Experts and Doctors on hmgb proteins in Tokyo, Japan


Locale: Tokyo, Japan
Topic: hmgb proteins

Top Publications

  1. Matsui T, Kanai Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, et al. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006;119:3513-26 pubmed
    ..Therefore, our findings indicate that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development. ..
  2. Sakamoto Y, Hara K, Kanai Azuma M, Matsui T, Miura Y, Tsunekawa N, et al. Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 2007;360:539-44 pubmed
    ..This suggests the region-specific redundant activities of three SoxF members along the anteroposterior axis of embryonic vascular network. ..
  3. Hara K, Kanai Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, et al. Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis. Dev Biol. 2009;330:427-39 pubmed publisher
    ..Therefore, these data indicate that hindgut morphogenic movement is crucial for directing PGC movement toward the embryonic gut side, but not for their relocation from the mesoderm into the endoderm. ..
  4. Yanai H, Ban T, Wang Z, Choi M, Kawamura T, Negishi H, et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 2009;462:99-103 pubmed publisher
    ..These findings may have implications for understanding the evolution of the innate immune system and for the treatment of immunological disorders. ..
  5. Yanai H, Chiba S, Ban T, Nakaima Y, Onoe T, Honda K, et al. Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs). Proc Natl Acad Sci U S A. 2011;108:11542-7 pubmed publisher
    ..We discuss our findings in relation to the critical role of HMGBs in initiating immune responses and the possible use of these ni-ODNs in therapeutic interventions. ..
  6. Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, et al. Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017;144:1906-1917 pubmed publisher
  7. Sagara N, Katoh M. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. Cancer Res. 2000;60:5959-62 pubmed
    ..MMC resistance induced by TCF-3 overexpression is probably due to DTD down-regulation, which might provide a possible target for new therapy of drug-resistant gastric cancer. ..
  8. Danno H, Michiue T, Hitachi K, Yukita A, Ishiura S, Asashima M. Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression. Proc Natl Acad Sci U S A. 2008;105:5408-13 pubmed publisher
    ..These results demonstrate that the direct interaction and interdependence between the Otx2 and Sox2 proteins coordinate Rax expression in eye development, providing molecular linkages among the genes responsible for ocular malformation...
  9. Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, et al. Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis. Biochem Biophys Res Commun. 2010;391:357-63 pubmed publisher
    ..Our findings show that Sox17 functions cell-autonomously to specify gallbladder/bile-duct in the mouse embryo. ..

More Information


  1. Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, et al. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum Mol Genet. 2010;19:480-93 pubmed publisher
    ..The findings implicated an important role for Hmgpi at the earliest stages of mammalian embryonic development. ..
  2. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011;102:1313-21 pubmed publisher
    ..These results indicate that Sox17 might be a key transcription factor controlling CD133 expression, and that it might also play a role in the control of gastric tumor progression. ..
  3. Uemura M, Ozawa A, Nagata T, Kurasawa K, Tsunekawa N, Nobuhisa I, et al. Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013;140:639-48 pubmed publisher
  4. Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, et al. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014;34:1976-90 pubmed publisher
    ..Furthermore, SoxF proteins play a pivotal role in controlling the HSC fate decision between indefinite self-renewal and differentiation during fetal hematopoiesis. ..