Experts and Doctors on mice in Fukuoka, Japan

Summary

Locale: Fukuoka, Japan
Topic: mice

Top Publications

  1. Nomura M, Bartsch S, Nawata H, Omura T, Morohashi K. An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. J Biol Chem. 1995;270:7453-61 pubmed
  2. Wang J, Koizumi T, Watanabe T. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med. 1996;184:831-8 pubmed
  3. Watanabe T, Oda Y, Tamiya S, Masuda K, Tsuneyoshi M. Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison between benign and malignant components. J Clin Pathol. 2001;54:631-6 pubmed
    ..On the basis of these findings, TGF-beta 1, HGF-alpha, and p53 might be involved in the malignant transformation of neurofibroma to MPNST. ..
  4. Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, et al. Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood. 2007;109:1756-64 pubmed
    ..These results also suggest that self-reactivity of donor T cells plays a role in this chronic GVHD, and improvement in the thymic function may have a potential to decrease chronic GVHD. ..
  5. Qiao H, Sonoda K, Ikeda Y, Yoshimura T, Hijioka K, Jo Y, et al. Interleukin-18 regulates pathological intraocular neovascularization. J Leukoc Biol. 2007;81:1012-21 pubmed
    ..We therefore concluded that IL-18 regulates pathogenic retinal NV by promoting its regression rather than inhibiting its development. This suggests some useful, new approaches to treating retinopathy in humans. ..
  6. Kosaka K, Kosaka T. Chemical properties of type 1 and type 2 periglomerular cells in the mouse olfactory bulb are different from those in the rat olfactory bulb. Brain Res. 2007;1167:42-55 pubmed
    ..We herein reveal the significant species differences in the chemical properties of periglomerular cells and suggest that the cellular organization of the mouse main olfactory bulb cannot be extrapolated from that of rats. ..
  7. Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, et al. Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses. Biol Chem. 2007;388:1173-81 pubmed
    ..These results thus indicate that CE expression in tumor cells induces tumor growth arrest via inhibition of angiogenesis and enhanced immune responses. ..
  8. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, et al. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008;283:23139-49 pubmed publisher
    ..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme. ..
  9. Minami R, Yamamoto M, Takahama S, Ando H, Miyamura T, Suematsu E. High molecular weight form of adiponectin in antiretroviral drug-induced dyslipidemia in HIV-infected Japanese individuals based on in vivo and in vitro analyses. Intern Med. 2009;48:1799-875 pubmed
    ..We also examined the effect of some antiretroviral drugs (ARVs) on adipocytes in vitro...

More Information

Publications524 found, 100 shown here

  1. Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, et al. Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol. 2009;183:7778-86 pubmed publisher
  2. Murata Y, Yasuo T, Yoshida R, Obata K, Yanagawa Y, Margolskee R, et al. Action potential-enhanced ATP release from taste cells through hemichannels. J Neurophysiol. 2010;104:896-901 pubmed publisher
    ..Our data support the hypothesis that action potentials in taste cells responsive to sweet, bitter, or umami tastants enhance ATP release through pannexin 1, not connexin-based hemichannels...
  3. Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack E, et al. CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. J Immunol. 2010;185:2222-30 pubmed publisher
    ..The results of these studies demonstrate that CD30L/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation, at least partly via downregulation of IL-2 production...
  4. Suzuki H, Onimaru M, Yonemitsu Y, Maehara Y, Nakamura S, Sueishi K. Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells. Mol Cancer. 2010;9:287 pubmed publisher
  5. Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, et al. SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling. Int Immunol. 2011;23:165-76 pubmed publisher
    ..This reduction in iNKT cells was not observed in mice of an IFN?-deficient background. These results suggest that SOCS1 is an important regulator of the balance between type I and type II NKT cells at the periphery. ..
