Experts and Doctors on female in Ōsaka, Japan


Locale: Ōsaka, Japan
Topic: female

Top Publications

  1. Kanemura Y, Sumida M, Okita Y, Yoshioka E, Yamamoto A, Kanematsu D, et al. Systemic Intravenous Adoptive Transfer of Autologous Lymphokine-activated ?? T-Cells Improves Temozolomide-induced Lymphopenia in Patients with Glioma. Anticancer Res. 2017;37:3921-3932 pubmed
    ..Future prospective study is needed to clarify the clinical merits of this immunotherapy. ..
  2. Nguyen T, Murakami Y, Sheridan E, Ehresmann S, Rousseau J, St Denis A, et al. Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia. Am J Hum Genet. 2017;101:856-865 pubmed publisher
    ..These findings highlight the role of the transamidase complex in the development and function of the cerebellum and the skeletal system. ..
  3. Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang K, et al. Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. Gastroenterology. 2017;153:191-204.e16 pubmed publisher
    ..RHBDF2 promotes cleavage of TGFBR1 by activating TACE and motility of CAFs in response to TGFB1. These highly motile CAFs induce DGCs to invade extracellular matrix and lymphatic vessels in nude mice. ..
  4. Anguille S, van de Velde A, Smits E, Van Tendeloo V, Juliusson G, Cools N, et al. Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia. Blood. 2017;130:1713-1721 pubmed publisher
    ..This trial was registered at as #NCT00965224. ..
  5. Shibata H, Aibiki M, Shirakawa Y, Ogli K. Dopamine infused continuously at high concentration with a low flow rate affects arterial blood pressure fluctuation waves. Crit Care Med. 1993;21:801-4 pubmed
  6. Ishitobi M, Fukui R, Hashimoto Y, Kittaka N, Nakayama T, Tamaki Y. Safety for Repeat Lumpectomy Without Radiotherapy for Ipsilateral Breast Tumor Recurrence. Anticancer Res. 2017;37:5293-5299 pubmed
    ..Patients in the low-risk group defined by the breast cancer subtype of IBTR and margin status of primary surgery could safely undergo repeat lumpectomy without radiotherapy for IBTR. ..
  7. Taniguchi Y, Tamiya A, Isa S, Nakahama K, Okishio K, Shiroyama T, et al. Predictive Factors for Poor Progression-free Survival in Patients with Non-small Cell Lung Cancer Treated with Nivolumab. Anticancer Res. 2017;37:5857-5862 pubmed
    ..Nivolumab has shown promising effects in patients with non-small-cell lung cancer (NSCLC) as a second- or later-line treatment. This study aimed to identify patients who would not experience any benefit from nivolumab treatment...
  8. Takemura H, Pestilli F, Weiner K, Keliris G, Landi S, Sliwa J, et al. Occipital White Matter Tracts in Human and Macaque. Cereb Cortex. 2017;27:3346-3359 pubmed publisher
    ..These similarities and differences between the occipital lobe tracts will be useful in establishing which circuitry in the macaque can serve as an accurate model for human visual cortex...
  9. Naito M, Yamamoto T, Shimamoto C, Miwa Y. Retrospective Analysis of the Risk Factors for Grade IV Neutropenia in Oesophageal Cancer Patients Treated with a Docetaxel, Cisplatin, and 5-Fluorouracil Regimen. Chemotherapy. 2017;62:215-224 pubmed publisher
    ..5 and 88.2%, respectively). Our findings suggest that a platelet count is the most significant predictor of grade IV neutropenia. ..

More Information

Publications123 found, 100 shown here

  1. Inoue S, Mizushima T, Fujita K, Meliti A, Ide H, Yamaguchi S, et al. GATA3 immunohistochemistry in urothelial carcinoma of the upper urinary tract as a urothelial marker and a prognosticator. Hum Pathol. 2017;64:83-90 pubmed publisher
    ..Moreover, loss of GATA3 expression was found to be an independent predictor of poor patient outcomes. Of note was that only roughly half of high-grade and/or muscle-invasive UUTUCs were immunoreactive for GATA3. ..
  2. Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, et al. Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma. PLoS ONE. 2017;12:e0178635 pubmed publisher
    ..The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients. ..
  3. Kyo M, Mii H, Takekita Y, Tokuhara D, Yazaki M, Nakamori Y, et al. Case of adult-onset type II citrullinemia treated as schizophrenia for a long time. Psychiatry Clin Neurosci. 2015;69:306-7 pubmed publisher
  4. Iwao K, Miyoshi Y, Egawa C, Ikeda N, Noguchi S. Quantitative analysis of estrogen receptor-beta mRNA and its variants in human breast cancers. Int J Cancer. 2000;88:733-6 pubmed
    ..Our results demonstrate that ER-alpha mRNA is up-regulated and ER-beta mRNA is down-regulated during carcinogenesis of breast cancers. Changes in proportions of ER-beta mRNA variants are also implicated in this process. ..
