Experts and Doctors on female in Tokyo, Japan


Locale: Tokyo, Japan
Topic: female

Top Publications

  1. Tanabe Y, Tsuda H, Yoshida M, Yunokawa M, Yonemori K, Shimizu C, et al. Pathological features of triple-negative breast cancers that showed progressive disease during neoadjuvant chemotherapy. Cancer Sci. 2017;108:1520-1529 pubmed publisher
    ..The combinations of high proliferation, metaplastic features, and immunohistochemical statuses of some EMT and basal-like markers and androgen receptor appeared to be able to characterize the TNBCs that showed cPD after NAC. ..
  2. Ito D, Yogosawa S, Mimoto R, Hirooka S, Horiuchi T, Eto K, et al. Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer. Cancer Sci. 2017;108:1565-1573 pubmed publisher
    ..Given the findings that DYRK2 regulates cancer cell metastasis, we concluded that the expression status of DYRK2 could be a predictive marker for liver metastases of colorectal cancer. ..
  3. Nakamichi S, Seike M, Miyanaga A, Chiba M, Matsuda K, Kobayashi K, et al. RT-PCR for Detecting ALK Translocations in Cytology Samples from Lung Cancer Patients. Anticancer Res. 2017;37:3295-3299 pubmed
    ..RT-PCR is a suitable method for detecting ALK translocations using cytology samples from patients with primary lung cancer, especially when tissue samples are not available. ..
  4. Tanaka M, Sakai R, Koike R, Harigai M. Pneumocystis Jirovecii Pneumonia in Japanese Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors: A Pooled Analysis of 3 Agents. J Rheumatol. 2015;42:1726-8 pubmed publisher
  5. Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, et al. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol. 2017;19:530-541 pubmed publisher
    ..These data indicate that non-cell-autonomous metabolic modulation is a crucial regulator for cell competition, shedding light on the unexplored events at the initial stage of carcinogenesis. ..
  6. Shoji H, Yoshio S, Mano Y, Doi H, Sugiyama M, Osawa Y, et al. Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma. Int J Cancer. 2017;141:1011-1017 pubmed publisher
    ..06-29.63, p?=?0.043) were independently associated with overall survival. Our results suggest that ?TEMs could serve as a biomarker for predicting radiologic response and overall survival in sorafenib-treated patients with advanced HCC. ..
  7. Nishiura C, Nanri A, Kashino I, Hori A, Kinugawa C, Endo M, et al. Age-, sex-, and diagnosis-specific incidence rate of medically certified long-term sick leave among private sector employees: The Japan Epidemiology Collaboration on Occupational Health (J-ECOH) study. J Epidemiol. 2017;27:590-595 pubmed publisher
    ..These results suggest that mental disorder, neoplasms, and pregnancy-related disease are the major causes of long-term sick-leave among private sector employees in Japan. ..
  8. Brose M, Smit J, Lin C, Pitoia F, Fellous M, Desanctis Y, et al. Timing of multikinase inhibitor initiation in differentiated thyroid cancer. Endocr Relat Cancer. 2017;24:237-242 pubmed publisher
    ..In total, 700 patients are estimated to be enrolled from >20 countries. Final analysis will be performed once the last enrolled patient has been followed up with for 24 months ( identifier: Nbib2303444). ..
  9. Hayashi N, Igarashi M, Imai A, Yoshizawa Y, Asamura K, Ishikawa Y, et al. Motivation factors for suicidal behavior and their clinical relevance in admitted psychiatric patients. PLoS ONE. 2017;12:e0176565 pubmed publisher
    ..These results provide a base for further research into clinical strategies for patient management and therapy. ..

More Information

Publications413 found, 100 shown here

  1. Uehara K, Ogura K, Akiyama T, Shinoda Y, Iwata S, Kobayashi E, et al. Reliability and Validity of the Musculoskeletal Tumor Society Scoring System for the Upper Extremity in Japanese Patients. Clin Orthop Relat Res. 2017;475:2253-2259 pubmed publisher
    ..To evaluate the mental state of patients with musculoskeletal tumors in the upper extremity, further study is needed. ..
