Experts and Doctors on guinea pigs in Tokyo, Japan


Locale: Tokyo, Japan
Topic: guinea pigs

Top Publications

  1. Tsukiyama M, Akaishi T, Ueki T, Okumura H, Abe K. The extract from Nandina domestica THUNBERG inhibits histamine- and serotonin-induced contraction in isolated guinea pig trachea. Biol Pharm Bull. 2007;30:2063-8 pubmed
    ..These results suggest that NDE has inhibitory effects on tracheal smooth muscle contraction, and nantenine cannot account solely for this effect of NDE...
  2. Qin X, Nakatsuru Y, Tada M, Ishikawa T. Species and organ differences in DNA adduct formation and repair after treatment with 4-hydroxyaminoquinoline 1-oxide. Jpn J Cancer Res. 1990;81:613-9 pubmed
    ..In the hamster organs and the rat lung and liver, DNA adduct formation was generally low and in the case of elevation in the initial phase, quickly removed...
  3. Shimizu A, Takumida M, Anniko M, Suzuki M. Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta Otolaryngol. 2003;123:459-65 pubmed
    ..Both caspase and calpain inhibitors protected hair cells against gentamicin ototoxicity. It is suggested that inhibition of apoptosis is essential in order to block aminoglycoside ototoxicity. ..
  4. Nagase H, Watanabe A, Nemoto T, Yamaotsu N, Hayashida K, Nakajima M, et al. Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010;20:121-4 pubmed publisher
    ..2.2]octane skeleton. KNT-63 showed profound antinociceptive effects via the kappa receptor which were as potent as that of TRK-820. ..
  5. Bai C, Kurokawa J, Tamagawa M, Nakaya H, Furukawa T. Nontranscriptional regulation of cardiac repolarization currents by testosterone. Circulation. 2005;112:1701-10 pubmed
    ..The nontranscriptional regulation of IKs and I(Ca,L) by testosterone is a novel regulatory mechanism of cardiac repolarization that can potentially contribute to the control of QTc intervals by androgen. ..
  6. Iwata K, Yamashita T, Uehara H. In vitro and in vivo activities of piritetrate (M-732), a new antidermatophytic thiocarbamate. Antimicrob Agents Chemother. 1989;33:2118-25 pubmed
    ..Piritetrate manifested no acute toxicity in laboratory animals when administered even in large quantities by the oral, intraperitoneal, and topical routes...
  7. Kanai K, Yamada S, Yamamoto Y, Fukui Y, Kurane I, Inoue N. Re-evaluation of the genome sequence of guinea pig cytomegalovirus. J Gen Virol. 2011;92:1005-20 pubmed publisher
    ..Our re-evaluation of the genetic content of GPCMV will provide a solid foundation for future studies...
  8. Sato R, Sakamoto K, Yamazaki J, Nagao T. Differences in protective profiles of diltiazem isomers in ischemic and reperfused guinea pig hearts. Eur J Pharmacol. 2002;434:125-31 pubmed
    ..These results suggest that the L-cis isomer may specifically improve postischemic function, in addition to the modest action on [K(+)]e and pH, in guinea pig hearts. ..
  9. Katayama Y, Hirai K, Homma T, Noda Y, Honda K. Actions of orexins on individual myenteric neurons of the guinea-pig ileum: orexin A or B?. Neuroreport. 2005;16:745-9 pubmed
    ..Orexin B was sometimes more effective than orexin A and vice versa. It is concluded that orexin B increased neuronal activity via mechanisms similar to orexin A in the guinea-pig myenteric plexus. ..

More Information


  1. Hagiwara M, Adachi Akahane S, Nagao T. High-affinity binding of [3H]DTZ323 to the diltiazem-binding site of L-type Ca2+ channels. Eur J Pharmacol. 2003;466:63-71 pubmed
    ..These results indicate that [3H]DTZ323 is a potent and selective radioligand for the diltiazem-binding site of L-type Ca(2+) channels. ..