  5. Brose M, Smit J, Lin C, Pitoia F, Fellous M, Desanctis Y, et al. Timing of multikinase inhibitor initiation in differentiated thyroid cancer. Endocr Relat Cancer. 2017;24:237-242 pubmed publisher
    ..In total, 700 patients are estimated to be enrolled from >20 countries. Final analysis will be performed once the last enrolled patient has been followed up with for 24 months ( identifier: Nbib2303444). ..
  6. Akayama K, Miyata Y, Kawahara T, Okada M, Kaneko M, Okajima M, et al. New noncontact sensor for detecting pulmonary tumors during video-assisted thoracic surgery. J Surg Res. 2017;214:62-68 pubmed publisher
    ..In six patients, all nodules were successfully detected. Our noncontact sensor is a safe and feasible tool for detecting small pulmonary tumors during VATS. ..
  7. Hosoe J, Kadowaki H, Miya F, Aizu K, Kawamura T, Miyata I, et al. Structural Basis and Genotype-Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance. Diabetes. 2017;66:2713-2723 pubmed publisher
  8. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, et al. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017;6: pubmed publisher
    ..The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis. Thus, the KP-10/GPR54 system may serve as a novel therapeutic target for atherosclerotic diseases. ..
  9. Suzuki Y, Matsuzaki S, Mimura K, Kumasawa K, Tomimatsu T, Endo M, et al. Investigation of perioperative complications associated with use of uterine compression sutures. Int J Gynaecol Obstet. 2017;139:28-33 pubmed publisher
    ..5%] vs 4/37 [10.8%]; P=0.021), but the frequency of ileus did not differ (1/39 [2.6%] vs 2/37 [5.4%]; P=0.61). Use of UCSs during emergency cesarean delivery might increase the risk of postoperative endometritis. ..
  10. Ono Minagi H, Sarper S, Kurosaka H, Kuremoto K, Taniuchi I, Sakai T, et al. Runx1 mediates the development of the granular convoluted tubules in the submandibular glands. PLoS ONE. 2017;12:e0184395 pubmed publisher
    ..Furthermore, RUNX1 could also be involved in the membrane trafficking of the AQP5 protein of the acinar cells in the SMG in order to allow for the proper secretion of saliva. ..
  11. Kono K, Nakamura H, Inoue Y, Okamura T, Shakudo M, Yamada R. Intraspinal extradural cysts communicating with adjacent herniated disks: imaging characteristics and possible pathogenesis. AJNR Am J Neuroradiol. 1999;20:1373-7 pubmed
    ..They had rim enhancement on contrast-enhanced MR images, and communication with a herniated disk was revealed by diskography. ..
  12. Hayashi T, Ichimura T, Kasai M, Sano K, Zharhary D, Shiozawa T, et al. Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination. Anticancer Res. 2017;37:1765-1772 pubmed
    ..These findings meet the definition of uterine LANT-like malignant tumour, and the research findings of our clinical case suggest that LANT is a special type of neuroendocrine neoplasm and is not organ specific. ..
  13. Tominaga Y, Kawata H, Iwai S, Yamauchi S. Fontan operation with bilateral conduits for the treatment of pulmonary arteriovenous fistulas in a patient with polysplenia after reconstruction of a non-confluent pulmonary artery. J Card Surg. 2017;32:387-389 pubmed publisher
    ..Bilateral extracardiac conduits were used to connect each hepatic vein to the pulmonary artery, opposite each superior vena cava. Clinical improvement in the pulmonary arteriovenous fistulas was observed within 4 months after surgery. ..
  14. Cao W, Kayama H, Chen M, Delmas A, Sun A, Kim S, et al. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity. 2017;47:1182-1196.e10 pubmed publisher
    ..Further, a subset of ileal Crohn's disease patients displayed MDR1 loss of function. Together, these results suggest that coordinated interaction between mucosal Teff cells and CBAs in the ileum regulate intestinal immune homeostasis. ..
  15. Miyabe J, Hanamoto A, Tatsumi M, Hamasaki T, Takenaka Y, Nakahara S, et al. Metabolic tumor volume of primary tumor predicts survival better than T classification in the larynx preservation approach. Cancer Sci. 2017;108:2030-2038 pubmed publisher
    ..10), respectively. ICC was 0.99 (95% CI, 0.99-1.00). Given the excellent interobserver reliability, T-MTV is better than T classification to identify patients who would benefit from the larynx preservation approach. ..
  16. Uchiyama Y, Kreiborg S, Murakami S, Tsujimoto T, Sumida I. Changes in the Submandibular Gland in Patients with Head and Neck Cancer After Radiation Therapy: A Preliminary Study. Anticancer Res. 2017;37:3239-3242 pubmed
    ..05). Both volume and CT value of the submandibular gland showed signs of impairment of the gland during the first several months after RT for head and neck cancer. ..
