Experts and Doctors on islets of langerhans in Chiba, Japan
Locale: Chiba, Japan
Topic: islets of langerhans
Otsuki K, Ito T, Kenmochi T, Maruyama M, Akutsu N, Saigo K, et al
. Positron Emission Tomography and Autoradiography of (18)F-Fluorodeoxyglucose Labeled Islets With or Without Warm Ischemic Stress in Portal Transplanted Rats. Transplant Proc. 2016;48:229-33 pubmed publisher
..However, islet survival was 1.4 times higher in the islets without WIT than that in those with WIT in the early engraftment phase. ..
Shinohara M, Masuyama T, Shoda T, Takahashi T, Katsuda Y, Komeda K, et al
. A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Int J Exp Diabetes Res. 2000;1:89-100 pubmed
..In conclusion, SDT rat is considered to be a potentially useful model for studies of diabetic retinopathy encountered in humans. ..
Kanatsuka A, Tokuyama Y, Nozaki O, Matsui K, Egashira T. Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4. Metabolism. 2002;51:1161-5 pubmed
..These homozygous mutations appear to play a part in the pathogenesis of beta-cell defect in about 2.5% of Japanese patients with late-onset diabetes. ..
Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, et al
. Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002;277:50497-502 pubmed
..Rim2. Piccolo complex is important in cAMP-induced insulin secretion. In addition, this study suggests that CAZ proteins similar to those in neurons are also function in pancreatic beta-cells. ..
Miki T, Tashiro F, Iwanaga T, Nagashima K, Yoshitomi H, Aihara H, et al
. Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel. Proc Natl Acad Sci U S A. 1997;94:11969-73 pubmed
Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S. Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. J Biol Chem. 1997;272:29407-10 pubmed
..Accordingly, Noc2 is probably involved in regulated exocytosis in endocrine cells by interacting with the cytoskeleton. ..
Zhang Y, Miki T, Iwanaga T, Koseki Y, Okuno M, Sunaga Y, et al
. Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. J Biol Chem. 2002;277:28065-9 pubmed
..These results suggest that Otx3 is a novel member of the Otx family and may be involved in the development of the central nervous system. ..
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, et al
. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004;101:8313-8 pubmed
..Thus, Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. ..