  2. Someya A, Nagaoka I, Nunoi H, Yamashita T. Translocation of guinea pig p40-phox during activation of NADPH oxidase. Biochim Biophys Acta. 1996;1277:217-25 pubmed
    ..These observations suggest that p40-phox is dissociated from p67-phox during activation, and translocates to the membrane by GTP-gamma-s-independent mechanism. ..
  3. Kuno M, Nemoto K, Ninomiya N, Inagaki E, Kubota M, Matsumoto T, et al. The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious Guinea-pigs. Clin Exp Pharmacol Physiol. 2009;36:589-93 pubmed publisher
    ..4. In conlusion, the results of the present study show that TAK-242 inhibited the symptoms associated with endotoxaemia in a guinea-pig model of sepsis and that it may, therefore, be an effective treatment for sepsis. ..
  4. Kobayashi T, Kato I, Nanno M, Shida K, Shibuya K, Matsuoka Y, et al. Oral administration of probiotic bacteria, Lactobacillus casei and Bifidobacterium breve, does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis. Immunopharmacol Immunotoxicol. 2010;32:116-24 pubmed publisher
    ..These results support the notion that neither LcS nor BbY exacerbates autoimmune disease. ..
  5. Machida T, Hashimoto N, Kuwahara I, Ogino Y, Matsuura J, Yamamoto W, et al. Effects of a highly selective acetylcholine-activated K+ channel blocker on experimental atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4:94-102 pubmed publisher
    ..These findings suggest that I(K,ACh) may be important in the development and maintenance of AF. ..
  6. Pourbakht A, Yamasoba T. Ebselen attenuates cochlear damage caused by acoustic trauma. Hear Res. 2003;181:100-8 pubmed
    ..These findings indicate that ebselen attenuates noise-induced cochlear damage. The concentration that provides optimal protection against such damage has now to be determined. ..
  7. Mizukami T, Masumi A, Momose H, Kuramitsu M, Takizawa K, Naito S, et al. An improved abnormal toxicity test by using reference vaccine-specific body weight curves and histopathological data for monitoring vaccine quality and safety in Japan. Biologicals. 2009;37:8-17 pubmed publisher
    ..The results of these analyses were similar using either 'clean' or specific pathogen-free guinea pigs. ..
  8. Mutoh T, Tsubone H. Hypersensitivity of laryngeal C-fibers induced by volatile anesthetics in young guinea pigs. Am J Respir Crit Care Med. 2003;167:557-62 pubmed
  9. Hasegawa M, Sasaki T, Sadakane K, Tabuchi M, Takeda Y, Kimura M, et al. Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: involvement of 5-hydroxytryptamine receptors. Jpn J Pharmacol. 2002;89:113-9 pubmed
    ..These results suggest that 5-HT3 receptor plays an important role in the emetic action of TJN-119, cephaeline and emetine, and the 5-HT4 receptor may be involved in their mechanisms. ..
  10. Goto N, Maeyama J, Yasuda Y, Isaka M, Matano K, Kozuka S, et al. Safety evaluation of recombinant cholera toxin B subunit produced by Bacillus brevis as a mucosal adjuvant. Vaccine. 2000;18:2164-71 pubmed
    ..These results suggest that, from a safety standpoint, rCTB is a useful candidate as mucosal vaccine adjuvant. ..
  11. Yamaguchi T, Mukaiyama O, Itoh K, Satoh Y, Terada A, Iizuka Y. Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. Eur J Pharmacol. 1993;236:43-50 pubmed
  12. Kanke T, Kabeya M, Kubo S, Kondo S, Yasuoka K, Tagashira J, et al. Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo. Br J Pharmacol. 2009;158:361-71 pubmed publisher
    ..These peptide-mimetic PAR(2) antagonists could be useful in evaluating PAR(2)-mediated biological events and might lead to a new generation of therapeutically useful antagonists. ..
  13. Suzuki O, Koura M, Noguchi Y, Takano K, Yamamoto Y, Matsuda J. Optimization of superovulation induction by human menopausal gonadotropin in guinea pigs based on follicular waves and FSH-receptor homologies. Mol Reprod Dev. 2003;64:219-25 pubmed
    ..These results indicate that hMG is an effective, albeit stage-dependent, inducer of superovulation in the guinea pig, and that FSH-R homologies should be taken into account when choosing hormones for superovulation. ..