  17. Bultmann Mellin I, Dinger K, Debuschewitz C, Loewe K, Melcher Y, Plum M, et al. Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs. Am J Physiol Lung Cell Mol Physiol. 2017;313:L687-L698 pubmed publisher
  18. Kashiyama N, Toda K, Nakamura T, Miyagawa S, Nishi H, Yoshikawa Y, et al. Evaluation of right ventricular function using liver stiffness in patients with left ventricular assist device. Eur J Cardiothorac Surg. 2017;51:715-721 pubmed publisher
  19. Ito E, Miyagawa S, Fukushima S, Yoshikawa Y, Saito S, Saito T, et al. Histone Modification Is Correlated With Reverse Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy. Ann Thorac Surg. 2017;104:1531-1539 pubmed publisher
    ..LVAD support partially reversed the epigenetic state and its upstream signals, in association with pathologic and functional reverse remodeling. ..
  20. Omi T, Ito H, Riku K, Kanai K, Takada H, Fujimi S, et al. Possible factors influencing the duration of hospital stay in patients with psychiatric disorders attempting suicide by jumping. BMC Psychiatry. 2017;17:99 pubmed publisher
    ..From these results, we suggest that clinicians should monitor the level of prolactin and cognitive function in patients with schizophrenia in future studies on managing of lower-limb fractures. ..
  21. Miyata H, Sugimura K, Motoori M, Fujiwara Y, Omori T, Yanagimoto Y, et al. Clinical Assessment of Sarcopenia and Changes in Body Composition During Neoadjuvant Chemotherapy for Esophageal Cancer. Anticancer Res. 2017;37:3053-3059 pubmed
    ..We should make an effort to reduce the incidence of adverse events in order to maintain an appropriate body composition during NAC. ..
  22. Otsu H, Watanabe M, Inoue N, Masutani R, Iwatani Y. Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases. Clin Chem Lab Med. 2017;55:626-635 pubmed publisher
    ..0256). The expression levels of miRNAs in plasma and PBMC showed wide intraindividual variation. In addition, miR-146a may be associated with the development of AITD. ..
  23. Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, et al. IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS Pathog. 2017;13:e1006630 pubmed publisher
    ..novicida infection. Altogether, our results indicate that GBPs are the master effectors of IFN-?-mediated responses against F. novicida to control antibacterial immune responses in inflammasome-dependent and independent manners...
  24. Kitahara M, Akagi H, Sakai K. Primary cardiac synovial sarcoma arising from the pulmonary valve. J Card Surg. 2014;29:216-7 pubmed publisher
  25. Kokuryo D, Aoki I, Yuba E, Kono K, Aoshima S, Kershaw J, et al. Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation. Transl Res. 2017;185:24-33 pubmed publisher
    ..The proposed strategy of combining high-LET irradiation and the nanodevice provides an effective approach for minimally invasive cancer treatment. ..
  26. Otsuka T, Nojiri T, Minami S, Hosoda H, Kuroyama M, Hirata H, et al. Evaluation of Natriuretic Peptide in Non-small Cell Lung Cancer Patients Treated with Bevacizumab Together with Carboplatin-Paclitaxel: A Prospective Study. Anticancer Res. 2017;37:3505-3512 pubmed
    ..0022). Decrease of plasma BNP concentration correlated with PFS after a treatment of combination bevacizumab plus carboplatin-paclitaxel. ..
  27. Itamochi H, Oishi T, Oumi N, Takeuchi S, Yoshihara K, Mikami M, et al. Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma. Br J Cancer. 2017;117:717-724 pubmed publisher
    ..Furthermore, our whole-genome sequencing data highlight important pathways for molecular and biological characterisations and potential therapeutic targeting in OCCC. ..
  28. Nakamura K, Miura D, Saito Y, Yunoki K, Koyama Y, Satoh M, et al. Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice. PLoS ONE. 2017;12:e0181009 pubmed publisher
    ..EPA prevents arterial calcification together with reduction of NOX gene expression and activity via GPR120 in klotho mutant mice. ..
  29. Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, et al. Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes. FASEB J. 2017;31:4053-4063 pubmed publisher
    ..Iwamoto, Y., Koriyama, H., Yoshida, S., Shimamura, M., Higuchi, M., Kawano, T., Takami, Y., Rakugi, H., Morishita, R., Nakagumi, H. Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes. ..
  30. Kanai Y, Yasoda A, Mori K, Watanabe Takano H, Nagai Okatani C, Yamashita Y, et al. Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance. J Clin Invest. 2017;127:4136-4147 pubmed publisher
    ..Together, these results support OSTN administration as an adjuvant agent for CNP therapy and provide a potential therapeutic approach for diseases with impaired skeletal growth. ..