  2. Morisaki N, Nagata C, Jwa S, Sago H, Saito S, Oken E, et al. Pre-pregnancy BMI-specific optimal gestational weight gain for women in Japan. J Epidemiol. 2017;27:492-498 pubmed publisher
  3. Tsujimoto T, Kajio H, Sugiyama T. Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study. Mayo Clin Proc. 2017;92:1190-1202 pubmed publisher
    ..46-0.77; P<.001), and 200 or more mg/d (HR, 0.65; 95% CI, 0.53-0.80; P<.001). Moderate caffeine intake was associated with a decreased risk of all-cause mortality, regardless of the presence or absence of coffee consumption. ..
  4. Morota N, Ihara S, Ogiwara H, Tamura G. Surgical management of cervical spine deformity in chondrodysplasia punctata. J Neurosurg Pediatr. 2017;20:378-387 pubmed publisher
    ..Nevertheless, the findings indicate that early surgical intervention for CDP with cervical involvement is feasible, suggesting that the role of neurosurgery should be reevaluated. ..
  5. Cavenagh J, Oakervee H, Baetiong Caguioa P, Davies F, Gharibo M, Rabin N, et al. A phase I/II study of KW-2478, an Hsp90 inhibitor, in combination with bortezomib in patients with relapsed/refractory multiple myeloma. Br J Cancer. 2017;117:1295-1302 pubmed publisher
  6. Sakurai M, Kasahara H, Yoshida K, Yoshimi A, Kunimoto H, Watanabe N, et al. Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele. Blood Cancer J. 2016;6:e392 pubmed publisher
  7. Kawai M, Obara K, Onodera T, Enomoto T, Ogasawara K, Tsuneyama H, et al. Mutations of the KLF1 gene detected in Japanese with the In(Lu) phenotype. Transfusion. 2017;57:1072-1077 pubmed publisher
    ..The prevalence of the In(Lu) phenotype in the Japanese population was 0.02%, and we identified 13 known and 21 novel KLF1 alleles. The KLF1 mutations cause the reduced expression of the P1 antigen. ..
  8. Hamada C, Okusaka T, Ikari T, Isayama H, Furuse J, Ishii H, et al. Efficacy and safety of gemcitabine plus S-1 in pancreatic cancer: a pooled analysis of individual patient data. Br J Cancer. 2017;116:1544-1550 pubmed publisher
    ..Gemcitabine plus S-1 is a viable treatment alternative to gemcitabine, which is one of the standard treatments in patients with LAPC. ..
  9. Bahwere P, Akomo P, Mwale M, Murakami H, Banda C, Kathumba S, et al. Soya, maize, and sorghum-based ready-to-use therapeutic food with amino acid is as efficacious as the standard milk and peanut paste-based formulation for the treatment of severe acute malnutrition in children: a noninferiority individually randomize. Am J Clin Nutr. 2017;106:1100-1112 pubmed publisher
    ..It is also better at correcting iron deficiency anemia than PM-RUTF. This trial was registered at as PACTR201505001101224. ..
  10. Asaoka R, Murata H, Yanagisawa M, Fujino Y, Matsuura M, Inoue T, et al. The association between photoreceptor layer thickness measured by optical coherence tomography and visual sensitivity in glaucomatous eyes. PLoS ONE. 2017;12:e0184064 pubmed publisher
    ..To assess the thickness of the photoreceptor layer in the macular region in glaucomatous eyes...
  11. Yamamoto M, Serizawa T, Higuchi Y, Sato Y, Kawagishi J, Yamanaka K, et al. A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Score. Int J Radiat Oncol Biol Phys. 2017;99:31-40 pubmed publisher
    ..This longer-term follow-up study further supports the already-reported noninferiority hypothesis of SRS alone for patients with 5 to 10 BMs versus 2 to 4 BMs. ..