  14. Nagaoka I, Someya A, Iwabuchi K, Yamashita T. Structure of the guinea pig neutrophil cationic peptide gene. FEBS Lett. 1992;303:31-5 pubmed
    ..Interestingly, the pyrimidine-rich sequences identified in the promoter regions of the human neutrophil elastase and myeloperoxidase genes were also found in the 5' flanking region of the GNCP-2 gene. ..
  15. Hishinuma S, Matsumoto Y, Sato R, Saito M. Ca2+-dependent differential development of carbachol-induced desensitization to receptor agonists and high K+ in guinea-pig taenia caeci. Clin Exp Pharmacol Physiol. 2007;34:15-21 pubmed
    ..4. These results suggest that cellular responsiveness to receptor agonists and non-receptor-mediated depolarizing stimulation is differentially regulated by Ca(2+)-dependent heterologous desensitization in smooth muscle. ..
  16. Ryu A, Arakane K, Koide C, Arai H, Nagano T. Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. Biol Pharm Bull. 2009;32:1504-9 pubmed
    ..These results suggest that squalene peroxide formation by singlet oxygen plays a key role in photo-induced skin damage. ..
  17. Javier R, Kunishita T, Koike F, Tabira T. Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis. J Neurol Sci. 1989;93:221-30 pubmed
    ..For control, chick embryo vaccine (CEV) was used and MBP was not detected. EAE was not induced in animals inoculated with it. These results suggest that MBP in vaccines may play a decisive role in the production of PVE. ..
  18. Kakigi A, Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, et al. Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase. ORL J Otorhinolaryngol Relat Spec. 2011;73:1-8 pubmed publisher
    ..The main endocytotic pathway of MPO did not depend on the Rho-associated protein kinase molecular switch or actin/myosin motor system, but was mainly regulated by the RhoA signaling cascade...
  19. Sasaki M, Miyazaki Y, Takahashi T. Hylan G-F 20 induces delayed foreign body inflammation in Guinea pigs and rabbits. Toxicol Pathol. 2003;31:321-5 pubmed
    ..The present results contradict previous reports on biocompatibility of hylan and suggest that hylan may potentially induce similar unfavorable reactions in humans...
  20. Sakitama K, Ozawa Y, Aoto N, Tomita H, Ishikawa M. Effects of a new centrally acting muscle relaxant, NK433 (lanperisone hydrochloride) on spinal reflexes. Eur J Pharmacol. 1997;337:175-87 pubmed
    ..LPS-9 could contribute to the potent activity of NK433 after oral administration. ..
  21. Tomioka K, Yamada T, Mase T, Murase K. Pharmacological properties of YM-11124, a selective immunosuppressive agent for cell-mediated immunity. Pharmacology. 1989;39:28-38 pubmed
  22. Yada H, Murata M, Shimoda K, Yuasa S, Kawaguchi H, Ieda M, et al. Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart. Circ Res. 2007;101:69-77 pubmed
  23. Mitobe J, Sinha R, Mitra S, Nag D, Saito N, Shimuta K, et al. An attenuated Shigella mutant lacking the RNA-binding protein Hfq provides cross-protection against Shigella strains of broad serotype. PLoS Negl Trop Dis. 2017;11:e0005728 pubmed publisher
    ..Therefore, vaccination is expected to cover not only the most prevalent serotypes of S. sonnei and S. flexneri 2a, but also various Shigella strains, including S. dysenteriae type 1, which produces Shiga toxin. ..
  24. Ishii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res. 2000;39:41-82 pubmed
    ..This review also describes the phenotypes of these mutant mice and discusses them by referring to previously reported pharmacological and genetical data. ..
  25. Octaviani C, Li C, Noda T, Kawaoka Y. Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture. Virus Res. 2011;156:147-50 pubmed publisher
    ..The emergence of such viruses in nature could, therefore, represent a threat...