  31. Nakajima N, Fukuda H, Adachi H, Sasaki N, Yamaguchi M, Mitsuno Y, et al. Long-Term Volume Reduction Effects of Endovascular Embolization for Intracranial Meningioma: Preliminary Experience of 5 Cases. World Neurosurg. 2017;105:591-598 pubmed publisher
  32. Nagasao T, Morotomi T, Kuriyama M, Kogure T, Kudo H, Hamamoto Y, et al. Thoracic outlet syndrome after the Nuss procedure for pectus excavatum: Is it a rare complication?. J Plast Reconstr Aesthet Surg. 2017;70:1433-1439 pubmed publisher
    ..Maturity of the thoracic wall, femininity, severity of the deformity (represented by greater Haller indices), and placement of correction bars at superior intercostal spaces are risk factors for postoperative thoracic outlet syndrome. ..
  33. Makino T, Yamasaki M, Tanaka K, Tatsumi M, Takiguchi S, Hatazawa J, et al. Importance of positron emission tomography for assessing the response of primary and metastatic lesions to induction treatments in T4 esophageal cancer. Surgery. 2017;162:836-845 pubmed publisher
    ..0245) as independent prognostic predictors. Positron emission tomography evaluation of the response of primary and metastatic lesions to induction treatments is important to formulate treatment strategies for cT4 esophageal cancer. ..
  34. Abe M, Hamano T, Wada A, Nakai S, Masakane I. Effect of dialyzer membrane materials on survival in chronic hemodialysis patients: Results from the annual survey of the Japanese Nationwide Dialysis Registry. PLoS ONE. 2017;12:e0184424 pubmed publisher
    ..However, further long-term prospective studies are needed to clarify these findings, including whether the use of the PMMA membrane can improve prognosis. ..
  35. Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, et al. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol. 2014;133:1474-7, 1477.e1-2 pubmed publisher
  36. Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, et al. Validation of the Japanese Severe Respiratory Insufficiency Questionnaire in hypercapnic patients with noninvasive ventilation. Respir Investig. 2017;55:166-172 pubmed publisher
    ..It has high psychometric properties with internal consistency and concurrent validity. The Japanese SRI Questionnaire can be used to assess HRQL in patients on NIV for CHRF. ..
  37. Moon J, Fujiwara Y, Hirao M, Imamura H, Kimura Y, Fujitani K, et al. Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines Versus Surgery-alone for Gastric Cancer. Anticancer Res. 2017;37:3061-3067 pubmed
    ..However, it may be effective for patients with stage II disease. Additionally, uracil-tegafur is a promising agent for adjuvant chemotherapy of gastric cancer if S-1 is not available because of its toxicity. ..
  38. Silventoinen K, Jelenkovic A, Sund R, Yokoyama Y, Hur Y, Cozen W, et al. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. Am J Clin Nutr. 2017;106:457-466 pubmed publisher
    ..Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population. ..
  39. Yamamoto M, Takahashi T, Serada S, Sugase T, Tanaka K, Miyazaki Y, et al. Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer. Cancer Sci. 2017;108:2052-2060 pubmed publisher
    ..These results suggest that LRG1 expression in tumors and serum may be a useful prognostic marker in gastric cancer patients. ..
  40. Yamamoto M, Serizawa T, Higuchi Y, Sato Y, Kawagishi J, Yamanaka K, et al. A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Score. Int J Radiat Oncol Biol Phys. 2017;99:31-40 pubmed publisher
    ..This longer-term follow-up study further supports the already-reported noninferiority hypothesis of SRS alone for patients with 5 to 10 BMs versus 2 to 4 BMs. ..
  41. Ukai H, Kiyonari H, Ueda H. Production of knock-in mice in a single generation from embryonic stem cells. Nat Protoc. 2017;12:2513-2530 pubmed publisher
    ..In this report, we describe the basic technologies and protocols for this procedure, and discuss the current challenges for next-generation mammalian genetics in organism-level systems biology studies...
  42. Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Noda S, et al. Use of Tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer. PLoS ONE. 2017;12:e0170634 pubmed publisher
    ..031, HR = 0.063). The results of this study suggest that TILs may be useful as a predictive marker of the therapeutic effect of eribulin chemotherapy in TNBC. ..
  43. Shigematsu T, Muraoka R, Sugimoto T, Nishizawa Y. Risedronate therapy in patients with mild-to-moderate chronic kidney disease with osteoporosis: post-hoc analysis of data from the risedronate phase III clinical trials. BMC Nephrol. 2017;18:66 pubmed publisher
    ..The risedronate therapy showed similar clinical effects in CKD patients with osteoporosis compared to those without CKD. ..