  12. Kaneshige T, Haryu E. Infants predict expressers' cooperative behavior through facial expressions. PLoS ONE. 2017;12:e0185840 pubmed publisher
    ..However at the same time, they do not clearly understand the incongruence between happy expressions and hindering behavior. The results were discussed by referring to a negativity bias and human environment in which infants grow up...
  13. Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang K, et al. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. Gastroenterology. 2017;153:191-204.e16 pubmed publisher
    ..RHBDF2 promotes cleavage of TGFBR1 by activating TACE and motility of CAFs in response to TGFB1. These highly motile CAFs induce DGCs to invade extracellular matrix and lymphatic vessels in nude mice. ..
  14. Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, et al. Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis. Nat Genet. 2017;49:1120-1125 pubmed publisher
    ..Our approach is an efficient way to characterize the polygenic contributions and potential biological mechanisms of complex diseases. ..
  15. Shinohara K, Shimada N, Moriyama M, Yoshida T, Jonas J, Yoshimura N, et al. Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2017;58:3750-3758 pubmed publisher
    ..Future studies using WF-OCT may explore the detailed morphologic characteristics of posterior staphylomas and give clues to the etiology of staphylomas. ..
  16. Kimura T, Sugaya M, Suga H, Morimura S, Miyamoto A, Kai H, et al. Variations in serum TARC and I-TAC levels reflect minor changes in disease activity and pruritus in atopic dermatitis. Acta Derm Venereol. 2014;94:331-2 pubmed publisher
  17. Ohki T, Kondo M, Karasawa Y, Kawamura S, Maeshima S, Kojima K, et al. Evaluation of the Efficacy of Sorafenib on Overall Survival in Patients with Hepatocellular Carcinoma using FT Rate: A Devised Index. Adv Ther. 2017;34:1097-1108 pubmed publisher
    ..The present study indicates that the FT rate is potentially a useful index in evaluating the outcome for patients at various stages and treatment regimens. Bayer Yakuhin, Ltd. ..
  18. Ikeda N, Fuse K, Nishi N. Changes in the effects of living with no siblings or living with grandparents on overweight and obesity in children: Results from a national cohort study in Japan. PLoS ONE. 2017;12:e0175726 pubmed publisher
    ..5 years and older, respectively. Child's age should be considered during formulation of strategies for prevention of overweight and obesity in these groups. ..
  19. Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, et al. The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Oncogene. 2017;36:5145-5157 pubmed publisher
    ..These findings unveiled an unexpected strategy whereby RB suppresses malignant features of cancer cells through metabolic reprogramming and cell-autonomous inflammation. ..
  20. Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S. Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer. Cancer Res. 2017;77:4026-4038 pubmed publisher
    ..Our findings suggest inhibition of autocrine BMP-4 as a candidate treatment strategy for colorectal cancer. Cancer Res; 77(15); 4026-38. ©2017 AACR. ..
  21. Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima Takagi Y, et al. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet. 2017;49:1274-1281 pubmed publisher
    ..Our findings highlight a unique role of SPI1 fusions in high-risk pediatric T-ALL. ..
  22. Sugawara K, Yamashita H, Uemura Y, Mitsui T, Yagi K, Nishida M, et al. Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma. Surgery. 2017;162:846-856 pubmed publisher
    ..Numeric nodal staging is an essential tool for stratifying the oncologic outcomes of patients with esophageal squamous cell carcinoma even in the cohort in which adequate numbers of lymph nodes were harvested. ..
  23. Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  24. Kanazawa Y, Yamada T, Fujita I, Kakinuma D, Matsuno K, Arai H, et al. In Vitro Chemosensitivity Test for Gastric Cancer Specimens Predicts Effectiveness of Oxaliplatin and 5-Fluorouracil. Anticancer Res. 2017;37:6401-6405 pubmed
    ..However, cisplatin is emetic and potentially nephrotoxic. Oxaliplatin may be less toxic, but few basic data are available for this setting. Here, we evaluated oxaliplatin for GC, by testing surgical specimens...
