Experts and Doctors on kidney in Saitama, Japan


Locale: Saitama, Japan
Topic: kidney

Top Publications

  1. Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato Watanabe M, Yasuda Y, et al. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol. 2001;133:325-9 pubmed
    ..The IC(50) value for HET0016 on cyclo-oxygenase activity was 2300 nM. These results indicate that HET0016 is a potent and selective inhibitor of CYP enzymes responsible for the formation of 20-HETE in man and rat. ..
  2. Shimo T, Moto M, Ashizawa N, Oba K, Nagata O. Study on toxicological aspects of crystal-mediated nephrotoxicity induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats. Drug Chem Toxicol. 2011;34:192-8 pubmed publisher
  3. Kikuchi Y, Ikee R, Hemmi N, Hyodo N, Saigusa T, Namikoshi T, et al. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Nephron Exp Nephrol. 2004;97:e17-25 pubmed
    ..These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy. ..
  4. Nakamura T, Kakinuma H, Amada H, Miyata N, Taniguchi K, Koda A, et al. Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. Bioorg Med Chem. 2004;12:6209-19 pubmed
    ..014 mg/mL at pH 6.8). Among the products, 2-piperazinoethoxy derivatives 3e and 6b showed solubility suitable for injection and potent inhibitory activity toward 20-HETE synthase (IC(50) 21.2 and 14.0 nM, respectively). ..
  5. Tsujimoto T, Yamamoto Honda R, Kajio H, Kishimoto M, Noto H, Hachiya R, et al. Accelerated decline of renal function in type 2 diabetes following severe hypoglycemia. J Diabetes Complications. 2016;30:681-5 pubmed publisher
    ..68; 95% confidence interval, 1.12-6.38; P=0.02). Renal function after severe hypoglycemia was significantly worse in type 2 diabetes patients with blood pressure surge during severe hypoglycemia than those without blood pressure surge. ..
  6. Omasu F, Oda T, Yamada M, Yoshizawa N, Yamakami K, Sakurai Y, et al. Effects of pioglitazone and candesartan on renal fibrosis and the intrarenal plasmin cascade in spontaneously hypercholesterolemic rats. Am J Physiol Renal Physiol. 2007;293:F1292-8 pubmed
    ..These results suggest that Pio and CD inhibit PAI-1 and exert renoprotective effects against chronic progressive renal disease, but its action is independent of the regulatory function on plasmin activity. ..
  7. Hirakawa H, Hayashida Y. Autonomic cardiovascular responses to heme oxygenase inhibition in conscious rats. Hypertension. 2006;48:1124-9 pubmed
    ..We conclude that the CO/HO system plays an important role in cardiovascular regulation by modulating sympathetic tone. ..
  8. Shiga T, Kimira Y, Mano H, Kawata T, Tadokoro T, Suzuki T, et al. Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a. Biosci Biotechnol Biochem. 2016;80:510-3 pubmed publisher
    ..Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis. ..
  9. Harada M, Sweed H, Catanzaro R, Kumari A, Bomba A, Minelli E, et al. Beneficial modification of functional renal parameters in 5/6 nephrectomized rats by nutraceutical. In view of a kidney-protective intervention. Acta Biomed. 2011;82:200-7 pubmed
    ..These data suggest that feeding with a normal protein diet and DTS supplementation improves renal function without any morphological effect in 5/6 nephrectomized rats if not a slight preservation.(