  44. Kiguchi T, Sato C, Takai K, Nakai Y, Kaneko Y, Matsuki M. CT findings in 11 patients with TAFRO syndrome: a variant of multicentric Castleman's disease. Clin Radiol. 2017;72:905.e1-905.e5 pubmed publisher
    ..A "matted" appearance of the enlarged anterior mediastinum is the characteristic CT finding of TAFRO syndrome, and it is possible to diagnose TAFRO syndrome from the combination of several CT findings. ..
  45. Takeuchi D, Kerdsin A, Akeda Y, Chiranairadul P, Loetthong P, Tanburawong N, et al. Impact of a Food Safety Campaign on Streptococcus suis Infection in Humans in Thailand. Am J Trop Med Hyg. 2017;96:1370-1377 pubmed publisher
    ..suis infection, and we present a role model public health intervention for prevalent areas affected by S. suis infection in humans. ..
  46. Matsushima J, Yazawa T, Suzuki M, Takahashi Y, Ota S, Nakajima T, et al. Clinicopathological, immunohistochemical, and mutational analyses of pulmonary enteric adenocarcinoma: usefulness of SATB2 and β-catenin immunostaining for differentiation from metastatic colorectal carcinoma. Hum Pathol. 2017;64:179-185 pubmed publisher
    ..The present study's findings indicate that β-catenin and SATB2 are useful immunohistochemical markers for differentiating between PEA and MCRC. ..
  47. Koh S, Maeda N, Ikeda C, Asonuma S, Ogawa M, Hiraoka T, et al. The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye. Invest Ophthalmol Vis Sci. 2017;58:2647-2651 pubmed publisher
    ..541, P < 0.001, respectively). In dry eye, reduced contrast sensitivity in part results from central SPK overlying the optical zone and the increased straylight results from tear film instability rather than central SPK. ..
  48. Kitano T, Miyagawa M, Nishio S, Moteki H, Oda K, Ohyama K, et al. POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss. PLoS ONE. 2017;12:e0177636 pubmed publisher
    ..The present study showed that variants in POU4F3 were a common cause of autosomal dominant HL. ..
  49. Okumura T, Boku N, Hishida T, Ohde Y, Sakao Y, Yoshiya K, et al. Surgical Outcome and Prognostic Stratification for Pulmonary Metastasis From Colorectal Cancer. Ann Thorac Surg. 2017;104:979-987 pubmed publisher
    ..Patients could be classified into three risk groups using five prognostic factors. This grouping may be useful for identifying an optimal treatment strategy according to risk in future studies. ..
  50. Shibutani M, Maeda K, Nagahara H, Fukuoka T, Nakao S, Matsutani S, et al. The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1+ to CD8+ Lymphocyte Ratio in Patients with Colorectal Cancer. Anticancer Res. 2017;37:4165-4172 pubmed
    ..The PD-1/CD8 ratio may, therefore, be a useful prognostic marker for stage II/III CRC. What is important for predicting the prognosis may be the PD-1/CD8 ratio rather than the absolute number of PD-1+ TILs. ..
  51. Matsunami S, Komasawa N, Konishi Y, Minami T. Head elevation and lateral head rotation effect on facemask ventilation efficiency: Randomized crossover trials. Am J Emerg Med. 2017;35:1709-1712 pubmed publisher
    ..Head elevation increased facemask ventilation volume in normal airway patients, while lateral head rotation did not. ..
  52. Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, et al. FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Cancer Res. 2017;77:4881-4893 pubmed publisher
    ..Overall, our results revealed a pathway that cyclin E1/CDK2 activation coupled with FBW7 loss promotes CIN and tumor progression via CENP-A-mediated centromere dysfunction. Cancer Res; 77(18); 4881-93. ©2017 AACR. ..
  53. Morioka M, Matsumoto M, Saito M, Kokame K, Miyata T, Fujimura Y. A first bout of thrombotic thrombocytopenic purpura triggered by herpes simplex infection in a 45-year-old nulliparous female with Upshaw-Schulman syndrome. Blood Transfus. 2014;12 Suppl 1:s153-5 pubmed publisher
  54. Omote N, Taniguchi H, Kondoh Y, Watanabe N, Sakamoto K, Kimura T, et al. Lung-Dominant Connective Tissue Disease: Clinical, Radiologic, and Histologic Features. Chest. 2015;148:1438-1446 pubmed publisher
    ..Two-thirds of patients had characteristic histologic features for LD-CTD. A majority of patients with h-UIP were considered to have unclassifiable IIP based on MDD. Patients with h-UIP had worse survival than those with h-NSIP. ..
  55. Jingu K, Matsuo Y, Onishi H, Yamamoto T, Aoki M, Murakami Y, et al. Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer. Anticancer Res. 2017;37:2709-2713 pubmed
    ..Dose escalation and adjuvant chemotherapy might improve local control in SBRT for pulmonary oligometastases from colorectal cancer. ..