  25. Panthee B, Panthee S, Gyawali S, Kawakami N. Prevalence and correlates of substance use among health care students in Nepal: a cross sectional study. BMC Public Health. 2017;17:950 pubmed publisher
    ..The prevalence of substance use among health care students at the three universities in Nepal was high. Peer influence, cigarette smoking, and heavy drinking were significant predictors of substance use. ..
  26. Nishizawa A, Nakajima R, Nakano H, Sawamura D, Takayama K, Satoh T, et al. A de novo missense mutation in the keratin 13 gene in oral white sponge naevus. Br J Dermatol. 2008;159:974-5 pubmed publisher
  27. Senkus E, Kyriakides S, Ohno S, Penault Llorca F, Poortmans P, Rutgers E, et al. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26 Suppl 5:v8-30 pubmed publisher
  28. Cardoso F, Costa A, Senkus E, Aapro M, Andre F, Barrios C, et al. 3rd ESO-ESMO international consensus guidelines for Advanced Breast Cancer (ABC 3). Breast. 2017;31:244-259 pubmed publisher
  29. Sawada Y, Araie M, Ishikawa M, Yoshitomi T. Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects. Ophthalmology. 2017;124:1600-1611 pubmed publisher
    ..This suggests that myopia may influence glaucomatous VF defects through optic disc tilt by way of an increased number of LC defects at the temporal periphery. ..
  30. Okumura T, Boku N, Hishida T, Ohde Y, Sakao Y, Yoshiya K, et al. Surgical Outcome and Prognostic Stratification for Pulmonary Metastasis From Colorectal Cancer. Ann Thorac Surg. 2017;104:979-987 pubmed publisher
    ..Patients could be classified into three risk groups using five prognostic factors. This grouping may be useful for identifying an optimal treatment strategy according to risk in future studies. ..
  31. Baba S, Kondo K, Suzukawa M, Ohta K, Yamasoba T. Distribution, subtype population, and IgE positivity of mast cells in chronic rhinosinusitis with nasal polyps. Ann Allergy Asthma Immunol. 2017;119:120-128 pubmed publisher
    ..Our results suggest a role for IgE-mediated mast cell activation in the pathogenesis of ECRS. ..
  32. Zenke Y, Ohara Y, Kobayashi D, Arai S, Kishimoto M, Okada M, et al. Nail findings in patients with psoriatic arthritis: A cross-sectional study with special reference to transverse grooves. J Am Acad Dermatol. 2017;77:863-867 pubmed publisher
    ..Nail findings enabled us to distinguish patients with PsA from those without arthritis. The presence of transverse grooves is significantly associated with PsA and may be associated with distal interphalangeal arthritis and enthesitis. ..
  33. Moriuchi T, Otsuka N, Hiramatsu Y, Shibayama K, Kamachi K. A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses. PLoS ONE. 2017;12:e0181181 pubmed publisher
    ..Our observations suggest that these adults had been infected with B. pertussis and other pathogen(s) during their adulthood...
  34. Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, et al. The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases. PLoS ONE. 2017;12:e0181270 pubmed publisher
    ..This clinicopathological study of 370 NSCLC cases and the cell biological studies of NSCLC cell lines clarified the tumor-suppressive role of miR-451 and its prognostic value. We also validated MIF as a target of miR-451 in NSCLC. ..
  35. Kajimoto K, Minami Y, Otsubo S, Sato N. Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction. Am J Cardiol. 2017;120:809-816 pubmed publisher
    ..In conclusion, among patients with acute decompensated HF with a preserved or reduced EF, the association of FMR with adverse outcomes may differ between patients who had an ischemic or nonischemic origin of HF. ..
  36. Mori S, Motohashi N, Takashima R, Kishi M, Nishimune H, Shigemoto K. Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis. Exp Neurol. 2017;297:158-167 pubmed publisher
    ..Further experimental and clinical studies are required to prove the pathogenicity of anti-LRP4 Abs in MG patients. ..