  26. Ogawa Y, Fukutomi T, Sugiura K, Sugiura K, Kato K, Tohya Y, et al. Comparison of Akabane virus isolated from sentinel cattle in Japan. Vet Microbiol. 2007;124:16-24 pubmed
    ..Although attenuated and inactivated vaccines have been developed for disease prevention, an outbreak may occur due to variant viruses arising from mutation. ..
  27. Watanabe K, Tomiyama S, Jinnouchi K, Pawankar R, Yagi T. Expression of inducible nitric oxide synthase in the cochlea following immune response in the endolymphatic sac of guinea pigs. ORL J Otorhinolaryngol Relat Spec. 2001;63:155-9 pubmed
    ..It is known that high levels of nitric oxide can lead to inner ear dysfunction. Our results suggest that iNOS may mediate the inner ear disturbance as seen in endolymphatic hydrops...
  28. Kamoshida S, Saito E, Fukuda S, Kato K, Iwasaki A, Arakawa Y. Anatomical location of enterochromaffin-like (ECL) cells, parietal cells, and chief cells in the stomach demonstrated by immunocytochemistry and electron microscopy. J Gastroenterol. 1999;34:315-20 pubmed
    ..These findings suggest that ECL cells have a paracrine effect on chief cells and parietal cells, and may have an important physiological role in pepsinogen secretion...
  29. Satoh T, Yokozeki H, Nishioka K. Pathogenic roles of eosinophils in guinea-pig contact sensitivity: regulation of dermal eosinophilia with remotely administered IL-5. Clin Exp Immunol. 2000;122:300-7 pubmed
    ..The guinea-pig model of contact sensitivity may be useful for evaluating therapies and pharmaceuticals targeted at eosinophil infiltration. ..
  30. Yamada S, Fukuchi S, Hashimoto K, Fukui Y, Tsuda M, Kataoka M, et al. Guinea pig cytomegalovirus GP129/131/133, homologues of human cytomegalovirus UL128/130/131A, are necessary for infection of monocytes and macrophages. J Gen Virol. 2014;95:1376-82 pubmed publisher
    ..Monocyte/macrophage tropism could be one of the important determinants for viral dissemination in vivo...
  31. Nagaoka I, Someya A, Iwabuchi K, Yamashita T. Characterization of cDNA clones encoding guinea pig neutrophil cationic peptides. FEBS Lett. 1991;280:287-91 pubmed
    ..These observations suggest that mature neutrophils, despite their abundant content of GNCPs, lose the capacity to synthesize GNCPs. ..
  32. Hashimoto K, Yamada S, Katano H, Fukuchi S, Sato Y, Kato M, et al. Effects of immunization of pregnant guinea pigs with guinea pig cytomegalovirus glycoprotein B on viral spread in the placenta. Vaccine. 2013;31:3199-205 pubmed publisher
    ..Although glycoprotein B (gB) vaccines have been reported to reduce the incidence and mortality of congenital infection in human clinical trials and guinea pig animal models, the mechanisms of protection remain unclear...
  33. Yoshida L, Nishida S, Shimoyama T, Kawahara T, Kondo Teshima S, Rokutan K, et al. Superoxide generation by Nox1 in guinea pig gastric mucosal cells involves a component with p67(phox)-ability. Biol Pharm Bull. 2004;27:147-55 pubmed
    ..This result suggests that GMC cytosol contains a component with p67(phox)-ability, and also Rac, but lacks p47(phox). These data indicate that GMC Nox1 requires at least a p67(phox) counterpart and Rac to acquire NADPH oxidase activity. ..
  34. Li L, Ikezono T, Sekine K, Shindo S, Matsumura T, Pawankar R, et al. Molecular cloning of the Coch gene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament. Acta Otolaryngol. 2010;130:868-80 pubmed publisher
    ..Cytokine stimulation did not alter the level of mRNA expression or isoform formation. ..
  35. Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, et al. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J Immunol. 2001;167:3329-38 pubmed
  36. Ishikawa M, Nago M, Miyazaki H, Fukuda H. Effects of centrally acting muscle relaxants on post-rotatory nystagmus in the rabbit. Gen Pharmacol. 1989;20:47-51 pubmed
    ..4. The prolonging action of diazepam is discussed with reference to GABAergic mechanisms...