  56. Mizushima T, Fukunaga M, Sueda T, Ikeda M, Kato T, Kim H, et al. Phase I/II study of bi-weekly XELIRI plus bevacizumab treatment in patients with metastatic colorectal cancer resistant to oxaliplatin-based first-line chemotherapy. Cancer Chemother Pharmacol. 2017;80:81-90 pubmed publisher
    ..Bi-weekly XELIRI plus bevacizumab was found to be a safe and effective second-line treatment in patients with metastatic colorectal cancer resistant to oxaliplatin-based first-line chemotherapy. ..
  57. Honda K, Asada R, Kageyama K, Fukuda T, Terada H, Yasui T, et al. Protein Complex of Fibrinogen Gamma Chain and Complement Factor H in Ovarian Cancer Patient Plasma. Anticancer Res. 2017;37:2861-2866 pubmed
    ..Fibrinogen gamma chain and complement factor H were found to be bound as a protein complex in the plasma of a patient with advanced ovarian cancer. ..
  58. Baselga J, Im S, Iwata H, Cortes J, De Laurentiis M, Jiang Z, et al. Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017;18:904-916 pubmed publisher
    ..No further studies are being pursued because of the toxicity associated with this combination. Novartis Pharmaceuticals Corporation. ..
  59. Tsuda E, Tsujii N, Hayama Y. Cardiac Events and the Maximum Diameter of Coronary Artery Aneurysms in Kawasaki Disease. J Pediatr. 2017;188:70-74.e1 pubmed publisher
    ..50 m2. At 30 years after the onset of KD, cardiac event-free survival was about 60%. Given the high rate of cardiac events in this patient population, life-long cardiovascular surveillance is advised. ..
  60. Tanaka T, Fujita M, Hasegawa H, Arimoto A, Nishi M, Fukuoka E, et al. Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence. Anticancer Res. 2017;37:3863-3869 pubmed
    ..Continuous monitoring of MDSCs in the peripheral blood might be a useful indicator of tumor recurrence. ..
  61. Fujiwara Y, Okada K, Omori T, Sugimura K, Miyata H, Ohue M, et al. Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. Int J Oncol. 2017;50:1655-1662 pubmed publisher
    ..The survival benefit of peptide vaccine monotherapy may not have been shown and further trials are needed to confirm these results. ..
  62. Nishide M, Nojima S, Ito D, Takamatsu H, Koyama S, Kang S, et al. Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis. Ann Rheum Dis. 2017;76:1440-1448 pubmed publisher
    ..Proteolytic cleavage of SEMA4D as observed in patients with AAV may amplify neutrophil-mediated inflammatory responses. SEMA4D is a promising biomarker and potential therapeutic target for AAV. ..
  63. Tanaka T, Zhang W, Sun Y, Shuai Z, Chida A, Kenny T, et al. Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics. Hepatology. 2017;66:885-895 pubmed publisher
    ..Importantly, cross-reactive mAbs also recognized lipoic acid, a mitochondrial fatty acid that is covalently bound to PDC-E2...
  64. Chau I, Peck Radosavljevic M, Borg C, Malfertheiner P, Seitz J, Park J, et al. Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib: Patient-focused outcome results from the randomised phase III REACH study. Eur J Cancer. 2017;81:17-25 pubmed publisher
    ..In patients with baseline AFP ?400 ng/mL, the significant survival benefit observed in patients treated with ramucirumab was coupled with a trend in patient-focused outcome benefits. NCT01140347. ..
  65. Koh S, Inoue Y, Ochi S, Takai Y, Maeda N, Nishida K. Quality of Vision in Eyes With Epiphora Undergoing Lacrimal Passage Intubation. Am J Ophthalmol. 2017;181:71-78 pubmed publisher
    ..019), and tear meniscus dimension decreased (P < .001). Lacrimal passage intubation for eyes with epiphora significantly improved visual function and optical quality via patency of the lacrimal passage. ..
  66. Maruyama D, Nagai H, Maeda Y, Nakane T, Shimoyama T, Nakazato T, et al. Phase I/II study of pralatrexate in Japanese patients with relapsed or refractory peripheral T-cell lymphoma. Cancer Sci. 2017;108:2061-2068 pubmed publisher
    ..These results indicate that pralatrexate is generally well tolerated and effective in Japanese patients with relapsed or refractory peripheral T-cell lymphoma. This trial was registered with (NCT02013362). ..
  67. Tada S, Ikebe K, Kamide K, Gondo Y, Inomata C, Takeshita H, et al. Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study. PLoS ONE. 2017;12:e0182563 pubmed publisher
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    ..We evaluated that chemotherapy with a TPD regimen (trastuzumab, pertuzumab, docetaxel) against HER2-positive breast cancer, using TILs as indicators...