More Information


  1. Yamamoto K, Uchida S, Kitano K, Fukuhara N, Okumura Kitajima L, Gunji E, et al. TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. Br J Pharmacol. 2011;164:181-91 pubmed publisher
    ..3 mg·kg(-1). These data indicate that TS-071 is a potent and selective SGLT2 inhibitor that improves glucose levels in rodent models of type 1 and 2 diabetes and may be useful for the treatment for diabetes mellitus. ..
  2. Sawai R, Kuroda K, Shibata T, Gomyou R, Osawa K, Shimizu K. Anti-influenza virus activity of Chaenomeles sinensis. J Ethnopharmacol. 2008;118:108-12 pubmed publisher
    ..High molecular weight polyphenols in the fruits of C. sinensis neutralizes influenza virus by inhibiting hemagglutination activity and by suppressing NS2 protein synthesis. ..
  3. Miyazaki M, Yamashita T, Hosokawa M, Taira H, Suzuki A. Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase. Comp Biochem Physiol B Biochem Mol Biol. 2006;145:270-7 pubmed
    ..cauxin functions as an esterase in the urine rather than in kidney cells, and 3. the decomposition products by cauxin are excreted in a species-, sex-, and age-dependent manner, as is cauxin itself. ..
  4. Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature. 1989;337:473-5 pubmed
    ..Thus we propose that the peptidyl-prolyl cis-trans isomerizing activity of PPIase may be involved in events, such as those occurring early in T-cell activation, that are suppressed by cyclosporin A. ..
  5. Kamiya K, Kaneda M, Sugawara T, Mazaki E, Okamura N, Montal M, et al. A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci. 2004;24:2690-8 pubmed
    ..2 protein is one plausible explanation for the pathology of this patient; however, our biophysical findings suggest that the R102X truncated protein exerts a dominant negative effect leading to the patient's intractable epilepsy. ..
  6. Okamoto T, Hara A, Hino O. Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. Cancer Sci. 2003;94:22-5 pubmed
    ..In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines. ..
  7. Urushitani M, Kurisu J, Tsukita K, Takahashi R. Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J Neurochem. 2002;83:1030-42 pubmed
    ..These results indicate that the sustained expression of mutant SOD1 leads to proteasomal inhibition and motor neuronal death, which in part explains the pathogenesis of mutant SOD1-linked ALS. ..
  8. Shirahata A, Takahashi N, Beppu T, Hosoda H, Samejima K. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Biochem Pharmacol. 1993;45:1897-903 pubmed
    ..These results suggested a separate role for spermidine or spermine in the in vivo enhancement of S-adenosylmethionine decarboxylase activity...
  9. Kasono K, Saito T, Saito T, Tamemoto H, Yanagidate C, Uchida S, et al. Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin. Nephrol Dial Transplant. 2005;20:509-15 pubmed
    ..1 and -4.3 kb 5'-flanking region of the AQP-2 gene, in which the structure and mechanism of response to hypertonicity could be distinct from those of TonE. ..
  10. Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, et al. Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. J Am Soc Nephrol. 2004;15:1785-93 pubmed
    ..Moreover, antibody titers remained elevated during the entire 10-yr follow-up period...
  11. Fukuda T, Kanomata K, Nojima J, Urakawa I, Suzawa T, Imada M, et al. FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1. Biochem Biophys Res Commun. 2007;353:147-51 pubmed
    ..A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23. ..
  12. Nakamura A, Sakai Y, Ohata C, Komurasaki T. Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. Exp Toxicol Pathol. 2007;59:1-7 pubmed
  13. Nakai H, Asanuma H, Shishido S, Kitahara S, Yasuda K. Changing concepts in urological management of the congenital anomalies of kidney and urinary tract, CAKUT. Pediatr Int. 2003;45:634-41 pubmed
    ..Herein, we present the emerging concepts in the urological management of CAKUT, specifically, multicystic dysplastic kidney, vesicoureteral reflux, congenital hydronephrosis, ectopic ureters and ureteroceles. ..
  14. Takenaka T, Inoue T, Kanno Y, Okada H, Meaney K, Hill C, et al. Expression and role of connexins in the rat renal vasculature. Kidney Int. 2008;73:415-22 pubmed
    ..Hence, connexins 37 and 40 are expressed in the rat juxtaglomerular apparatus and these proteins control, in part, the renin-angiotensin system and renal autoregulation. ..
  15. Kaneko N, Kobayashi Y, Okada Y. Anatomic variations of the renal vessels pertinent to transperitoneal vascular control in the management of trauma. Surgery. 2008;143:616-22 pubmed publisher
    ..In such cases, the colon should be mobilized promptly. On the right side of the IVC, the vessels are located so as to require clamping together almost always. ..
  16. Miyazato A, Nakamura K, Yamamoto N, Mora Montes H, Tanaka M, Abe Y, et al. Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans. Infect Immun. 2009;77:3056-64 pubmed publisher
    ..These results suggested that C. albicans DNA activated BM-DCs through a TLR9-mediated signaling pathway using a mechanism independent of the unmethylated CpG motif. ..
  17. Nakagawa J, Ishikura S, Asami J, Isaji T, Usami N, Hara A, et al. Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. J Biol Chem. 2002;277:17883-91 pubmed
  18. Okada H, Inoue T, Kanno Y, Kobayashi T, Ban S, Kalluri R, et al. Renal fibroblast-like cells in Goodpasture syndrome rats. Kidney Int. 2001;60:597-606 pubmed
    ..Interstitial fibroblast-like cells (FbLCs) are presumably involved in the fibrotic process. However, such FbLCs have never been well characterized in the kidney...
  19. Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, et al. Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res. 2001;89:55-62 pubmed
    ..These findings suggest that site-specific overexpression of HO-1 in VSMCs suppresses vasodilatory response to NO and thereby leads to an elevation of arterial pressure. ..