequently, degree of muscle damage was equivalent between MIS-TKA and conventional TKA, whereas types of vastus-splitting approach appeared closely related to muscle damage. ..
  46. Nishimura T, Hasegawa N, Watanabe M, Takebayashi T, Tasaka S, Ishizaka A. Bronchoscopic microsampling to analyze the epithelial lining fluid of patients with pulmonary Mycobacterium avium complex disease. Respiration. 2008;76:338-43 pubmed publisher
    ..While the number of immunocompetent patients with pulmonary Mycobacterium avium complex(MAC) disease is growing, the precise pathogenesis of the disease remains to be clarified...
  47. Hosoya K, Yamashita S, Ando T, Nakajima T, Itoh F, Ushijima T. Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. Cancer Lett. 2009;285:182-9 pubmed publisher
    ..These findings strongly indicated that methylation of APC promoter 1A is a passenger, and suggested that marked down-regulation of 1B expression could be related to formation of a field predisposed to gastric cancers. ..
  48. Iijima M, Osawa M, Momose M, Kobayakawa T, Saito S, Iwata M, et al. Cardiac sympathetic degeneration correlates with olfactory function in Parkinson's disease. Mov Disord. 2010;25:1143-9 pubmed publisher
    ..The results suggest that the cardiac sympathetic nervous system might degenerate in parallel with the olfactory system in patients with early PD, and that these two systems might degenerate at a different rate of speed in advanced PD. ..
  49. Goto T, Maeshima A, Oyamada Y, Kato R. Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer. Interact Cardiovasc Thorac Surg. 2010;10:1051-3 pubmed publisher
    ..Pathological examination of the ribs revealed IgG-lambda myeloma. Herein, we report a patient with lung cancer in whom multiple myeloma was definitively diagnosed from rib specimens resected at thoracotomy. ..
  50. Takahashi Y, Suzuki M, Fukusato T. Plexiform angiomyxoid myofibroblastic tumor of the stomach. World J Gastroenterol. 2010;16:2835-40 pubmed
    ..Some authors proposed that this tumor should be designated as "plexiform fibromyxoma", but this designation might cause confusion. The tumor is probably benign and thus far, neither recurrence nor metastasis has been reported. ..
  51. Shinohara Y, Katayama Y, Uchiyama S, Yamaguchi T, Handa S, Matsuoka K, et al. Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial. Lancet Neurol. 2010;9:959-68 pubmed publisher
    ..Therefore, cilostazol could be used for prevention of stroke in patients with non-cardioembolic stroke. Otsuka Pharmaceutical. ..
  52. Namikawa K, Yamazaki N. Sentinel lymph node biopsy guided by indocyanine green fluorescence for cutaneous melanoma. Eur J Dermatol. 2011;21:184-90 pubmed publisher
    ..Because it is difficult to detect anatomically deep SLNs and residual SLNs after SLN biopsy using the fluorescence method alone, the combined use with other identification methods is advisable. ..
  53. Yoshida A, Tsuta K, Nakamura H, Kohno T, Takahashi F, Asamura H, et al. Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol. 2011;35:1226-34 pubmed publisher
    ..ALK-positive cancers commonly showed coexpression of thyroid transcription factor-1 and p63, and its significance is currently unclear. ..
  54. Ichinose J, Nakahara K, Kina S, Miyanaga S. A case of sclerosing hemangioma forming a pedunculated mass. Ann Thorac Cardiovasc Surg. 2011;17:408-10 pubmed
    ..By thoracoscopic surgery, we successfully diagnosed and treated the patient in a minimally invasive manner. Since there have been reported cases of recurrence, we anticipate that periodic follow-up observations will be required. ..
  55. Qian Y, Takao H, Umezu M, Murayama Y. Risk analysis of unruptured aneurysms using computational fluid dynamics technology: preliminary results. AJNR Am J Neuroradiol. 2011;32:1948-55 pubmed publisher
    ..On the contrary, the flow inside stable-IAs passed smoothly through the aneurysms. These preliminary results indicated that EL may be a useful parameter for the quantitative estimation of the risks of rupture for IAs. ..