  37. Hashimoto Y, Nagaoka I, Yamashita T. Purification of the antibacterial fragments of guinea-pig major basic protein. Biochim Biophys Acta. 1993;1203:236-42 pubmed
  38. Tsukiyama M, Ueki T, Yasuda Y, Kikuchi H, Akaishi T, Okumura H, et al. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta Med. 2009;75:1393-9 pubmed publisher
    ..These results indicate that the major constituent responsible for the effect of NDE is higenamine, which probably causes the tracheal relaxation through stimulation of beta (2) adrenoceptors...
  39. Oka T, Miyashita K, Katayama K, Wakita T, Takeda N. Distinct genotype and antigenicity among genogroup II sapoviruses. Microbiol Immunol. 2009;53:417-20 pubmed publisher
    ..An antigen ELISA demonstrated for the first time that strains in the same GII SaV genogroup, but within different clusters, have distinct antigenicities. ..
  40. Yamazaki Y, Nakano Y, Imamura T, Morita T. Augmentation of vascular permeability of VEGF is enhanced by KDR-binding proteins. Biochem Biophys Res Commun. 2007;355:693-9 pubmed
    ..Our findings implicate TIMP-3 as a critical player in the vascular leakage-enhancing effect of VEGF165 in vivo. ..
  41. Matsumoto T, Horiuchi M, Kamata K, Seyama Y. Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells. J Smooth Muscle Res. 2009;45:75-86 pubmed
    ..These results suggest that the primary antagonists of H(1)- receptor are different from the components in eMMBP that inhibit histamine release, and that these components participate in the anti-allergic activity of eMMBP. ..
  42. Hiratsuka A, Tobita K, Saito H, Sakamoto Y, Nakano H, Ogura K, et al. (S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats. Biochem J. 2001;355:237-44 pubmed
    ..All the hepatic rat GSTs, A1-1(2), A1-3, A4-4, M1-1, M1-2 and M2-2, also catalysed the (S)-preferential conjugation of HNE enantiomers...
  43. Chiba Y, Matsuo K, Sakai H, Abe K, Misawa M. Increased expression of inducible nitric oxide synthase in nasal mucosae of guinea pigs with induced allergic rhinitis. Am J Rhinol. 2006;20:336-41 pubmed
    ..However, the pathophysiological role(s) of NO generated by iNOS in nasal allergy is still unclear. ..
  44. Iwaki M, Komiya T, Fukuda T, Arakawa Y, Takahashi M. Collaborative study: Standardization of Japanese reference diphtheria and tetanus toxoids, (adsorbed, lot 2), for potency determination of diphtheria-tetanus- acellular pertussis combined vaccine. Jpn J Infect Dis. 2003;56:183-5 pubmed
  45. Nagaoka I, Tsutsumi Ishii Y, Yomogida S, Yamashita T. Isolation of cDNA encoding guinea pig neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11) and evaluation of CAP11 mRNA expression during neutrophil maturation. J Biol Chem. 1997;272:22742-50 pubmed
    ..e. metamyelocyte stage). Furthermore, CAP11 may be stored in the granule subset, possibly the gelatinase granule...
  46. Hansman G, Natori K, Oka T, Ogawa S, Tanaka K, Nagata N, et al. Cross-reactivity among sapovirus recombinant capsid proteins. Arch Virol. 2005;150:21-36 pubmed publisher
    ..The ELISA showed that the GI VLPs were antigenically distinct from GII and GV VLPs...
  47. Takigami S, Mori Y, Tanioka Y, Ichikawa M. Morphological evidence for two types of Mammalian vomeronasal system. Chem Senses. 2004;29:301-10 pubmed
    ..These results suggest that many mammals have uniform-type VN systems, and at least two types of VN systems exist in terrestrial mammals. This morphological evidence will help us determine the processing function of VN systems...
  48. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem Pharmacol. 2004;67:2093-102 pubmed
    ..TAM N(+)-glucuronide still had binding affinity similar to TAM itself for human estrogen receptors, ERalpha and ERbeta, suggesting that TAM N(+)-glucuronide might contribute to the biological activity of TAM in vivo. ..