  6. Ichiyanagi K. Inhibition of MspI cleavage activity by hydroxymethylation of the CpG site: a concern for DNA modification studies using restriction endonucleases. Epigenetics. 2012;7:131-6 pubmed publisher
    ..Therefore, DNA modification studies that use MspI, for example, reduced representation bisulfite shotgun sequencing, quantitative analysis of 5-hmC, and cleavage-sensitivity analysis, should be carefully interpreted. ..
  7. Fukuda T, Sanui T, Toyoda K, Tanaka U, Taketomi T, Uchiumi T, et al. Identification of novel amelogenin-binding proteins by proteomics analysis. PLoS ONE. 2013;8:e78129 pubmed publisher
  8. Oiki S, Hiyama E, Gotoh T, Iida H. Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa. Zoolog Sci. 2014;31:101-7 pubmed publisher
    ..These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction. ..
  9. Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, et al. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. EMBO J. 2017;36:1888-1907 pubmed publisher
    ..By establishing a paradigm for PGCLC expansion, our system reconstitutes the epigenetic "blank slate" of the germ line, an immediate precursory state for sexually dimorphic differentiation. ..
  10. Takano T, Motozono C, Imai T, Sonoda K, Nakanishi Y, Yamasaki S. Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity. J Biol Chem. 2017;292:16933-16941 pubmed publisher
    ..These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile. ..
  11. Fujii M, Kanematsu T, Ishibashi H, Fukami K, Takenawa T, Nakayama K, et al. Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem. 2010;285:4837-46 pubmed publisher
    ..Taken together, these results suggest that PRIP is involved in insulin-induced GABA(A) receptor insertion by recruiting active Akt to the receptor complex. ..
  12. Shiratori M, Tozaki Saitoh H, Yoshitake M, Tsuda M, Inoue K. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem. 2010;114:810-9 pubmed publisher
    ..These results suggest that ATP increased CXCL2 production via both NFAT and protein kinase C/MAPK signaling pathways through P2X7 receptor stimulation in microglia. ..
  13. Dohgu S, Ryerse J, Robinson S, Banks W. Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. PLoS ONE. 2012;7:e39565 pubmed publisher
    ..We conclude that M6PR is an important receptor used by HIV-1 to cross the BBB. ..
  14. Sugiyama D, Kulkeaw K, Mizuochi C. TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013;130:195-206 pubmed publisher
    ..Taken together, our observations suggest that hepatoblasts predominantly produce ECM factors under control of TGF-beta-1 in fetal liver. ..
  15. Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, et al. Involvement of peripheral cannabinoid and opioid receptors in ?-caryophyllene-induced antinociception. Eur J Pain. 2013;17:664-75 pubmed publisher
    ..pl. BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid ?-endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain. ..
  16. Nitta H, Unoki M, Ichiyanagi K, Kosho T, Shigemura T, Takahashi H, et al. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. J Hum Genet. 2013;58:455-60 pubmed publisher
    ..We further revealed that the proper localization of wild-type Zbtb24 protein does not require DNA methylation. ..
  17. Matsushita K, Tozaki Saitoh H, Kojima C, Masuda T, Tsuda M, Inoue K, et al. Chemokine (C-C motif) receptor 5 is an important pathological regulator in the development and maintenance of neuropathic pain. Anesthesiology. 2014;120:1491-503 pubmed publisher
    ..05, n = 4 each). Pharmacological blockade of CCR5 was effective in the treatment of the development and maintenance phases of neuropathic pain. Thus, CCR5 antagonists may be potential new drugs for the treatment of neuropathic pain. ..
  18. Takata F, Dohgu S, Yamauchi A, Sumi N, Nakagawa S, Naito M, et al. Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. Cell Mol Neurobiol. 2007;27:317-28 pubmed
    ..4. These findings suggest that an inhibition of brain pericyte-derived TGF-beta1 contributes to the occurrence of CsA-induced dysfunction of the BBB. ..
  19. Hiramoto T, Chida Y, Sonoda J, Yoshihara K, Sudo N, Kubo C. The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor. Gastroenterology. 2008;134:2122-31 pubmed publisher
  20. Matsunaga N, Ikeda M, Takiguchi T, Koyanagi S, Ohdo S. The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver. Hepatology. 2008;48:240-51 pubmed publisher
    ..Our results suggest that the transcription activator of HNF-1alpha acts periodically and the negative limbs of molecular clocks periodically inhibit CYP2E1 transcription, resulting in the 24-hour rhythm of its mRNA expression. ..