  56. Yamamoto S, Fuchi M, Yasui T. Change of rocker function in the gait of stroke patients using an ankle foot orthosis with an oil damper: immediate changes and the short-term effects. Prosthet Orthot Int. 2011;35:350-9 pubmed publisher
    ..An ankle foot orthosis (AFO) using an oil damper (AFO-OD) to assist the first rocker during gait was previously developed but the effect on the other rocker functions has not been clarified...
  57. Takayama T, Hiro T, Yamagishi M, Daida H, Hirayama A, Saito S, et al. Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS). Circ J. 2009;73:2110-7 pubmed
    ..Rosuvastatin might be useful in the setting of secondary prevention in patients with stable CAD. ..
  58. Takizawa Y, Akiyama M, Nagashima M, Shimizu H. A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens. J Invest Dermatol. 2000;114:193-5 pubmed
    ..Our data indicate aspartic acid substitution in codon 192 in the 1A helix initiation site is deleterious to keratin filament network integrity and leads to ichthyosis bullosa of Siemens phenotype. ..
  59. Sato N, Katsumata N, Kagami M, Hasegawa T, Hori N, Kawakita S, et al. Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients. J Clin Endocrinol Metab. 2004;89:1079-88 pubmed
  60. Kamisawa T, Yoshiike M, Egawa N, Tsuruta K, Okamoto A, Matsukawa M. Classification of choledochocele. Hepatogastroenterology. 2005;52:29-32 pubmed
    ..This classification of choledochocele is useful for analysis of pathophysiology and determination of therapeutic strategy. ..
  61. Iino Y, Kakizaki K, Saruya S, Katano H, Komiya T, Kodera K, et al. Eustachian tube function in patients with eosinophilic otitis media associated with bronchial asthma evaluated by sonotubometry. Arch Otolaryngol Head Neck Surg. 2006;132:1109-14 pubmed
    ..One of the most important causes of otitis media (OM) is eustachian tube dysfunction...
  62. Hayashi T, Hirano T, Taira T, Tokuno A, Mori Y, Koba S, et al. Remarkable increase of apolipoprotein B48 level in diabetic patients with end-stage renal disease. Atherosclerosis. 2008;197:154-8 pubmed
    ..The remarkably high level of apoB48 in diabetic ESRD seems to be attributable to dyslipidemia induced by both diabetic nephropathy and ESRD. ..
  63. Omata M, Yoshida H, Toyota J, Tomita E, Nishiguchi S, Hayashi N, et al. A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C. Gut. 2007;56:1747-53 pubmed
    ..A 600 mg/day UDCA dose was optimal to decrease ALT and AST levels in CH-C patients. The 900 mg/day dose decreased GGT levels further, and may be preferable in patients with prevailing biliary injuries. ..
  64. Kobayashi M, Otani T, Iwasaki M, Natsukawa S, Shaura K, Koizumi Y, et al. Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. Scand J Gastroenterol. 2009;44:952-9 pubmed publisher
    ..In the present study in subjects with low HCA exposure and with a limited sample size, no association was found between HCA intake and colorectal cancer, or any evidence of influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2. ..
  65. Wakakura M, Fujie W, Emoto Y. Initial temporal field defect in Leber hereditary optic neuropathy. Jpn J Ophthalmol. 2009;53:603-607 pubmed publisher
    ..This suggests that the most susceptible cells during the early stages of LHON are the retinal ganglion cells located in the corresponding region of the retina. ..
  66. Ito H, Hagiwara M, Furuuchi T, Kanai K, Kodaira K, Ninomiya A, et al. [A case of double cancer involving the urachus and the bladder]. Hinyokika Kiyo. 2010;56:41-3 pubmed
    ..Under a diagnosis of double cancer, adenocarcinoma of the urachus and urothelial carcinoma of bladder, we performed a total cystectomy, neobladder and total resection of the urachus...
  67. Kato H, Nakajima M, Ohnaka Y, Ishihara K, Kawamura M. Recurrent abducens nerve palsy associated with neurovascular compression. J Neurol Sci. 2010;295:135-6 pubmed publisher
    ..Together with a lack of the preceding headache or febrile illness, we propose that neurovascular compression is a possible etiology of recurrent, isolated abducens nerve palsy. ..
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