  37. Araie M, Iwase A, Sugiyama K, Nakazawa T, Tomita G, Hangai M, et al. Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population. Invest Ophthalmol Vis Sci. 2017;58:4106-4113 pubmed publisher
    ..023) and negatively with age (P < 0.001) (R2 = 0.157). BMO-MRW and RNFLT declined with age with a difference between them in their relationship to BMO area. BMO area positively correlated with axial length and negatively with age. ..
  38. Okahara K, Nagata N, Shimada T, Joya A, Hayashida T, Gatanaga H, et al. Colonic cytomegalovirus detection by mucosal PCR and antiviral therapy in ulcerative colitis. PLoS ONE. 2017;12:e0183951 pubmed publisher
    ..UC treatment without anti-CMV therapy may be warranted, particularly in patients with low-load CMV-DNA. Anti-CMV therapy alone does not always achieve clinical response in UC even in cases with high-load PCR. ..
  39. Abe M, Hamano T, Wada A, Nakai S, Masakane I. Effect of dialyzer membrane materials on survival in chronic hemodialysis patients: Results from the annual survey of the Japanese Nationwide Dialysis Registry. PLoS ONE. 2017;12:e0184424 pubmed publisher
    ..However, further long-term prospective studies are needed to clarify these findings, including whether the use of the PMMA membrane can improve prognosis. ..
  40. Ueshima C, Kataoka T, Takei Y, Hirata M, Sugimoto A, Hirokawa M, et al. CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells. Cancer Med. 2017;6:845-856 pubmed publisher
    ..These studies suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. ..
  41. Maruyama K, Maruyama Y, Sugita S, Mori K, Yokoyama Y, Sanuki Kunimatsu S, et al. Characteristics of cases needing advanced treatment for intractable Posner-Schlossman syndrome. BMC Ophthalmol. 2017;17:45 pubmed publisher
    ..PSS patients with a higher CEC reduction ratio, higher maximum IOP, greater visual field loss and higher positive number for CMV in the aqueous humor tended to be more likely to require progressive treatment, such as glaucoma surgery. ..
  42. Futagawa Y, Takano Y, Furukawa K, Kanehira M, Onda S, Sakamoto T, et al. Comparison of Outcomes with Hand-sewn Versus Stapler Closure of Pancreatic Stump in Distal Pancreatectomy. Anticancer Res. 2017;37:2515-2521 pubmed
    ..03). When indicating stapler closure, caution should be exercised for pancreatic consistency and thickness, device and cartridge type, and pancreatic duct ligation to more effectively control POPF rates. ..
  43. Jingu K, Matsuo Y, Onishi H, Yamamoto T, Aoki M, Murakami Y, et al. Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer. Anticancer Res. 2017;37:2709-2713 pubmed
    ..Dose escalation and adjuvant chemotherapy might improve local control in SBRT for pulmonary oligometastases from colorectal cancer. ..
  44. Kumagai N, Nusser J, Inoue H, Okumura K, Yamashita T, Kubo T, et al. Effect of Addition of a Statin to Warfarin on Thromboembolic Events in Japanese Patients With Nonvalvular Atrial Fibrillation and Diabetes Mellitus. Am J Cardiol. 2017;120:230-235 pubmed publisher
    ..In conclusion, in Japanese patients with NVAF with DM, a combination of warfarin and a statin could be clinically beneficial for preventing thromboembolic events. ..
  45. Zhao J, van Mierlo K, Gomez Ramirez J, Kim H, Pilgrim C, Pessaux P, et al. Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases. Br J Surg. 2017;104:990-1002 pubmed publisher
    ..Postoperative liver failure occurred more often in patients with severe SD. ..