  49. Inai S, Watanabe K, Okubo K. Inducible nitric oxide synthase participates in cochlear damage after acoustic stimulation in Guinea pigs. J Nippon Med Sch. 2012;79:121-8 pubmed
    ..A NOS inhibitor (L-NAME) reduced the elevation of hearing thresholds. Our results suggest that the expression of iNOS participates in the pathogenesis of cochlear damage caused by acoustic trauma. ..
  50. Katagiri T, Harada Y, Emi M, Nakamura Y. Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. Cytogenet Cell Genet. 1995;68:39-44 pubmed
    ..These results show that human MDC contains a mosaic of exons capable of encoding several functional domains. ..
  51. Komine Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, et al. Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis. Clin Vaccine Immunol. 2010;17:1500-6 pubmed publisher
    ..Our findings suggest that BCG-Tokyo has a protective effect against tuberculosis infection regardless of age. ..
  52. Kubota M, Miyamoto A, Hosokawa Y, Sugimoto S, Horikawa J. Spatiotemporal dynamics of neural activity related to auditory induction in the core and belt fields of guinea-pig auditory cortex. Neuroreport. 2012;23:474-8 pubmed publisher
    ..Moreover, the findings indicate that field DC is the first area in which these changes emerge, suggesting that it may be an important region for auditory induction of simple sounds. ..
  53. Masuda K, Yokomizo T, Izumi T, Shimizu T. cDNA cloning and characterization of guinea-pig leukotriene B4 receptor. Biochem J. 1999;342 ( Pt 1):79-85 pubmed
    ..The present study demonstrated that although LTB(4) and 20-hydroxy-LTB(4) bind to the receptor with similar affinities, they do differ in activating intracellular signalling...
  54. Nakashima N, Miyazaki K, Ishikawa M, Yatohgo T, Ogawa H, Uchibori H, et al. Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide. Biochim Biophys Acta. 1992;1120:1-10 pubmed
    ..Almost all of these vitronectin-like proteins showed marked species-specific variations in their apparent molecular weights from 51 to 96 kDa in SDS-PAGE. ..
  55. Maeyama J, Komiya T, Takahashi M, Isaka M, Goto N, Yamamoto S. The mucosal adjuvanticity of the oligodeoxynucleotides containing a non-methylated CpG motif on BCG and diphtheria toxoid. Vaccine. 2009;27:1166-73 pubmed publisher
    ..In contrast, there was no or little production of the anti-DT serum IgE. Taken together our data suggest that oligo B is a powerful adjuvant in mucosal immunization. ..
  56. Fukui Y, Shindoh K, Yamamoto Y, Koyano S, Kosugi I, Yamaguchi T, et al. Establishment of a cell-based assay for screening of compounds inhibiting very early events in the cytomegalovirus replication cycle and characterization of a compound identified using the assay. Antimicrob Agents Chemother. 2008;52:2420-7 pubmed publisher
    ..DPPC is a unique compound that targets the very early phase of cytomegalovirus infection, probably by disrupting a pathway that is important after viral entry but before immediate-early gene expression...
  57. Yamashita D, Shiotani A, Kanzaki S, Nakagawa M, Ogawa K. Neuroprotective effects of T-817MA against noise-induced hearing loss. Neurosci Res. 2008;61:38-42 pubmed publisher
    ..T-817MA significantly reduced threshold deficits and hair cell death. These results suggest T-817MA reduces noise-induced hearing loss and cochlear damage, suggesting functional and morphological protection...
  58. Egami N, Kakigi A, Sakamoto T, Takeda T, Hyodo M, Yamasoba T. Morphological and functional changes in a new animal model of Ménière's disease. Lab Invest. 2013;93:1001-11 pubmed publisher
  59. Kokornaczyk A, Schepmann D, Yamaguchi J, Itami K, Laurini E, Fermeglia M, et al. Thiazole-Based ?1 Receptor Ligands: Diversity by Late-Stage C-H Arylation of Thiazoles, Structure-Affinity and Selectivity Relationships, and Molecular Interactions. ChemMedChem. 2017;12:1070-1080 pubmed publisher
  60. Kotani S, Kawahara S, Kirino Y. Purkinje cell activity during learning a new timing in classical eyeblink conditioning. Brain Res. 2003;994:193-202 pubmed
    ..These results suggest that some Purkinje cells code the timing of the CR, but do not play a consistent role in shaping the CR over a range of ISIs...