  69. Kataoka K, Taniguchi H, Kondoh Y, Nishiyama O, Kimura T, Matsuda T, et al. Recombinant Human Thrombomodulin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Chest. 2015;148:436-443 pubmed publisher
    ..047) was an independent significant determinant for 3-month survival. We found that rhTM therapy improved 3-month survival of AE-IPF. The results observed here warrant further investigation of rhTM in randomized control trials. ..
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    ..These results indicate that EV Ag delivery via DNA vaccination offers a new strategy for eliciting strong CD8+ T cell responses to the encoded Ag, making it a potentially useful cancer vaccine. ..
  71. Agatsuma H, Yoshida K, Yoshino I, Okumura M, Higashiyama M, Suzuki K, et al. Video-Assisted Thoracic Surgery Thymectomy Versus Sternotomy Thymectomy in Patients With Thymoma. Ann Thorac Surg. 2017;104:1047-1053 pubmed publisher
    ..However, additional follow-up is required to evaluate long-term outcomes. ..
  72. Takashima Y, Murakami T, Inoue T, Hagiyama M, Yoneshige A, Nishimura S, et al. Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma. Tumour Biol. 2017;39:1010428317704365 pubmed publisher
    ..These results indicate that osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues. ..
  73. Tabei Y, Murotomi K, Umeno A, Horie M, Tsujino Y, Masutani B, et al. Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway. Food Chem Toxicol. 2017;107:129-137 pubmed publisher
    ..Thus, our study demonstrated that 5H4PB enhanced cellular resistance to oxidative damage via activation of the Nrf2/ARE signaling pathway. ..
  74. Naito N, Nishimura T, Iizuka K, Fujii Y, Takewa Y, Umeki A, et al. Novel Rotational Speed Modulation System Used With Venoarterial Extracorporeal Membrane Oxygenation. Ann Thorac Surg. 2017;104:1488-1495 pubmed publisher
    ..Our system enabled an increase in coronary arterial flow and a decrease in LV work load and afterload during VA-ECMO. The system offers the effects of VA-ECMO and an IABP in a single device. ..
  75. Honjo H, Toh Y, Sohda M, Suzuki S, Kaira K, Kanai Y, et al. Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma. Anticancer Res. 2017;37:4147-4155 pubmed
    ..013) and CD34 (p=0.034) expression, but not with Ki-67 (p=0.078). MTA1 shows promise as a diagnostic and prognostic marker in esophageal cancer, and we anticipate that the gene will also prove to be a good therapeutic target. ..
  76. Takasugi J, Yamagami H, Noguchi T, Morita Y, Tanaka T, Okuno Y, et al. Detection of Left Ventricular Thrombus by Cardiac Magnetic Resonance in Embolic Stroke of Undetermined Source. Stroke. 2017;48:2434-2440 pubmed publisher
    ..URL: Unique identifier: NCT02251665. ..
  77. Mano H, Yoshida W, Shibata K, Zhang S, Koltzenburg M, Kawato M, et al. Thermosensory Perceptual Learning Is Associated with Structural Brain Changes in Parietal-Opercular (SII) Cortex. J Neurosci. 2017;37:9380-9388 pubmed publisher
    ..Furthermore, we show that cold and warm pathways are behaviorally and anatomically dissociable, suggesting that the temperature system has distinct temperature-dependent processing modules. ..
  78. Ichiba T, Hara M, Yunoki K, Urashima M, Naitou H. Serial Follow-Up Evaluation With Computed Tomography After Conservative Medical Treatment in Patients With Symptomatic Spontaneous Isolated Superior Mesenteric Artery Dissection. Vasc Endovascular Surg. 2017;51:538-544 pubmed publisher
    ..There is no detailed information available about trend in the morphological change after conservative medical treatment in patients with symptomatic spontaneous isolated superior mesenteric artery dissection (SISMAD)...
  79. Tsuda Y, Ogura K, Hakozaki M, Kikuta K, Ae K, Tsuchiya H, et al. Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. J Surg Oncol. 2017;115:760-767 pubmed publisher
    ..This study aimed to elucidate the clinical features and prognostic factors of mesenchymal chondrosarcoma (MCS) and investigate optimal treatment strategies...
  80. Takata M, Fukuda H, Kinosada M, Miyake K, Murao K. Use of Simple Neck Extension to Improve Guiding Catheter Accessibility in Tortuous Cervical Internal Carotid Artery for Endovascular Embolization of Intracranial Aneurysm: A Technical Note. World Neurosurg. 2017;105:529-533 pubmed publisher
    ..As the need for safe and highly skilled intervention increases, our technique may be useful because it can reduce procedure-related complications and allow balloon-assisted techniques. ..