  46. Masaoka H, Matsuo K, Sawada N, Yamaji T, Goto A, Shimazu T, et al. Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center-based Prospective Study. Int J Cancer. 2017;141:2480-2488 pubmed publisher
    ..083) may support our hypothesis that acetaldehyde derived from alcohol consumption is associated with bladder cancer risk. A prospective study considering polymorphisms of genes involved in acetaldehyde metabolism is warranted. ..
  47. Moriya C, Taniguchi H, Nagatoishi S, Igarashi H, Tsumoto K, Imai K. PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78. Cancer Sci. 2018;109:373-383 pubmed publisher
    ..These results suggest that HSP90α and GRP78 interact with PRDM14 and participate in cancer regulation. ..
  48. Wong J, Son D, Miura W. Cross-Cultural Interprofessional Faculty Development in Japan: Results of an Integrated Workshop for Clinical Teachers. Am J Med Sci. 2017;354:597-602 pubmed publisher
    ..Faculty development for improving clinical teaching can be performed across the cultures of medicine and nursing, as well as across the cultures of the United States and Japan. ..
  49. Tsujimoto T, Kajio H, Sugiyama T. Association between hyperinsulinemia and increased risk of cancer death in nonobese and obese people: A population-based observational study. Int J Cancer. 2017;141:102-111 pubmed publisher
  50. Deneau M, El Matary W, Valentino P, Abdou R, Alqoaer K, Amin M, et al. The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017;66:518-527 pubmed publisher
    ..Hepatology 2017;66:518-527). ..
  51. Oike A, Kodama M, Yasumasu S, Yamamoto T, Nakamura Y, Ito E, et al. Participation of androgen and its receptor in sex determination of an amphibian species. PLoS ONE. 2017;12:e0178067 pubmed publisher
    ..These results suggest that AR with its androgen ligand functions as a male sex-determinant in the ZW type R. rugosa frogs. ..
  52. Itoh M, Ujiie Y, Nagae N, Niwa M, Kamo T, Lin M, et al. The Japanese version of the Posttraumatic Diagnostic Scale: Validity in participants with and without traumatic experiences. Asian J Psychiatr. 2017;25:1-5 pubmed publisher
    ..92). The findings suggest that the Japanese version of the PDS is useful for diagnostically screening PTSD and assessing symptom severity. ..
  53. West A, Tang K, Tye H, Yu L, Deng N, Najdovska M, et al. Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer. Oncogene. 2017;36:5134-5144 pubmed publisher
  54. Gabriele M, Vulto van Silfhout A, Germain P, Vitriolo A, Kumar R, Douglas E, et al. YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. Am J Hum Genet. 2017;100:907-925 pubmed publisher
    ..Collectively, these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators. ..
  55. Yokoi N, Georgiev G, Kato H, Komuro A, Sonomura Y, Sotozono C, et al. Classification of Fluorescein Breakup Patterns: A Novel Method of Differential Diagnosis for Dry Eye. Am J Ophthalmol. 2017;180:72-85 pubmed publisher
    ..05 in each comparison). The 5 different FBUPs constituted different groups, reflecting different pathophysi-ologies. ..
  56. Inohara T, Kimura T, Ueda I, Ikemura N, Tanimoto K, Nishiyama N, et al. Effect of Compliance to Updated AHA/ACC Performance and Quality Measures Among Patients With Atrial Fibrillation on Outcome (from Japanese Multicenter Registry). Am J Cardiol. 2017;120:595-600 pubmed publisher
    ..There remains an important opportunity to improve the quality of care in patients with AF. Adherence to the AF PMs might lead to the improvement of patient's quality of life. ..
  57. Fujishima S, Sasaki J, Shinozawa Y, Takuma K, Kimura H, Suzuki M, et al. Serum MIP-1 alpha and IL-8 in septic patients. Intensive Care Med. 1996;22:1169-75 pubmed
    ..05). The production of MIP-1 alpha and IL-8 was increased in sepsis. Furthermore, an initially detectable level of circulating IL-8, but not MIP-1 alpha, predicted a high mortality in sepsis diagnosed according to the ACCP/SCCM criteria. ..