  61. Seino A, Kobayashi M, Momose K, Yasumoto T, Ohizumi Y. The mode of inotropic action of ciguatoxin on guinea-pig cardiac muscle. Br J Pharmacol. 1988;95:876-82 pubmed
    ..It is also suggested that CTX activates cardiac muscle Na channels by modifying the voltage-dependence of channel activation to increase Na inward currents, thus producing cardiotonic actions...
  62. Nonaka M, Wang G, Mori T, Okada H, Nonaka M. Novel androgen-dependent promoters direct expression of the C4b-binding protein alpha-chain gene in epididymis. J Immunol. 2001;166:4570-7 pubmed
    ..Furthermore, variation in the 5'-untranslated regions, arising from alternative splicing of the newly identified exons, is demonstrable in the guinea pig C4BP alpha transcripts...
  63. Tsutsumi K, Obata Y, Nagai T, Loftsson T, Takayama K. Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs. Int J Pharm. 2002;238:161-70 pubmed
  64. Ueki T, Akaishi T, Okumura H, Morioka T, Abe K. Biphasic tracheal relaxation induced by higenamine and nantenine from Nandina domestica Thunberg. J Pharmacol Sci. 2011;115:254-7 pubmed
    ..These results suggest that NDE relaxes the trachea quickly through ?-adrenoceptor stimulation by higenamine and slowly through Ca(2+) antagonism by nantenine. ..
  65. Ikarashi Y, Kaniwa M, Tsuchiya T. Sensitization potential of gold sodium thiosulfate in mice and guinea pigs. Biomaterials. 2002;23:4907-14 pubmed
    ..It may suggest that the sensitization responses from gold would appear not only at the contact site but also systematically...
  66. Yamashita T, Saito K. Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides. Infect Immun. 1989;57:2405-9 pubmed
    ..The sequence of GNCP-2 is identical except for the substitution of isoleucine for leucine at residue 21...
  67. Kakigi A, Salt A, Takeda T. Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:16-8 pubmed publisher
    ..To investigate the relationship between endolymphatic hydrops and perilymphatic potassium...
  68. Nagaoka I, Nonoguchi A, Yamashita T. Cloning and characterization of the guinea pig neutrophil cationic peptide-1 and -2 genes. DNA Seq. 1993;4:123-8 pubmed
    ..Together these observations indicate that GNCP-1 and GNCP-2 are encoded by the very homologous but different genes, and that GNCP gene expression is regulated by glucocorticoid. ..
  69. Xie L, Li X, Funeshima Fuji N, Kimura H, Matsumoto Y, Isaka Y, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol. 2009;9:575-81 pubmed publisher
  70. Oishi K, Itoh Y, Isshiki Y, Kai C, Takeda Y, Yamaura K, et al. Agonist-induced isometric contraction of smooth muscle cell-populated collagen gel fiber. Am J Physiol Cell Physiol. 2000;279:C1432-42 pubmed
    ..The expression of contractile proteins in the fibers was similar to that in cultured SM cells. These results suggest that, although the fiber is not a model for fully differentiated SM, contractile mechanisms are maintained...
  71. Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, et al. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 2013;13:570-583 pubmed publisher
    ..These findings highlight the importance of caspase-4-dependent innate immune responses and demonstrate that Shigella delivers a caspase-4-specific inhibitor to delay epithelial cell death and promote infection. ..
  72. Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla T, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 2007;226:185-93 pubmed
    ..Together these findings indicate that decreased energy metabolism due to accumulation of mtDNA mutations/deletions and decline of respiratory chain function play an important role in the manifestation of AHL. ..
  73. Kocic I, Hirano Y, Hiraoka M. Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes. J Pharmacol Sci. 2004;95:189-95 pubmed
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