  21. Tang C, Yamada H, Shibata K, Muta H, Wajjwalku W, Podack E, et al. A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 2008;181:6316-27 pubmed
    ..These results suggest that CD30L/CD30 signaling executed by CD30(+) T-CD30L(+) T cell interaction partly play a critical role in augmentation of Th1 response capable of producing IFN-gamma against BCG infection. ..
  22. Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, et al. Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer. Ann Surg Oncol. 2011;18:2057-65 pubmed publisher
    ..001). Our results strongly suggest that p600 is involved in gastric cancer progression, and has a potential to be a new molecular target for gastric cancer therapy. ..
  23. Sato M, Ito A, Kawabe Y, Nagamori E, Kamihira M. Enhanced contractile force generation by artificial skeletal muscle tissues using IGF-I gene-engineered myoblast cells. J Biosci Bioeng. 2011;112:273-8 pubmed publisher
  24. Sakai A, Valanezahad A, Ozaki M, Ishikawa K, Matsuya S. Preparation of Sr-containing carbonate apatite as a bone substitute and its properties. Dent Mater J. 2012;31:197-205 pubmed
    ..ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity. ..
  25. Onishi H, Morisaki T, Nakao F, Odate S, Morisaki T, Katano M. Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1? pathways under hypoxia. Cancer Lett. 2013;335:289-98 pubmed publisher
    ..In conclusion, we found new PSK-related pathways in invasiveness and proliferation in PDAC under hypoxia. PSK may be a promising therapeutic drug to treat refractory PDAC. ..
  26. Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama K. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell. 2013;23:347-61 pubmed publisher
    ..Purging of LICs by targeting Fbxw7 to interrupt their quiescence and subsequent treatment with imatinib may thus provide the basis for a promising therapeutic approach to CML. ..
  27. Shi J, Geshi N, Takahashi S, Kiyonaka S, Ichikawa J, Hu Y, et al. Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II. J Physiol. 2013;591:2851-66 pubmed publisher
    ..This mechanism may be of physiological significance in a native environment such as in vascular smooth muscle cells. ..
  28. Swain A, Kulkeaw K, Tanaka Y, Nakanishi Y, Shirasawa S, Sugiyama D. DBA Lectin Binds to Highly Proliferative Mouse Erythroleukemia Cells. Anticancer Res. 2016;36:3625-33 pubmed
    ..Ki-67 expression and MTS assay correlated with the DBA-binding pattern, with DBA(High) reflecting the highest proliferative tendency. Labeling with DBA allows selection of proliferating cells using flow cytometry. ..
  29. Yamada T, Sasaki H, Dohura K, Goto I, Sakaki Y. Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor. Biochem Biophys Res Commun. 1989;158:906-12 pubmed
    ..These data suggest that the individual BPP mRNA species were produced in a tissue-specific manner in mouse as in the case of human. ..
  30. Aikawa Y, Kuraoka A, Kondo H, Kawabuchi M, Watanabe T. Involvement of PITPnm, a mammalian homologue of Drosophila rdgB, in phosphoinositide synthesis on Golgi membranes. J Biol Chem. 1999;274:20569-77 pubmed
    ..These results suggest that PITPnm plays a role in phosphoinositide synthesis on the Golgi vacuoles and possibly in the PtdIns signaling pathway in mammalian cells...
  31. Yamaza H, Matsuo K, Kobayashi I, Wada H, Kiyoshima T, Akhtar M, et al. Expression of Set-alpha during morphogenesis of mouse lower first molar. Histochem J. 2001;33:437-41 pubmed
  32. Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002;416:865-9 pubmed
    ..These results suggest that PKC-delta has an indispensable function in negative regulation of B-cell proliferation, and is particularly important for the establishment of B-cell tolerance. ..