  58. Hatake K, Ogura M, Takada K, Taniwaki M, Zhang F, Fujita T, et al. Ofatumumab combined with chlorambucil for previously untreated chronic lymphocytic leukemia: a phase I/II, open-label study in Japan. Int J Hematol. 2017;106:240-247 pubmed publisher
    ..One grade 3 serious AE related to the study drug occurred (hypoxia). The results indicate that ofatumumab combined with chlorambucil is an effective treatment for Japanese CLL patients, with a manageable safety profile. ..
  59. Takahashi H, Nishimura R, Onda Y, Ando K, Tsujino D, Utsunomiya K. Prediction of nocturnal hypoglycemia unawareness by fasting glucose levels or post-breakfast glucose fluctuations in patients with type 1 diabetes receiving insulin degludec: A pilot study. PLoS ONE. 2017;12:e0177283 pubmed publisher
    ..It was also shown that the occurrence of hypoglycemia led to greater post-breakfast glucose fluctuations and steeper post-breakfast glucose gradients. ..
  60. Kuboki Y, Nishina T, Shinozaki E, Yamazaki K, Shitara K, Okamoto W, et al. TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): an investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study. Lancet Oncol. 2017;18:1172-1181 pubmed publisher
    ..Taiho Pharmaceutical. ..
  61. Maruyama D, Nagai H, Maeda Y, Nakane T, Shimoyama T, Nakazato T, et al. Phase I/II study of pralatrexate in Japanese patients with relapsed or refractory peripheral T-cell lymphoma. Cancer Sci. 2017;108:2061-2068 pubmed publisher
    ..These results indicate that pralatrexate is generally well tolerated and effective in Japanese patients with relapsed or refractory peripheral T-cell lymphoma. This trial was registered with (NCT02013362). ..
  62. Hattori N, Tanaka M, Ozawa T, Mizuno Y. Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease. Ann Neurol. 1991;30:563-71 pubmed
    ..These results are consistent with our findings that there is a deletion of gene coding for the four subunits in the mitochondrial DNA located in the striata of parkinsonian patients. ..
  63. Keum N, Yuan C, Nishihara R, Zoltick E, Hamada T, Martínez Fernandez A, et al. Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers. Int J Cancer. 2017;140:2648-2656 pubmed publisher
    ..12). While additional studies are needed for definitive evidence, a high-insulinogenic diet after CRC diagnosis may contribute to worse CRC survival. ..
  64. Takane K, Akagi K, Fukuyo M, Yagi K, Takayama T, Kaneda A. DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. Cancer Med. 2017;6:1023-1035 pubmed publisher
    ..NRAS-mutation(+) CRC may constitute a different subgroup from KRAS-mutation(+) CRC, showing significant correlation with LME, older age, distal colon, and relatively better prognosis. ..
  65. Saji M, Katz M, Ailawadi G, Fowler D, Ragosta M, Lim D. Predictive Value of Age-Adjusted Charlson Co-Morbidity Index for 1-, 3-, and 5-Year Mortality in Patients Requiring Transcatheter Mitral Valve Repair. Am J Cardiol. 2017;120:309-314 pubmed publisher
    ..In conclusions, the age-adjusted CCI could predict mortality and had a good discriminative performance for predicting longer term outcomes in patients who underwent TMVr. ..
  66. Hamanaka T, Kimura M, Sakurai T, Ishida N, Yasuda J, Nagasaki M, et al. A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients. Invest Ophthalmol Vis Sci. 2017;58:2818-2831 pubmed publisher
    ..The four detected MYOC mutations appeared to be associated with morphologic changes in the TM and the underlying pathogenesis of a subtype of familial POAG. ..
  67. Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, et al. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J. 2017;36:2146-2160 pubmed publisher
    ..Our results indicate that ATX-LPA-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways. ..
