Experts and Doctors on lysine in Ōsaka, Japan


Locale: Ōsaka, Japan
Topic: lysine

Top Publications

  1. Yokoyama Y, Hieda M, Nishioka Y, Matsumoto A, Higashi S, Kimura H, et al. Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo. Cancer Sci. 2013;104:889-95 pubmed publisher
    ..These data indicate that H3K9 trimethylation plays an important role in human colorectal cancer progression, possibly by promoting collective cell invasion. ..
  2. Yoshikawa T, Miyazaki A, Fujimoto S. Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females. Med Sci Monit. 2009;15:PH65-73 pubmed
    ..007) and body fat mass (P=0.038). The present findings suggest lifestyle modification as a promising approach to reducing circulating AGE levels even in healthy middle-aged females with neither overt diabetes nor renal dysfunction. ..
  3. Ichikawa N, Karaki A, Kawabata M, Ushida S, Mizushima M, Hashimoto T. The region from phenylalanine-17 to phenylalanine-28 of a yeast mitochondrial ATPase inhibitor is essential for its ATPase inhibitory activity. J Biochem. 2001;130:687-93 pubmed
    ..These results show that the region from the position 17 to 28 of the yeast inhibitor is the most important for its activity and is required for the inhibition of F(1), rather than binding to the enzyme. ..
  4. Yoshinaga E, Kawada A, Ono K, Fujimoto E, Wachi H, Harumiya S, et al. N(?)-(carboxymethyl)lysine modification of elastin alters its biological properties: implications for the accumulation of abnormal elastic fibers in actinic elastosis. J Invest Dermatol. 2012;132:315-23 pubmed publisher
    ..The glycated elastin is likely to cause the accumulation of abnormally aggregated elastic fibers and unusual interaction with lysozyme in actinic elastosis. ..
  5. Onishi H, Maita T, Matsuda G, Fujiwara K. Lys-65 and Glu-168 are the residues for carbodiimide-catalyzed cross-linking between the two heads of rigor smooth muscle heavy meromyosin. J Biol Chem. 1990;265:19362-8 pubmed
    ..Based on the head-to-head contact, we propose a three-dimensional model for the attachment of gizzard HMM heads to F-actin. ..
  6. Ishikawa K, Kimura S, Kanaya S, Morikawa K, Nakamura H. Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. Protein Eng. 1993;6:85-91 pubmed
  7. Sato C, Kim J, Abe Y, Saito K, Yokoyama S, Kohda D. Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor. J Biochem. 2000;127:65-72 pubmed
    ..Therefore, sEGFR with the mutation of Asn(32) -> Lys(32 )is useful for biophysical and biochemical studies, and, particularly, for X-ray crystallography. ..
  8. Tanaka C, Kamide K, Takiuchi S, Kawano Y, Miyata T. Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene. Hypertens Res. 2004;27:367-71 pubmed
  9. Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, et al. Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin Cancer Res. 2004;10:8293-300 pubmed
    ..These results indicated that this functionalized TNF-alpha may be useful not only as an antitumor agent but also as a selective enhancer of vascular permeability in tumors for improving antitumor chemotherapy. ..

More Information


  1. Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam M, et al. Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. J Biol Chem. 2005;280:37246-56 pubmed
    ..The structural data suggest that there is a larger effect of oxidation on the interdomain loop and residues surrounding the CXXC center in hBCATm than in hBCATc. ..
  2. Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, et al. Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 2008;19:503-11 pubmed publisher
    ..These results indicate that the plasminogen-plasmin system on the surface of mouse hepatocytes plays an important role in liver regeneration...
  3. Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, et al. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity. 2010;33:765-76 pubmed publisher
    ..Taken together, these results indicate that TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses. ..
  4. Amano K, Ishiguchi M, Aikawa T, Kimata M, Kishi N, Fujimaki T, et al. Cleft lip in oculodentodigital dysplasia suggests novel roles for connexin43. J Dent Res. 2012;91:38S-44S pubmed
    ..Therefore, we suggest that CX43/GJA1 is involved in lip formation. Our case report of ODDD with a bilateral cleft lip suggests that CX43/GJA1 might be a novel candidate gene for syndromic cleft lip...
  5. Nakamura T, Liu Y, Nakashima H, Umehara H, Inoue K, Matoba S, et al. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature. 2012;486:415-9 pubmed publisher
    ..This type of regulatory mechanism could be involved in DNA modifications in somatic cells as well as in early embryos. ..