  33. Sakurada C, Sakurada S, Hayashi T, Katsuyama S, Tan No K, Sakurada T. Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study. Biochem Pharmacol. 2003;66:653-61 pubmed
    ..These results indicate that dipeptidyl peptidase IV may be an important peptidase responsible for terminating endomorphin-2-induced antinociception at the supraspinal level in mice. ..
  34. Behmanesh M, Sakumi K, Tsuchimoto D, Torisu K, Ohnishi Honda Y, Rancourt D, et al. Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome. DNA Res. 2005;12:39-51 pubmed
  35. Saito K, Yajima T, Kumabe S, Doi T, Yamada H, Sad S, et al. Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice. J Immunol. 2006;176:2496-504 pubmed
    ..These results suggest that IL-15 plays an important role in the development of long-lasting protective immunity to BCG infection via sustaining CD8 responses in the lung. ..
  36. Kakehashi H, Nishioku T, Tsukuba T, Kadowaki T, Nakamura S, Yamamoto K. Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. J Immunol. 2007;179:5728-37 pubmed
    ..These results indicate that cathepsin E differentially regulates the nature and function of DCs and macrophages. ..
  37. Sengoku A, Inai T, Shibata Y. Formation of aberrant TJ strands by overexpression of claudin-15 in MDCK II cells. Histochem Cell Biol. 2008;129:211-22 pubmed
    ..These results suggest that not only binding to ZO-1, but also head-to-head compatibility between claudin species, is involved in organizing claudin proteins at the apical junctional region. ..
  38. Zhu H, Aishima M, Morinaga H, Wassall R, Shibata A, Iwasa K, et al. Molecular and biophysical properties of voltage-gated Na+ channels in murine vas deferens. Biophys J. 2008;94:3340-51 pubmed publisher
    ..6(+/+)) littermates. This study demonstrates that the molecular identity of the voltage-gated Na(+) channels responsible for the TTX-sensitive I(Na) in murine vas deferens myocytes is primarily Na(V)1.6...
  39. Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, et al. Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol. 2009;587:4425-39 pubmed publisher
    ..We did not find any NaCl-best cells among the gustducin and GAD67 taste cells, raising the possibility that salt sensitive taste cells comprise a different population...
  40. Hayashida S, Arimoto A, Kuramoto Y, Kozako T, Honda S, Shimeno H, et al. Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice. Mol Cell Biochem. 2010;339:285-92 pubmed publisher
    ..The cell experiments using SIRT1 antagonists and a PPARalpha agonist suggested that PPARalpha is a key molecule located upstream from SIRT1, and has a role in regulating SIRT1 gene expression in fasting-induced anti-aging pathways. ..
  41. Kajiya H, Okamoto F, Nemoto T, Kimachi K, Toh Goto K, Nakayana S, et al. RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations. Cell Calcium. 2010;48:260-9 pubmed publisher
    ..In summary, Ca(2+) oscillations in preosteoclasts are triggered by RANKL-dependent TRPV2 and SOCE activation and intracellular Ca(2+) release. Subsequent activation of NFATc1 promotes osteoclastogenesis. ..
  42. Kozono S, Ohuchida K, Eguchi D, Ikenaga N, Fujiwara K, Cui L, et al. Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res. 2013;73:2345-56 pubmed publisher
    ..In conclusion, our findings indicate that pirfenidone is a promising antitumor agent for pancreatic cancer, owing to its suppression of desmoplasia through regulating PSCs. ..
  43. Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, et al. IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13. PLoS ONE. 2013;8:e54623 pubmed publisher
    ..Overexpressing the IL-18 protein in the lungs induces type 1 and type 2 cytokines and airway inflammation, and results in increasing airway hyperresponsiveness via CD4(+) T cells and IL-13 in asthma. ..
  44. Tane S, Ikenishi A, Okayama H, Iwamoto N, Nakayama K, Takeuchi T. CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014;443:1105-9 pubmed publisher
    ..These results indicate that p21(Cip1) and p27(Kip) play important roles in the cell cycle exit of postnatal cardiomyocytes. ..