  68. Hara T, Murakami Y, Seiki M, Sakamoto T. Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice. Biochem Biophys Res Commun. 2017;490:688-692 pubmed publisher
    ..Thus, targeting Mint3 in bone marrow-derived cells might be a good strategy for preventing metastasis and improving the prognosis of breast cancer patients. ..
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    ..Patients receiving treatment with tofacitinib and GCs appear to have a greater risk of developing HZ compared with patients receiving tofacitinib monotherapy without GCs. ..
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    ..The molecular-based pN classification determines the prognosis of breast cancer patients and could guide therapeutic decision making. ..
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    ..The findings presented herein advance our knowledge and understanding of the relationship between humans and bacterial communities in built environments, and will help improve public health in urban communities. ..
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    ..5 cm or less had a good prognosis. Adenocarcinoma with a predominantly lepidic pattern and invasion of 0.5 cm or less can be regarded as minimally invasive adenocarcinoma even if the tumor is larger than 3.0 cm in diameter. ..
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    ..16; 95% CI: -0.30 to -0.03; d = -0.02). The results of these fixed-effects models suggest that strengthening neighborhood collective efficacy is related to improvements in child psychosocial development. ..
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    ..We observed a high rate of antibiotic prescription changes after the Verigene test in a population with COB especially in GP. The Verigene test would be a useful tool in antimicrobial stewardship programs among patients with COB. ..
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    ..To our knowledge, this is the first study reporting a greater prognostic power of histology of the fibrotic stroma than that of tumor factors. ..
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    ..In this study, we aimed to analyze the root apex positions of impacted maxillary canines on panoramic radiographs according to their labiopalatal positions and to propose a new panoramic radiographic predictor of impacted maxillary canines...
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    ..This report aimed to scrutinize the prevalence of Behçet's disease (BD)-related clinical manifestations based on age- and sex-specific subgroups using a Japanese nationwide registration database...
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    ..High-load AECT using the bicycle ergometer was more effective than CT for decreasing lower-limb volume. These results suggest that high-load AECT has marked effects on severe LLL. ..
  87. Ohsawa M, Okamura T, Tanno K, Ogasawara K, Itai K, Yonekura Y, et al. Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers. J Epidemiol. 2017;27:360-367 pubmed publisher
    ..41; 95% CI, 3.86-14.2 in elderly individuals). AF increased the risk of stroke by the same magnitude as that reported previously in Western countries. AF increased the RR of heart failure more than that in Western populations. ..
  88. Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Kamo Y, et al. Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotechnol Biochem. 2017;81:1120-1124 pubmed publisher
    ..These findings suggest that AHRR plays distinct roles in kidney functions and hemoglobin values. The effects of the AHRR polymorphism might be intensified in the kidneys of patients with CKD. ..
  89. Yamashita H, Seto Y, Takenaka R, Okuma K, Kiritooshi T, Mori K, et al. Survival comparison between radical surgery and definitive chemoradiation in 267 esophageal squamous cell carcinomas in a single institution: A propensity-matched study. PLoS ONE. 2017;12:e0177133 pubmed publisher
    ..A prospective randomized clinical trial will be necessary to draw a definite conclusion. ..
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    ..Our results suggest that the proper organization of the placental labyrinth depends on coordinated inter-endothelial repulsion, which prevents uncontrolled layering of the endothelium. ..
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    ..Analysis of the biology of the Prl3c1 gene has provided insight into a previously unappreciated homeostatic setpoint control system programming testicular growth and function. ..
  92. Ishii F, Yoshida Y, Yamauchi Y, Aisu N, Kojima D, Mera T, et al. Hepatectomy for Liver Metastases of Colorectal Cancer After Adoptive Chemoimmunotherapy Using Activated ?? T-cells. Anticancer Res. 2017;37:3933-3939 pubmed
    ..There was no postoperative complication of Clavien-Dindo grade 3A or higher. One patient had multiple lung metastases. Hepatectomy after chemoimmunotherapy using activated ?? T-cells for CLM can be performed safely. ..