  81. Inoue K, Suna S, Iwakura K, Oka T, Masuda M, Furukawa Y, et al. Outcomes for Atrial Fibrillation Patients with Silent Left Atrial Thrombi Detected by Transesophageal Echocardiography. Am J Cardiol. 2017;120:940-946 pubmed publisher
    ..Advanced age and HF were predictors for worse outcomes in AF patients with silent LA thrombi. ..
  82. Tamiya A, Tamiya M, Nakahama K, Taniguchi Y, Shiroyama T, Isa S, et al. Correlation of Radiation Pneumonitis History Before Nivolumab with Onset of Interstitial Lung Disease and Progression-free Survival of Patients with Pre-treated Advanced Non-small Cell Lung Cancer. Anticancer Res. 2017;37:5199-5205 pubmed
    ..023). Although increasing the risk of ILD, a history of radiation pneumonitis before nivolumab also contributes to the prolongation of PFS after nivolumab. ..
  83. Sugiyama Y, Asai K, Yamada K, Kureya Y, Ijiri N, Watanabe T, et al. Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2017;12:765-772 pubmed publisher
    ..05). Decreased serum irisin levels are related to emphysema in patients with COPD and involved in epithelial apoptosis, resulting in emphysema. Irisin could be a novel treatment for emphysema in patients with COPD. ..
  84. Ohuchi H, Miyazaki A, Negishi J, Hayama Y, Nakai M, Nishimura K, et al. Hemodynamic determinants of mortality after Fontan operation. Am Heart J. 2017;189:9-18 pubmed publisher
    ..End-diastolic volume index and EF are associated with mortality only in the earlier cohort, whereas interestingly, elevated cardiac output is associated with increased mortality in the later cohort. ..
  85. Nishigami T, Mibu A, Tanaka K, Yamashita Y, Yamada E, Wand B, et al. Development and psychometric properties of knee-specific body-perception questionnaire in people with knee osteoarthritis: The Fremantle Knee Awareness Questionnaire. PLoS ONE. 2017;12:e0179225 pubmed publisher
    ..We developed FreKAQ-J by modifying the FreBAQ-J. The FreKAQ-J fits the Rasch measurement model well and is suitable for use in people with knee OA. Altered body perception may be worth evaluating when managing people with knee OA. ..
  86. Nakahama K, Isa S, Tamiya A, Taniguchi Y, Shiroyama T, Suzuki H, et al. The Association Between Chemotherapy Immediately Before Nivolumab and Outcomes Thereafter. Anticancer Res. 2017;37:5885-5891 pubmed
    ..9.1%, p=0.02). Achievement of a clinical response to chemotherapy immediately before nivolumab, particularly when combined with bevacizumab, increases the likelihood of disease control post-nivolumab. ..
  87. Shimizu T, Sato T, Tsukiyama K, Fujita H, Kato S, Hoizumi M, et al. Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice. Endocrinology. 2017;158:2134-2144 pubmed publisher
    ..Thus, proper regulation of GIP signaling in the testis could be a potential unique therapeutic target for male infertility in obese and diabetic individuals. ..
  88. Kashiura M, Hamabe Y, Akashi A, Sakurai A, Tahara Y, Yonemoto N, et al. Association between cardiopulmonary resuscitation duration and one-month neurological outcomes for out-of-hospital cardiac arrest: a prospective cohort study. BMC Anesthesiol. 2017;17:59 pubmed publisher
    ..The CPR duration required to achieve return of spontaneous circulation in >99% of out-of-hospital cardiac arrest patients with a 1-month favorable neurological outcome was 45 min, considering both pre- and in-hospital settings. ..
  89. Yamauchi T, Miyagawa S, Yoshikawa Y, Toda K, Sawa Y. Risk Index for Postoperative Acute Kidney Injury After Valvular Surgery Using Cardiopulmonary Bypass. Ann Thorac Surg. 2017;104:868-875 pubmed publisher
    ..86). Based on these risk factors, the study investigators were able to predict the postoperative incidence of renal dysfunction after valvular operations with cardiopulmonary bypass. ..
  90. Suzuki T, Murakami S, Biswal S, Sakaguchi S, Harigae H, Yamamoto M, et al. Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice. Mol Cell Biol. 2017;37: pubmed publisher
    ..This study emphasizes the possible therapeutic application of NRF2 inducers in autoimmune diseases that are accompanied by Treg dysfunction. ..
  91. Okami J, Tokunaga T, Kanou T, Kunou H, Ishida D, Fujiwara A, et al. Randomized Study Comparing Equal Height Staples With Graduated Height Staples in Bronchial Closure. Ann Thorac Surg. 2017;104:1012-1019 pubmed publisher
    ..From the clinical point of view, both the equal height staples and the graduated height staples showed acceptable performance in the stapling ability. ..
  92. Aung T, Ozaki M, Lee M, Schlötzer Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993-1004 pubmed publisher
    ..3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology. ..