  45. Koyabu N, Takanaga H, Matsuo H, Naito M, Tsuruo T, Ohtani H, et al. Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line. Drug Metab Pharmacokinet. 2004;19:270-9 pubmed
    ..29+/-0.43 mM). These observations indicate the existence of a pH- and membrane-potential-dependent anion exchange and/or proton-cotransport system(s) for concentrative uptake of tolbutamide and sulfa drugs in MBEC4 cells. ..
  46. Takahashi H, Hatakeyama S, Saitoh H, Nakayama K. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J Biol Chem. 2005;280:5611-21 pubmed
    ..These results suggest that SUMO-1 functions to tether proteins to PML-containing nuclear bodies through post-translational modification and noncovalent protein-protein interaction. ..
  47. Fukushima H, Jimi E, Kajiya H, Motokawa W, Okabe K. Parathyroid-hormone-related protein induces expression of receptor activator of NF-{kappa}B ligand in human periodontal ligament cells via a cAMP/protein kinase A-independent pathway. J Dent Res. 2005;84:329-34 pubmed
  48. Kakumitsu H, Kamezaki K, Shimoda K, Karube K, Haro T, Numata A, et al. Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. Leuk Res. 2005;29:761-9 pubmed
  49. Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, et al. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 2005;8:855-7 pubmed
    ..Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells. ..
  50. Egashira N, Iwasaki K, Takashima A, Watanabe T, Kawabe H, Matsuda T, et al. Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice. Brain Res. 2005;1059:7-12 pubmed
    ..These results suggest that R406W Tg mice exhibit changes in depression-related behavior involving serotonergic neurons and provide an animal model for investigating AD with depression. ..
  51. Yamayoshi A, Kato K, Suga S, Ichinoe A, Arima T, Matsuda T, et al. Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation. Oligonucleotides. 2007;17:66-79 pubmed
    ..These results suggest that the photodynamic antisense strategy has the great therapeutic potential in HPV-positive cervical cancers. ..
  52. Yamaji Y, Yoshida S, Ishikawa K, Sengoku A, Sato K, Yoshida A, et al. TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008;49:3151-7 pubmed publisher
    ..If correct, TEM7 may be a molecular target for new diagnostic and therapeutic strategies for PDR. ..
  53. Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, et al. Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. DNA Repair (Amst). 2008;7:1437-54 pubmed publisher
    ..The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair. ..
  54. Kim J, Matsunaga N, Koyanagi S, Ohdo S. Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene. Biochem Pharmacol. 2009;78:1075-82 pubmed publisher
    ..Our present findings would provide a molecular link between the circadian clock and DNA repair pathway. ..
  55. Itsumi M, Yoshikai Y, Yamada H. IL-15 is critical for the maintenance and innate functions of self-specific CD8(+) T cells. Eur J Immunol. 2009;39:1784-93 pubmed publisher
  56. Hayashi Y, Kawaji K, Sun L, Zhang X, Koyano K, Yokoyama T, et al. Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. J Neurosci. 2011;31:17370-82 pubmed publisher
    ..Therefore, the preferential inhibition of microglial BK channels in addition to neuronal NMDA receptors may account for the preferential and potent analgesic effects of S-ketamine on neuropathic pain. ..
  57. Fukumitsu Y, Irie K, Satho T, Aonuma H, Dieng H, Ahmad A, et al. Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus. Parasit Vectors. 2012;5:92 pubmed publisher
    ..Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito Ae. albopictus. ..
  58. Yamada J, Jinno S. Upregulation of calcium binding protein, S100A6, in activated astrocytes is linked to glutamate toxicity. Neuroscience. 2012;226:119-29 pubmed publisher
    ..Our results indicate that upregulation of astrocytic S100A6 in response to extracellular glutamate may be involved in neuronal damage under pathophysiological conditions. ..
  59. Tajima K, Fukuda T. Region-specific diversity of striosomes in the mouse striatum revealed by the differential immunoreactivities for mu-opioid receptor, substance P, and enkephalin. Neuroscience. 2013;241:215-28 pubmed publisher
    ..The results further suggest the necessity of viewing the striosomes as non-uniform compartments in addition to the traditional dichotomous view, which focuses on discrimination between the striosomes and the matrix. ..
  60. Zhang S, Chen Q, Liu Q, Li Y, Sun X, Hong L, et al. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell. 2017;31:669-684.e7 pubmed publisher
    ..Thus, we conclude that Hippo-Yap signaling suppresses cell polyploidy and oncogenesis through Skp2. ..
  61. Iwamoto T, Kita S, Zhang J, Blaustein M, Arai Y, Yoshida S, et al. Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med. 2004;10:1193-9 pubmed
    ..3 mutants. These findings indicate that salt-sensitive hypertension is triggered by Ca(2+) entry through NCX1 in arterial smooth muscle and suggest that NCX1 inhibitors might be useful therapeutically. ..
  62. Kimura C, Nakanishi T, Tojo K. Skin permeation of ketotifen applied from stick-type formulation. Eur J Pharm Biopharm. 2007;67:420-4 pubmed
    ..The rate of skin permeation of KT was approximately proportional to the loading dose of the drug. ..
  63. Tsukada Y, Ishitani T, Nakayama K. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010;24:432-7 pubmed publisher
    ..Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development...
  64. Sakumi K, Abolhassani N, Behmanesh M, Iyama T, Tsuchimoto D, Nakabeppu Y. ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. Mutat Res. 2010;703:43-50 pubmed publisher
    ..The biological significance of ITP and dITP in the nucleotide pool remains to be elucidated. ..
  65. Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama K. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem. 2011;286:13754-64 pubmed publisher
    ..Our results thus implicate Fbxw7 as a key regulator of the maintenance and differentiation of neural stem cells in the brain. ..
  66. Shima Y, Miyabayashi K, Baba T, Otake H, Katsura Y, Oka S, et al. Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal Leydig cells. Endocrinology. 2012;153:417-25 pubmed publisher
    ..Our identification of a fetal Leydig cell-specific enhancer in the Ad4BP/SF-1 gene would be a powerful tool to address these gaps in the knowledge base...
  67. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, et al. Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia. Cell Host Microbe. 2013;13:477-88 pubmed publisher
    ..These results demonstrate that Mincle and Dectin-2 recognize distinct ligands in Malassezia to induce host immune responses. ..
  68. Agarwala K, Kawabata S, Takao T, Murata H, Shimonishi Y, Nishimura H, et al. Activation peptide of human factor IX has oligosaccharides O-glycosidically linked to threonine residues at 159 and 169. Biochemistry. 1994;33:5167-71 pubmed
    ..From these results, it was concluded that a part of the activation peptide of human factor IX in circulating blood has tri- and tetrasaccharides O-glycosidically linked to the threonine residues at 159 and 169. ..
  69. Mizuki K, Kadomatsu K, Hata K, Ito T, Fan Q, Kage Y, et al. Functional modules and expression of mouse p40(phox) and p67(phox), SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complex. Eur J Biochem. 1998;251:573-82 pubmed
    ..These observations raise the possibility that the adaptor protein p40phox plays a heretofore unsuspected role via interacting with other proteins in the cells that do not express p67phox or p47phox. ..
  70. Takade A, Umeda A, Matsuoka M, Yoshida S, Nakamura M, Amako K. Comparative studies of the cell structures of Mycobacterium leprae and M. tuberculosis using the electron microscopy freeze-substitution technique. Microbiol Immunol. 2003;47:265-70 pubmed
    ..The cell widths measured on electron micrographs were 0.44 microm for M. tuberculosis and 0.38 microm for M. leprae. The peptidoglycan layer of M. leprae was 4-5 nm, while the corresponding layer of M. tuberculosis was 10-15 nm. ..
  71. Ikari T, Hiraki A, Seki K, Sugiura T, Matsumoto K, Shirasuna K. Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn. 2003;228:173-84 pubmed
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